JPS56139492A - Novel schiff base of ampicillin, and its preparation - Google Patents

Novel schiff base of ampicillin, and its preparation

Info

Publication number
JPS56139492A
JPS56139492A JP4295380A JP4295380A JPS56139492A JP S56139492 A JPS56139492 A JP S56139492A JP 4295380 A JP4295380 A JP 4295380A JP 4295380 A JP4295380 A JP 4295380A JP S56139492 A JPS56139492 A JP S56139492A
Authority
JP
Japan
Prior art keywords
formula
preparation
schiff base
ampicillin
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4295380A
Other languages
Japanese (ja)
Inventor
Dotaro Fujimoto
Toshimitsu Shigeari
Takeshi Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujimoto Pharmaceutical Corp
Original Assignee
Fujimoto Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujimoto Pharmaceutical Corp filed Critical Fujimoto Pharmaceutical Corp
Priority to JP4295380A priority Critical patent/JPS56139492A/en
Publication of JPS56139492A publication Critical patent/JPS56139492A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:α- (5-Chloro-2-hydroxy-benzylidene)-aminobenzylpenicillanic acid of formula I.
USE: Intermediate for the preparation of synthetic penicillin compound.
PROCESS: The novel Schiff base derivative of amplicillin (formula I can be prepared by reacting ampicillin (chemical name; α-aminobenzylpenicillin) with 5-chloro- salicyl-aldehyde (formula II) in the presence of an alkali bicarbonate in a polar solvent. Since the compound of formula I has an intramolecular hydrogen bond shown as formula III, it is highly stable and easily separable, and can be converted into amino group easily under acidic conditions.
COPYRIGHT: (C)1981,JPO&Japio
JP4295380A 1980-04-02 1980-04-02 Novel schiff base of ampicillin, and its preparation Pending JPS56139492A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4295380A JPS56139492A (en) 1980-04-02 1980-04-02 Novel schiff base of ampicillin, and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4295380A JPS56139492A (en) 1980-04-02 1980-04-02 Novel schiff base of ampicillin, and its preparation

Publications (1)

Publication Number Publication Date
JPS56139492A true JPS56139492A (en) 1981-10-30

Family

ID=12650376

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4295380A Pending JPS56139492A (en) 1980-04-02 1980-04-02 Novel schiff base of ampicillin, and its preparation

Country Status (1)

Country Link
JP (1) JPS56139492A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5852291A (en) * 1981-09-22 1983-03-28 Kureha Chem Ind Co Ltd Penicillin antibiotic derivative and its medicinal preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5852291A (en) * 1981-09-22 1983-03-28 Kureha Chem Ind Co Ltd Penicillin antibiotic derivative and its medicinal preparation
JPS6234038B2 (en) * 1981-09-22 1987-07-24 Kureha Chemical Ind Co Ltd

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