JPS57169479A - 7-hydroxy-pgi2 and its preparation - Google Patents
7-hydroxy-pgi2 and its preparationInfo
- Publication number
- JPS57169479A JPS57169479A JP56053127A JP5312781A JPS57169479A JP S57169479 A JPS57169479 A JP S57169479A JP 56053127 A JP56053127 A JP 56053127A JP 5312781 A JP5312781 A JP 5312781A JP S57169479 A JPS57169479 A JP S57169479A
- Authority
- JP
- Japan
- Prior art keywords
- pgi
- hydroxy
- preparation
- diacetate
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A compound of formulaI(R1 is H, 1W10C alkyl; R2, R3 are acyl) and when R1, is H, salts of the acid.
EXAMPLE: 7-Hydroxy-PGI2-11,15-diacetate.
USE: Blood platelet coagulation inhibitor, smooth muscle relaxant, hypotensor, antiasthma, antiulcerative and synthetic intermediate of other compounds.
PREPARATION: The reaction of Δ5-sulfinyl-PGI2 of formula II (R11 is 1W10C alkyl) such as 5-phenylsulfinyl-Δ5-PGI1 methyl ester 11,15-diacetate) with sulfur- philic compound such as diethylamine (1.2W20 times the molar quantity of the PGI2) is effected in a solvent of methanol at 0W60°C for 3W24hr. Then, when desired, the product is made into a salt.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56053127A JPS57169479A (en) | 1981-04-10 | 1981-04-10 | 7-hydroxy-pgi2 and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56053127A JPS57169479A (en) | 1981-04-10 | 1981-04-10 | 7-hydroxy-pgi2 and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57169479A true JPS57169479A (en) | 1982-10-19 |
Family
ID=12934136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56053127A Pending JPS57169479A (en) | 1981-04-10 | 1981-04-10 | 7-hydroxy-pgi2 and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57169479A (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55121210A (en) * | 1979-03-13 | 1980-09-18 | Matsushita Electric Ind Co Ltd | Nonncombustible inorganic coating material for electronic part |
JPS5799580A (en) * | 1980-10-27 | 1982-06-21 | Chinoin Gyogyszer Es Vegyeszet | 7-substituted pgi2 derivative and manufacture |
-
1981
- 1981-04-10 JP JP56053127A patent/JPS57169479A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55121210A (en) * | 1979-03-13 | 1980-09-18 | Matsushita Electric Ind Co Ltd | Nonncombustible inorganic coating material for electronic part |
JPS5799580A (en) * | 1980-10-27 | 1982-06-21 | Chinoin Gyogyszer Es Vegyeszet | 7-substituted pgi2 derivative and manufacture |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS57169479A (en) | 7-hydroxy-pgi2 and its preparation | |
JPS5791953A (en) | 4-fluoro-4'-hydroxybiphenyl benzoic acid ester derivative | |
JPS559060A (en) | Thia(oxa)zolidinecarboxylic acid derivative and its prepatation | |
JPS57165382A (en) | Fluoro-pgi2 compound and its preparation | |
JPS579771A (en) | Tetrazole derivative | |
JPS5566592A (en) | 7-alkoxythiazolo 3,2-a pyrimidine derivative, its preparation, and drug containing the same | |
JPS5759897A (en) | Thiazolineazatidinone | |
JPS5589245A (en) | 9,10-dihydroanthracene-2-alkanoic acid derivative | |
JPS56127378A (en) | 2-alkoxyindolizine derivative and its preparation | |
JPS54112892A (en) | Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid | |
JPS5673064A (en) | Isoquinoline derivative | |
JPS5287129A (en) | 4-trifluoromethyl phenoxy phenoxyankane carboxylic acid | |
JPS57144254A (en) | 2-substituted-2-oxoazetidine derivative and its preparation | |
JPS5527142A (en) | Novel 1-phthalazone derivative | |
JPS5495580A (en) | Isocarbostyril derivative | |
JPS54115387A (en) | Tetrahydro-1,3,5-thiadiazine-4-one, insecticides and acaricides containing it | |
JPS5283714A (en) | Novel alkyl ester derivatives of 16-alkyl-20-alkoxyprostadienoic acids | |
JPS56125340A (en) | Cyclohexenone derivative | |
JPS5618985A (en) | Furoindole compound | |
JPS52116490A (en) | Novel 7alpha-methoxycephalosporanic acid derivatives and method of preparing the same | |
JPS54157582A (en) | Dibenzoxepin derivative and its preparation | |
JPS55162747A (en) | 2-aminomethylphenol derivative and its preparation | |
JPS5555168A (en) | Novel 4-carboxy-2-phenyl-1-phthalazone derivative | |
JPS55139378A (en) | 6-diarylmethyleneindolitidine derivative | |
JPS52133959A (en) | 2-cyano-3-methyl-3-(naphthyl)acrylic acids and method of preparing the same |