JPS5042087A - - Google Patents
Info
- Publication number
- JPS5042087A JPS5042087A JP49083733A JP8373374A JPS5042087A JP S5042087 A JPS5042087 A JP S5042087A JP 49083733 A JP49083733 A JP 49083733A JP 8373374 A JP8373374 A JP 8373374A JP S5042087 A JPS5042087 A JP S5042087A
- Authority
- JP
- Japan
- Prior art keywords
- biocatalyst
- polyalkyl
- polyalkoxy
- polyalkoxy polymer
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
A method for suppressing the immunogenic action of a biocatalyst which has a large number of peptide linkages, with at least partial retention of its physiological activity, entails attaching polymers to the biocatalyst; the biocatalyst is attached to a virtually linear polyalkyl or polyalkoxy polymer via at least one terminal carbon atom thereof; the polyalkyl or polyalkoxy polymer is unsubstituted or substituted by an alkoxy or alkyl group containing fewer than 5 C atoms.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38119173A | 1973-07-20 | 1973-07-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5042087A true JPS5042087A (en) | 1975-04-16 |
JPS5623587B2 JPS5623587B2 (en) | 1981-06-01 |
Family
ID=23504063
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8373374A Expired JPS5623587B2 (en) | 1973-07-20 | 1974-07-20 |
Country Status (9)
Country | Link |
---|---|
JP (1) | JPS5623587B2 (en) |
CA (1) | CA1033673A (en) |
CH (1) | CH616942A5 (en) |
DE (1) | DE2433883C2 (en) |
FR (1) | FR2313939A1 (en) |
GB (1) | GB1469472A (en) |
IL (1) | IL45291A0 (en) |
NL (1) | NL7409770A (en) |
SE (1) | SE441753B (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59204130A (en) * | 1983-04-30 | 1984-11-19 | Nippon Chemiphar Co Ltd | Oral administration drug containing novel plasminogen activator derivative |
JPS6094999A (en) * | 1983-09-23 | 1985-05-28 | ヘキスト・アクチエンゲゼルシヤフト | Insulin derivative and manufacture |
WO1985003934A1 (en) * | 1984-03-06 | 1985-09-12 | Takeda Chemical Industries, Ltd. | Chemically modified protein and process for its preparation |
JP2003508498A (en) * | 1999-09-10 | 2003-03-04 | ザ、プロクター、エンド、ギャンブル、カンパニー | Enzyme inhibitor |
JP2005506351A (en) * | 2001-10-18 | 2005-03-03 | ネクター セラピューティックス エイエル,コーポレイション | Polymer conjugate opioid antagonist |
JP2005528372A (en) * | 2002-03-26 | 2005-09-22 | バイオシネクサス インコーポレイテッド | Antibacterial polymer composite |
JP2006510396A (en) * | 2002-10-21 | 2006-03-30 | アルヴィヴォ インコーポレイテッド | Surface coating containing bioactive compounds |
JP2006510601A (en) * | 2002-09-30 | 2006-03-30 | マウンテン ビュー ファーマシューティカルズ,インコーポレイテッド | Polymer conjugate with reduced antigenicity, method of preparation and use thereof |
JP2009507943A (en) * | 2005-08-26 | 2009-02-26 | エンゾン ファーマスーティカルズ インコーポレイテッド | Process for preparing polymers having terminal amine groups |
JP2016037503A (en) * | 2001-10-10 | 2016-03-22 | ノボ ノルデイスク エイ エス | Remodeling and glycoconjugation of peptides |
JP2017536387A (en) * | 2014-12-02 | 2017-12-07 | アントリアバイオ インコーポレイテッドAntriabio,Inc. | Proteins and protein conjugates with increased hydrophobicity |
JP2019521179A (en) * | 2016-06-01 | 2019-07-25 | セルヴィエ アイピー ユーケー リミテッド | Preparation of polyalkylene oxide-asparaginase and process for its preparation and use |
JP2019527246A (en) * | 2016-05-31 | 2019-09-26 | ローベルト ボツシユ ゲゼルシヤフト ミツト ベシユレンクテル ハフツングRobert Bosch Gmbh | Azlactone-functionalized substrates for conjugating biomolecules |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2930542A1 (en) * | 1979-07-27 | 1981-02-12 | Hoechst Ag | NEW INSULINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
JPS58145691U (en) * | 1982-03-29 | 1983-09-30 | 株式会社タイト− | table type video game machine |
JPS5976288U (en) * | 1982-11-15 | 1984-05-23 | 大平技研工業株式会社 | table type video game machine |
JPH0327674Y2 (en) * | 1984-10-02 | 1991-06-14 | ||
JPS61163687U (en) * | 1985-03-28 | 1986-10-09 | ||
JPS62207485A (en) * | 1986-03-07 | 1987-09-11 | 大平技研工業株式会社 | Television game machine |
US5037969A (en) * | 1986-07-03 | 1991-08-06 | Takeda Chemical Industries, Ltd. | Glycosyl derivatives and use thereof |
US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
WO1993012145A1 (en) * | 1991-12-19 | 1993-06-24 | Baylor College Of Medicine | Pva or peg conjugates of peptides for epitope-specific immunosuppression |
US5578496A (en) * | 1991-12-19 | 1996-11-26 | Board Of Regents, Baylor College Of Medicine | Detection of autoantibodies associated with the disease myasthenia gravis |
US5618528A (en) * | 1994-02-28 | 1997-04-08 | Sterling Winthrop Inc. | Biologically compatible linear block copolymers of polyalkylene oxide and peptide units |
US6323311B1 (en) | 1999-09-22 | 2001-11-27 | University Of Utah Research Foundation | Synthesis of insulin derivatives |
WO2005028515A1 (en) | 2003-09-24 | 2005-03-31 | Kyowa Hakko Kogyo Co., Ltd. | Recombinant antibody against human insulin-like growth factor |
US7790835B2 (en) | 2003-12-03 | 2010-09-07 | Nektar Therapeutics | Method of preparing maleimide functionalized polymers |
CA2611836A1 (en) * | 2005-06-13 | 2006-12-21 | Nastech Pharmaceutical Company Inc. | Transmucosal delivery of peptide derivatives |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3645852A (en) * | 1967-05-23 | 1972-02-29 | Pharmacia Ab | Method of binding water-soluble proteins and water-soluble peptides to water-insoluble polymers using cyanogen halide |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3619371A (en) * | 1967-07-03 | 1971-11-09 | Nat Res Dev | Production of a polymeric matrix having a biologically active substance bound thereto |
US3674767A (en) * | 1967-07-14 | 1972-07-04 | Nat Res Dev | Novel polymeric materials containing triazinyl groups |
-
1974
- 1974-07-15 DE DE2433883A patent/DE2433883C2/en not_active Expired
- 1974-07-17 IL IL45291A patent/IL45291A0/en unknown
- 1974-07-18 GB GB3186174A patent/GB1469472A/en not_active Expired
- 1974-07-18 SE SE7409366A patent/SE441753B/en not_active IP Right Cessation
- 1974-07-19 CH CH997274A patent/CH616942A5/en not_active IP Right Cessation
- 1974-07-19 CA CA205,144A patent/CA1033673A/en not_active Expired
- 1974-07-19 NL NL7409770A patent/NL7409770A/en unknown
- 1974-07-19 FR FR7425288A patent/FR2313939A1/en active Granted
- 1974-07-20 JP JP8373374A patent/JPS5623587B2/ja not_active Expired
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3645852A (en) * | 1967-05-23 | 1972-02-29 | Pharmacia Ab | Method of binding water-soluble proteins and water-soluble peptides to water-insoluble polymers using cyanogen halide |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59204130A (en) * | 1983-04-30 | 1984-11-19 | Nippon Chemiphar Co Ltd | Oral administration drug containing novel plasminogen activator derivative |
JPS6094999A (en) * | 1983-09-23 | 1985-05-28 | ヘキスト・アクチエンゲゼルシヤフト | Insulin derivative and manufacture |
WO1985003934A1 (en) * | 1984-03-06 | 1985-09-12 | Takeda Chemical Industries, Ltd. | Chemically modified protein and process for its preparation |
JP5020451B2 (en) * | 1999-09-10 | 2012-09-05 | ザ プロクター アンド ギャンブル カンパニー | Enzyme inhibitor |
JP2003508498A (en) * | 1999-09-10 | 2003-03-04 | ザ、プロクター、エンド、ギャンブル、カンパニー | Enzyme inhibitor |
JP2016037503A (en) * | 2001-10-10 | 2016-03-22 | ノボ ノルデイスク エイ エス | Remodeling and glycoconjugation of peptides |
JP2005506351A (en) * | 2001-10-18 | 2005-03-03 | ネクター セラピューティックス エイエル,コーポレイション | Polymer conjugate opioid antagonist |
JP2009167214A (en) * | 2001-10-18 | 2009-07-30 | Nektar Therapeutics Al Corp | Polymer conjugates of opioid antagonists |
JP4814488B2 (en) * | 2001-10-18 | 2011-11-16 | ネクター セラピューティックス | Polymer conjugate opioid antagonist |
JP2005528372A (en) * | 2002-03-26 | 2005-09-22 | バイオシネクサス インコーポレイテッド | Antibacterial polymer composite |
JP2006510601A (en) * | 2002-09-30 | 2006-03-30 | マウンテン ビュー ファーマシューティカルズ,インコーポレイテッド | Polymer conjugate with reduced antigenicity, method of preparation and use thereof |
JP2011157379A (en) * | 2002-09-30 | 2011-08-18 | Mountain View Pharmaceuticals Inc | Polymer conjugate with decreased antigenicity, method of preparation and use thereof |
JP2006510396A (en) * | 2002-10-21 | 2006-03-30 | アルヴィヴォ インコーポレイテッド | Surface coating containing bioactive compounds |
JP2009507943A (en) * | 2005-08-26 | 2009-02-26 | エンゾン ファーマスーティカルズ インコーポレイテッド | Process for preparing polymers having terminal amine groups |
JP2017536387A (en) * | 2014-12-02 | 2017-12-07 | アントリアバイオ インコーポレイテッドAntriabio,Inc. | Proteins and protein conjugates with increased hydrophobicity |
JP2019527246A (en) * | 2016-05-31 | 2019-09-26 | ローベルト ボツシユ ゲゼルシヤフト ミツト ベシユレンクテル ハフツングRobert Bosch Gmbh | Azlactone-functionalized substrates for conjugating biomolecules |
JP2019521179A (en) * | 2016-06-01 | 2019-07-25 | セルヴィエ アイピー ユーケー リミテッド | Preparation of polyalkylene oxide-asparaginase and process for its preparation and use |
Also Published As
Publication number | Publication date |
---|---|
DE2433883A1 (en) | 1976-02-05 |
GB1469472A (en) | 1977-04-06 |
SE441753B (en) | 1985-11-04 |
NL7409770A (en) | 1975-01-22 |
CA1033673A (en) | 1978-06-27 |
JPS5623587B2 (en) | 1981-06-01 |
DE2433883C2 (en) | 1986-03-27 |
CH616942A5 (en) | 1980-04-30 |
SE7409366L (en) | 1975-01-21 |
FR2313939B1 (en) | 1979-05-18 |
FR2313939A1 (en) | 1977-01-07 |
IL45291A0 (en) | 1974-10-22 |
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