JPS5042087A - - Google Patents

Info

Publication number
JPS5042087A
JPS5042087A JP49083733A JP8373374A JPS5042087A JP S5042087 A JPS5042087 A JP S5042087A JP 49083733 A JP49083733 A JP 49083733A JP 8373374 A JP8373374 A JP 8373374A JP S5042087 A JPS5042087 A JP S5042087A
Authority
JP
Japan
Prior art keywords
biocatalyst
polyalkyl
polyalkoxy
polyalkoxy polymer
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP49083733A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5623587B2 (pt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of JPS5042087A publication Critical patent/JPS5042087A/ja
Publication of JPS5623587B2 publication Critical patent/JPS5623587B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP8373374A 1973-07-20 1974-07-20 Expired JPS5623587B2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38119173A 1973-07-20 1973-07-20

Publications (2)

Publication Number Publication Date
JPS5042087A true JPS5042087A (pt) 1975-04-16
JPS5623587B2 JPS5623587B2 (pt) 1981-06-01

Family

ID=23504063

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8373374A Expired JPS5623587B2 (pt) 1973-07-20 1974-07-20

Country Status (9)

Country Link
JP (1) JPS5623587B2 (pt)
CA (1) CA1033673A (pt)
CH (1) CH616942A5 (pt)
DE (1) DE2433883C2 (pt)
FR (1) FR2313939A1 (pt)
GB (1) GB1469472A (pt)
IL (1) IL45291A0 (pt)
NL (1) NL7409770A (pt)
SE (1) SE441753B (pt)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59204130A (ja) * 1983-04-30 1984-11-19 Nippon Chemiphar Co Ltd 新規プラスミノ−ゲンアクチベ−タ誘導体を含有してなる経口投与薬剤
JPS6094999A (ja) * 1983-09-23 1985-05-28 ヘキスト・アクチエンゲゼルシヤフト インシユリン誘導体およびその製法
WO1985003934A1 (en) * 1984-03-06 1985-09-12 Takeda Chemical Industries, Ltd. Chemically modified protein and process for its preparation
JP2003508498A (ja) * 1999-09-10 2003-03-04 ザ、プロクター、エンド、ギャンブル、カンパニー 酵素インヒビター
JP2005506351A (ja) * 2001-10-18 2005-03-03 ネクター セラピューティックス エイエル，コーポレイション 重合体共役物オピオイドアンタゴニスト
JP2005528372A (ja) * 2002-03-26 2005-09-22 バイオシネクサス インコーポレイテッド 抗菌ポリマー複合体
JP2006510601A (ja) * 2002-09-30 2006-03-30 マウンテン ビュー ファーマシューティカルズ，インコーポレイテッド 抗原性が低下したポリマー結合体、その調製方法および使用方法
JP2006510396A (ja) * 2002-10-21 2006-03-30 アルヴィヴォ インコーポレイテッド 生物活性化合物を含む表面コーティング
JP2009507943A (ja) * 2005-08-26 2009-02-26 エンゾン ファーマスーティカルズ インコーポレイテッド 末端アミン基を有するポリマーの調製方法
JP2016037503A (ja) * 2001-10-10 2016-03-22 ノボ ノルデイスク エイ エス ペプチドの改造および複合糖質化
JP2017536387A (ja) * 2014-12-02 2017-12-07 アントリアバイオ インコーポレイテッドＡｎｔｒｉａｂｉｏ，Ｉｎｃ． 疎水性が高められたタンパク質及びタンパク質コンジュゲート
JP2019521179A (ja) * 2016-06-01 2019-07-25 セルヴィエ アイピー ユーケー リミテッド ポリアルキレンオキシド−アスパラギナーゼの製剤ならびにその製造法および使用法
JP2019527246A (ja) * 2016-05-31 2019-09-26 ローベルト ボツシユ ゲゼルシヤフト ミツト ベシユレンクテル ハフツングＲｏｂｅｒｔ Ｂｏｓｃｈ Ｇｍｂｈ 生体分子をコンジュゲートするためのアズラクトン官能化基材

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2930542A1 (de) * 1979-07-27 1981-02-12 Hoechst Ag Neue insulinderivate und verfahren zu ihrer herstellung
JPS58145691U (ja) * 1982-03-29 1983-09-30 株式会社タイト− テ−ブル型ビデオゲ−ム機
JPS5976288U (ja) * 1982-11-15 1984-05-23 大平技研工業株式会社 テ−ブル型テレビゲ−ム機
JPH0327674Y2 (pt) * 1984-10-02 1991-06-14
JPS61163687U (pt) * 1985-03-28 1986-10-09
JPS62207485A (ja) * 1986-03-07 1987-09-11 大平技研工業株式会社 テレビゲ−ム機
US5037969A (en) * 1986-07-03 1991-08-06 Takeda Chemical Industries, Ltd. Glycosyl derivatives and use thereof
US5166322A (en) * 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5578496A (en) * 1991-12-19 1996-11-26 Board Of Regents, Baylor College Of Medicine Detection of autoantibodies associated with the disease myasthenia gravis
AU3423293A (en) * 1991-12-19 1993-07-19 Baylor College Of Medicine Pva or peg conjugates of peptides for epitope-specific immunosuppression
US5618528A (en) * 1994-02-28 1997-04-08 Sterling Winthrop Inc. Biologically compatible linear block copolymers of polyalkylene oxide and peptide units
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
WO2005028515A1 (ja) 2003-09-24 2005-03-31 Kyowa Hakko Kogyo Co., Ltd. ヒトインスリン様成長因子に対する遺伝子組換え抗体
WO2005056636A2 (en) 2003-12-03 2005-06-23 Nektar Therapeutics Al, Corporation Method of preparing maleimide functionalized polymers
CA2611836A1 (en) * 2005-06-13 2006-12-21 Nastech Pharmaceutical Company Inc. Transmucosal delivery of peptide derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3645852A (en) * 1967-05-23 1972-02-29 Pharmacia Ab Method of binding water-soluble proteins and water-soluble peptides to water-insoluble polymers using cyanogen halide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3619371A (en) * 1967-07-03 1971-11-09 Nat Res Dev Production of a polymeric matrix having a biologically active substance bound thereto
US3674767A (en) * 1967-07-14 1972-07-04 Nat Res Dev Novel polymeric materials containing triazinyl groups

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3645852A (en) * 1967-05-23 1972-02-29 Pharmacia Ab Method of binding water-soluble proteins and water-soluble peptides to water-insoluble polymers using cyanogen halide

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59204130A (ja) * 1983-04-30 1984-11-19 Nippon Chemiphar Co Ltd 新規プラスミノ−ゲンアクチベ−タ誘導体を含有してなる経口投与薬剤
JPS6094999A (ja) * 1983-09-23 1985-05-28 ヘキスト・アクチエンゲゼルシヤフト インシユリン誘導体およびその製法
WO1985003934A1 (en) * 1984-03-06 1985-09-12 Takeda Chemical Industries, Ltd. Chemically modified protein and process for its preparation
JP5020451B2 (ja) * 1999-09-10 2012-09-05 ザ プロクター アンド ギャンブル カンパニー 酵素インヒビター
JP2003508498A (ja) * 1999-09-10 2003-03-04 ザ、プロクター、エンド、ギャンブル、カンパニー 酵素インヒビター
JP2016037503A (ja) * 2001-10-10 2016-03-22 ノボ ノルデイスク エイ エス ペプチドの改造および複合糖質化
JP2005506351A (ja) * 2001-10-18 2005-03-03 ネクター セラピューティックス エイエル，コーポレイション 重合体共役物オピオイドアンタゴニスト
JP2009167214A (ja) * 2001-10-18 2009-07-30 Nektar Therapeutics Al Corp 重合体共役物オピオイドアンタゴニスト
JP4814488B2 (ja) * 2001-10-18 2011-11-16 ネクター セラピューティックス 重合体共役物オピオイドアンタゴニスト
JP2005528372A (ja) * 2002-03-26 2005-09-22 バイオシネクサス インコーポレイテッド 抗菌ポリマー複合体
JP2011157379A (ja) * 2002-09-30 2011-08-18 Mountain View Pharmaceuticals Inc 抗原性が低下したポリマー結合体、その調製方法および使用方法
JP2006510601A (ja) * 2002-09-30 2006-03-30 マウンテン ビュー ファーマシューティカルズ，インコーポレイテッド 抗原性が低下したポリマー結合体、その調製方法および使用方法
JP2006510396A (ja) * 2002-10-21 2006-03-30 アルヴィヴォ インコーポレイテッド 生物活性化合物を含む表面コーティング
JP2009507943A (ja) * 2005-08-26 2009-02-26 エンゾン ファーマスーティカルズ インコーポレイテッド 末端アミン基を有するポリマーの調製方法
JP2017536387A (ja) * 2014-12-02 2017-12-07 アントリアバイオ インコーポレイテッドＡｎｔｒｉａｂｉｏ，Ｉｎｃ． 疎水性が高められたタンパク質及びタンパク質コンジュゲート
JP2019527246A (ja) * 2016-05-31 2019-09-26 ローベルト ボツシユ ゲゼルシヤフト ミツト ベシユレンクテル ハフツングＲｏｂｅｒｔ Ｂｏｓｃｈ Ｇｍｂｈ 生体分子をコンジュゲートするためのアズラクトン官能化基材
JP2019521179A (ja) * 2016-06-01 2019-07-25 セルヴィエ アイピー ユーケー リミテッド ポリアルキレンオキシド−アスパラギナーゼの製剤ならびにその製造法および使用法

Also Published As

Publication number Publication date
CH616942A5 (en) 1980-04-30
DE2433883A1 (de) 1976-02-05
NL7409770A (nl) 1975-01-22
JPS5623587B2 (pt) 1981-06-01
GB1469472A (en) 1977-04-06
CA1033673A (en) 1978-06-27
SE441753B (sv) 1985-11-04
FR2313939B1 (pt) 1979-05-18
DE2433883C2 (de) 1986-03-27
SE7409366L (pt) 1975-01-21
IL45291A0 (en) 1974-10-22
FR2313939A1 (fr) 1977-01-07

Similar Documents

Publication Publication Date Title
FR2313939B1 (pt)
ES474044A1 (es) Procedimiento para la preparacion de soluciones de compues- tos de magnesio
IE41440L (en) Thiatetracyclines
SE7412347L (pt)
ES441678A1 (es) Un procedimiento de obtencion de nuevas composiciones poli- meras.
BE848604A (fr) Tetrakis-alkyl-piperidone-4 oximes substituees utilisables comme stabilisants de matieres organiques,
SU651409A1 (ru) Св зующее вещество рабочего сло носител магнитной записи
SU480711A1 (ru) Способ получени производных 3-оксиметилтиазолиндиона-2,4
ES427869A1 (es) Procedimiento para la preparacion de esteres alcoholicos deacido 5-fenilsulfinil-2-bencimidazol-carbamico.
ES390952A1 (es) Procedimiento para la preparacion de 2-piperidilcarbinoles.
ES412047A1 (es) Un procedimiento para la preparacion de dihidrocumarina o una alcohil-dihidrocumarina.
ES404965A1 (es) Un procedimiento para la preparacion de nuevos derivados n,n'-disustituidos de acido 4-cloro-5-sulfamoil antranilico.
ES429691A1 (es) Proceso para la preparacion del acido p. isobutil-hidratro-pico.
DE3267690D1 (en) Process for the preparation of 3-alkyl-6-methyl-beta-resorcylic-acid esters
GB1315670A (en) Pyrolysis of nickel salts of phosphonic acid monoesters
ES394637A1 (es) Procedimiento para estabilizar material organico posible dedegradacion oxidatica o termica.
ES442022A1 (es) Procedimiento para la preparacion de derivados de propanol.
SU593451A1 (ru) Способ стабилизации бутилкаучука
ES428011A1 (es) Procedimiento para la preparacion de 2-amino-3,5-dibromo- bencilamina.
ES427954A1 (es) Procedimiento para la preparacion de 2-amino - n - ciclohe-xil-3,5-dibromo - n - metil-bencilamina.
ZM9378A1 (en) Use of cyclic esters to prepare 2,3-dichloro-4-(2-thenoyl) phenoxyacetic acid
JPS5416466A (en) Novel 3-hydroxypyrrolldine-3-carboxylic derivative
JPS5247899A (en) Process for preparing polymers of norbornene derivatives
ES427622A1 (es) Procedimiento para la preparacion de 2-amino-bencil-aminas.
FR2288738A1 (fr) Esters hydroxyphenyl-alkylcarboxyliques de bis-thioalkyl-alcools et de bis-thioalkyl-diols, utilisables comme stabilisants de matieres organiques.