JPS54128539A - Preparation of acrylophenone derivative - Google Patents

Preparation of acrylophenone derivative

Info

Publication number
JPS54128539A
JPS54128539A JP3529378A JP3529378A JPS54128539A JP S54128539 A JPS54128539 A JP S54128539A JP 3529378 A JP3529378 A JP 3529378A JP 3529378 A JP3529378 A JP 3529378A JP S54128539 A JPS54128539 A JP S54128539A
Authority
JP
Japan
Prior art keywords
compound
derivative
chloride
friedel
moles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3529378A
Other languages
Japanese (ja)
Inventor
Kiyohide Sako
Masahiro Murakami
Takanori Sone
Mikio Wakabayashi
Ryoji Kodaira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd filed Critical Asahi Chemical Industry Co Ltd
Priority to JP3529378A priority Critical patent/JPS54128539A/en
Publication of JPS54128539A publication Critical patent/JPS54128539A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the title compound useful as an intermediate of medicines, by the Friedel-Crafts condensation reaction of a benzene derivative with methacroyl chloride using said denzene derivative as solvent, in the presence of aluminum chloride as catalsyt, at low temperature.
CONSTITUTION: The compound III (R is alkyl), e.g. 4'-2-dimethyl-acrylophenone, etc., is prepared by the Friedel-Crafts condensation reaction of a benzene derivative I (R is alkyl) (5W20 moles), e.g. toluene, etc., with methacryloyl chloride II (1 mole) in the presence of aluminum chloride (1.0W1.2 moles) as catalyst, pref. at -15 -+20°C. The compound I acts as a reaction solvent.
EFFECT: The objective compound can be easily produced in high yield without producing intramolecular ring-closing product.
USE: The compound I wherein R is methyl, is an intermediate of an excellent anti- spasmodic agent.
COPYRIGHT: (C)1979,JPO&Japio
JP3529378A 1978-03-29 1978-03-29 Preparation of acrylophenone derivative Pending JPS54128539A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3529378A JPS54128539A (en) 1978-03-29 1978-03-29 Preparation of acrylophenone derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3529378A JPS54128539A (en) 1978-03-29 1978-03-29 Preparation of acrylophenone derivative

Publications (1)

Publication Number Publication Date
JPS54128539A true JPS54128539A (en) 1979-10-05

Family

ID=12437716

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3529378A Pending JPS54128539A (en) 1978-03-29 1978-03-29 Preparation of acrylophenone derivative

Country Status (1)

Country Link
JP (1) JPS54128539A (en)

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