JPS56139492A - Novel schiff base of ampicillin, and its preparation - Google Patents
Novel schiff base of ampicillin, and its preparationInfo
- Publication number
- JPS56139492A JPS56139492A JP4295380A JP4295380A JPS56139492A JP S56139492 A JPS56139492 A JP S56139492A JP 4295380 A JP4295380 A JP 4295380A JP 4295380 A JP4295380 A JP 4295380A JP S56139492 A JPS56139492 A JP S56139492A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- preparation
- schiff base
- ampicillin
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:α- (5-Chloro-2-hydroxy-benzylidene)-aminobenzylpenicillanic acid of formula I.
USE: Intermediate for the preparation of synthetic penicillin compound.
PROCESS: The novel Schiff base derivative of amplicillin (formula I can be prepared by reacting ampicillin (chemical name; α-aminobenzylpenicillin) with 5-chloro- salicyl-aldehyde (formula II) in the presence of an alkali bicarbonate in a polar solvent. Since the compound of formula I has an intramolecular hydrogen bond shown as formula III, it is highly stable and easily separable, and can be converted into amino group easily under acidic conditions.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4295380A JPS56139492A (en) | 1980-04-02 | 1980-04-02 | Novel schiff base of ampicillin, and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4295380A JPS56139492A (en) | 1980-04-02 | 1980-04-02 | Novel schiff base of ampicillin, and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56139492A true JPS56139492A (en) | 1981-10-30 |
Family
ID=12650376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4295380A Pending JPS56139492A (en) | 1980-04-02 | 1980-04-02 | Novel schiff base of ampicillin, and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56139492A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5852291A (en) * | 1981-09-22 | 1983-03-28 | Kureha Chem Ind Co Ltd | Penicillin antibiotic derivative and its medicinal preparation |
-
1980
- 1980-04-02 JP JP4295380A patent/JPS56139492A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5852291A (en) * | 1981-09-22 | 1983-03-28 | Kureha Chem Ind Co Ltd | Penicillin antibiotic derivative and its medicinal preparation |
JPS6234038B2 (en) * | 1981-09-22 | 1987-07-24 | Kureha Chemical Ind Co Ltd |
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