JPS5459246A - 2-thio-2-(4-isobutylphenyl) alkane acid derivatives and their preparation - Google Patents
2-thio-2-(4-isobutylphenyl) alkane acid derivatives and their preparationInfo
- Publication number
- JPS5459246A JPS5459246A JP12350677A JP12350677A JPS5459246A JP S5459246 A JPS5459246 A JP S5459246A JP 12350677 A JP12350677 A JP 12350677A JP 12350677 A JP12350677 A JP 12350677A JP S5459246 A JPS5459246 A JP S5459246A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compounds
- isobutylphenyl
- acid derivatives
- iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:2-(Arylthio or alkylthio)-2-(4-isobutyl-phenyl) alkane acid derivatives of formulas I and III (R1 is H, alkyl, or aryl group; R2 is lower alkyl group).
EXAMPLE: 2-Phenylthio-2-(4-isobutylphenyl) acctic acid.
USE: Intermediate for synthesis of an anti-inflammatory drug, 2-(4-isobutyl-phenyl) propionic acid (Ibuprofen), etc. which can be continuously administered with little side effects.
PROCESS: Compounds of formula II: (X is halogen) are reacted with mercaptans of formula R'SH in the presence of a base, e.g. KOH, etc. in a protonic solvent, e.g. water, methanol, etc. to give compounds of formula III. The compounds of formula III are then reacted with alkylating agents, e.g. methyl iodide, etc. of formula R2Z (Z is halogen, alkyl, arylsulfonyloxy, or sulfate residue) in the presence of 2 equivalents or more of a base in a solvent, e.g. liquid ammonia, etc. to form the compounds of formula I
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12350677A JPS5459246A (en) | 1977-10-17 | 1977-10-17 | 2-thio-2-(4-isobutylphenyl) alkane acid derivatives and their preparation |
GB7833298A GB2007220B (en) | 1977-08-18 | 1978-08-14 | Process for preparing 2-thio-2-substituted alkanoic acid dricatives |
DE19782836257 DE2836257A1 (en) | 1977-08-18 | 1978-08-18 | PROCESS FOR THE PRODUCTION OF 2-SUBSTITUTED 2-THIOALCANIC ACID DERIVATIVES |
FR7824142A FR2400507A1 (en) | 1977-08-18 | 1978-08-18 | PROCESS FOR PREPARING 2-THIOALCANOIC ACID DERIVATIVES SUBSTITUTED IN POSITION 2 |
CA309,676A CA1103684A (en) | 1977-08-18 | 1978-08-18 | Process for preparing 2-thio-2-substituted-alkanoic acid derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12350677A JPS5459246A (en) | 1977-10-17 | 1977-10-17 | 2-thio-2-(4-isobutylphenyl) alkane acid derivatives and their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5459246A true JPS5459246A (en) | 1979-05-12 |
JPS568030B2 JPS568030B2 (en) | 1981-02-20 |
Family
ID=14862300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12350677A Granted JPS5459246A (en) | 1977-08-18 | 1977-10-17 | 2-thio-2-(4-isobutylphenyl) alkane acid derivatives and their preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5459246A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7122118B2 (en) * | 2018-01-24 | 2022-08-19 | 太陽誘電株式会社 | Ceramic capacitor and manufacturing method thereof |
-
1977
- 1977-10-17 JP JP12350677A patent/JPS5459246A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS568030B2 (en) | 1981-02-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IT7850735A0 (en) | PHARMACEUTICAL COMPOSITIONS BASED ON ALUMINUM SALTS OF 2(4-ISOBUTYLPHENYL)PROPIONIC ACID | |
ES8706632A1 (en) | Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives. | |
JPS5459246A (en) | 2-thio-2-(4-isobutylphenyl) alkane acid derivatives and their preparation | |
JPS5543078A (en) | Preparation of 1,3-dithiolan-2-ylidenemalonate derivative | |
ES480827A1 (en) | Phenylaminothiophene acetic acids, process for their preparation and medicaments containing them. | |
JPS52106897A (en) | Synthesis of piperazine derivatives | |
SE8200891L (en) | 2-AMINO-3- (HALOGENEBENZOYL) -METHYLPHENYLETIC ACIDS AND ESTARS AND SALTS THEREOF | |
JPS5492946A (en) | 2-aminomethylphenol derivative and its production | |
EP0074130A3 (en) | New imidazole compounds, process for the preparation thereof and pharmaceutical compositions containing them | |
JPS5788170A (en) | Thiazolidone derivative | |
FR2536071B1 (en) | 2-PIPERAZINOPYRIMIDINE ACID SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | |
JPS54148757A (en) | (2-fluoro-4-biphenylyl) ketene mercaptal s-oxide | |
IE45693L (en) | 2-(phenylalkylhydrazono)-propionic acids | |
JPS5764639A (en) | Novel stilbene derivative, its preparation, and medical composition containing the same as active ingredent | |
JPS5551089A (en) | Triazolopyrimidine derivative | |
ES455699A1 (en) | Process for the preparation of para-substituted derivatives of alpha-phenylpropionic acid | |
JPS55118452A (en) | Production of alpha-cyanopropionic ester derivative | |
JPS5646889A (en) | Gold compound and its preparation | |
JPS5587765A (en) | 1,1-bis(alkylthio)-2- n-benzyl-0-(2,6-dichloroanilino) phenyl -ethylene derivative and its preparation | |
JPS5750952A (en) | Benzoic acid derivative | |
JPS5441867A (en) | Alpha-thio--alpha(2-thienyl)alkanoic acid derivative and its preparation | |
JPS5535056A (en) | 3-substituted acetophenone and its preparation | |
JPS54119428A (en) | Novel benzoic acid derivative | |
ES465758A1 (en) | Procedure for obtaining monoester from p-chlorophenoxy-isobutirico acid with 2,6-pyridindimethanol, new pharmacy with hypocolesteramient action. (Machine-translation by Google Translate, not legally binding) | |
JPS57169479A (en) | 7-hydroxy-pgi2 and its preparation |