JPS55151588A - Preparation of cephalosporin salt crystal - Google Patents
Preparation of cephalosporin salt crystalInfo
- Publication number
- JPS55151588A JPS55151588A JP5948179A JP5948179A JPS55151588A JP S55151588 A JPS55151588 A JP S55151588A JP 5948179 A JP5948179 A JP 5948179A JP 5948179 A JP5948179 A JP 5948179A JP S55151588 A JPS55151588 A JP S55151588A
- Authority
- JP
- Japan
- Prior art keywords
- salt crystal
- acid
- compound
- addition salt
- reaction solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013078 crystal Substances 0.000 title abstract 4
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- -1 cephalosporin salt Chemical class 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 229940126062 Compound A Drugs 0.000 abstract 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5948179A JPS55151588A (en) | 1979-05-14 | 1979-05-14 | Preparation of cephalosporin salt crystal |
| GR61865A GR68203B (enExample) | 1979-05-14 | 1980-05-03 | |
| NZ193634A NZ193634A (en) | 1979-05-14 | 1980-05-06 | Crystalline addition salts of a certain cephalosporin ester medicinal preparations |
| US06/147,053 US4316018A (en) | 1979-05-14 | 1980-05-06 | Crystallized cephalosporin salts |
| SE8003548A SE8003548L (sv) | 1979-05-14 | 1980-05-12 | Kristalliserade cefalosporinsalter |
| ES491386A ES8102132A1 (es) | 1979-05-14 | 1980-05-12 | Un metodo para preparar sales de adicion cristalina de cefa-losporina |
| NO801428A NO801428L (no) | 1979-05-14 | 1980-05-13 | Krystalliserte cefalosporinsalter og fremgangsmaate til deres fremstilling |
| DE19803018340 DE3018340A1 (de) | 1979-05-14 | 1980-05-13 | Kristallines additionssalz und verfahren zu dessen herstellung |
| GB8015741A GB2052483A (en) | 1979-05-14 | 1980-05-13 | Crystalline cephalosporin salts |
| IT22020/80A IT1132053B (it) | 1979-05-14 | 1980-05-13 | Sali cristallizzati di cefalosporina |
| BE1/9820A BE883250A (fr) | 1979-05-14 | 1980-05-13 | Sels cristallises du 7beta-(2-(2-aminothiazol-4-yl)acetamido) - 3-(((1-(2-dimethylaminoethyl)-1h-tetrazol-5-yl)thio)methyl) - 3-cephem-4-carboxyalte de pivaloyloxymethyl et leur procede de preparation |
| NL8002758A NL8002758A (nl) | 1979-05-14 | 1980-05-13 | Gekristalliseerde cefalosporinezouten. |
| DK209380A DK209380A (da) | 1979-05-14 | 1980-05-13 | Fremgangsmaade til fremstilling af krystalliserede cephalosporinsalte |
| PT71241A PT71241B (en) | 1979-05-14 | 1980-05-14 | Crystallized cephalosporin salts |
| AT0259180A AT367427B (de) | 1979-05-14 | 1980-05-14 | Verfahren zur herstellung neuer kristalliner additionssalze |
| AU58380/80A AU5838080A (en) | 1979-05-14 | 1980-05-14 | Crystallised cephalosporin salts |
| FI801563A FI801563A7 (fi) | 1979-05-14 | 1980-05-14 | Kristalliserade kefalosporinsalter |
| SU802921250A SU973024A3 (ru) | 1979-05-14 | 1980-05-14 | Способ получени аддитивных солей пивалоилоксиметилового эфира 7 @ -[2-(2-аминотиазол-4-ил) ацетамидо]-3-[1-(2-диметиламиноэтил)-1н-тетразол-5-илтиометил]-3-цефем-4-карбоновой кислоты с сол ной,винной или лимонной кислотой |
| ZA00802874A ZA802874B (en) | 1979-05-14 | 1980-05-14 | Crystallized cephalosporin salts |
| FR8010921A FR2456746A1 (fr) | 1979-05-14 | 1980-05-14 | Sels cristallises du 7b-(2-(2-aminothiazol-4-yl)acetamido) -3- (((1-(2-dimethylaminoethyl)-1h-tetrazol-5-yl)thio)methyl)3-cephem-4-carboxylate de pivaloyloxymethyle et leur procede de preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5948179A JPS55151588A (en) | 1979-05-14 | 1979-05-14 | Preparation of cephalosporin salt crystal |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS55151588A true JPS55151588A (en) | 1980-11-26 |
Family
ID=13114535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5948179A Pending JPS55151588A (en) | 1979-05-14 | 1979-05-14 | Preparation of cephalosporin salt crystal |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4316018A (enExample) |
| JP (1) | JPS55151588A (enExample) |
| AT (1) | AT367427B (enExample) |
| AU (1) | AU5838080A (enExample) |
| BE (1) | BE883250A (enExample) |
| DE (1) | DE3018340A1 (enExample) |
| DK (1) | DK209380A (enExample) |
| ES (1) | ES8102132A1 (enExample) |
| FI (1) | FI801563A7 (enExample) |
| FR (1) | FR2456746A1 (enExample) |
| GB (1) | GB2052483A (enExample) |
| GR (1) | GR68203B (enExample) |
| IT (1) | IT1132053B (enExample) |
| NL (1) | NL8002758A (enExample) |
| NO (1) | NO801428L (enExample) |
| NZ (1) | NZ193634A (enExample) |
| PT (1) | PT71241B (enExample) |
| SE (1) | SE8003548L (enExample) |
| SU (1) | SU973024A3 (enExample) |
| ZA (1) | ZA802874B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62103090A (ja) * | 1985-08-05 | 1987-05-13 | ブリストル―マイアーズ スクイブ コムパニー | セフアロスポリン塩および注射可能組成物 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR78221B (enExample) * | 1980-02-01 | 1984-09-26 | Ciba Geigy Ag | |
| US4616008A (en) * | 1984-05-02 | 1986-10-07 | Takeda Chemical Industries, Ltd. | Antibacterial solid composition for oral administration |
| US4910301A (en) * | 1985-08-05 | 1990-03-20 | Bristol-Myers Company | Cefepime cephalosporin salts |
| US5244891A (en) * | 1985-08-05 | 1993-09-14 | Bristol-Myers Squibb Company | Injectable compositions of cefepime dihydrochloride hydrate |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS603314B2 (ja) * | 1976-08-31 | 1985-01-26 | 武田薬品工業株式会社 | セフアロスポリン誘導体およびその製造法 |
| US4189479A (en) * | 1977-12-22 | 1980-02-19 | Takeda Chemical Industries, Ltd. | Cephalosporin esters |
-
1979
- 1979-05-14 JP JP5948179A patent/JPS55151588A/ja active Pending
-
1980
- 1980-05-03 GR GR61865A patent/GR68203B/el unknown
- 1980-05-06 US US06/147,053 patent/US4316018A/en not_active Expired - Lifetime
- 1980-05-06 NZ NZ193634A patent/NZ193634A/xx unknown
- 1980-05-12 SE SE8003548A patent/SE8003548L/ not_active Application Discontinuation
- 1980-05-12 ES ES491386A patent/ES8102132A1/es not_active Expired
- 1980-05-13 NO NO801428A patent/NO801428L/no unknown
- 1980-05-13 DE DE19803018340 patent/DE3018340A1/de not_active Withdrawn
- 1980-05-13 BE BE1/9820A patent/BE883250A/fr unknown
- 1980-05-13 DK DK209380A patent/DK209380A/da unknown
- 1980-05-13 NL NL8002758A patent/NL8002758A/nl not_active Application Discontinuation
- 1980-05-13 GB GB8015741A patent/GB2052483A/en not_active Withdrawn
- 1980-05-13 IT IT22020/80A patent/IT1132053B/it active
- 1980-05-14 AT AT0259180A patent/AT367427B/de not_active IP Right Cessation
- 1980-05-14 PT PT71241A patent/PT71241B/pt unknown
- 1980-05-14 FR FR8010921A patent/FR2456746A1/fr not_active Withdrawn
- 1980-05-14 ZA ZA00802874A patent/ZA802874B/xx unknown
- 1980-05-14 AU AU58380/80A patent/AU5838080A/en not_active Abandoned
- 1980-05-14 SU SU802921250A patent/SU973024A3/ru active
- 1980-05-14 FI FI801563A patent/FI801563A7/fi not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62103090A (ja) * | 1985-08-05 | 1987-05-13 | ブリストル―マイアーズ スクイブ コムパニー | セフアロスポリン塩および注射可能組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| BE883250A (fr) | 1980-11-13 |
| NZ193634A (en) | 1982-05-25 |
| IT8022020A0 (it) | 1980-05-13 |
| ES491386A0 (es) | 1980-12-16 |
| SE8003548L (sv) | 1980-11-15 |
| AT367427B (de) | 1982-07-12 |
| ATA259180A (de) | 1981-11-15 |
| DE3018340A1 (de) | 1980-11-27 |
| FI801563A7 (fi) | 1980-11-15 |
| PT71241A (en) | 1980-06-01 |
| PT71241B (en) | 1982-06-08 |
| DK209380A (da) | 1980-11-15 |
| US4316018A (en) | 1982-02-16 |
| IT1132053B (it) | 1986-06-25 |
| GR68203B (enExample) | 1981-11-10 |
| SU973024A3 (ru) | 1982-11-07 |
| AU5838080A (en) | 1980-11-20 |
| FR2456746A1 (fr) | 1980-12-12 |
| ZA802874B (en) | 1980-12-31 |
| GB2052483A (en) | 1981-01-28 |
| NL8002758A (nl) | 1980-11-18 |
| ES8102132A1 (es) | 1980-12-16 |
| NO801428L (no) | 1980-11-17 |
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