JPS56128773A - Anilinomethylenemalonic ester derivative and its preparation - Google Patents

Anilinomethylenemalonic ester derivative and its preparation

Info

Publication number
JPS56128773A
JPS56128773A JP3236880A JP3236880A JPS56128773A JP S56128773 A JPS56128773 A JP S56128773A JP 3236880 A JP3236880 A JP 3236880A JP 3236880 A JP3236880 A JP 3236880A JP S56128773 A JPS56128773 A JP S56128773A
Authority
JP
Japan
Prior art keywords
formula
compound
lower alkyl
anilinomethylenemalonic
ester derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3236880A
Other languages
Japanese (ja)
Other versions
JPS642108B2 (en
Inventor
Tsutomu Irikura
Seigo Suzue
Hiroshi Koga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Priority to JP3236880A priority Critical patent/JPS56128773A/en
Publication of JPS56128773A publication Critical patent/JPS56128773A/en
Publication of JPS642108B2 publication Critical patent/JPS642108B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:An anilinomethylenemalonic ester derivative expressed by formula I (R1 is lower alkyl; R2 is lower alkyl or acyl; X and X1 are H or halogen; however, are not H at the same time).
EXAMPLE: N-(2,2-Diethoxycarbonylvinyl)-4-fluoro-3-(4-acetyl-1-piperazinyl)aniline.
USE: An intermediate for a quinolone carboxylic acid derivative useful as an antimicrobial agent.
PROCESS: A novel aniline derivative of formula II is reacted with a malonic acid derivative of formula III (R3 is lower alkyl), preferably at room temperature to 180°C, to give the compound of formula I. A compound useful as an antimicrobial agent of formula IV (R4 is alkyl which may have a substituent, e.g. OH or an unsaturated bond; R5 is H or R2) can be synthesized from the resultant compound. The compound of formula II can be synthesized from o-fluorophenylpiperazine as a starting material.
COPYRIGHT: (C)1981,JPO&Japio
JP3236880A 1980-03-14 1980-03-14 Anilinomethylenemalonic ester derivative and its preparation Granted JPS56128773A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3236880A JPS56128773A (en) 1980-03-14 1980-03-14 Anilinomethylenemalonic ester derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3236880A JPS56128773A (en) 1980-03-14 1980-03-14 Anilinomethylenemalonic ester derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS56128773A true JPS56128773A (en) 1981-10-08
JPS642108B2 JPS642108B2 (en) 1989-01-13

Family

ID=12356997

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3236880A Granted JPS56128773A (en) 1980-03-14 1980-03-14 Anilinomethylenemalonic ester derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS56128773A (en)

Also Published As

Publication number Publication date
JPS642108B2 (en) 1989-01-13

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