JPS5470241A - Guanidinobenzoic acid derivative and its preparation - Google Patents
Guanidinobenzoic acid derivative and its preparationInfo
- Publication number
- JPS5470241A JPS5470241A JP13337977A JP13337977A JPS5470241A JP S5470241 A JPS5470241 A JP S5470241A JP 13337977 A JP13337977 A JP 13337977A JP 13337977 A JP13337977 A JP 13337977A JP S5470241 A JPS5470241 A JP S5470241A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- formula
- compound
- guanidinobenzoic
- acid salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FCEQRBOTYXIORK-UHFFFAOYSA-N 2-(diaminomethylideneamino)benzoic acid Chemical class NC(=N)NC1=CC=CC=C1C(O)=O FCEQRBOTYXIORK-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- SXTSBZBQQRIYCU-UHFFFAOYSA-N 4-guanidinobenzoic acid Chemical compound NC(=N)NC1=CC=C(C(O)=O)C=C1 SXTSBZBQQRIYCU-UHFFFAOYSA-N 0.000 abstract 1
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 206010033647 Pancreatitis acute Diseases 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 201000003229 acute pancreatitis Diseases 0.000 abstract 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 208000031169 hemorrhagic disease Diseases 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940012957 plasmin Drugs 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13337977A JPS5470241A (en) | 1977-11-09 | 1977-11-09 | Guanidinobenzoic acid derivative and its preparation |
| DE19782846251 DE2846251A1 (de) | 1977-11-09 | 1978-10-24 | Guanidinbenzoesaeureverbindungen, verfahren zu deren herstellung und arzneimittel, welche diese enthalten |
| GB7842081A GB2007653B (en) | 1977-11-09 | 1978-10-26 | Guanidinobenzoic acid compounds and process for preparing the same |
| US05/959,276 US4224342A (en) | 1977-11-09 | 1978-11-09 | Guanidinobenzoic acid compounds and process for preparing the same |
| FR7831718A FR2408584A1 (fr) | 1977-11-09 | 1978-11-09 | Composes guanidinobenzoiques et possedant une activite antifibrinolysine et antitrypsine et leur procede de preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13337977A JPS5470241A (en) | 1977-11-09 | 1977-11-09 | Guanidinobenzoic acid derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5470241A true JPS5470241A (en) | 1979-06-05 |
| JPS5735870B2 JPS5735870B2 (en, 2012) | 1982-07-31 |
Family
ID=15103351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13337977A Granted JPS5470241A (en) | 1977-11-09 | 1977-11-09 | Guanidinobenzoic acid derivative and its preparation |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4224342A (en, 2012) |
| JP (1) | JPS5470241A (en, 2012) |
| DE (1) | DE2846251A1 (en, 2012) |
| FR (1) | FR2408584A1 (en, 2012) |
| GB (1) | GB2007653B (en, 2012) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2044760B (en) | 1979-03-01 | 1983-03-23 | Ono Pharmaceutical Co | Guanidinobenzoic acid derivatives |
| US4490388A (en) * | 1981-02-27 | 1984-12-25 | Torii & Co., Ltd. | Amidine compound and anticomplement agent comprising same |
| US4423069A (en) * | 1982-01-20 | 1983-12-27 | University Of Illinois Foundation | Contraceptive method |
| JPS6254A (ja) * | 1985-03-08 | 1987-01-06 | Kanebo Ltd | 新規グアニジノメチルシクロヘキサンカルボン酸誘導体および該化合物を有効成分とする抗潰瘍薬 |
| US5247084A (en) * | 1985-11-12 | 1993-09-21 | Ono Pharmaceutical Co., Ltd. | Derivatives of p-guanidinobenzoic acid |
| US4843094A (en) * | 1985-11-12 | 1989-06-27 | Ono Pharmaceutical Co., Ltd. | Derivatives of p-guantidinobenzoic acid and pharmaceutical agents containing them as active ingredient |
| EP0222608B1 (en) * | 1985-11-12 | 1991-09-11 | Ono Pharmaceutical Co., Ltd. | Derivatives of p-guanidinobenzoic acid and pharmaceutical agents containing them as active ingredient |
| JPH0676373B2 (ja) * | 1985-12-27 | 1994-09-28 | エーザイ株式会社 | グアニジノ安息香酸エステル誘導体 |
| EP0893437A4 (en) * | 1996-04-10 | 2000-12-27 | Ono Pharmaceutical Co | GUANIDINO TRYPTASE INHIBITOR |
| US6066673A (en) * | 1998-03-12 | 2000-05-23 | The Procter & Gamble Company | Enzyme inhibitors |
| US6849605B1 (en) * | 1999-03-05 | 2005-02-01 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of viral infections |
| US6489308B1 (en) | 1999-03-05 | 2002-12-03 | Trustees Of University Of Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of nitric-oxide-induced clinical conditions |
| WO2000051625A1 (en) * | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses |
| US20040220242A1 (en) * | 2003-05-02 | 2004-11-04 | Leland Shapiro | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions |
| EP3192872A1 (en) * | 2003-08-26 | 2017-07-19 | The Regents of the University of Colorado, a body corporate | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
| WO2012178102A2 (en) | 2011-06-24 | 2012-12-27 | The Regents Of The Unversity Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| JP2015504675A (ja) | 2012-01-10 | 2015-02-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | アルファ−１アンチトリプシン融合分子の組成物、方法、及び使用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1905813A1 (de) * | 1968-07-04 | 1970-03-05 | Akad Wissenschaften Ddr | 3- oder 4-Guanidobenzoesaeurebenzyl- oder -phenylestern und deren Verwendung als Inhibitoren |
| JPS5440534B2 (en, 2012) * | 1972-05-12 | 1979-12-04 | ||
| JPS5116631A (ja) * | 1974-07-31 | 1976-02-10 | Ono Pharmaceutical Co | Guanijinoansokukosanjudotaino seizohoho |
| GB1472700A (en) * | 1974-11-01 | 1977-05-04 | Ono Pharmaceutical Co | Guanidinobehzoic acid derivatives and process for preparing the same |
-
1977
- 1977-11-09 JP JP13337977A patent/JPS5470241A/ja active Granted
-
1978
- 1978-10-24 DE DE19782846251 patent/DE2846251A1/de active Granted
- 1978-10-26 GB GB7842081A patent/GB2007653B/en not_active Expired
- 1978-11-09 US US05/959,276 patent/US4224342A/en not_active Expired - Lifetime
- 1978-11-09 FR FR7831718A patent/FR2408584A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2408584B1 (en, 2012) | 1983-12-09 |
| US4224342A (en) | 1980-09-23 |
| FR2408584A1 (fr) | 1979-06-08 |
| GB2007653A (en) | 1979-05-23 |
| GB2007653B (en) | 1982-04-07 |
| DE2846251A1 (de) | 1979-05-10 |
| JPS5735870B2 (en, 2012) | 1982-07-31 |
| DE2846251C2 (en, 2012) | 1988-08-04 |
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