JPS5612393A - Novel camptothecin derivative - Google Patents
Novel camptothecin derivativeInfo
- Publication number
- JPS5612393A JPS5612393A JP8641279A JP8641279A JPS5612393A JP S5612393 A JPS5612393 A JP S5612393A JP 8641279 A JP8641279 A JP 8641279A JP 8641279 A JP8641279 A JP 8641279A JP S5612393 A JPS5612393 A JP S5612393A
- Authority
- JP
- Japan
- Prior art keywords
- camptothecin derivative
- formula
- carboxylic acid
- acyl group
- novel camptothecin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- HPDRGGNSEBLDKL-NRFANRHFSA-N ac1l3zgz Chemical compound C1=CC=C2C(CO)=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 HPDRGGNSEBLDKL-NRFANRHFSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- -1 carboxylic acid halide Chemical class 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8641279A JPS5612393A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative |
US06/166,953 US4399282A (en) | 1979-07-10 | 1980-07-08 | Camptothecin derivatives |
GB8022438A GB2056973B (en) | 1979-07-10 | 1980-07-09 | Camptothecin derivatives useful as antitumour agents |
CH5265/80A CH648316A5 (de) | 1979-07-10 | 1980-07-09 | Camptothecinderivate und verfahren zu ihrer herstellung. |
AU60273/80A AU536181B2 (en) | 1979-07-10 | 1980-07-09 | Derivatives of camptothecin |
IT23348/80A IT1199976B (it) | 1979-07-10 | 1980-07-09 | Derivati della camptotecima e processi per la loro preparazione |
ES493287A ES493287A0 (es) | 1979-07-10 | 1980-07-10 | Un procedimiento para la preparacion de derivados de campto tecina. |
FR8015418A FR2462437A1 (fr) | 1979-07-10 | 1980-07-10 | Nouveaux derives de la camptothecine doues d'activite antitumorale et leur procede de preparation |
AR281720A AR228575A1 (es) | 1979-07-10 | 1980-07-10 | Procedimiento para obtener derivados de 7-hidroximetil o 7-carboxicamptotecina y sus sales |
DE19803026172 DE3026172A1 (de) | 1979-07-10 | 1980-07-10 | Camptothecinderivate und ihre herstellung |
NLAANVRAGE8003988,A NL188219C (nl) | 1979-07-10 | 1980-07-10 | Camptothecinederivaten, werkwijze voor het bereiden daarvan, farmaceutische preparaten met anti-tumorwerking, werkwijze voor het bereiden daarvan. |
ES499986A ES499986A0 (es) | 1979-07-10 | 1981-03-02 | Un procedimiento para la preparacion de derivados de campto-tecina |
ES499987A ES8202012A1 (es) | 1979-07-10 | 1981-03-02 | Un procedimiento para la preparacion de derivados de campto-tecina |
US06/676,248 USRE32518E (en) | 1979-07-10 | 1984-11-29 | Camptothecin derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8641279A JPS5612393A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5612393A true JPS5612393A (en) | 1981-02-06 |
JPS6242913B2 JPS6242913B2 (en, 2012) | 1987-09-10 |
Family
ID=13886146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8641279A Granted JPS5612393A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5612393A (en, 2012) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005536464A (ja) * | 2002-05-06 | 2005-12-02 | ザ ステーリン ファンデーション フォー キャンサー リサーチ | カンプトテシンのハロアルキルエステルおよびこれらの化合物を使用する癌治療方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03104504A (ja) * | 1989-09-14 | 1991-05-01 | Tanaka Kikinzoku Kogyo Kk | チップブレーカー付ドリル |
-
1979
- 1979-07-10 JP JP8641279A patent/JPS5612393A/ja active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005536464A (ja) * | 2002-05-06 | 2005-12-02 | ザ ステーリン ファンデーション フォー キャンサー リサーチ | カンプトテシンのハロアルキルエステルおよびこれらの化合物を使用する癌治療方法 |
Also Published As
Publication number | Publication date |
---|---|
JPS6242913B2 (en, 2012) | 1987-09-10 |
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