JPS5668665A - Thioamide derivative and its salt - Google Patents
Thioamide derivative and its saltInfo
- Publication number
- JPS5668665A JPS5668665A JP14505679A JP14505679A JPS5668665A JP S5668665 A JPS5668665 A JP S5668665A JP 14505679 A JP14505679 A JP 14505679A JP 14505679 A JP14505679 A JP 14505679A JP S5668665 A JPS5668665 A JP S5668665A
- Authority
- JP
- Japan
- Prior art keywords
- hypertension
- compound
- formula
- salt
- pref
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formula I (R is H or lower alkyl) or its salt.
EXAMPLE: 1,1'-[3,3'-Dithiobis[(2R)-2-methyl-2-thiopropionyl]]-bis(L-proline).
USE: Remedy for hypertension, having low toxicity, excellent suppressing activity to angiotensin I converting enzyme, and useful for the remedy of essential hypertension renal hypertension and malignant hypertension. Dose: 10W1,500mg daily for adult in one to several doses.
PROCESS: The compound of formula I is prepared, e.g. by reacting a compound of formula II (X is reactive atom or group such as Cl, alkoxy, alkylthio, benzylthio, etc.) with proline in a solvent such as water, methanol, etc., pref. in the presence of a base such as K2CO3 at 0W150°C. The Schotten-Baumann reaction is pref. used when X is Cl.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14505679A JPS5668665A (en) | 1979-11-08 | 1979-11-08 | Thioamide derivative and its salt |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14505679A JPS5668665A (en) | 1979-11-08 | 1979-11-08 | Thioamide derivative and its salt |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5668665A true JPS5668665A (en) | 1981-06-09 |
Family
ID=15376353
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14505679A Pending JPS5668665A (en) | 1979-11-08 | 1979-11-08 | Thioamide derivative and its salt |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5668665A (en) |
-
1979
- 1979-11-08 JP JP14505679A patent/JPS5668665A/en active Pending
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