ATE136551T1 - Festphase-verfahren zur gewinnung von thymosin- alpha-1 - Google Patents
Festphase-verfahren zur gewinnung von thymosin- alpha-1Info
- Publication number
- ATE136551T1 ATE136551T1 AT89304584T AT89304584T ATE136551T1 AT E136551 T1 ATE136551 T1 AT E136551T1 AT 89304584 T AT89304584 T AT 89304584T AT 89304584 T AT89304584 T AT 89304584T AT E136551 T1 ATE136551 T1 AT E136551T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha
- moz
- amino acids
- trifluoroacetic acid
- groups
- Prior art date
Links
- 239000007790 solid phase Substances 0.000 title abstract 2
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 6
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 5
- 239000011347 resin Substances 0.000 abstract 3
- 229920005989 resin Polymers 0.000 abstract 3
- -1 4-methyloxybenzyloxycarbonyl Chemical group 0.000 abstract 2
- 108010078233 Thymalfasin Proteins 0.000 abstract 2
- 102400000800 Thymosin alpha-1 Human genes 0.000 abstract 2
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000003776 cleavage reaction Methods 0.000 abstract 2
- 230000007017 scission Effects 0.000 abstract 2
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 abstract 2
- 229960004231 thymalfasin Drugs 0.000 abstract 2
- 239000000159 acid neutralizing agent Substances 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 238000011109 contamination Methods 0.000 abstract 1
- 238000010511 deprotection reaction Methods 0.000 abstract 1
- 239000010808 liquid waste Substances 0.000 abstract 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 abstract 1
- SHDMMLFAFLZUEV-UHFFFAOYSA-N n-methyl-1,1-diphenylmethanamine Chemical compound C=1C=CC=CC=1C(NC)C1=CC=CC=C1 SHDMMLFAFLZUEV-UHFFFAOYSA-N 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 238000004064 recycling Methods 0.000 abstract 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 abstract 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57581—Thymosin; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19234988A | 1988-05-10 | 1988-05-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE136551T1 true ATE136551T1 (de) | 1996-04-15 |
Family
ID=22709272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89304584T ATE136551T1 (de) | 1988-05-10 | 1989-05-05 | Festphase-verfahren zur gewinnung von thymosin- alpha-1 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5610272A (de) |
| EP (1) | EP0341935B1 (de) |
| JP (1) | JP2812709B2 (de) |
| KR (1) | KR970010922B1 (de) |
| AT (1) | ATE136551T1 (de) |
| DE (1) | DE68926178T2 (de) |
| HK (1) | HK1014627A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68926178T2 (de) * | 1988-05-10 | 1996-11-28 | Alpha 1 Biomedicals Inc | Festphase-Verfahren zur Gewinnung von Thymosin-alpha-1 |
| US6262230B1 (en) * | 1994-01-28 | 2001-07-17 | Sciclone Pharmaceuticals Inc. | Analogs of thymosin α1 |
| US8680059B2 (en) * | 1998-05-20 | 2014-03-25 | Biotempt B.V. | Oligopeptide acetate and formulations thereof |
| US20050227925A1 (en) * | 2004-04-08 | 2005-10-13 | Robbert Benner | Compositions capable of reducing elevated blood urea concentration |
| US20030220258A1 (en) * | 2001-12-21 | 2003-11-27 | Robbert Benner | Treatment of ischemic events |
| US6844315B2 (en) | 1998-05-20 | 2005-01-18 | Erasmus Universiteit Rotterdam | Immunoregulator |
| US6921751B1 (en) * | 1998-05-20 | 2005-07-26 | Erasmus Universiteit Rotterdam | Immunoregulator |
| US20040202645A1 (en) * | 2003-04-08 | 2004-10-14 | Khan Nisar Ahmed | Administration of gene-regulatory peptides |
| EP1300418A1 (de) * | 2001-10-04 | 2003-04-09 | Erasmus Universiteit Rotterdam | Genregulation durch Oligopeptide |
| US7358330B2 (en) * | 2001-03-29 | 2008-04-15 | Biotempt B.V. | Immunoregulatory compositions |
| US20050037430A1 (en) * | 2000-03-29 | 2005-02-17 | Biotempt B.V. | Methods and uses for protein breakdown products |
| US20050020495A1 (en) * | 2001-10-24 | 2005-01-27 | Martins Eduardo Bruno Guimaraes | Antiretroviral compositions comprising thymosin alpha peptides and protease inhibitors |
| US7786084B2 (en) * | 2001-12-21 | 2010-08-31 | Biotempt B.V. | Treatment of burns |
| US20030220257A1 (en) * | 2001-12-21 | 2003-11-27 | Robbert Benner | Treatment of trauma |
| US20080242837A1 (en) * | 2001-12-21 | 2008-10-02 | Khan Nisar A | Peptide compositions |
| US7560433B2 (en) | 2001-12-21 | 2009-07-14 | Biotempt B.V. | Treatment of multiple sclerosis (MS) |
| US20080318871A1 (en) * | 2001-12-21 | 2008-12-25 | Khan Nisar A | Treatment of neurological disorders |
| US20090227505A1 (en) * | 2004-01-07 | 2009-09-10 | Biotempt B.V. | Methods and uses for protein breakdown products |
| DE602006008781D1 (de) * | 2005-05-04 | 2009-10-08 | Lonza Ag | Festphasengebundenes thymosin-alpha1 und dessen synthese |
| JP4846799B2 (ja) * | 2005-07-05 | 2011-12-28 | バイオテンプト ベー．フェー． | 腫瘍の治療 |
| EP1864692A1 (de) * | 2006-06-07 | 2007-12-12 | Biotempt B.V. | Verwendung von peptiden zum Schutz von Strahlenschäden |
| ES2288118B1 (es) | 2006-05-10 | 2008-11-01 | Bcn Peptides, S.A. | Procedimiento para sintetizar timosinas. |
| CA2677948C (en) * | 2007-02-12 | 2014-12-09 | Biotempt B.V. | Treatment of trauma-hemorrhage with short oligopeptides |
| US20080217002A1 (en) * | 2007-03-07 | 2008-09-11 | Floyd Randolph Simonds | Sand control screen having a micro-perforated filtration layer |
| CN101104638B (zh) * | 2007-06-18 | 2011-06-01 | 苏州天马医药集团天吉生物制药有限公司 | 胸腺素α1的固相合成工艺 |
| CN103980357B (zh) * | 2013-09-10 | 2017-07-07 | 杭州阿诺生物医药科技股份有限公司 | 一种合成胸腺法新的方法 |
| CN108218980B (zh) * | 2016-12-21 | 2020-12-08 | 鲁南制药集团股份有限公司 | 一种胸腺法新的合成方法 |
| CN109748954B (zh) * | 2017-11-06 | 2022-03-01 | 正大天晴药业集团股份有限公司 | 一种地加瑞克的纯化方法 |
| WO2022196797A1 (ja) | 2021-03-19 | 2022-09-22 | 富士フイルム株式会社 | アミノ酸又はペプチドの製造方法、保護基形成用試薬、及び、化合物 |
| CN116159514B (zh) * | 2023-01-17 | 2026-01-02 | 希施生物科技（上海）有限公司 | 裂解喷雾沉淀冷凝系统及除去三氟乙酸的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4207311A (en) * | 1977-07-18 | 1980-06-10 | The Salk Institute For Biological Studies | Peptides having analgesic and thermoregulative properties |
| US4148788A (en) * | 1978-01-23 | 1979-04-10 | Hoffmann-La Roche Inc. | Synthesis of thymosin α1 |
| JPS54148722A (en) * | 1978-05-12 | 1979-11-21 | Takeda Chem Ind Ltd | Nonapeptide and its preparation |
| US4215112A (en) * | 1979-03-14 | 1980-07-29 | Ortho Pharmaceutical Corporation | Tripeptides and methods |
| US4244946A (en) * | 1979-06-11 | 1981-01-13 | The Salk Institute For Biological Studies | Water-soluble peptides affecting gonadal function |
| US4382922A (en) * | 1980-08-29 | 1983-05-10 | The Salk Institute For Biological Studies | Peptides affecting gonadal function |
| US4361673A (en) * | 1980-09-19 | 1982-11-30 | American Home Products Corporation | Polypeptide compositions |
| US4406832A (en) * | 1981-09-03 | 1983-09-27 | Mallinckrodt, Inc. | Peptide-type substrates useful in the quantitative determination of endotoxin |
| US4507230A (en) * | 1982-05-12 | 1985-03-26 | Research Corporation | Peptide synthesis reagents and method of use |
| US4855407A (en) * | 1985-04-11 | 1989-08-08 | Alpha-1 Biomedicals, Inc. | Solid phase process for synthesizing peptides |
| DE68926178T2 (de) * | 1988-05-10 | 1996-11-28 | Alpha 1 Biomedicals Inc | Festphase-Verfahren zur Gewinnung von Thymosin-alpha-1 |
-
1989
- 1989-05-05 DE DE68926178T patent/DE68926178T2/de not_active Expired - Lifetime
- 1989-05-05 EP EP89304584A patent/EP0341935B1/de not_active Expired - Lifetime
- 1989-05-05 AT AT89304584T patent/ATE136551T1/de not_active IP Right Cessation
- 1989-05-09 JP JP1115944A patent/JP2812709B2/ja not_active Expired - Lifetime
- 1989-05-10 KR KR1019890006267A patent/KR970010922B1/ko not_active Expired - Fee Related
-
1991
- 1991-04-15 US US07/684,520 patent/US5610272A/en not_active Expired - Lifetime
-
1996
- 1996-08-08 US US08/695,772 patent/US5856440A/en not_active Expired - Lifetime
-
1998
- 1998-06-19 HK HK98105713A patent/HK1014627A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE68926178D1 (de) | 1996-05-15 |
| JPH0236197A (ja) | 1990-02-06 |
| EP0341935A2 (de) | 1989-11-15 |
| HK1014627A1 (en) | 1999-09-30 |
| US5610272A (en) | 1997-03-11 |
| DE68926178T2 (de) | 1996-11-28 |
| KR970010922B1 (ko) | 1997-07-02 |
| EP0341935B1 (de) | 1996-04-10 |
| KR890017267A (ko) | 1989-12-15 |
| EP0341935A3 (de) | 1991-05-22 |
| JP2812709B2 (ja) | 1998-10-22 |
| US5856440A (en) | 1999-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |