JPS57169479A - 7-hydroxy-pgi2 and its preparation - Google Patents

7-hydroxy-pgi2 and its preparation

Info

Publication number
JPS57169479A
JPS57169479A JP56053127A JP5312781A JPS57169479A JP S57169479 A JPS57169479 A JP S57169479A JP 56053127 A JP56053127 A JP 56053127A JP 5312781 A JP5312781 A JP 5312781A JP S57169479 A JPS57169479 A JP S57169479A
Authority
JP
Japan
Prior art keywords
pgi
hydroxy
preparation
diacetate
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56053127A
Other languages
Japanese (ja)
Inventor
Kiyoshi Sakauchi
Takeshi Yu
Takeo Oba
Toshio Tanaka
Noriaki Okamura
Kenzo Watanabe
Seiji Kurozumi
Akira Otsu
Tatsuyuki Naritomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP56053127A priority Critical patent/JPS57169479A/en
Publication of JPS57169479A publication Critical patent/JPS57169479A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound of formulaI(R1 is H, 1W10C alkyl; R2, R3 are acyl) and when R1, is H, salts of the acid.
EXAMPLE: 7-Hydroxy-PGI2-11,15-diacetate.
USE: Blood platelet coagulation inhibitor, smooth muscle relaxant, hypotensor, antiasthma, antiulcerative and synthetic intermediate of other compounds.
PREPARATION: The reaction of Δ5-sulfinyl-PGI2 of formula II (R11 is 1W10C alkyl) such as 5-phenylsulfinyl-Δ5-PGI1 methyl ester 11,15-diacetate) with sulfur- philic compound such as diethylamine (1.2W20 times the molar quantity of the PGI2) is effected in a solvent of methanol at 0W60°C for 3W24hr. Then, when desired, the product is made into a salt.
COPYRIGHT: (C)1982,JPO&Japio
JP56053127A 1981-04-10 1981-04-10 7-hydroxy-pgi2 and its preparation Pending JPS57169479A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56053127A JPS57169479A (en) 1981-04-10 1981-04-10 7-hydroxy-pgi2 and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56053127A JPS57169479A (en) 1981-04-10 1981-04-10 7-hydroxy-pgi2 and its preparation

Publications (1)

Publication Number Publication Date
JPS57169479A true JPS57169479A (en) 1982-10-19

Family

ID=12934136

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56053127A Pending JPS57169479A (en) 1981-04-10 1981-04-10 7-hydroxy-pgi2 and its preparation

Country Status (1)

Country Link
JP (1) JPS57169479A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55121210A (en) * 1979-03-13 1980-09-18 Matsushita Electric Ind Co Ltd Nonncombustible inorganic coating material for electronic part
JPS5799580A (en) * 1980-10-27 1982-06-21 Chinoin Gyogyszer Es Vegyeszet 7-substituted pgi2 derivative and manufacture

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55121210A (en) * 1979-03-13 1980-09-18 Matsushita Electric Ind Co Ltd Nonncombustible inorganic coating material for electronic part
JPS5799580A (en) * 1980-10-27 1982-06-21 Chinoin Gyogyszer Es Vegyeszet 7-substituted pgi2 derivative and manufacture

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