DK156400C - Analogifremgangsmaade til fremstilling af aminosubstituerede spiro-hydantoin-forbindelser eller farmaceutisk acceptable salte deraf - Google Patents
Analogifremgangsmaade til fremstilling af aminosubstituerede spiro-hydantoin-forbindelser eller farmaceutisk acceptable salte derafInfo
- Publication number
- DK156400C DK156400C DK056581A DK56581A DK156400C DK 156400 C DK156400 C DK 156400C DK 056581 A DK056581 A DK 056581A DK 56581 A DK56581 A DK 56581A DK 156400 C DK156400 C DK 156400C
- Authority
- DK
- Denmark
- Prior art keywords
- amino
- acceptable salts
- analogue
- preparation
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/120,944 US4248882A (en) | 1980-02-12 | 1980-02-12 | Treating diabetes-associated complications with hydantoin amines |
US12094480 | 1980-02-12 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK56581A DK56581A (da) | 1981-08-13 |
DK156400B DK156400B (da) | 1989-08-14 |
DK156400C true DK156400C (da) | 1990-01-08 |
Family
ID=22393428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK056581A DK156400C (da) | 1980-02-12 | 1981-02-11 | Analogifremgangsmaade til fremstilling af aminosubstituerede spiro-hydantoin-forbindelser eller farmaceutisk acceptable salte deraf |
Country Status (8)
Country | Link |
---|---|
US (1) | US4248882A (da) |
EP (1) | EP0034063B1 (da) |
JP (1) | JPS56127379A (da) |
AT (1) | ATE3865T1 (da) |
DE (1) | DE3160449D1 (da) |
DK (1) | DK156400C (da) |
GR (1) | GR73856B (da) |
IE (1) | IE50895B1 (da) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU532110B2 (en) * | 1979-11-13 | 1983-09-15 | Ici Ltd. | Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives |
ATE10940T1 (de) * | 1981-05-12 | 1985-01-15 | Imperial Chemical Industries Plc | Pyrrolderivate. |
US4556670A (en) * | 1982-12-06 | 1985-12-03 | Pfizer Inc. | Spiro-3-hetero-azolones for treatment of diabetic complications |
US4474967A (en) * | 1983-04-27 | 1984-10-02 | Pfizer Inc. | 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione |
US4464380A (en) * | 1983-05-25 | 1984-08-07 | Pfizer Inc. | Imidazolidinedione derivatives |
DK277484A (da) * | 1983-06-23 | 1984-12-24 | Hoffmann La Roche | Thiazolidinderivater |
ATE56007T1 (de) * | 1984-06-22 | 1990-09-15 | Beecham Group Plc | Wirksame benzopyranverbindungen. |
HU198212B (en) * | 1984-07-20 | 1989-08-28 | Pfizer | Process for production of spiro-imidasolones |
EP0172719B1 (en) * | 1984-08-20 | 1988-09-21 | Pfizer Inc. | Process for the production as asymmetric hydantoins |
US4966911A (en) * | 1984-11-20 | 1990-10-30 | Washington Research Foundation | Immunoregulatory agents |
US5340829A (en) * | 1984-11-20 | 1994-08-23 | Washington Research Foundation | Immunoregulatory agents |
JPH0772190B2 (ja) * | 1985-02-26 | 1995-08-02 | エーザイ株式会社 | ヒダントイン誘導体 |
US4575507A (en) * | 1985-05-29 | 1986-03-11 | Pfizer Inc. | Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use |
US4762839A (en) * | 1985-06-06 | 1988-08-09 | Tanabe Seiyaku Co., Ltd. | Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications |
JPS63126881A (ja) * | 1986-11-14 | 1988-05-30 | Sanwa Kagaku Kenkyusho Co Ltd | ヒダントイン誘導体、その塩、これらの製法並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤 |
JPS63132889A (ja) * | 1986-11-21 | 1988-06-04 | Tanabe Seiyaku Co Ltd | キナゾリノン誘導体 |
MX12896A (es) * | 1987-09-04 | 1993-06-01 | Pfizer | Procedimiento para preparar un compuesto de espiro-heteroazolonas |
US4952694A (en) * | 1988-07-27 | 1990-08-28 | Pfizer Inc. | Novel resolution process for racemic spiro-hydantoins |
WO1992000071A1 (en) * | 1989-02-10 | 1992-01-09 | Washington Research Foundation | Immunoregulatory agents |
JP2678499B2 (ja) * | 1989-08-09 | 1997-11-17 | 日本臓器製薬 株式会社 | 尿毒症毒素低下剤 |
JPH03215435A (ja) * | 1990-01-12 | 1991-09-20 | Sanwa Kagaku Kenkyusho Co Ltd | アルドース還元酵素阻害剤を主成分とする潰瘍治療剤 |
DE60239793D1 (de) * | 2001-04-05 | 2011-06-01 | Nissan Chemical Ind Ltd | Verfahren zur herstellung von 7-chinolinyl-3,5-dihydroxyhept-6-enoat |
US7795203B2 (en) * | 2002-09-30 | 2010-09-14 | Babizhayev Mark A | Method for topical treatment of eye disease and composition and device for said treatment |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1135915B (de) * | 1961-06-29 | 1962-09-06 | Asta Werke Ag Chem Fab | Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine |
US3534037A (en) * | 1968-05-10 | 1970-10-13 | Smithkline Corp | Spiro-(imidazolidine and pyrimidine-quinoline and cyclopropa(c)quinoline) compounds |
US3821383A (en) * | 1972-07-10 | 1974-06-28 | Ayerst Mckenna & Harrison | Compositions for and a method of treating diabetic complications |
US4117230A (en) * | 1976-10-18 | 1978-09-26 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
US4177282A (en) * | 1977-05-23 | 1979-12-04 | Pfizer Inc. | Hydantoin therapeutic agents |
US4130714A (en) * | 1977-05-23 | 1978-12-19 | Pfizer Inc. | Hydantoin therapeutic agents |
US4176185A (en) * | 1979-01-22 | 1979-11-27 | Pfizer Inc. | Spiro-quinolylhydantoins |
US4181729A (en) * | 1979-03-21 | 1980-01-01 | Pfizer Inc. | Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives |
-
1980
- 1980-02-12 US US06/120,944 patent/US4248882A/en not_active Expired - Lifetime
-
1981
- 1981-02-09 AT AT81300521T patent/ATE3865T1/de not_active IP Right Cessation
- 1981-02-09 DE DE8181300521T patent/DE3160449D1/de not_active Expired
- 1981-02-09 EP EP81300521A patent/EP0034063B1/en not_active Expired
- 1981-02-10 JP JP1886581A patent/JPS56127379A/ja active Granted
- 1981-02-11 GR GR64101A patent/GR73856B/el unknown
- 1981-02-11 DK DK056581A patent/DK156400C/da not_active IP Right Cessation
- 1981-02-11 IE IE261/81A patent/IE50895B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
IE810261L (en) | 1981-08-12 |
JPS6237636B2 (da) | 1987-08-13 |
EP0034063B1 (en) | 1983-06-22 |
DK156400B (da) | 1989-08-14 |
JPS56127379A (en) | 1981-10-06 |
US4248882A (en) | 1981-02-03 |
GR73856B (da) | 1984-05-08 |
EP0034063A1 (en) | 1981-08-19 |
ATE3865T1 (de) | 1983-07-15 |
DE3160449D1 (en) | 1983-07-28 |
IE50895B1 (en) | 1986-08-06 |
DK56581A (da) | 1981-08-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed |