JPS57139060A - Prostaglandin derivative and its preparation - Google Patents

Prostaglandin derivative and its preparation

Info

Publication number
JPS57139060A
JPS57139060A JP2297481A JP2297481A JPS57139060A JP S57139060 A JPS57139060 A JP S57139060A JP 2297481 A JP2297481 A JP 2297481A JP 2297481 A JP2297481 A JP 2297481A JP S57139060 A JPS57139060 A JP S57139060A
Authority
JP
Japan
Prior art keywords
formula
give
compound
derivative
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2297481A
Other languages
Japanese (ja)
Inventor
Tetsuji Kametani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SENDAI FUKUSOKAN KAGAKU KENKYU
SENDAI FUKUSOKAN KAGAKU KENKYUSHO
Original Assignee
SENDAI FUKUSOKAN KAGAKU KENKYU
SENDAI FUKUSOKAN KAGAKU KENKYUSHO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SENDAI FUKUSOKAN KAGAKU KENKYU, SENDAI FUKUSOKAN KAGAKU KENKYUSHO filed Critical SENDAI FUKUSOKAN KAGAKU KENKYU
Priority to JP2297481A priority Critical patent/JPS57139060A/en
Publication of JPS57139060A publication Critical patent/JPS57139060A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound shown by the formulaI[R1 is H, lower alkyl; Y is a group shown by the formula X (R2 is H, tetrahydropyranyl, tertiary butyldimethylsilyl), a group shown by the formula XI (R3 and R4 are H, OH)].
EXAMPLE: A compound shown by the formula XII.
USE: A drug, or an agent for animals.
PROCESS: A compound shown by the formula II is reduced with 3.5W4.5mol equivalent diisobutyl aluminum hydride to give an alcohol derivative (e.g., trans- 1-cyanomethyl-2-hydroxymethylbicyclo[2,2,1]heptane, etc.) shown by the formula III, which is oxidized with dimethyl sulfide and an N-halogenated succinic acid to give an aldehyde derivative shown by the formula IV. This derivative is then reacted with 2-oxopentyl photosphonate in the presence of a base to give a compound shown by the formula V, which is reduced, the OH group is protected, and the compound is reduced to give an aldehyde derivative shown by the formula VIII. This derivative is reacted with 4-carboxybutyltriphosphonium compound to give a compound shown by the formula IX, which is treated with an acid and the group R2 is removed, to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP2297481A 1981-02-20 1981-02-20 Prostaglandin derivative and its preparation Pending JPS57139060A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2297481A JPS57139060A (en) 1981-02-20 1981-02-20 Prostaglandin derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2297481A JPS57139060A (en) 1981-02-20 1981-02-20 Prostaglandin derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS57139060A true JPS57139060A (en) 1982-08-27

Family

ID=12097528

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2297481A Pending JPS57139060A (en) 1981-02-20 1981-02-20 Prostaglandin derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS57139060A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2572725A1 (en) * 1984-11-08 1986-05-09 Squibb & Sons Inc BICYCLOHEPTANE-SUBSTITUTED ETHERS WITH THERAPEUTIC ACTION

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2572725A1 (en) * 1984-11-08 1986-05-09 Squibb & Sons Inc BICYCLOHEPTANE-SUBSTITUTED ETHERS WITH THERAPEUTIC ACTION

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