JPH11514549A - レーザー光学音響画像形成装置 - Google Patents
レーザー光学音響画像形成装置Info
- Publication number
- JPH11514549A JPH11514549A JP9519218A JP51921897A JPH11514549A JP H11514549 A JPH11514549 A JP H11514549A JP 9519218 A JP9519218 A JP 9519218A JP 51921897 A JP51921897 A JP 51921897A JP H11514549 A JPH11514549 A JP H11514549A
- Authority
- JP
- Japan
- Prior art keywords
- tissue
- laser
- stress
- transducer
- diseased tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000003287 optical effect Effects 0.000 title claims abstract description 16
- 238000003384 imaging method Methods 0.000 title abstract description 19
- 238000000034 method Methods 0.000 claims abstract description 44
- 238000001514 detection method Methods 0.000 claims abstract description 31
- 238000003325 tomography Methods 0.000 claims abstract description 30
- 230000001052 transient effect Effects 0.000 claims abstract description 18
- 210000000056 organ Anatomy 0.000 claims abstract description 11
- 230000002123 temporal effect Effects 0.000 claims description 13
- 230000005540 biological transmission Effects 0.000 claims description 9
- 230000031700 light absorption Effects 0.000 claims description 7
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 5
- 208000026310 Breast neoplasm Diseases 0.000 claims description 5
- 210000001835 viscera Anatomy 0.000 claims description 5
- 208000006787 Port-Wine Stain Diseases 0.000 claims description 4
- 238000004458 analytical method Methods 0.000 claims description 4
- 238000003745 diagnosis Methods 0.000 claims description 4
- 239000013307 optical fiber Substances 0.000 claims description 4
- 206010067193 Naevus flammeus Diseases 0.000 claims description 3
- 230000003143 atherosclerotic effect Effects 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 208000002026 familial multiple nevi flammei Diseases 0.000 claims description 3
- 230000001678 irradiating effect Effects 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 239000000523 sample Substances 0.000 claims description 3
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims description 2
- 206010036030 Polyarthritis Diseases 0.000 claims description 2
- 206010003246 arthritis Diseases 0.000 claims description 2
- 208000030533 eye disease Diseases 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 239000003068 molecular probe Substances 0.000 claims description 2
- 208000030428 polyarticular arthritis Diseases 0.000 claims description 2
- 230000002490 cerebral effect Effects 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000003595 spectral effect Effects 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 abstract description 4
- 230000002159 abnormal effect Effects 0.000 abstract description 2
- 239000000975 dye Substances 0.000 abstract description 2
- 230000005284 excitation Effects 0.000 abstract description 2
- 102000001554 Hemoglobins Human genes 0.000 abstract 1
- 108010054147 Hemoglobins Proteins 0.000 abstract 1
- 230000002745 absorbent Effects 0.000 abstract 1
- 239000002250 absorbent Substances 0.000 abstract 1
- 230000004089 microcirculation Effects 0.000 abstract 1
- 231100000915 pathological change Toxicity 0.000 abstract 1
- 230000036285 pathological change Effects 0.000 abstract 1
- 238000012800 visualization Methods 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 82
- 206010028980 Neoplasm Diseases 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 6
- 210000000481 breast Anatomy 0.000 description 5
- 238000002405 diagnostic procedure Methods 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- 206010053942 Cerebral haematoma Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 238000007405 data analysis Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 230000001902 propagating effect Effects 0.000 description 2
- 238000012285 ultrasound imaging Methods 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 201000007741 female breast cancer Diseases 0.000 description 1
- 201000002276 female breast carcinoma Diseases 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 238000009607 mammography Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 238000012634 optical imaging Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000004867 photoacoustic spectroscopy Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/1702—Systems in which incident light is modified in accordance with the properties of the material investigated with opto-acoustic detection, e.g. for gases or analysing solids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Clinical applications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00115—Electrical control of surgical instruments with audible or visual output
- A61B2017/00128—Electrical control of surgical instruments with audible or visual output related to intensity or progress of surgical action
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00844—Feedback systems
- A61F2009/00851—Optical coherence topography [OCT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00897—Scanning mechanisms or algorithms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Radiology & Medical Imaging (AREA)
- Acoustics & Sound (AREA)
- Optics & Photonics (AREA)
- General Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Lasers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/594,758 US5840023A (en) | 1996-01-31 | 1996-01-31 | Optoacoustic imaging for medical diagnosis |
| US08/594,758 | 1996-01-31 | ||
| PCT/US1997/001815 WO1997027801A1 (en) | 1996-01-31 | 1997-01-31 | Laser opto-acoustic imaging system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH11514549A true JPH11514549A (ja) | 1999-12-14 |
| JPH11514549A5 JPH11514549A5 (show.php) | 2004-11-18 |
Family
ID=24380282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9519218A Ceased JPH11514549A (ja) | 1996-01-31 | 1997-01-31 | レーザー光学音響画像形成装置 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5840023A (show.php) |
| EP (1) | EP0920277B1 (show.php) |
| JP (1) | JPH11514549A (show.php) |
| AU (1) | AU732799B2 (show.php) |
| CA (1) | CA2244732C (show.php) |
| DE (1) | DE69734203T2 (show.php) |
| WO (1) | WO1997027801A1 (show.php) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008523881A (ja) * | 2004-12-20 | 2008-07-10 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 体の構造を調査する装置及び方法 |
| JP2008178676A (ja) * | 2006-12-22 | 2008-08-07 | Biosense Webster Inc | 電気生理学的カテーテルを用いたリアルタイムの光音響モニタリング |
| JP2008307372A (ja) * | 2007-05-15 | 2008-12-25 | Canon Inc | 生体情報イメージング装置、生体情報の解析方法、及び生体情報のイメージング方法 |
| JP2009031262A (ja) * | 2007-06-22 | 2009-02-12 | Canon Inc | 生体情報イメージング装置 |
| JP2010012295A (ja) * | 2009-09-14 | 2010-01-21 | Toshiba Corp | 生体情報映像装置 |
| JP2010088496A (ja) * | 2008-10-03 | 2010-04-22 | Canon Inc | 生体情報取得装置 |
| JP2010088499A (ja) * | 2008-10-03 | 2010-04-22 | Canon Inc | 生体情報処理装置及び生体情報処理方法 |
| JP2010104858A (ja) * | 2004-05-06 | 2010-05-13 | Nippon Telegr & Teleph Corp <Ntt> | 成分濃度測定装置及び成分濃度測定装置制御方法 |
| JP2011507651A (ja) * | 2007-12-28 | 2011-03-10 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 光音響病変形成フィードバックを備えた組織切除装置 |
| JP2011528923A (ja) * | 2008-07-25 | 2011-12-01 | ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト（ゲーエムベーハー） | 組織をターゲットにしたバイオマーカーを定量的に検出する多重スペクトル光音響トモグラフィ |
| JP2012505065A (ja) * | 2008-10-13 | 2012-03-01 | アカデミッシュ メディッシュ セントラム ビジ デ ユニバーシタット ファン アムステルダム | 悪性細胞の存在をスクリーニングするためのマンモグラフィ装置及び方法 |
| JP2012524285A (ja) * | 2009-04-20 | 2012-10-11 | ザ キュレイターズ オブ ザ ユニバーシティ オブ ミズーリ | 固形組織内の検体の光音響検出法及び検出システム |
| JP2013099590A (ja) * | 2007-05-15 | 2013-05-23 | Canon Inc | 生体情報イメージング装置、生体情報の解析方法、及び生体情報のイメージング方法 |
| JP2014079485A (ja) * | 2012-10-18 | 2014-05-08 | Canon Inc | 被検体情報取得装置および被検体情報取得装置の制御方法 |
Families Citing this family (306)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
| US5776429A (en) | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
| US20020150539A1 (en) | 1989-12-22 | 2002-10-17 | Unger Evan C. | Ultrasound imaging and treatment |
| US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
| US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
| US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
| US5922304A (en) | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
| US5874062A (en) | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
| US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
| US7083572B2 (en) | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| US6743779B1 (en) | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
| US5997898A (en) | 1995-06-06 | 1999-12-07 | Imarx Pharmaceutical Corp. | Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery |
| US6231834B1 (en) | 1995-06-07 | 2001-05-15 | Imarx Pharmaceutical Corp. | Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same |
| US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
| US6033645A (en) | 1996-06-19 | 2000-03-07 | Unger; Evan C. | Methods for diagnostic imaging by regulating the administration rate of a contrast agent |
| US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
| US6309352B1 (en) * | 1996-01-31 | 2001-10-30 | Board Of Regents, The University Of Texas System | Real time optoacoustic monitoring of changes in tissue properties |
| US6405069B1 (en) * | 1996-01-31 | 2002-06-11 | Board Of Regents, The University Of Texas System | Time-resolved optoacoustic method and system for noninvasive monitoring of glucose |
| AU736301B2 (en) | 1996-05-01 | 2001-07-26 | Imarx Therapeutics, Inc. | Methods for delivering compounds into a cell |
| US6414139B1 (en) | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
| US5846517A (en) | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
| WO1998010798A1 (en) | 1996-09-11 | 1998-03-19 | Imarx Pharmaceutical Corp. | Improved methods for diagnostic imaging using a contrast agent and a vasodilator |
| US5713356A (en) * | 1996-10-04 | 1998-02-03 | Optosonics, Inc. | Photoacoustic breast scanner |
| US6745067B1 (en) * | 1998-09-14 | 2004-06-01 | Lucid, Inc. | System for marking the locations of imaged tissue with respect to the surface of the tissue |
| US6424852B1 (en) * | 1996-10-18 | 2002-07-23 | Lucid, Inc. | System for confocal imaging within dermal tissue |
| GB9704737D0 (en) * | 1997-03-07 | 1997-04-23 | Optel Instr Limited | Biological measurement system |
| US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
| US6537246B1 (en) | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
| US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
| US7452551B1 (en) | 2000-10-30 | 2008-11-18 | Imarx Therapeutics, Inc. | Targeted compositions for diagnostic and therapeutic use |
| US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
| GB9712524D0 (en) * | 1997-06-16 | 1997-08-20 | Nycomed Imaging As | Method |
| US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
| US6091981A (en) * | 1997-09-16 | 2000-07-18 | Assurance Medical Inc. | Clinical tissue examination |
| US6063031A (en) * | 1997-10-14 | 2000-05-16 | Assurance Medical, Inc. | Diagnosis and treatment of tissue with instruments |
| US6123923A (en) | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| US5977538A (en) * | 1998-05-11 | 1999-11-02 | Imarx Pharmaceutical Corp. | Optoacoustic imaging system |
| US6104942A (en) * | 1998-05-12 | 2000-08-15 | Optosonics, Inc. | Thermoacoustic tissue scanner |
| US6478735B1 (en) * | 1999-01-28 | 2002-11-12 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Physiological feedback method and system |
| US6216025B1 (en) | 1999-02-02 | 2001-04-10 | Optosonics, Inc. | Thermoacoustic computed tomography scanner |
| GB9915082D0 (en) * | 1999-06-28 | 1999-08-25 | Univ London | Optical fibre probe |
| WO2001010295A1 (en) * | 1999-08-06 | 2001-02-15 | The Board Of Regents Of The University Of Texas System | Optoacoustic monitoring of blood oxygenation |
| US6253621B1 (en) | 1999-08-31 | 2001-07-03 | Advanced Micro Devices | Micro-void detection |
| US6212421B1 (en) * | 1999-09-03 | 2001-04-03 | Lockheed Martin Energy Research Corp. | Method and apparatus of spectro-acoustically enhanced ultrasonic detection for diagnostics |
| US6421811B1 (en) | 1999-09-30 | 2002-07-16 | Advanced Micro Devices, Inc. | Defect detection via acoustic analysis |
| US6277656B1 (en) | 1999-09-30 | 2001-08-21 | Rama R. Goruganthu | Substrate removal as a function of acoustic analysis |
| US6430728B1 (en) | 1999-09-30 | 2002-08-06 | Advanced Micro Devices, Inc. | Acoustic 3D analysis of circuit structures |
| WO2001035881A1 (en) * | 1999-11-12 | 2001-05-25 | Thomas Bende | Non-contact photoacoustic spectroscopy for photoablation control |
| US6751490B2 (en) | 2000-03-01 | 2004-06-15 | The Board Of Regents Of The University Of Texas System | Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit |
| GB0015250D0 (en) * | 2000-06-22 | 2000-08-16 | Payne Peter A | Ophthalmic uses of lasers |
| IL138073A0 (en) * | 2000-08-24 | 2001-10-31 | Glucon Inc | Photoacoustic assay and imaging system |
| US6669926B1 (en) * | 2000-10-16 | 2003-12-30 | Mallinckrodt, Inc. | Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients |
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| US5840023A (en) | 1998-11-24 |
| WO1997027801A1 (en) | 1997-08-07 |
| AU732799B2 (en) | 2001-05-03 |
| CA2244732A1 (en) | 1997-08-07 |
| DE69734203T2 (de) | 2006-07-13 |
| DE69734203D1 (de) | 2005-10-20 |
| EP0920277A4 (show.php) | 1999-06-09 |
| AU1857097A (en) | 1997-08-22 |
| EP0920277A1 (en) | 1999-06-09 |
| CA2244732C (en) | 2010-04-20 |
| EP0920277B1 (en) | 2005-09-14 |
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