JPS5459246A - 2-thio-2-(4-isobutylphenyl) alkane acid derivatives and their preparation - Google Patents

2-thio-2-(4-isobutylphenyl) alkane acid derivatives and their preparation

Info

Publication number
JPS5459246A
JPS5459246A JP12350677A JP12350677A JPS5459246A JP S5459246 A JPS5459246 A JP S5459246A JP 12350677 A JP12350677 A JP 12350677A JP 12350677 A JP12350677 A JP 12350677A JP S5459246 A JPS5459246 A JP S5459246A
Authority
JP
Japan
Prior art keywords
formula
compounds
isobutylphenyl
acid derivatives
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12350677A
Other languages
Japanese (ja)
Other versions
JPS568030B2 (en
Inventor
Sei Kondo
Daiei Tsunemoto
Kumiko Kishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP12350677A priority Critical patent/JPS5459246A/en
Priority to GB7833298A priority patent/GB2007220B/en
Priority to DE19782836257 priority patent/DE2836257A1/en
Priority to FR7824142A priority patent/FR2400507A1/en
Priority to CA309,676A priority patent/CA1103684A/en
Publication of JPS5459246A publication Critical patent/JPS5459246A/en
Publication of JPS568030B2 publication Critical patent/JPS568030B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:2-(Arylthio or alkylthio)-2-(4-isobutyl-phenyl) alkane acid derivatives of formulas I and III (R1 is H, alkyl, or aryl group; R2 is lower alkyl group).
EXAMPLE: 2-Phenylthio-2-(4-isobutylphenyl) acctic acid.
USE: Intermediate for synthesis of an anti-inflammatory drug, 2-(4-isobutyl-phenyl) propionic acid (Ibuprofen), etc. which can be continuously administered with little side effects.
PROCESS: Compounds of formula II: (X is halogen) are reacted with mercaptans of formula R'SH in the presence of a base, e.g. KOH, etc. in a protonic solvent, e.g. water, methanol, etc. to give compounds of formula III. The compounds of formula III are then reacted with alkylating agents, e.g. methyl iodide, etc. of formula R2Z (Z is halogen, alkyl, arylsulfonyloxy, or sulfate residue) in the presence of 2 equivalents or more of a base in a solvent, e.g. liquid ammonia, etc. to form the compounds of formula I
COPYRIGHT: (C)1979,JPO&Japio
JP12350677A 1977-08-18 1977-10-17 2-thio-2-(4-isobutylphenyl) alkane acid derivatives and their preparation Granted JPS5459246A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP12350677A JPS5459246A (en) 1977-10-17 1977-10-17 2-thio-2-(4-isobutylphenyl) alkane acid derivatives and their preparation
GB7833298A GB2007220B (en) 1977-08-18 1978-08-14 Process for preparing 2-thio-2-substituted alkanoic acid dricatives
DE19782836257 DE2836257A1 (en) 1977-08-18 1978-08-18 PROCESS FOR THE PRODUCTION OF 2-SUBSTITUTED 2-THIOALCANIC ACID DERIVATIVES
FR7824142A FR2400507A1 (en) 1977-08-18 1978-08-18 PROCESS FOR PREPARING 2-THIOALCANOIC ACID DERIVATIVES SUBSTITUTED IN POSITION 2
CA309,676A CA1103684A (en) 1977-08-18 1978-08-18 Process for preparing 2-thio-2-substituted-alkanoic acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12350677A JPS5459246A (en) 1977-10-17 1977-10-17 2-thio-2-(4-isobutylphenyl) alkane acid derivatives and their preparation

Publications (2)

Publication Number Publication Date
JPS5459246A true JPS5459246A (en) 1979-05-12
JPS568030B2 JPS568030B2 (en) 1981-02-20

Family

ID=14862300

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12350677A Granted JPS5459246A (en) 1977-08-18 1977-10-17 2-thio-2-(4-isobutylphenyl) alkane acid derivatives and their preparation

Country Status (1)

Country Link
JP (1) JPS5459246A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7122118B2 (en) * 2018-01-24 2022-08-19 太陽誘電株式会社 Ceramic capacitor and manufacturing method thereof

Also Published As

Publication number Publication date
JPS568030B2 (en) 1981-02-20

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