JPS56128740A - Preparation of erythro-2-amino-1-phenylpropanol derivative - Google Patents

Preparation of erythro-2-amino-1-phenylpropanol derivative

Info

Publication number
JPS56128740A
JPS56128740A JP3168080A JP3168080A JPS56128740A JP S56128740 A JPS56128740 A JP S56128740A JP 3168080 A JP3168080 A JP 3168080A JP 3168080 A JP3168080 A JP 3168080A JP S56128740 A JPS56128740 A JP S56128740A
Authority
JP
Japan
Prior art keywords
derivative
erythro
amino
aminopropiophenone
threo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3168080A
Other languages
Japanese (ja)
Other versions
JPS6261019B2 (en
Inventor
Kazuo Kikazawa
Mineji Hiiragi
Nagatoshi Azuma
Toshitaka Kohagisawa
Hitoshi Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Priority to JP3168080A priority Critical patent/JPS56128740A/en
Publication of JPS56128740A publication Critical patent/JPS56128740A/en
Publication of JPS6261019B2 publication Critical patent/JPS6261019B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled erythro-derivative, useful as pharmaceuticals for the circulatory system, exclusively, in high selectivity, easily, and economically, by reducing an α-aminopropiophenone derivative in the form of salt or in the presence of an acidic substance, with HaBH4.
CONSTITUTION: An α-aminopropiophenone derivative of formula I (X is H, OH, benzyloxy, or halogen; R1 and R2 are H, 1W6C alkyl, aralkyl, or R1 and R2 together with a 4W6C group form a nitrogen-containing ring) is reduced in the form of salt or in the presence of an acidic substance (e.g. hydrochloric acid, acetic acid, etc.) with NaBH4 to give erythro-2-amino-1-phenylpropanol derivative of formula II.
EFFECT: The reduction of the hydrochloride of the propiophenone derivative gives the erythro-isomer in an extremely high selectively (erythro/threo is 96.6%/0.2%), in contrast with the reduction of the derivative in the form of free base, in which the ratio of the threo-isomer or the undesirable type of the steric isomers, becomes high.
COPYRIGHT: (C)1981,JPO&Japio
JP3168080A 1980-03-14 1980-03-14 Preparation of erythro-2-amino-1-phenylpropanol derivative Granted JPS56128740A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3168080A JPS56128740A (en) 1980-03-14 1980-03-14 Preparation of erythro-2-amino-1-phenylpropanol derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3168080A JPS56128740A (en) 1980-03-14 1980-03-14 Preparation of erythro-2-amino-1-phenylpropanol derivative

Publications (2)

Publication Number Publication Date
JPS56128740A true JPS56128740A (en) 1981-10-08
JPS6261019B2 JPS6261019B2 (en) 1987-12-18

Family

ID=12337812

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3168080A Granted JPS56128740A (en) 1980-03-14 1980-03-14 Preparation of erythro-2-amino-1-phenylpropanol derivative

Country Status (1)

Country Link
JP (1) JPS56128740A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0387605A2 (en) * 1989-03-15 1990-09-19 Bayer Ag Process for the stereoselective preparation of optically active S,S or R,R-beta-aminoalcohols
JP2004043433A (en) * 2002-04-26 2004-02-12 Kitai Kagi Kofun Yugenkoshi Morpholinoketone derivative and its use

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08329441A (en) * 1996-06-17 1996-12-13 Hitachi Ltd Polishing method of floating face of magnetic head slider

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4985035A (en) * 1972-09-07 1974-08-15
JPS51141829A (en) * 1975-06-02 1976-12-07 Yoshitomi Pharmaceut Ind Ltd Process for preparing aminoalcohol derivatives.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4985035A (en) * 1972-09-07 1974-08-15
JPS51141829A (en) * 1975-06-02 1976-12-07 Yoshitomi Pharmaceut Ind Ltd Process for preparing aminoalcohol derivatives.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0387605A2 (en) * 1989-03-15 1990-09-19 Bayer Ag Process for the stereoselective preparation of optically active S,S or R,R-beta-aminoalcohols
JP2004043433A (en) * 2002-04-26 2004-02-12 Kitai Kagi Kofun Yugenkoshi Morpholinoketone derivative and its use

Also Published As

Publication number Publication date
JPS6261019B2 (en) 1987-12-18

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