JPS5272284A - Enzymeeimmunoassay reagent - Google Patents

Enzymeeimmunoassay reagent

Info

Publication number
JPS5272284A
JPS5272284A JP50148787A JP14878775A JPS5272284A JP S5272284 A JPS5272284 A JP S5272284A JP 50148787 A JP50148787 A JP 50148787A JP 14878775 A JP14878775 A JP 14878775A JP S5272284 A JPS5272284 A JP S5272284A
Authority
JP
Japan
Prior art keywords
enzymeeimmunoassay
reagent
enzymeeimmunoassay reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP50148787A
Other languages
English (en)
Other versions
JPS556193B2 (ja
Inventor
Tsunehiro Kitagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP50148787A priority Critical patent/JPS5272284A/ja
Priority to US05/748,135 priority patent/US4150033A/en
Priority to FR7637367A priority patent/FR2334954A1/fr
Priority to DE19762656155 priority patent/DE2656155A1/de
Priority to GB48612/78A priority patent/GB1570533A/en
Priority to GB51653/76A priority patent/GB1570532A/en
Publication of JPS5272284A publication Critical patent/JPS5272284A/ja
Priority to US05/900,167 priority patent/US4214048A/en
Publication of JPS556193B2 publication Critical patent/JPS556193B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/964—Chemistry: molecular biology and microbiology including enzyme-ligand conjugate production, e.g. reducing rate of nonproductive linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP50148787A 1975-12-12 1975-12-12 Enzymeeimmunoassay reagent Granted JPS5272284A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP50148787A JPS5272284A (en) 1975-12-12 1975-12-12 Enzymeeimmunoassay reagent
US05/748,135 US4150033A (en) 1975-12-12 1976-12-06 Reagent suitable for enzyme immuno assay
FR7637367A FR2334954A1 (fr) 1975-12-12 1976-12-10 Reactif convenant pour la determination immunologique enzymatique
DE19762656155 DE2656155A1 (de) 1975-12-12 1976-12-10 Maleinimidobenzoesaeure-n-hydroxysuccinimidester und ihre verwendung zur enzymmarkierung von antigenen
GB48612/78A GB1570533A (en) 1975-12-12 1976-12-10 Maleimidobenzoic acid n-hydroxysuccinimide esters and their use in enzyme immunoassays
GB51653/76A GB1570532A (en) 1975-12-12 1976-12-10 Reagent suitable for enzyme immuno assay
US05/900,167 US4214048A (en) 1975-12-12 1978-04-26 Reagent suitable for enzyme immuno assay

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50148787A JPS5272284A (en) 1975-12-12 1975-12-12 Enzymeeimmunoassay reagent

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP10155679A Division JPS588395B2 (ja) 1979-08-08 1979-08-08 マレイミド安息香酸誘導体の製法

Publications (2)

Publication Number Publication Date
JPS5272284A true JPS5272284A (en) 1977-06-16
JPS556193B2 JPS556193B2 (ja) 1980-02-14

Family

ID=15460663

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50148787A Granted JPS5272284A (en) 1975-12-12 1975-12-12 Enzymeeimmunoassay reagent

Country Status (5)

Country Link
US (2) US4150033A (ja)
JP (1) JPS5272284A (ja)
DE (1) DE2656155A1 (ja)
FR (1) FR2334954A1 (ja)
GB (2) GB1570533A (ja)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5290621A (en) * 1976-01-23 1977-07-30 Eiji Ishikawa Microchemical analysis for polypeptide
JPS5299210A (en) * 1976-02-12 1977-08-19 Eiji Ishikawa Analysis of antigenic substance
JPS58149700A (ja) * 1982-03-02 1983-09-06 Takeda Chem Ind Ltd ペルオキシダ−ゼ含有複合体，その製造法および試薬
JPS58208238A (ja) * 1982-03-17 1983-12-03 サノフイ・ソシエテ・アノニム 共有結合によつて酵素と抗体を結合させる新しい共役物とこの共役物を用いた医薬会合
JPS5990054A (ja) * 1982-11-15 1984-05-24 Takeda Chem Ind Ltd ヒト絨毛性ゴナドトロピンの免疫化学的測定法および試薬
JPS60183557A (ja) * 1984-02-29 1985-09-19 Otsuka Pharmaceut Co Ltd 標識メタロチオネイン及びこれを用いたメタロチオネインの測定法
JPH01227961A (ja) * 1988-03-09 1989-09-12 Kissei Pharmaceut Co Ltd アンジオテンシン２の酵素免疫化学的測定方法
JPH0299863A (ja) * 1988-10-07 1990-04-11 Kazuo Murakami アンジオテンシン−ｉの測定法
JPH0299864A (ja) * 1988-10-07 1990-04-11 Kazuo Murakami アンジオテンシン−２の測定法
JPH04231872A (ja) * 1990-05-11 1992-08-20 Eastman Kodak Co 免疫反応性リガンドを測定するための試験キットおよび測定方法

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1153999B (it) * 1977-03-15 1987-01-21 Snam Progetti Composizione atta alla determinazione della triiodotironina e metodo diagnostico impiegante la stessa
EP0000938B1 (en) * 1977-08-22 1984-10-17 National Research Development Corporation Macromolecular covalent conjugates, methods for preparing and pharmaceutical compositions containing them
US4220565A (en) * 1979-01-18 1980-09-02 Scripps Clinic & Research Foundation Immunochemical conjugates: method and composition
DE2923139A1 (de) * 1979-06-07 1980-12-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von immunologisch aktiven enzymmarkierten konjugaten
FR2470773B1 (ja) * 1979-11-28 1983-01-28 Pasteur Institut
JPS5714748A (en) * 1980-07-01 1982-01-26 Dainippon Pharmaceut Co Ltd Kit for quantitative determination of valproic acid and its method for quantitative determination
DE3037858A1 (de) * 1980-10-07 1982-05-19 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von reaktiven, kupplungsfaehigen derivaten der schilddruesenhormone t (pfeil abwaerts)3(pfeil abwaerts) und t (pfeil abwaerts)4(pfeil abwaerts) und deren verwendung
FR2498192A2 (fr) * 1981-01-22 1982-07-23 Pasteur Institut Nouveau compose polypeptidique thiole provenant d'un fragment de la toxine tetanique, son procede d'obtention et ses applications
US4560648A (en) * 1983-09-23 1985-12-24 Syntex (U.S.A.) Inc. Homogeneous enzyme immunoassay for ferritin
US4943636A (en) * 1984-03-10 1990-07-24 Cetus Corporation Certain pyridyl-di-sulfide-alkylenecarbonxylate-ortho-nitro-phenylsulfonic acid esters useful for coupling biological materials
US4954637A (en) * 1984-03-10 1990-09-04 Cetus Corporation Certain maleimide-N-alkylenecarboxylate-ortho-nitrobenzenesulfonic acid esters and derivatives useful for coupling biological materials
EP0158291A3 (en) * 1984-04-10 1988-07-27 Takeda Chemical Industries, Ltd. A method for purifying carcinoembryonic antigen and a method for producing a carcinoembryonic antigen-reactive monoclonal antibody
US4693969A (en) * 1984-05-04 1987-09-15 Cornell Research Foundation, Inc. Reagent for use in a sandwich solid-phase enzyme-immunoassay and process for employing same
US4764368A (en) * 1984-08-29 1988-08-16 Dana-Farber Cancer Institute, Inc. Acid-cleavable compound
US4542225A (en) * 1984-08-29 1985-09-17 Dana-Farber Cancer Institute, Inc. Acid-cleavable compound
US4659839A (en) * 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
US4680338A (en) * 1985-10-17 1987-07-14 Immunomedics, Inc. Bifunctional linker
IT1211749B (it) * 1986-09-24 1989-11-03 Bayer Aktinegesellschaft Procedimento per la polimerizzazio ne di derivati acrilici
US5066490A (en) * 1988-06-01 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Protein crosslinking reagents cleavable within acidified intracellular vesicles
US5294536A (en) * 1992-04-23 1994-03-15 Pb Diagnostic Systems, Inc. Conjugates
US8481334B1 (en) 2001-11-06 2013-07-09 Charm Sciences, Inc. Method of attaching a ligand to a solid support
WO2005012346A1 (en) * 2003-07-25 2005-02-10 Conjuchem, Inc. Long lasting insulin derivatives and methods thereof
CN109574901A (zh) * 2019-01-17 2019-04-05 苏州昊帆生物股份有限公司 3-马来酰亚胺基苯甲酸琥珀酰亚胺酯的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770820A (en) * 1967-05-11 1973-11-06 J Ackerman Iodinated anilic acids
US3651012A (en) * 1969-04-25 1972-03-21 Gen Electric Novel bis-imide compositions and polymers therefrom
NL154599B (nl) * 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3852157A (en) * 1971-05-14 1974-12-03 Syva Corp Compounds for enzyme amplification assay
DE2237083A1 (de) * 1972-07-28 1974-02-14 Batz Hans Georg Dr Reaktive ester monomerer, polymerisierbarer carbon- und carbaminsaeuren, ihre verwendung und verfahren zu ihrer herstellung
US3875011A (en) * 1972-11-06 1975-04-01 Syva Co Enzyme immunoassays with glucose-6-phosphate dehydrogenase
CA1023287A (en) * 1972-12-08 1977-12-27 Boehringer Mannheim G.M.B.H. Process for the preparation of carrier-bound proteins

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5290621A (en) * 1976-01-23 1977-07-30 Eiji Ishikawa Microchemical analysis for polypeptide
JPS5299210A (en) * 1976-02-12 1977-08-19 Eiji Ishikawa Analysis of antigenic substance
JPS5938545B2 (ja) * 1976-02-12 1984-09-18 栄治 石川 抗原性を有する物質の分折法
JPS58149700A (ja) * 1982-03-02 1983-09-06 Takeda Chem Ind Ltd ペルオキシダ−ゼ含有複合体，その製造法および試薬
JPH048748B2 (ja) * 1982-03-02 1992-02-18
JPS58208238A (ja) * 1982-03-17 1983-12-03 サノフイ・ソシエテ・アノニム 共有結合によつて酵素と抗体を結合させる新しい共役物とこの共役物を用いた医薬会合
JPH038512B2 (ja) * 1982-11-15 1991-02-06 Takeda Chemical Industries Ltd
JPS5990054A (ja) * 1982-11-15 1984-05-24 Takeda Chem Ind Ltd ヒト絨毛性ゴナドトロピンの免疫化学的測定法および試薬
JPS60183557A (ja) * 1984-02-29 1985-09-19 Otsuka Pharmaceut Co Ltd 標識メタロチオネイン及びこれを用いたメタロチオネインの測定法
JPH01227961A (ja) * 1988-03-09 1989-09-12 Kissei Pharmaceut Co Ltd アンジオテンシン２の酵素免疫化学的測定方法
JPH0299864A (ja) * 1988-10-07 1990-04-11 Kazuo Murakami アンジオテンシン−２の測定法
JPH0299863A (ja) * 1988-10-07 1990-04-11 Kazuo Murakami アンジオテンシン−ｉの測定法
JPH04231872A (ja) * 1990-05-11 1992-08-20 Eastman Kodak Co 免疫反応性リガンドを測定するための試験キットおよび測定方法

Also Published As

Publication number Publication date
FR2334954A1 (fr) 1977-07-08
US4214048A (en) 1980-07-22
JPS556193B2 (ja) 1980-02-14
DE2656155C2 (ja) 1988-05-11
DE2656155A1 (de) 1977-06-23
US4150033A (en) 1979-04-17
GB1570533A (en) 1980-07-02
GB1570532A (en) 1980-07-02
FR2334954B1 (ja) 1982-01-08

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