JPH11513031A - 多種サブタイプfivワクチン - Google Patents
多種サブタイプfivワクチンInfo
- Publication number
- JPH11513031A JPH11513031A JP9510430A JP51043097A JPH11513031A JP H11513031 A JPH11513031 A JP H11513031A JP 9510430 A JP9510430 A JP 9510430A JP 51043097 A JP51043097 A JP 51043097A JP H11513031 A JPH11513031 A JP H11513031A
- Authority
- JP
- Japan
- Prior art keywords
- fiv
- cell line
- virus
- fet
- vaccine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.FIV感受性動物において複数のFIVサブタイプに対して免疫反応を誘発するこ とが可能なFIV免疫源を含むワクチン組成物。 2.組換えウイルスベクターFIV構築物、多種FIVサブタイプに由来するFIVポリ ペプチド、多種の無細胞FIVウイルス全体、およびそれぞれが異なるFIVサブタイ プ由来のFIV株に感染している多種の細胞株からなる群より選択される、請求項 1記載のワクチン組成物。 3.ワクチンを宿主動物に投与する前に、FIVウイルスまたはFIV感染細胞株を、 該ウイルスまたは該細胞株が不活化されるよう処置する、請求項2記載のワクチ ン組成物。 4.ワクチンを宿主動物に投与する前に、FIVウイルスまたはFIV感染細胞株を、 該ウイルスまたは該細胞株が弱毒化されるよう処置する、請求項2記載のワクチ ン組成物。 5.複数のFIVサブタイプに対して免疫反応を誘発することが可能なワクチン組 成物の有効量を宿主に投与することを含む、感受性宿主動物においてFIV感染に 対する防御的免疫反応を誘導する方法。 6.ワクチン組成物が、組換えウイルスベクターFIV構築物、多種FIVサブタイプ に由来するFIVポリペプチド、多種の無細胞FIVウイルス全体、およびそれぞれが 異なるFIVサブタイプのFIV株に感染している多種の細胞株からなる群より選択さ れる、請求項5記載の方法。 7.FIVウイルスまたはFIV感染細胞株が、ワクチンを宿主動物へ投与する前に、 不活化されるよう処置される、請求項6記載の方法。 8.FIVウイルスまたはFIV感染細胞株が、ワクチンを宿主動物へ投与する前に、 弱毒化されるよう処置される、請求項6記載の方法。 9.FIVサブタイプが、サブタイプA、B、CおよびDからなる群より選択される、 請求項5記載の方法。 10.少なくとも一次免疫が組換えウイルスベクターFIV構築物を投与することを 含み、その後、組換えウイルスベクターFIV構築物、FIVポリペプチド、無細胞FI Vウイルス全体、およびFIV感染細胞株からなる群より選択されるワクチン組成物 で追 加免疫が行われる、請求項5記載の方法。 11.細胞株が、少なくとも1つのFIVサブタイプによる注射に感受性であり、該F IVサブタイプが、サブタイプA、B、CおよびDからなる群より選択される、ネコ科 由来T細胞株。 12.FeT-1Cと称される、請求項11記載の細胞株。 13.細胞株が、FIVDix、FIVUK8、FIVBang、FIVAom1、FIVAom2、FIVPet、およびF IVshiからなる群より選択されるFIVウイルス株の少なくとも1つに感染する、請 求項11記載の細胞株。 14.IL-2非依存的である、請求項11記載の細胞株。 15.FIVDix、FIVUK8、FIVBang、FIVAom1、FIVAom2、FIVPet、およびFIVShiから なる群より選択されるFIVウイルス株の少なくとも1つに感染する、請求項14記 載の細胞株。 16.FeT-Jと称される、請求項14記載の細胞株。 17.試料伝FIVに接触させ、次に請求項10記載の細胞株を該試料中で有効な時間 培養し、該細胞を新鮮な培養培地で培養し、次に該培養培地中の逆転写酵素活性 量を定量することを含む、試料中のFIVウイルス中和抗体の検出または定量法。 18.細胞株が、FeT-1CおよびFeT-Jと称される細胞株からなる群より選択される 、請求項17記載の方法。
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US51938695A | 1995-08-25 | 1995-08-25 | |
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JP2007121532A Division JP5339687B2 (ja) | 1995-08-25 | 2007-05-02 | 多種サブタイプfivワクチン |
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WO2009014207A1 (ja) * | 2007-07-25 | 2009-01-29 | The Kitasato Institute | 猫免疫不全ウイルスワクチン接種猫の検査方法、および該検査用抗原 |
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US6254872B1 (en) * | 1995-08-25 | 2001-07-03 | University Of Florida | Multi-subtype FIV vaccines |
PT1090985E (pt) | 1995-08-25 | 2006-12-29 | Univ California | Células t derivadas de felino independentes de il-2 |
US6458528B1 (en) * | 1998-05-15 | 2002-10-01 | Idexx Laboratories, Inc. | Diagnosis of feline immunodeficiency virus infection using ENV/GAG polypeptide markers |
US20030091987A1 (en) * | 2001-02-22 | 2003-05-15 | Yamamoto Janet K. | Materials and methods for detecting, preventing, and treating retroviral infection |
JP4283544B2 (ja) | 2001-05-10 | 2009-06-24 | ワイス | レンチウイルスで感染した細胞培養物において細胞密度を増すための組成物および方法 |
CN100387301C (zh) * | 2003-05-12 | 2008-05-14 | 佛罗里达大学研究基金公司 | 针对fiv感染的免疫接种材料和方法 |
US7658927B2 (en) * | 2003-05-12 | 2010-02-09 | University Of Florida Research Foundation, Inc. | Materials and methods for immunizing against FIV infection |
WO2006011919A1 (en) | 2004-06-30 | 2006-02-02 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus |
JP2007505320A (ja) * | 2003-09-11 | 2007-03-08 | アイデックス ラボラトリーズ インコーポレイテッド | ネコ免疫不全ウイルスの検出のための方法と装置 |
WO2005062053A2 (en) | 2003-12-18 | 2005-07-07 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus |
US7348136B2 (en) | 2004-02-19 | 2008-03-25 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus |
JP4662988B2 (ja) * | 2004-06-30 | 2011-03-30 | アイデックス ラボラトリーズ インコーポレイテッド | ネコ免疫不全ウイルスを検出するための方法および装置 |
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AU8007991A (en) * | 1990-06-29 | 1992-01-23 | Daniel Zagury | Methods of inducing immune response to aids virus |
AU2299892A (en) * | 1991-07-05 | 1993-02-11 | Regents Of The University Of California, The | Feline lymphoid cell lines capable of producing fiv |
GB9219936D0 (en) * | 1992-09-21 | 1992-11-04 | Pitman Moore Inc | Vaccines |
EP0670901A1 (en) * | 1993-03-11 | 1995-09-13 | Akzo Nobel N.V. | Polypeptide fragment capable of inducing neutralising antibodies against feline immuno-deficiency virus |
IT1276509B1 (it) * | 1995-03-31 | 1997-10-31 | Istituto Superiore Della Sanit | Vaccino per la profilassiimmunitaria dell'infezione da virus della immunodeficienza felina del gatto domestico. |
US6254872B1 (en) | 1995-08-25 | 2001-07-03 | University Of Florida | Multi-subtype FIV vaccines |
PT1090985E (pt) * | 1995-08-25 | 2006-12-29 | Univ California | Células t derivadas de felino independentes de il-2 |
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Cited By (2)
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WO2009014207A1 (ja) * | 2007-07-25 | 2009-01-29 | The Kitasato Institute | 猫免疫不全ウイルスワクチン接種猫の検査方法、および該検査用抗原 |
US8394581B2 (en) | 2007-07-25 | 2013-03-12 | The Kitasato Institute | Test method on feline vaccinated with feline immunodeficiency virus vaccine, and antigen for use in the test |
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