JPS56127379A - Hydantoin amine compound - Google Patents
Hydantoin amine compoundInfo
- Publication number
- JPS56127379A JPS56127379A JP1886581A JP1886581A JPS56127379A JP S56127379 A JPS56127379 A JP S56127379A JP 1886581 A JP1886581 A JP 1886581A JP 1886581 A JP1886581 A JP 1886581A JP S56127379 A JPS56127379 A JP S56127379A
- Authority
- JP
- Japan
- Prior art keywords
- compounds
- hydantoin
- analogs
- amino
- amine compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/120,944 US4248882A (en) | 1980-02-12 | 1980-02-12 | Treating diabetes-associated complications with hydantoin amines |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56127379A true JPS56127379A (en) | 1981-10-06 |
JPS6237636B2 JPS6237636B2 (ja) | 1987-08-13 |
Family
ID=22393428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1886581A Granted JPS56127379A (en) | 1980-02-12 | 1981-02-10 | Hydantoin amine compound |
Country Status (8)
Country | Link |
---|---|
US (1) | US4248882A (ja) |
EP (1) | EP0034063B1 (ja) |
JP (1) | JPS56127379A (ja) |
AT (1) | ATE3865T1 (ja) |
DE (1) | DE3160449D1 (ja) |
DK (1) | DK156400C (ja) |
GR (1) | GR73856B (ja) |
IE (1) | IE50895B1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61197581A (ja) * | 1985-02-26 | 1986-09-01 | Eisai Co Ltd | ヒダントイン誘導体 |
JPS63126881A (ja) * | 1986-11-14 | 1988-05-30 | Sanwa Kagaku Kenkyusho Co Ltd | ヒダントイン誘導体、その塩、これらの製法並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤 |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4490381A (en) * | 1979-11-13 | 1984-12-25 | Imperial Chemical Industries Plc | 1'-Substituted spiro[imidazolidine-4,3'-indoline]2,2',5-triones |
ATE10940T1 (de) * | 1981-05-12 | 1985-01-15 | Imperial Chemical Industries Plc | Pyrrolderivate. |
US4556670A (en) * | 1982-12-06 | 1985-12-03 | Pfizer Inc. | Spiro-3-hetero-azolones for treatment of diabetic complications |
US4474967A (en) * | 1983-04-27 | 1984-10-02 | Pfizer Inc. | 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione |
US4464380A (en) * | 1983-05-25 | 1984-08-07 | Pfizer Inc. | Imidazolidinedione derivatives |
DK277484A (da) * | 1983-06-23 | 1984-12-24 | Hoffmann La Roche | Thiazolidinderivater |
ATE56007T1 (de) * | 1984-06-22 | 1990-09-15 | Beecham Group Plc | Wirksame benzopyranverbindungen. |
US4680306A (en) * | 1984-07-20 | 1987-07-14 | Pfizer Inc. | Sprio-imidazolones for treatment of diabetes complications |
ATE37371T1 (de) * | 1984-08-20 | 1988-10-15 | Pfizer | Verfahren zur herstellung asymmetrischer hydantoine. |
US4966911A (en) * | 1984-11-20 | 1990-10-30 | Washington Research Foundation | Immunoregulatory agents |
US5340829A (en) * | 1984-11-20 | 1994-08-23 | Washington Research Foundation | Immunoregulatory agents |
US4575507A (en) * | 1985-05-29 | 1986-03-11 | Pfizer Inc. | Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use |
US4762839A (en) * | 1985-06-06 | 1988-08-09 | Tanabe Seiyaku Co., Ltd. | Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications |
JPS63132889A (ja) * | 1986-11-21 | 1988-06-04 | Tanabe Seiyaku Co Ltd | キナゾリノン誘導体 |
HU204832B (en) * | 1987-09-04 | 1992-02-28 | Pfizer | Process for producing spiro-(imidazolidine-4,4'-pyrano/2,3-b/pyridine) derivatives and pharmaceutical compositions comprising same |
US4952694A (en) * | 1988-07-27 | 1990-08-28 | Pfizer Inc. | Novel resolution process for racemic spiro-hydantoins |
EP0536119A4 (en) * | 1989-02-10 | 1993-08-04 | Washington Research Foundation | Immunoregulatory agents |
JP2678499B2 (ja) * | 1989-08-09 | 1997-11-17 | 日本臓器製薬 株式会社 | 尿毒症毒素低下剤 |
JPH03215435A (ja) * | 1990-01-12 | 1991-09-20 | Sanwa Kagaku Kenkyusho Co Ltd | アルドース還元酵素阻害剤を主成分とする潰瘍治療剤 |
UA76984C2 (en) * | 2001-04-05 | 2006-10-16 | Nissan Chemical Ind Ltd | A method for preparing a 7-qunolinyl-3,5-dihydroxyhept-6-enoate |
JP2006504701A (ja) * | 2002-09-30 | 2006-02-09 | マーク・エー・バビザイェフ | 眼疾患の局所的治療方法、並びに、その治療用組成物及び治療用手段 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1135915B (de) * | 1961-06-29 | 1962-09-06 | Asta Werke Ag Chem Fab | Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine |
US3534037A (en) * | 1968-05-10 | 1970-10-13 | Smithkline Corp | Spiro-(imidazolidine and pyrimidine-quinoline and cyclopropa(c)quinoline) compounds |
US3821383A (en) * | 1972-07-10 | 1974-06-28 | Ayerst Mckenna & Harrison | Compositions for and a method of treating diabetic complications |
US4117230A (en) * | 1976-10-18 | 1978-09-26 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
US4130714A (en) * | 1977-05-23 | 1978-12-19 | Pfizer Inc. | Hydantoin therapeutic agents |
US4177282A (en) * | 1977-05-23 | 1979-12-04 | Pfizer Inc. | Hydantoin therapeutic agents |
US4176185A (en) * | 1979-01-22 | 1979-11-27 | Pfizer Inc. | Spiro-quinolylhydantoins |
US4181729A (en) * | 1979-03-21 | 1980-01-01 | Pfizer Inc. | Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives |
-
1980
- 1980-02-12 US US06/120,944 patent/US4248882A/en not_active Expired - Lifetime
-
1981
- 1981-02-09 AT AT81300521T patent/ATE3865T1/de not_active IP Right Cessation
- 1981-02-09 EP EP81300521A patent/EP0034063B1/en not_active Expired
- 1981-02-09 DE DE8181300521T patent/DE3160449D1/de not_active Expired
- 1981-02-10 JP JP1886581A patent/JPS56127379A/ja active Granted
- 1981-02-11 DK DK056581A patent/DK156400C/da not_active IP Right Cessation
- 1981-02-11 IE IE261/81A patent/IE50895B1/en unknown
- 1981-02-11 GR GR64101A patent/GR73856B/el unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61197581A (ja) * | 1985-02-26 | 1986-09-01 | Eisai Co Ltd | ヒダントイン誘導体 |
JPS63126881A (ja) * | 1986-11-14 | 1988-05-30 | Sanwa Kagaku Kenkyusho Co Ltd | ヒダントイン誘導体、その塩、これらの製法並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤 |
Also Published As
Publication number | Publication date |
---|---|
ATE3865T1 (de) | 1983-07-15 |
IE50895B1 (en) | 1986-08-06 |
DK56581A (da) | 1981-08-13 |
DK156400B (da) | 1989-08-14 |
EP0034063A1 (en) | 1981-08-19 |
US4248882A (en) | 1981-02-03 |
DE3160449D1 (en) | 1983-07-28 |
EP0034063B1 (en) | 1983-06-22 |
IE810261L (en) | 1981-08-12 |
GR73856B (ja) | 1984-05-08 |
DK156400C (da) | 1990-01-08 |
JPS6237636B2 (ja) | 1987-08-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS56127379A (en) | Hydantoin amine compound | |
DK0564924T3 (da) | 2-Oxoethylderivater som immunosuppressiva | |
HU9600962D0 (en) | Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases | |
IE790088L (en) | Thienohydantoin derivatives | |
ES486007A1 (es) | Un procedimiento de preparacion de un derivado de espiro- policicloimidazolidindiona | |
AU581442B2 (en) | 2-substituted-1, 3-propylidenediphosphonate derivatives, the process for their preparation and pharmaceutical compositions containing them | |
ZA85327B (en) | Therapeutic compounds | |
AU5801286A (en) | Spiro-imidazolidines as aldose reductase inhibitors | |
CA2030346A1 (en) | Treatment of cardiac dysfunction with 15-keto-prostaglandin compounds | |
SE8500387D0 (sv) | Hydantoinderivat | |
AU670491B2 (en) | Pharmaceutical for the treatment of skin disorders | |
IE800109L (en) | Spiro-quinolylhydantoins | |
IE800672L (en) | Spiro-quinolone hydantoins | |
EP0117035A3 (en) | Aldose reductase inhibiting 5-(2-alkoxyphenyl)thiazolidinediones | |
AU639322B2 (en) | Biochemical treatment with 15-dehydroxy-16-oxoprostaglandin compounds | |
GR3022217T3 (en) | Treatment of cataract with prostacyclin compounds | |
ES8504144A1 (es) | Un procedimiento para la preparacion de una 5-(2-alcoxi-fenil 3-sustituido)hidantoina | |
DE3467166D1 (en) | Spiro-succinimides for treatment of diabetes complications | |
ES8507119A1 (es) | Procedimiento para la preparacion de un compuesto de 5-(fenil sustituido) hidantoina. |