JPS56128773A - Anilinomethylenemalonic ester derivative and its preparation - Google Patents
Anilinomethylenemalonic ester derivative and its preparationInfo
- Publication number
- JPS56128773A JPS56128773A JP3236880A JP3236880A JPS56128773A JP S56128773 A JPS56128773 A JP S56128773A JP 3236880 A JP3236880 A JP 3236880A JP 3236880 A JP3236880 A JP 3236880A JP S56128773 A JPS56128773 A JP S56128773A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- lower alkyl
- anilinomethylenemalonic
- ester derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:An anilinomethylenemalonic ester derivative expressed by formula I (R1 is lower alkyl; R2 is lower alkyl or acyl; X and X1 are H or halogen; however, are not H at the same time).
EXAMPLE: N-(2,2-Diethoxycarbonylvinyl)-4-fluoro-3-(4-acetyl-1-piperazinyl)aniline.
USE: An intermediate for a quinolone carboxylic acid derivative useful as an antimicrobial agent.
PROCESS: A novel aniline derivative of formula II is reacted with a malonic acid derivative of formula III (R3 is lower alkyl), preferably at room temperature to 180°C, to give the compound of formula I. A compound useful as an antimicrobial agent of formula IV (R4 is alkyl which may have a substituent, e.g. OH or an unsaturated bond; R5 is H or R2) can be synthesized from the resultant compound. The compound of formula II can be synthesized from o-fluorophenylpiperazine as a starting material.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3236880A JPS56128773A (en) | 1980-03-14 | 1980-03-14 | Anilinomethylenemalonic ester derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3236880A JPS56128773A (en) | 1980-03-14 | 1980-03-14 | Anilinomethylenemalonic ester derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56128773A true JPS56128773A (en) | 1981-10-08 |
JPS642108B2 JPS642108B2 (en) | 1989-01-13 |
Family
ID=12356997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3236880A Granted JPS56128773A (en) | 1980-03-14 | 1980-03-14 | Anilinomethylenemalonic ester derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56128773A (en) |
-
1980
- 1980-03-14 JP JP3236880A patent/JPS56128773A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS642108B2 (en) | 1989-01-13 |
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