JPS54138577A - Preparation of n-substituted o-(aminomethyl)phenylacetic acid - Google Patents

Preparation of n-substituted o-(aminomethyl)phenylacetic acid

Info

Publication number
JPS54138577A
JPS54138577A JP4542878A JP4542878A JPS54138577A JP S54138577 A JPS54138577 A JP S54138577A JP 4542878 A JP4542878 A JP 4542878A JP 4542878 A JP4542878 A JP 4542878A JP S54138577 A JPS54138577 A JP S54138577A
Authority
JP
Japan
Prior art keywords
pref
acid
formaldehyde
substituted
phenylacetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4542878A
Other languages
Japanese (ja)
Other versions
JPS6347709B2 (en
Inventor
Ryosuke Ushijima
Kusuo Osumi
Ikuo Matsumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Priority to JP4542878A priority Critical patent/JPS54138577A/en
Publication of JPS54138577A publication Critical patent/JPS54138577A/en
Publication of JPS6347709B2 publication Critical patent/JPS6347709B2/ja
Granted legal-status Critical Current

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  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the title compound useful for the synthesis of a phenylacetic acid derivative which is an important intermediate for the production of β-lactam antibiotics, easily, in one step, by the ring-closure of a specific, easily available N- substituted phenylacetamide with formaldehyde.
CONSTITUTION: The compound II is prepared by the intramolecular cyclization of an N-substituted phenylacetamide I(R is lower alkyl, aralkyl) (1 mole) with formaldehyde (pref. 1W2 moles) or a reagent which produces formaldehyde under the reaction conditions, e.g. formalin, paraformaldehyde, trioxane, etc., in the presence of a condensation agent comprising a strong acid (pref. a mixture of sulfuric acid and acetic acid, or trifluoroacetic acid), pref. at 70W100°C.
COPYRIGHT: (C)1979,JPO&Japio
JP4542878A 1978-04-19 1978-04-19 Preparation of n-substituted o-(aminomethyl)phenylacetic acid Granted JPS54138577A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4542878A JPS54138577A (en) 1978-04-19 1978-04-19 Preparation of n-substituted o-(aminomethyl)phenylacetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4542878A JPS54138577A (en) 1978-04-19 1978-04-19 Preparation of n-substituted o-(aminomethyl)phenylacetic acid

Publications (2)

Publication Number Publication Date
JPS54138577A true JPS54138577A (en) 1979-10-27
JPS6347709B2 JPS6347709B2 (en) 1988-09-26

Family

ID=12719011

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4542878A Granted JPS54138577A (en) 1978-04-19 1978-04-19 Preparation of n-substituted o-(aminomethyl)phenylacetic acid

Country Status (1)

Country Link
JP (1) JPS54138577A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49132080A (en) * 1972-06-16 1974-12-18

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49132080A (en) * 1972-06-16 1974-12-18

Also Published As

Publication number Publication date
JPS6347709B2 (en) 1988-09-26

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