JPS5649399A - Preparation of adenosine-3',5'-cyclic phosphoric acid alkyl triester - Google Patents

Preparation of adenosine-3',5'-cyclic phosphoric acid alkyl triester

Info

Publication number
JPS5649399A
JPS5649399A JP10228279A JP10228279A JPS5649399A JP S5649399 A JPS5649399 A JP S5649399A JP 10228279 A JP10228279 A JP 10228279A JP 10228279 A JP10228279 A JP 10228279A JP S5649399 A JPS5649399 A JP S5649399A
Authority
JP
Japan
Prior art keywords
adenosine
dissolved
base
water
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10228279A
Other languages
English (en)
Other versions
JPS6023120B2 (ja
Inventor
Nobuyuki Yamatsugu
Motohiko Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kikkoman Corp
Original Assignee
Kikkoman Corp
Kikkoman Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kikkoman Corp, Kikkoman Shoyu KK filed Critical Kikkoman Corp
Priority to JP54102282A priority Critical patent/JPS6023120B2/ja
Publication of JPS5649399A publication Critical patent/JPS5649399A/ja
Priority to US06/317,282 priority patent/US4401808A/en
Publication of JPS6023120B2 publication Critical patent/JPS6023120B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP54102282A 1979-08-13 1979-08-13 アデノシン−３′，５′−環状リン酸アルキルトリエステルの製造法 Expired JPS6023120B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP54102282A JPS6023120B2 (ja) 1979-08-13 1979-08-13 アデノシン−３′，５′−環状リン酸アルキルトリエステルの製造法
US06/317,282 US4401808A (en) 1979-08-13 1981-11-02 Adenosine cyclic 3',5'-phosphate triesters and the acid addition salts thereof, and process for production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54102282A JPS6023120B2 (ja) 1979-08-13 1979-08-13 アデノシン−３′，５′−環状リン酸アルキルトリエステルの製造法

Publications (2)

Publication Number Publication Date
JPS5649399A true JPS5649399A (en) 1981-05-02
JPS6023120B2 JPS6023120B2 (ja) 1985-06-05

Family

ID=14323243

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54102282A Expired JPS6023120B2 (ja) 1979-08-13 1979-08-13 アデノシン−３′，５′−環状リン酸アルキルトリエステルの製造法

Country Status (2)

Country Link
US (1) US4401808A (ja)
JP (1) JPS6023120B2 (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559102A (en) * 1988-08-16 1996-09-24 Nippon Shinyaku Company, Limited Adenosine and guanosine-3'-5'-cyclic methylphosphonate derivatives
EP0355899B1 (en) * 1988-08-16 1994-11-02 Nippon Shinyaku Company, Limited Nucleotide derivatives
US6989386B2 (en) * 2002-04-30 2006-01-24 Dana-Farber Cancer Institute Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same
CN106459127A (zh) * 2014-05-28 2017-02-22 艾登尼克斯药业有限公司 用于治疗癌症的核苷衍生物
WO2019139920A1 (en) 2018-01-10 2019-07-18 Nucorion Pharmaceuticals, Inc. Phosphor(n)amidatacetal and phosph(on)atalcetal compounds
US11427550B2 (en) 2018-01-19 2022-08-30 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
EP3966221A4 (en) * 2019-04-22 2023-05-24 Ligand Pharmaceuticals, Inc. CYCLIC PHOSPHATE COMPOUNDS
US12110311B2 (en) 2019-07-17 2024-10-08 Nucorion Pharmaceuticals, Inc. Cyclic deoxyribonucleotide compounds
WO2021216427A1 (en) 2020-04-21 2021-10-28 Ligand Pharmaceuticals, Inc. Nucleotide prodrug compounds
US20240294565A1 (en) * 2021-05-17 2024-09-05 Ligand Pharmaceuticals Incorporated Unnatural configuration nucleotide prodrug compounds

Also Published As

Publication number Publication date
JPS6023120B2 (ja) 1985-06-05
US4401808A (en) 1983-08-30

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