JPS5536436A - Production of pyrido 2,3-d pyrimidinecarboxylic acid derivative - Google Patents
Production of pyrido 2,3-d pyrimidinecarboxylic acid derivativeInfo
- Publication number
- JPS5536436A JPS5536436A JP11026878A JP11026878A JPS5536436A JP S5536436 A JPS5536436 A JP S5536436A JP 11026878 A JP11026878 A JP 11026878A JP 11026878 A JP11026878 A JP 11026878A JP S5536436 A JPS5536436 A JP S5536436A
- Authority
- JP
- Japan
- Prior art keywords
- pyrido
- oxazoline
- piperazinyl
- formula
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZFCHNZDUMIOWFV-UHFFFAOYSA-N pyrimidine-2-carboxylic acid Chemical class OC(=O)C1=NC=CC=N1 ZFCHNZDUMIOWFV-UHFFFAOYSA-N 0.000 title 1
- -1 2-oxazoline-2-yl Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 159000000018 pyrido[2,3-d]pyrimidines Chemical class 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- WBJINCZRORDGAQ-UHFFFAOYSA-N formic acid ethyl ester Natural products CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- NHKJPPKXDNZFBJ-UHFFFAOYSA-N phenyllithium Chemical compound [Li]C1=CC=CC=C1 NHKJPPKXDNZFBJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- GKASDNZWUGIAMG-UHFFFAOYSA-N triethyl orthoformate Chemical compound CCOC(OCC)OCC GKASDNZWUGIAMG-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PURPOSE: A specific 6-(Δ2-oxazoline-2-yl)pyrido[2,3-d]pyrimidine derivative is used as the starting material to be hydrolyzed, thus producing title compound useful as an antibacterial.
CONSTITUTION: The hydrolysis of 6-(Δ2-oxazoline-2-yl)pyrido[2,3-d]pyrimidine derivative of formula I (R1 is 1-pyrrolidinyl, 1-piperazinyl, 4-acyl-1-piperazinyl, 4-trimethyl-1-piperazinyl; r2, R3, R4, R5 are H, lower alkyl) is effected using a basic catalyst to form the compound of formula II (R1 is 1-pyrrolydinyl). The compound of formula I is novel, for example, prepared by reacting 2-substituted- 4-ethylaminopyrimidine-5-carboxylic chloride with 2-methyl-Δ2-oxazoline in the presence of phenyl lithium and being followed by acting ethyl orthoformate on the reaction product.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11026878A JPS5536436A (en) | 1978-09-07 | 1978-09-07 | Production of pyrido 2,3-d pyrimidinecarboxylic acid derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11026878A JPS5536436A (en) | 1978-09-07 | 1978-09-07 | Production of pyrido 2,3-d pyrimidinecarboxylic acid derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5536436A true JPS5536436A (en) | 1980-03-14 |
| JPS6111233B2 JPS6111233B2 (en) | 1986-04-01 |
Family
ID=14531370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11026878A Granted JPS5536436A (en) | 1978-09-07 | 1978-09-07 | Production of pyrido 2,3-d pyrimidinecarboxylic acid derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5536436A (en) |
-
1978
- 1978-09-07 JP JP11026878A patent/JPS5536436A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6111233B2 (en) | 1986-04-01 |
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