JPS5461198A - Selective hydronated reactants of cc076 compound and manufacture - Google Patents

Selective hydronated reactants of cc076 compound and manufacture

Info

Publication number
JPS5461198A
JPS5461198A JP12128478A JP12128478A JPS5461198A JP S5461198 A JPS5461198 A JP S5461198A JP 12128478 A JP12128478 A JP 12128478A JP 12128478 A JP12128478 A JP 12128478A JP S5461198 A JPS5461198 A JP S5461198A
Authority
JP
Japan
Prior art keywords
hydronated
reactants
selective
manufacture
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12128478A
Other languages
English (en)
Other versions
JPH0317837B2 (ja
Inventor
Shii Chiyabara Jiyon
Etsuchi Fuitsushiyaa Maikeru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25277555&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS5461198(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS5461198A publication Critical patent/JPS5461198A/ja
Publication of JPH0317837B2 publication Critical patent/JPH0317837B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pest Control & Pesticides (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP12128478A 1977-10-03 1978-10-03 Selective hydronated reactants of cc076 compound and manufacture Granted JPS5461198A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83860377A 1977-10-03 1977-10-03

Publications (2)

Publication Number Publication Date
JPS5461198A true JPS5461198A (en) 1979-05-17
JPH0317837B2 JPH0317837B2 (ja) 1991-03-11

Family

ID=25277555

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12128478A Granted JPS5461198A (en) 1977-10-03 1978-10-03 Selective hydronated reactants of cc076 compound and manufacture

Country Status (27)

Country Link
EP (1) EP0001689B1 (ja)
JP (1) JPS5461198A (ja)
AT (1) AT366690B (ja)
AU (1) AU519569B2 (ja)
BG (1) BG34340A3 (ja)
CS (1) CS207678B2 (ja)
DD (1) DD140458A5 (ja)
DE (1) DE2862390D1 (ja)
DK (1) DK152128C (ja)
ES (1) ES473926A1 (ja)
FI (1) FI67857C (ja)
GR (1) GR64919B (ja)
GT (1) GT197854449A (ja)
HU (1) HU179244B (ja)
IE (1) IE48032B1 (ja)
IL (1) IL55603A (ja)
IT (1) IT1107561B (ja)
NL (1) NL930116I1 (ja)
NO (1) NO149662C (ja)
NZ (1) NZ188460A (ja)
OA (1) OA06064A (ja)
PH (1) PH15982A (ja)
PL (1) PL115455B1 (ja)
PT (1) PT68580A (ja)
RO (1) RO75612A (ja)
YU (1) YU41319B (ja)
ZM (1) ZM8278A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5524165A (en) * 1978-08-04 1980-02-21 Merck & Co Inc Alkyl derivative of cc076 compound
JPS58167591A (ja) * 1982-03-16 1983-10-03 メルク　エンド　カムパニー　インコーポレーテッド ４”―アミノ―４”―デオキシアベルメクチン化合物及びその置換アミノ誘導体
JPS59141582A (ja) * 1983-01-28 1984-08-14 メルク　エンド　カムパニー　インコーポレーテッド アベルメクチン及びミルベマイシンのリン酸エステル類
JPS61200993A (ja) * 1985-02-25 1986-09-05 メルク　エンド　カムパニー　インコーポレーテツド 新規なアベルメクチンアグリコンの置換された又は置換されていない１３‐（アルコキシ）メトキシ誘導体
JPS63238083A (ja) * 1987-03-16 1988-10-04 メルク　エンド　カムパニー　インコーポレーテツド アベルメクチン誘導体

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203976A (en) * 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4550160A (en) * 1979-08-13 1985-10-29 Merck & Co., Inc. Processes for the interconversion of C-076 compounds
US4285963A (en) * 1980-08-07 1981-08-25 Merck & Co., Inc. Novel derivatives of C-076 compounds
JPS57139012A (en) * 1981-02-23 1982-08-27 Sankyo Co Ltd Anthelmintic composition
US4333925A (en) * 1981-05-11 1982-06-08 Merck & Co., Inc. Derivatives of C-076 compounds
NZ201681A (en) * 1981-09-03 1985-11-08 Merck & Co Inc Avermectin derivatives and parasiticidal compositions
DE3273198D1 (en) * 1981-10-06 1986-10-16 Ici Plc Method of combating nematode pests of plants and compositions therefor
HUT39739A (en) * 1984-12-04 1986-10-29 Ciba Geigy Ag Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
GB2168345B (en) * 1984-12-14 1988-05-25 Ciba Geigy Ag Pesticidal 13b-substituted milbemycin derivatives
US4666937A (en) * 1985-03-04 1987-05-19 Merck & Co., Inc. Avermectin bioconversion products
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
ES8605582A1 (es) * 1985-12-11 1986-03-16 Antibioticos Sa Un procedimiento para la preparacion de avermectinas
RU2024527C1 (ru) * 1986-03-25 1994-12-15 Санкио Компани Лимитед Способ получения макролидных соединений
CA1296329C (en) * 1986-06-06 1992-02-25 Derek R. Sutherland Macrolide compounds
US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
US4831016A (en) * 1986-10-31 1989-05-16 Merck & Co., Inc. Reduced avermectin derivatives
US5525506A (en) * 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5238848A (en) * 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
DE3880088T2 (de) * 1987-11-09 1993-07-22 Pfizer Ethylierte avermectine.
US4963667A (en) * 1987-11-10 1990-10-16 Merck & Co., Inc. Ivermectin derivative compounds and process for preparing the same
GB8726730D0 (en) 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
GB8813760D0 (en) * 1988-06-10 1988-07-13 American Cyanamid Co Chemical process
GB8815967D0 (en) * 1988-07-05 1988-08-10 Pfizer Ltd Antiparasitic agents
CA1339481C (en) * 1988-10-18 1997-09-30 Shieh-Shung Tom Chen Anthelmintic bioconversion products
US5188944A (en) * 1990-06-22 1993-02-23 Merck & Co., Inc. Process for the glycosylation of avermectin agylcones
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
US5380838A (en) * 1993-10-08 1995-01-10 Merck & Co. Inc. Stable solvates of avermectin compounds
DE19507018A1 (de) * 1995-03-01 1996-09-05 Bayer Ag Verfahren zur Herstellung von Ivermectin
EP0928136B1 (en) 1996-06-05 2003-10-22 Ashmont Holdings Limited Injectable compositions
DE19644050A1 (de) * 1996-10-31 1998-05-07 Bayer Ag Verfahren zur Herstellung von Ivermectin
US7001889B2 (en) 2002-06-21 2006-02-21 Merial Limited Anthelmintic oral homogeneous veterinary pastes
DE10353281A1 (de) 2003-11-14 2005-06-16 Bayer Cropscience Ag Wirkstoffkombination mit insektiziden und akariziden Eigenschaften
DE102007045922A1 (de) 2007-09-26 2009-04-02 Bayer Cropscience Ag Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
EP2127522A1 (de) 2008-05-29 2009-12-02 Bayer CropScience AG Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
EP2382865A1 (de) 2010-04-28 2011-11-02 Bayer CropScience AG Synergistische Wirkstoffkombinationen
EP2878309A4 (en) 2012-07-26 2016-06-08 Univ Kyoto FILAGGRIN PRODUCTION PHOTOMOTOR, THERAPEUTIC FOR DISORDERS ASSOCIATED WITH REDUCED FILAGGINE PRODUCTION AND METHOD FOR SCREENING THIS THERAPEUTIC
EP4062907A1 (fr) 2021-03-23 2022-09-28 Substipharm Formulation par voie orale d'ivermectine et utilisations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4914624A (ja) * 1972-06-08 1974-02-08
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5524165A (en) * 1978-08-04 1980-02-21 Merck & Co Inc Alkyl derivative of cc076 compound
JPH0238596B2 (ja) * 1978-08-04 1990-08-31 Merck & Co Inc
JPS58167591A (ja) * 1982-03-16 1983-10-03 メルク　エンド　カムパニー　インコーポレーテッド ４”―アミノ―４”―デオキシアベルメクチン化合物及びその置換アミノ誘導体
JPS59141582A (ja) * 1983-01-28 1984-08-14 メルク　エンド　カムパニー　インコーポレーテッド アベルメクチン及びミルベマイシンのリン酸エステル類
JPS61200993A (ja) * 1985-02-25 1986-09-05 メルク　エンド　カムパニー　インコーポレーテツド 新規なアベルメクチンアグリコンの置換された又は置換されていない１３‐（アルコキシ）メトキシ誘導体
JP2509560B2 (ja) * 1985-02-25 1996-06-19 メルク エンド カムパニー インコーポレーテツド 新規なアベルメクチンアグリコンの置換された又は置換されていない１３―（アルコキシ）メトキシ誘導体
JPS63238083A (ja) * 1987-03-16 1988-10-04 メルク　エンド　カムパニー　インコーポレーテツド アベルメクチン誘導体
JP2669635B2 (ja) * 1987-03-16 1997-10-29 メルク エンド カムパニー インコーポレーテツド アベルメクチン誘導体

Also Published As

Publication number Publication date
IL55603A0 (en) 1978-12-17
IT1107561B (it) 1985-11-25
PL115455B1 (en) 1981-04-30
YU41319B (en) 1987-02-28
GT197854449A (es) 1980-03-25
IE781963L (en) 1979-04-03
AT366690B (de) 1982-04-26
EP0001689B1 (en) 1984-03-21
DD140458A5 (de) 1980-03-05
FI67857C (fi) 1985-06-10
RO75612A (ro) 1981-01-30
CS207678B2 (en) 1981-08-31
FI782880A (fi) 1979-04-04
JPH0317837B2 (ja) 1991-03-11
AU3999678A (en) 1980-03-27
ATA711378A (de) 1981-09-15
GR64919B (en) 1980-06-09
PH15982A (en) 1983-05-18
AU519569B2 (en) 1981-12-10
IT7851277A0 (it) 1978-09-27
NZ188460A (en) 1980-05-08
NO149662C (no) 1984-05-30
HU179244B (en) 1982-09-28
NO149662B (no) 1984-02-20
YU231978A (en) 1983-01-21
ZM8278A1 (en) 1980-07-21
PT68580A (en) 1978-10-01
EP0001689A1 (en) 1979-05-02
PL210030A1 (pl) 1979-06-18
IL55603A (en) 1982-07-30
FI67857B (fi) 1985-02-28
NL930116I1 (nl) 1993-10-18
DK152128C (da) 1988-06-20
BG34340A3 (en) 1983-08-15
OA06064A (fr) 1981-06-30
ES473926A1 (es) 1980-01-16
DE2862390D1 (en) 1984-04-26
IE48032B1 (en) 1984-09-05
NO783307L (no) 1979-04-04
DK152128B (da) 1988-02-01
DK434578A (da) 1979-04-04

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Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term