AU8134887A - Novel cephalosporin derivatives with improved pharmacokinetics, process for their preparation and pharmaceutical compositions in which they are present - Google Patents

Novel cephalosporin derivatives with improved pharmacokinetics, process for their preparation and pharmaceutical compositions in which they are present

Info

Publication number
AU8134887A
AU8134887A AU81348/87A AU8134887A AU8134887A AU 8134887 A AU8134887 A AU 8134887A AU 81348/87 A AU81348/87 A AU 81348/87A AU 8134887 A AU8134887 A AU 8134887A AU 8134887 A AU8134887 A AU 8134887A
Authority
AU
Australia
Prior art keywords
preparation
pharmaceutical compositions
present
improved pharmacokinetics
cephalosporin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU81348/87A
Other versions
AU597748C (en
AU597748B2 (en
Inventor
Bernard Labeeuw
Dominique Olliero
Gilles Roche
Ali Salhi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of AU8134887A publication Critical patent/AU8134887A/en
Application granted granted Critical
Publication of AU597748B2 publication Critical patent/AU597748B2/en
Publication of AU597748C publication Critical patent/AU597748C/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Derivatives corresponding to the general formula: <IMAGE> in which: - R1, R2 and R3 denote H, or R1 and R2 denote H or CH3 and R3 = COOH or else <IMAGE> form a cyclobutyl group and R3 = COOH; - A and B are different and occupy the meta and para positions of the benzene nucleus; one denotes a hydroxyl group and the other is chosen from the groups <IMAGE> and the pharmaceutically acceptable salts and esters of the said derivatives. Use in therapeutics.
AU81348/87A 1986-11-20 1987-11-18 Novel cephalosporin derivatives with improved pharmacokinetics, process for their preparation and pharmaceutical compositions in which they are present Ceased AU597748C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8616175 1986-11-20
FR8616175A FR2607135B1 (en) 1986-11-20 1986-11-20 NOVEL CEPHALOSPORINS DERIVATIVES WITH IMPROVED PHARMACOKINETICS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (3)

Publication Number Publication Date
AU8134887A true AU8134887A (en) 1988-05-26
AU597748B2 AU597748B2 (en) 1990-06-07
AU597748C AU597748C (en) 1991-03-28

Family

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Also Published As

Publication number Publication date
EP0269512A1 (en) 1988-06-01
NZ222593A (en) 1989-04-26
ES2038997T3 (en) 1993-08-16
ZA878710B (en) 1988-05-20
DK611987D0 (en) 1987-11-20
EP0269512B1 (en) 1991-09-11
DK611987A (en) 1988-05-21
PT86164B (en) 1990-11-20
FR2607135B1 (en) 1989-04-28
FR2607135A1 (en) 1988-05-27
DE3772936D1 (en) 1991-10-17
GR3002769T3 (en) 1993-01-25
KR880006251A (en) 1988-07-22
JPS63141985A (en) 1988-06-14
PT86164A (en) 1987-12-01
ATE67208T1 (en) 1991-09-15
IL84539A (en) 1992-12-01
IL84539A0 (en) 1988-04-29
AU597748B2 (en) 1990-06-07

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