JPS5668665A - Thioamide derivative and its salt - Google Patents

Thioamide derivative and its salt

Info

Publication number
JPS5668665A
JPS5668665A JP14505679A JP14505679A JPS5668665A JP S5668665 A JPS5668665 A JP S5668665A JP 14505679 A JP14505679 A JP 14505679A JP 14505679 A JP14505679 A JP 14505679A JP S5668665 A JPS5668665 A JP S5668665A
Authority
JP
Japan
Prior art keywords
hypertension
compound
formula
salt
pref
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14505679A
Other languages
Japanese (ja)
Inventor
Tomohiko Munakata
Nobunao Tsuda
Masahiro Yatabe
Osamu Murakami
Kunio Osuge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to JP14505679A priority Critical patent/JPS5668665A/en
Publication of JPS5668665A publication Critical patent/JPS5668665A/en
Pending legal-status Critical Current

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  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I (R is H or lower alkyl) or its salt.
EXAMPLE: 1,1'-[3,3'-Dithiobis[(2R)-2-methyl-2-thiopropionyl]]-bis(L-proline).
USE: Remedy for hypertension, having low toxicity, excellent suppressing activity to angiotensin I converting enzyme, and useful for the remedy of essential hypertension renal hypertension and malignant hypertension. Dose: 10W1,500mg daily for adult in one to several doses.
PROCESS: The compound of formula I is prepared, e.g. by reacting a compound of formula II (X is reactive atom or group such as Cl, alkoxy, alkylthio, benzylthio, etc.) with proline in a solvent such as water, methanol, etc., pref. in the presence of a base such as K2CO3 at 0W150°C. The Schotten-Baumann reaction is pref. used when X is Cl.
COPYRIGHT: (C)1981,JPO&Japio
JP14505679A 1979-11-08 1979-11-08 Thioamide derivative and its salt Pending JPS5668665A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14505679A JPS5668665A (en) 1979-11-08 1979-11-08 Thioamide derivative and its salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14505679A JPS5668665A (en) 1979-11-08 1979-11-08 Thioamide derivative and its salt

Publications (1)

Publication Number Publication Date
JPS5668665A true JPS5668665A (en) 1981-06-09

Family

ID=15376353

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14505679A Pending JPS5668665A (en) 1979-11-08 1979-11-08 Thioamide derivative and its salt

Country Status (1)

Country Link
JP (1) JPS5668665A (en)

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