|
US5703073A
(en)
|
1995-04-19 |
1997-12-30 |
Nitromed, Inc. |
Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
|
|
US6043232A
(en)
*
|
1997-07-23 |
2000-03-28 |
Nitromed, Inc. |
Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
|
|
IT1276071B1
(it)
*
|
1995-10-31 |
1997-10-24 |
Nicox Ltd |
Compositi ad attivita' anti-infiammatoria
|
|
US20050137191A1
(en)
*
|
1996-06-04 |
2005-06-23 |
Thatcher Gregory R. |
Nitrate esters and their use for mitigating cellular damage
|
|
US7115661B1
(en)
|
1999-12-29 |
2006-10-03 |
Queen's University At Kingston |
Methods and compositions for mitigating pain
|
|
IT1288123B1
(it)
*
|
1996-09-04 |
1998-09-10 |
Nicox Sa |
Uso di nitroderivati per l'incontinenza urinaria
|
|
US20040082652A1
(en)
*
|
1996-09-04 |
2004-04-29 |
Nicox S.A. |
Nitric ester derivatives and their use in treating gastrointestinal tumors
|
|
GB9801398D0
(en)
|
1998-01-22 |
1998-03-18 |
Anggard Erik E |
Chemical compounds
|
|
US6136804A
(en)
|
1998-03-13 |
2000-10-24 |
Merck & Co., Inc. |
Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions
|
|
JP2002506024A
(ja)
*
|
1998-03-13 |
2002-02-26 |
メルク エンド カムパニー インコーポレーテッド |
急性冠動脈虚血症候群および関連状態に対する併用療法および組成物
|
|
ES2136581B1
(es)
|
1998-05-27 |
2000-09-16 |
Uriach & Cia Sa J |
Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb.
|
|
AU4428899A
(en)
|
1998-06-08 |
1999-12-30 |
Advanced Medicine, Inc. |
Multibinding inhibitors of cyclooxygenase-2
|
|
WO2000018352A2
(en)
*
|
1998-09-28 |
2000-04-06 |
Merck & Co., Inc. |
A method for treating inflammatory diseases by administering a thrombin inhibitor
|
|
WO2000025776A1
(en)
*
|
1998-10-30 |
2000-05-11 |
Nitromed, Inc. |
Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
|
|
IT1307928B1
(it)
*
|
1999-01-26 |
2001-11-29 |
Nicox Sa |
Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.
|
|
IT1308633B1
(it)
*
|
1999-03-02 |
2002-01-09 |
Nicox Sa |
Nitrossiderivati.
|
|
IT1311924B1
(it)
*
|
1999-04-13 |
2002-03-20 |
Nicox Sa |
Composti farmaceutici.
|
|
US6509377B1
(en)
*
|
1999-05-26 |
2003-01-21 |
J. Uriach & Cia, S.A. |
Use of a 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-κB
|
|
IT1312115B1
(it)
*
|
1999-06-24 |
2002-04-04 |
Nicox Sa |
Composti amorfi e relative composizioni farmaceutiche
|
|
ITMI991517A1
(it)
*
|
1999-07-09 |
2001-01-09 |
Nicox Sa |
Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico
|
|
IT1313596B1
(it)
|
1999-08-04 |
2002-09-09 |
Nicox Sa |
Processo per la preparazione di nitrossialchil esteri del naproxene
|
|
CA2393724A1
(en)
|
1999-12-23 |
2001-06-28 |
Nitromed, Inc. |
Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
|
|
US6538033B2
(en)
*
|
2000-08-29 |
2003-03-25 |
Huntington Medical Research Institutes |
Nitric oxide donor compounds
|
|
IT1319202B1
(it)
*
|
2000-10-12 |
2003-09-26 |
Nicox Sa |
Farmaci per le malattie a base infiammatoria.
|
|
IT1319201B1
(it)
*
|
2000-10-12 |
2003-09-26 |
Nicox Sa |
Farmaci per il diabete.
|
|
EP1406609B1
(en)
*
|
2000-12-21 |
2006-09-06 |
Nitromed, Inc. |
Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
|
|
GB0111872D0
(en)
*
|
2001-05-15 |
2001-07-04 |
Northwick Park Inst For Medica |
Therapeutic agents and methods
|
|
US6696592B2
(en)
|
2001-05-22 |
2004-02-24 |
Nicox-S.A. |
Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
|
|
ITMI20011240A1
(it)
*
|
2001-06-13 |
2002-12-13 |
Nicox Sa |
Farmaci per le vasculopatie
|
|
ITMI20011308A1
(it)
|
2001-06-21 |
2002-12-21 |
Nicox Sa |
Farmaci per il dolore cronico
|
|
ITMI20011307A1
(it)
*
|
2001-06-21 |
2002-12-21 |
Nicox Sa |
Farmaci per l'epilessia
|
|
US7968605B2
(en)
*
|
2002-02-04 |
2011-06-28 |
ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. |
Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
|
|
US20080026984A1
(en)
*
|
2002-02-04 |
2008-01-31 |
Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda |
Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
|
|
EP2042181A1
(en)
*
|
2002-02-04 |
2009-04-01 |
ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda. |
Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
|
|
US20050215611A1
(en)
*
|
2002-05-10 |
2005-09-29 |
Hunt Richard H |
Combination therapy for treating cyclooxygenase-2 mediated diseases in patients at risk of thrombotic cardiovascular events
|
|
EP1505985A1
(en)
*
|
2002-05-10 |
2005-02-16 |
Merck & Co., Inc. |
Combination therapy for treating cyclooxygenase-2 mediated diseases in patients at risk of thrombotic cardiovascular events
|
|
US7220749B2
(en)
|
2002-06-11 |
2007-05-22 |
Nitromed, Inc. |
Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
|
|
AU2003247622A1
(en)
|
2002-06-27 |
2004-01-19 |
Nitromed, Inc. |
Cyclooxygenase-2 selective inhibitors, compositions and methods of use
|
|
CA2492066A1
(en)
*
|
2002-06-28 |
2004-01-08 |
Nitromed, Inc. |
Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
|
|
WO2004004648A2
(en)
*
|
2002-07-03 |
2004-01-15 |
Nitromed, Inc. |
Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
|
|
US7199154B2
(en)
|
2002-07-26 |
2007-04-03 |
Merck Frosst Company |
Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
|
|
EP1542972A4
(en)
*
|
2002-07-29 |
2008-01-23 |
Nitromed Inc |
CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITION AND METHOD OF USE
|
|
ITMI20021861A1
(it)
*
|
2002-08-29 |
2004-02-29 |
Nicox Sa |
Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
|
|
PL375321A1
(en)
*
|
2002-09-20 |
2005-11-28 |
Nicox S.A. |
Manufacturing process for no-donating compounds such as no-donating diclofenac
|
|
US20060247216A1
(en)
*
|
2002-10-25 |
2006-11-02 |
Haj-Yehia Abdullah I |
Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
|
|
GB2395432B
(en)
*
|
2002-11-20 |
2005-09-14 |
Northwick Park Inst For Medica |
Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
|
|
ITMI20022658A1
(it)
|
2002-12-17 |
2004-06-18 |
Nicox Sa |
Farmaci per il dolore cronico.
|
|
US20070207217A1
(en)
*
|
2003-02-03 |
2007-09-06 |
Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda |
Method for treating a mammal by administration of a compound having the ability to release CO
|
|
US7166638B2
(en)
|
2003-05-27 |
2007-01-23 |
Nicox S.A. |
Statin derivatives
|
|
US7169805B2
(en)
|
2003-05-28 |
2007-01-30 |
Nicox S.A. |
Captopril derivatives
|
|
PL379197A1
(pl)
|
2003-06-19 |
2006-07-24 |
Nicox S.A. |
Nitroksylowe pochodne enalaprilu i pokrewne związki jako inhibitory ACE do leczenia chorób sercowo-naczyniowych
|
|
WO2005065361A2
(en)
*
|
2003-12-31 |
2005-07-21 |
Khosrow Kashfi |
Compounds and compositions for treating dysproliferative diseases, and methods of use thereof
|
|
TW200616604A
(en)
|
2004-08-26 |
2006-06-01 |
Nicholas Piramal India Ltd |
Nitric oxide releasing prodrugs containing bio-cleavable linker
|
|
EP2266622A3
(en)
|
2004-08-26 |
2012-06-20 |
Piramal Life Sciences Limited |
Prodrugs containing novel bio-cleavable linkers
|
|
US7521435B2
(en)
*
|
2005-02-18 |
2009-04-21 |
Pharma Diagnostics, N.V. |
Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same
|
|
EP1951653B1
(en)
|
2005-11-23 |
2010-10-20 |
NicOx S.A. |
Salicylic acid derivatives
|
|
GB0601394D0
(en)
|
2006-01-24 |
2006-03-01 |
Hemocorm Ltd |
Therapeutic delivery of carbon monoxide
|
|
JP2007275193A
(ja)
*
|
2006-04-04 |
2007-10-25 |
Fujifilm Corp |
光プローブおよび光断層画像化装置
|
|
PL2180788T3
(pl)
*
|
2007-08-10 |
2017-06-30 |
Basil Rigas |
Związki przeciwzapalne i ich zastosowanie
|
|
WO2010118968A1
(en)
|
2009-04-16 |
2010-10-21 |
Nicox S.A. |
No-donor aspirin derivatives
|
|
WO2011160974A2
(en)
|
2010-06-21 |
2011-12-29 |
Nicox S.A. |
Statin derivatives
|
|
US9163044B2
(en)
|
2011-04-19 |
2015-10-20 |
Alfama, Inc. |
Carbon monoxide releasing molecules and uses thereof
|
|
EP2734235B1
(en)
|
2011-07-21 |
2017-03-22 |
Alfama, Inc. |
Ruthenium carbon monoxide releasing molecules and uses thereof
|
|
CA2897571C
(en)
|
2013-01-21 |
2018-12-18 |
Apparao Satyam |
Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
|
|
US20140271923A1
(en)
|
2013-03-14 |
2014-09-18 |
Christopher Brian Reid |
Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions
|
|
CN117843491A
(zh)
*
|
2023-12-29 |
2024-04-09 |
陕西中医药大学 |
4-(2-(硝基氧基)乙基)-1,2-亚苯基二乙酸酯及其合成方法、应用和药物
|