JPS54148722A - Nonapeptide and its preparation - Google Patents
Nonapeptide and its preparationInfo
- Publication number
- JPS54148722A JPS54148722A JP5700778A JP5700778A JPS54148722A JP S54148722 A JPS54148722 A JP S54148722A JP 5700778 A JP5700778 A JP 5700778A JP 5700778 A JP5700778 A JP 5700778A JP S54148722 A JPS54148722 A JP S54148722A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- residue
- compound
- immunity
- caused
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C07K5/06069—Ser-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/18—Thymus derived hormone or factor; related peptides
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5700778A JPS54148722A (en) | 1978-05-12 | 1978-05-12 | Nonapeptide and its preparation |
US06/036,988 US4229438A (en) | 1978-05-12 | 1979-05-07 | Nonapeptides |
GB7916256A GB2020669B (en) | 1978-05-12 | 1979-05-10 | Nonapeptides |
FR7912110A FR2432503A1 (fr) | 1978-05-12 | 1979-05-11 | Nouveaux nonapeptides, leur procede de preparation et leur application comme medicaments |
DE19792919218 DE2919218A1 (de) | 1978-05-12 | 1979-05-12 | Nonapeptide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5700778A JPS54148722A (en) | 1978-05-12 | 1978-05-12 | Nonapeptide and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54148722A true JPS54148722A (en) | 1979-11-21 |
JPS6126799B2 JPS6126799B2 (ja) | 1986-06-21 |
Family
ID=13043390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5700778A Granted JPS54148722A (en) | 1978-05-12 | 1978-05-12 | Nonapeptide and its preparation |
Country Status (5)
Country | Link |
---|---|
US (1) | US4229438A (ja) |
JP (1) | JPS54148722A (ja) |
DE (1) | DE2919218A1 (ja) |
FR (1) | FR2432503A1 (ja) |
GB (1) | GB2020669B (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989006136A1 (en) * | 1987-12-25 | 1989-07-13 | Mitsui Toatsu Chemicals, Incorporated | Agent for prophylaxis and treatment of pancreatic disease or the like |
WO1989009613A1 (en) * | 1988-04-04 | 1989-10-19 | Mitsui Toatsu Chemicals, Incorporated | Protective agent for radiation hazard |
US5288706A (en) * | 1987-12-25 | 1994-02-22 | Mitsui Toatsu Chemicals, Incorporated | Medicament for prevention and remedy of diseases of the pancreas and others |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4396606A (en) * | 1979-11-05 | 1983-08-02 | Addiction Research Foundation | Novel polypeptide analgesics |
JPS5711950A (en) * | 1980-06-25 | 1982-01-21 | Kureha Chem Ind Co Ltd | Peptide and its synthesis |
JPS5852225A (ja) * | 1981-09-22 | 1983-03-28 | Mitsui Pharmaceut Inc | 脱髄疾患治療剤 |
DE3224379A1 (de) * | 1982-06-30 | 1984-01-12 | Hoechst Ag, 6230 Frankfurt | Nonapeptid mit immunstimulierender wirkung, verfahren zu dessen herstellung und dessen verwendung |
US4497801A (en) * | 1982-09-17 | 1985-02-05 | Fujisawa Pharmaceutical Co., Ltd. | New peptides, process for preparation thereof and use thereof |
US4855407A (en) * | 1985-04-11 | 1989-08-08 | Alpha-1 Biomedicals, Inc. | Solid phase process for synthesizing peptides |
JP2525798B2 (ja) * | 1987-03-12 | 1996-08-21 | 第一製薬株式会社 | ペプチド誘導体 |
ATE136551T1 (de) * | 1988-05-10 | 1996-04-15 | Alpha 1 Biomedicals Inc | Festphase-verfahren zur gewinnung von thymosin- alpha-1 |
US5068221A (en) * | 1989-05-09 | 1991-11-26 | Mathias John R | Treatment of motility disorders with a gnrh analog |
US5166192A (en) * | 1989-05-09 | 1992-11-24 | Mathias John R | Treatment of motility disorders with a GnRH analog |
CA2026306A1 (en) * | 1989-10-04 | 1991-04-05 | Akira Awaya | Medicament for prevention and remedy of disorders of decrease in the number of blood corpuscles |
DK0477499T3 (da) * | 1990-08-04 | 1994-05-30 | Hoechst Ag | Gonadoliberin-antagonister |
US5434136A (en) * | 1990-12-14 | 1995-07-18 | Mathias; John R. | Treatment of motility disorders with a GNRH analog |
ES2110573T3 (es) | 1992-08-07 | 1998-02-16 | Takeda Chemical Industries Ltd | Produccion de microcapsulas de farmacos solubles en agua. |
CA2143044C (en) * | 1994-02-21 | 2005-04-12 | Yasutaka Igari | Matrix for sustained-release preparation |
US6117455A (en) * | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
US5837281A (en) | 1995-03-17 | 1998-11-17 | Takeda Chemical Industries, Ltd. | Stabilized interface for iontophoresis |
CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
EP0813887A3 (en) * | 1996-06-20 | 1999-11-03 | Hisamitsu Pharmaceutical Co. Inc. | A device structure for iontophoresis |
US6309633B1 (en) | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
US7169889B1 (en) | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
EP2062593A3 (en) | 2000-12-01 | 2011-08-17 | Takeda Pharmaceutical Company Limited | Method for producing preparation containing bioactive peptide |
US6867183B2 (en) | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7060675B2 (en) | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US6713452B2 (en) * | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6828305B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7713932B2 (en) | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
US6835802B2 (en) * | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7196059B2 (en) | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7166571B2 (en) | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US6913903B2 (en) * | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US7601688B2 (en) * | 2002-06-13 | 2009-10-13 | Biocon Limited | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
CA2910494C (en) | 2004-07-19 | 2018-10-23 | Biocon Limited | Insulin-oligomer conjugates, formulations and uses thereof |
MX2010003979A (es) | 2007-10-16 | 2010-06-02 | Biocon Ltd | Composicion farmaceutica oralmente administrable y proceso para su preparacion. |
EP2873422A4 (en) | 2012-07-10 | 2015-12-30 | Takeda Pharmaceutical | PHARMACEUTICAL PREPARATION FOR INJECTION |
CN109535035A (zh) * | 2019-01-08 | 2019-03-29 | 吉尔生化(上海)有限公司 | 一种n-苄氧羰基-3-氨基-丙氨酸叔丁酯的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4098777A (en) * | 1977-03-14 | 1978-07-04 | Merck & Co., Inc. | Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn |
FR2390419A1 (fr) * | 1977-04-29 | 1978-12-08 | Merck & Co Inc | Peptides ayant une activite de stimulation des cellules t |
FR2423481A2 (fr) * | 1978-04-21 | 1979-11-16 | Anvar | Nouveaux polypeptides a activite thymique ou a activite antagoniste et leurs procedes de synthese |
FR2391994A1 (fr) * | 1977-05-25 | 1978-12-22 | Anvar | Nouveaux polypeptides a activite thymique ou a activite antagoniste et leurs procedes de synthese |
-
1978
- 1978-05-12 JP JP5700778A patent/JPS54148722A/ja active Granted
-
1979
- 1979-05-07 US US06/036,988 patent/US4229438A/en not_active Expired - Lifetime
- 1979-05-10 GB GB7916256A patent/GB2020669B/en not_active Expired
- 1979-05-11 FR FR7912110A patent/FR2432503A1/fr active Granted
- 1979-05-12 DE DE19792919218 patent/DE2919218A1/de not_active Withdrawn
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989006136A1 (en) * | 1987-12-25 | 1989-07-13 | Mitsui Toatsu Chemicals, Incorporated | Agent for prophylaxis and treatment of pancreatic disease or the like |
US5288706A (en) * | 1987-12-25 | 1994-02-22 | Mitsui Toatsu Chemicals, Incorporated | Medicament for prevention and remedy of diseases of the pancreas and others |
WO1989009613A1 (en) * | 1988-04-04 | 1989-10-19 | Mitsui Toatsu Chemicals, Incorporated | Protective agent for radiation hazard |
Also Published As
Publication number | Publication date |
---|---|
JPS6126799B2 (ja) | 1986-06-21 |
GB2020669A (en) | 1979-11-21 |
GB2020669B (en) | 1982-08-25 |
FR2432503A1 (fr) | 1980-02-29 |
US4229438A (en) | 1980-10-21 |
DE2919218A1 (de) | 1979-11-22 |
FR2432503B1 (ja) | 1983-10-28 |
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