JPS54138577A - Preparation of n-substituted o-(aminomethyl)phenylacetic acid - Google Patents
Preparation of n-substituted o-(aminomethyl)phenylacetic acidInfo
- Publication number
- JPS54138577A JPS54138577A JP4542878A JP4542878A JPS54138577A JP S54138577 A JPS54138577 A JP S54138577A JP 4542878 A JP4542878 A JP 4542878A JP 4542878 A JP4542878 A JP 4542878A JP S54138577 A JPS54138577 A JP S54138577A
- Authority
- JP
- Japan
- Prior art keywords
- pref
- acid
- formaldehyde
- substituted
- phenylacetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the title compound useful for the synthesis of a phenylacetic acid derivative which is an important intermediate for the production of β-lactam antibiotics, easily, in one step, by the ring-closure of a specific, easily available N- substituted phenylacetamide with formaldehyde.
CONSTITUTION: The compound II is prepared by the intramolecular cyclization of an N-substituted phenylacetamide I(R is lower alkyl, aralkyl) (1 mole) with formaldehyde (pref. 1W2 moles) or a reagent which produces formaldehyde under the reaction conditions, e.g. formalin, paraformaldehyde, trioxane, etc., in the presence of a condensation agent comprising a strong acid (pref. a mixture of sulfuric acid and acetic acid, or trifluoroacetic acid), pref. at 70W100°C.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4542878A JPS54138577A (en) | 1978-04-19 | 1978-04-19 | Preparation of n-substituted o-(aminomethyl)phenylacetic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4542878A JPS54138577A (en) | 1978-04-19 | 1978-04-19 | Preparation of n-substituted o-(aminomethyl)phenylacetic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54138577A true JPS54138577A (en) | 1979-10-27 |
JPS6347709B2 JPS6347709B2 (en) | 1988-09-26 |
Family
ID=12719011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4542878A Granted JPS54138577A (en) | 1978-04-19 | 1978-04-19 | Preparation of n-substituted o-(aminomethyl)phenylacetic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54138577A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49132080A (en) * | 1972-06-16 | 1974-12-18 |
-
1978
- 1978-04-19 JP JP4542878A patent/JPS54138577A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49132080A (en) * | 1972-06-16 | 1974-12-18 |
Also Published As
Publication number | Publication date |
---|---|
JPS6347709B2 (en) | 1988-09-26 |
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