JPS56128740A - Preparation of erythro-2-amino-1-phenylpropanol derivative - Google Patents
Preparation of erythro-2-amino-1-phenylpropanol derivativeInfo
- Publication number
- JPS56128740A JPS56128740A JP3168080A JP3168080A JPS56128740A JP S56128740 A JPS56128740 A JP S56128740A JP 3168080 A JP3168080 A JP 3168080A JP 3168080 A JP3168080 A JP 3168080A JP S56128740 A JPS56128740 A JP S56128740A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- erythro
- amino
- aminopropiophenone
- threo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To obtain the titled erythro-derivative, useful as pharmaceuticals for the circulatory system, exclusively, in high selectivity, easily, and economically, by reducing an α-aminopropiophenone derivative in the form of salt or in the presence of an acidic substance, with HaBH4.
CONSTITUTION: An α-aminopropiophenone derivative of formula I (X is H, OH, benzyloxy, or halogen; R1 and R2 are H, 1W6C alkyl, aralkyl, or R1 and R2 together with a 4W6C group form a nitrogen-containing ring) is reduced in the form of salt or in the presence of an acidic substance (e.g. hydrochloric acid, acetic acid, etc.) with NaBH4 to give erythro-2-amino-1-phenylpropanol derivative of formula II.
EFFECT: The reduction of the hydrochloride of the propiophenone derivative gives the erythro-isomer in an extremely high selectively (erythro/threo is 96.6%/0.2%), in contrast with the reduction of the derivative in the form of free base, in which the ratio of the threo-isomer or the undesirable type of the steric isomers, becomes high.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3168080A JPS56128740A (en) | 1980-03-14 | 1980-03-14 | Preparation of erythro-2-amino-1-phenylpropanol derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3168080A JPS56128740A (en) | 1980-03-14 | 1980-03-14 | Preparation of erythro-2-amino-1-phenylpropanol derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56128740A true JPS56128740A (en) | 1981-10-08 |
JPS6261019B2 JPS6261019B2 (en) | 1987-12-18 |
Family
ID=12337812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3168080A Granted JPS56128740A (en) | 1980-03-14 | 1980-03-14 | Preparation of erythro-2-amino-1-phenylpropanol derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56128740A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0387605A2 (en) * | 1989-03-15 | 1990-09-19 | Bayer Ag | Process for the stereoselective preparation of optically active S,S or R,R-beta-aminoalcohols |
JP2004043433A (en) * | 2002-04-26 | 2004-02-12 | Kitai Kagi Kofun Yugenkoshi | Morpholinoketone derivative and its use |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08329441A (en) * | 1996-06-17 | 1996-12-13 | Hitachi Ltd | Polishing method of floating face of magnetic head slider |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4985035A (en) * | 1972-09-07 | 1974-08-15 | ||
JPS51141829A (en) * | 1975-06-02 | 1976-12-07 | Yoshitomi Pharmaceut Ind Ltd | Process for preparing aminoalcohol derivatives. |
-
1980
- 1980-03-14 JP JP3168080A patent/JPS56128740A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4985035A (en) * | 1972-09-07 | 1974-08-15 | ||
JPS51141829A (en) * | 1975-06-02 | 1976-12-07 | Yoshitomi Pharmaceut Ind Ltd | Process for preparing aminoalcohol derivatives. |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0387605A2 (en) * | 1989-03-15 | 1990-09-19 | Bayer Ag | Process for the stereoselective preparation of optically active S,S or R,R-beta-aminoalcohols |
JP2004043433A (en) * | 2002-04-26 | 2004-02-12 | Kitai Kagi Kofun Yugenkoshi | Morpholinoketone derivative and its use |
Also Published As
Publication number | Publication date |
---|---|
JPS6261019B2 (en) | 1987-12-18 |
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