JPS57139060A - Prostaglandin derivative and its preparation - Google Patents
Prostaglandin derivative and its preparationInfo
- Publication number
- JPS57139060A JPS57139060A JP2297481A JP2297481A JPS57139060A JP S57139060 A JPS57139060 A JP S57139060A JP 2297481 A JP2297481 A JP 2297481A JP 2297481 A JP2297481 A JP 2297481A JP S57139060 A JPS57139060 A JP S57139060A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- give
- compound
- derivative
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A compound shown by the formulaI[R1 is H, lower alkyl; Y is a group shown by the formula X (R2 is H, tetrahydropyranyl, tertiary butyldimethylsilyl), a group shown by the formula XI (R3 and R4 are H, OH)].
EXAMPLE: A compound shown by the formula XII.
USE: A drug, or an agent for animals.
PROCESS: A compound shown by the formula II is reduced with 3.5W4.5mol equivalent diisobutyl aluminum hydride to give an alcohol derivative (e.g., trans- 1-cyanomethyl-2-hydroxymethylbicyclo[2,2,1]heptane, etc.) shown by the formula III, which is oxidized with dimethyl sulfide and an N-halogenated succinic acid to give an aldehyde derivative shown by the formula IV. This derivative is then reacted with 2-oxopentyl photosphonate in the presence of a base to give a compound shown by the formula V, which is reduced, the OH group is protected, and the compound is reduced to give an aldehyde derivative shown by the formula VIII. This derivative is reacted with 4-carboxybutyltriphosphonium compound to give a compound shown by the formula IX, which is treated with an acid and the group R2 is removed, to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2297481A JPS57139060A (en) | 1981-02-20 | 1981-02-20 | Prostaglandin derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2297481A JPS57139060A (en) | 1981-02-20 | 1981-02-20 | Prostaglandin derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57139060A true JPS57139060A (en) | 1982-08-27 |
Family
ID=12097528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2297481A Pending JPS57139060A (en) | 1981-02-20 | 1981-02-20 | Prostaglandin derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57139060A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2572725A1 (en) * | 1984-11-08 | 1986-05-09 | Squibb & Sons Inc | BICYCLOHEPTANE-SUBSTITUTED ETHERS WITH THERAPEUTIC ACTION |
-
1981
- 1981-02-20 JP JP2297481A patent/JPS57139060A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2572725A1 (en) * | 1984-11-08 | 1986-05-09 | Squibb & Sons Inc | BICYCLOHEPTANE-SUBSTITUTED ETHERS WITH THERAPEUTIC ACTION |
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