JPS5315493A - Production of androstann177 one derivative - Google Patents

Production of androstann177 one derivative

Info

Publication number
JPS5315493A
JPS5315493A JP8493277A JP8493277A JPS5315493A JP S5315493 A JPS5315493 A JP S5315493A JP 8493277 A JP8493277 A JP 8493277A JP 8493277 A JP8493277 A JP 8493277A JP S5315493 A JPS5315493 A JP S5315493A
Authority
JP
Japan
Prior art keywords
derivative
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8493277A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6117477B2 (enExample
Inventor
Bueebaa Arufureeto
Kennetsuke Mario
Daaru Herumuuto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of JPS5315493A publication Critical patent/JPS5315493A/ja
Publication of JPS6117477B2 publication Critical patent/JPS6117477B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0048—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/863—Mycobacterium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP8493277A 1976-07-16 1977-07-15 Production of androstann177 one derivative Granted JPS5315493A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762632677 DE2632677A1 (de) 1976-07-16 1976-07-16 Verfahren zur herstellung von androstan-17-on-derivaten und deren verwendung

Publications (2)

Publication Number Publication Date
JPS5315493A true JPS5315493A (en) 1978-02-13
JPS6117477B2 JPS6117477B2 (enExample) 1986-05-07

Family

ID=5983514

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8493277A Granted JPS5315493A (en) 1976-07-16 1977-07-15 Production of androstann177 one derivative

Country Status (18)

Country Link
US (1) US4179336A (enExample)
JP (1) JPS5315493A (enExample)
AT (1) AT363196B (enExample)
BE (1) BE856860A (enExample)
CH (3) CH627190A5 (enExample)
CS (1) CS200517B2 (enExample)
DD (4) DD136142A5 (enExample)
DE (1) DE2632677A1 (enExample)
DK (1) DK142372C (enExample)
FR (4) FR2365588A1 (enExample)
GB (1) GB1585786A (enExample)
HU (4) HU182789B (enExample)
IE (1) IE45304B1 (enExample)
IT (1) IT1077339B (enExample)
NL (1) NL7706638A (enExample)
SE (1) SE440779B (enExample)
SU (1) SU980628A3 (enExample)
YU (1) YU164277A (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55148083A (en) * 1979-05-04 1980-11-18 Mitsubishi Chem Ind Ltd Microorganism
JPS55150893A (en) * 1979-05-11 1980-11-25 Mitsubishi Chem Ind Ltd Novel microorganism
US5834576A (en) * 1995-02-28 1998-11-10 Nippon Shokubai Co., Ltd. Acrylic acid derivatives, method for preparing the acrylic acid derivatives, and acrylic acid polymers
JP2013509401A (ja) * 2009-10-29 2013-03-14 インダストリー−アカデミック コーポレーション ファウンデーション，ヨンセイ ユニバーシティ 新規血管漏出遮断剤

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS578794A (en) * 1980-06-17 1982-01-18 Mitsubishi Chem Ind Ltd Preparation of androstane-type steroid
US4444884A (en) * 1982-05-25 1984-04-24 Wisconsin Alumni Research Foundation Process for preparing steroids
US4755463A (en) * 1982-05-25 1988-07-05 Wisconsin Alumni Research Foundation Process for preparing steroids
PT2644206T (pt) * 2003-05-23 2019-07-10 Nektar Therapeutics Derivados de peg contendo duas cadeias de peg
US9388210B2 (en) 2011-02-25 2016-07-12 Washington University Neuroactive 17(20)-Z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same
EP4717314A2 (en) 2011-10-14 2026-04-01 Sage Therapeutics, LLC 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof
DK2935307T3 (en) 2012-12-18 2018-07-30 Univ Washington NEUROACTIVE 19-ALKOXY-17-SUBSTITUTED STEROIDS USED IN METHODS OF TREATMENT
WO2014127201A1 (en) * 2013-02-15 2014-08-21 Washington University Neuroactive enantiomeric 15-, 16- and 17-substituted steroids as modulators for gaba type-a receptors
US9512170B2 (en) 2013-03-01 2016-12-06 Washington University Neuroactive 13, 17-substituted steroids as modulators for GABA type-A receptors
US9365502B2 (en) 2013-03-11 2016-06-14 Washington University Neuroactive substituted cyclopenta[b]phenanthrenes as modulators for GABA type-A receptors
US9562026B2 (en) 2013-03-14 2017-02-07 Washington University Neuroactive substituted cyclopent[a]anthracenes as modulators for GABA type-A receptors
CN117304245A (zh) 2013-04-17 2023-12-29 萨奇治疗股份有限公司 刺激神经活性的19-去甲类固醇及其使用方法
SMT202100509T1 (it) 2013-04-17 2021-11-12 Sage Therapeutics Inc Steroide di c21-n-pirazolile 19-nor c3,3-disostituito per l'uso in terapia
US9725481B2 (en) 2013-04-17 2017-08-08 Sage Therapeutics, Inc. 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
WO2014169836A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
CA2918735C (en) 2013-07-19 2023-08-01 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
CN105579043B (zh) 2013-08-23 2021-09-14 萨奇治疗股份有限公司 神经活性类固醇、组合物和其用途
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
MY190408A (en) 2014-10-16 2022-04-21 Sage Therapeutics Inc Compositions and methods for treating cns disorders
US20170233433A1 (en) 2014-10-16 2017-08-17 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
LT3250210T (lt) 2015-01-26 2021-04-12 Sage Therapeutics, Inc. Kompozicijos ir būdai, skirti gydyti cns sutrikimus
DK3258939T3 (da) 2015-02-20 2022-12-12 Sage Therapeutics Inc Neuroaktive steroider, sammensætninger og anvendelser heraf
CA3030420C (en) 2016-07-11 2025-11-18 Sage Therapeutics, Inc. C7, C12 AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND ASSOCIATED METHODS OF USE
WO2018013613A1 (en) 2016-07-11 2018-01-18 Sage Therapeutics, Inc. C17, c20, and c21 substituted neuroactive steroids and their methods of use
JP7670626B2 (ja) 2019-05-31 2025-04-30 セージ セラピューティクス， インコーポレイテッド 神経刺激性ステロイド及びその組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3451892A (en) * 1965-10-19 1969-06-24 Schering Corp Process for the preparation of steroidal compounds
NL6705450A (enExample) * 1965-10-22 1968-10-21
US3684657A (en) * 1970-05-11 1972-08-15 Searle & Co Selective microbiological degradation of steroidal 17-alkyls
US3759791A (en) * 1970-12-10 1973-09-18 Searle & Co Selective microbiological preparation of androst-4-ene-3,17-dione
US3738983A (en) * 1971-08-06 1973-06-12 Searle & Co Process for the preparation of 3-(3beta,17beta-dihydroxyandrost-5-en-17alpha-yl) propionic acid gamma-lactone
DE2534911C2 (de) * 1975-08-01 1985-04-18 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von 5-Androsten-17-on-Derivaten

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55148083A (en) * 1979-05-04 1980-11-18 Mitsubishi Chem Ind Ltd Microorganism
JPS55150893A (en) * 1979-05-11 1980-11-25 Mitsubishi Chem Ind Ltd Novel microorganism
US5834576A (en) * 1995-02-28 1998-11-10 Nippon Shokubai Co., Ltd. Acrylic acid derivatives, method for preparing the acrylic acid derivatives, and acrylic acid polymers
JP2013509401A (ja) * 2009-10-29 2013-03-14 インダストリー−アカデミック コーポレーション ファウンデーション，ヨンセイ ユニバーシティ 新規血管漏出遮断剤

Also Published As

Publication number Publication date
DD136142A5 (de) 1979-06-20
SU980628A3 (ru) 1982-12-07
DD132439A5 (de) 1978-09-27
IT1077339B (it) 1985-05-04
DD137235A5 (de) 1979-08-22
JPS6117477B2 (enExample) 1986-05-07
GB1585786A (en) 1981-03-11
DE2632677C2 (enExample) 1988-06-16
HU182789B (en) 1984-03-28
DK323677A (da) 1978-01-17
SE7708192L (sv) 1978-01-17
DK142372B (da) 1980-10-20
SE440779B (sv) 1985-08-19
FR2372176A1 (fr) 1978-06-23
IE45304B1 (en) 1982-07-28
DE2632677A1 (de) 1978-01-26
FR2372174A1 (fr) 1978-06-23
HU182790B (en) 1984-03-28
FR2365588A1 (fr) 1978-04-21
ATA504677A (de) 1980-12-15
BE856860A (fr) 1978-01-16
FR2372175A1 (fr) 1978-06-23
CH629222A5 (de) 1982-04-15
US4179336A (en) 1979-12-18
HU179344B (en) 1982-10-28
CH629503A5 (de) 1982-04-30
CS200517B2 (en) 1980-09-15
CH627190A5 (enExample) 1981-12-31
DD136141A5 (de) 1979-06-20
HU182681B (en) 1984-02-28
IE45304L (en) 1978-01-16
FR2365588B1 (enExample) 1982-06-25
NL7706638A (nl) 1978-01-18
YU164277A (en) 1982-08-31
DK142372C (da) 1981-03-23
AT363196B (de) 1981-07-10

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