ZA878710B - Cephalosporin derivatives with improved pharmacokinetics process for their preparation and pharmaceutical compositions in which they are present - Google Patents

Cephalosporin derivatives with improved pharmacokinetics process for their preparation and pharmaceutical compositions in which they are present

Info

Publication number
ZA878710B
ZA878710B ZA878710A ZA878710A ZA878710B ZA 878710 B ZA878710 B ZA 878710B ZA 878710 A ZA878710 A ZA 878710A ZA 878710 A ZA878710 A ZA 878710A ZA 878710 B ZA878710 B ZA 878710B
Authority
ZA
South Africa
Prior art keywords
preparation
pharmaceutical compositions
present
improved pharmacokinetics
cephalosporin derivatives
Prior art date
Application number
ZA878710A
Inventor
Olliero Dominique
Labeeuw Bernarl
Roche Gilles
Salhi Ali
Original Assignee
Societe Anonyme: Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe Anonyme: Sanofi filed Critical Societe Anonyme: Sanofi
Publication of ZA878710B publication Critical patent/ZA878710B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivatives corresponding to the general formula: <IMAGE> in which: - R1, R2 and R3 denote H, or R1 and R2 denote H or CH3 and R3 = COOH or else <IMAGE> form a cyclobutyl group and R3 = COOH; - A and B are different and occupy the meta and para positions of the benzene nucleus; one denotes a hydroxyl group and the other is chosen from the groups <IMAGE> and the pharmaceutically acceptable salts and esters of the said derivatives. Use in therapeutics.
ZA878710A 1986-11-20 1987-11-20 Cephalosporin derivatives with improved pharmacokinetics process for their preparation and pharmaceutical compositions in which they are present ZA878710B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8616175A FR2607135B1 (en) 1986-11-20 1986-11-20 NOVEL CEPHALOSPORINS DERIVATIVES WITH IMPROVED PHARMACOKINETICS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
ZA878710B true ZA878710B (en) 1988-05-20

Family

ID=9341024

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA878710A ZA878710B (en) 1986-11-20 1987-11-20 Cephalosporin derivatives with improved pharmacokinetics process for their preparation and pharmaceutical compositions in which they are present

Country Status (13)

Country Link
EP (1) EP0269512B1 (en)
JP (1) JPS63141985A (en)
KR (1) KR880006251A (en)
AT (1) ATE67208T1 (en)
DE (1) DE3772936D1 (en)
DK (1) DK611987A (en)
ES (1) ES2038997T3 (en)
FR (1) FR2607135B1 (en)
GR (1) GR3002769T3 (en)
IL (1) IL84539A (en)
NZ (1) NZ222593A (en)
PT (1) PT86164B (en)
ZA (1) ZA878710B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2621589B1 (en) * 1987-10-08 1990-03-02 Sanofi Sa CEPHALOSPORIN DERIVATIVES WITH IMPROVED PHARMACOKINETICS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5189157A (en) * 1987-06-16 1993-02-23 Hoffmann La Roche Inc. Antibacterial cephalosporin compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2546520B1 (en) * 1983-05-27 1985-08-30 Sanofi Sa NOVEL ANTIBIOTIC COMPOUNDS DERIVED FROM CEPHALOSPORINS
FR2570702B1 (en) * 1984-09-27 1987-01-09 Sanofi Sa CEPHALOSPORIN DERIVATIVES, PROCESSES FOR OBTAINING THEM AND THEIR APPLICATION AS ANTIBIOTICS

Also Published As

Publication number Publication date
EP0269512A1 (en) 1988-06-01
NZ222593A (en) 1989-04-26
AU8134887A (en) 1988-05-26
ES2038997T3 (en) 1993-08-16
DK611987D0 (en) 1987-11-20
EP0269512B1 (en) 1991-09-11
DK611987A (en) 1988-05-21
PT86164B (en) 1990-11-20
FR2607135B1 (en) 1989-04-28
FR2607135A1 (en) 1988-05-27
DE3772936D1 (en) 1991-10-17
GR3002769T3 (en) 1993-01-25
KR880006251A (en) 1988-07-22
JPS63141985A (en) 1988-06-14
PT86164A (en) 1987-12-01
ATE67208T1 (en) 1991-09-15
IL84539A (en) 1992-12-01
IL84539A0 (en) 1988-04-29
AU597748B2 (en) 1990-06-07

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