JPH11508813A - 血漿を濃縮するための装置及び方法 - Google Patents
血漿を濃縮するための装置及び方法Info
- Publication number
- JPH11508813A JPH11508813A JP9500939A JP50093997A JPH11508813A JP H11508813 A JPH11508813 A JP H11508813A JP 9500939 A JP9500939 A JP 9500939A JP 50093997 A JP50093997 A JP 50093997A JP H11508813 A JPH11508813 A JP H11508813A
- Authority
- JP
- Japan
- Prior art keywords
- valve
- chamber
- concentrate
- fluid delivery
- delivery system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 61
- 239000012530 fluid Substances 0.000 claims abstract description 175
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 106
- 239000012141 concentrate Substances 0.000 claims abstract description 105
- 210000004369 blood Anatomy 0.000 claims abstract description 104
- 239000008280 blood Substances 0.000 claims abstract description 104
- 238000010926 purge Methods 0.000 claims abstract description 52
- 239000012528 membrane Substances 0.000 claims description 52
- 239000000706 filtrate Substances 0.000 claims description 19
- 210000003743 erythrocyte Anatomy 0.000 claims description 16
- 238000012546 transfer Methods 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 13
- 239000012510 hollow fiber Substances 0.000 claims description 8
- 238000004891 communication Methods 0.000 claims description 7
- 210000000265 leukocyte Anatomy 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims 1
- 239000000565 sealant Substances 0.000 abstract description 24
- 238000007599 discharging Methods 0.000 abstract description 3
- 238000005086 pumping Methods 0.000 abstract description 2
- 210000002381 plasma Anatomy 0.000 description 36
- 108010049003 Fibrinogen Proteins 0.000 description 25
- 102000008946 Fibrinogen Human genes 0.000 description 25
- 206010052428 Wound Diseases 0.000 description 25
- 208000027418 Wounds and injury Diseases 0.000 description 25
- 229940012952 fibrinogen Drugs 0.000 description 23
- 238000012545 processing Methods 0.000 description 19
- 239000000203 mixture Substances 0.000 description 16
- 239000000243 solution Substances 0.000 description 8
- 238000007873 sieving Methods 0.000 description 7
- 239000003146 anticoagulant agent Substances 0.000 description 6
- 229940127219 anticoagulant drug Drugs 0.000 description 6
- 238000011084 recovery Methods 0.000 description 6
- 239000000835 fiber Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000003805 procoagulant Substances 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- PYHRZPFZZDCOPH-QXGOIDDHSA-N (S)-amphetamine sulfate Chemical compound [H+].[H+].[O-]S([O-])(=O)=O.C[C@H](N)CC1=CC=CC=C1.C[C@H](N)CC1=CC=CC=C1 PYHRZPFZZDCOPH-QXGOIDDHSA-N 0.000 description 4
- 206010018873 Haemoconcentration Diseases 0.000 description 4
- 229950003499 fibrin Drugs 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 3
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 3
- 238000005773 Enders reaction Methods 0.000 description 3
- 108010073385 Fibrin Proteins 0.000 description 3
- 102000009123 Fibrin Human genes 0.000 description 3
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 3
- 239000012190 activator Substances 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 230000000712 assembly Effects 0.000 description 3
- 238000000429 assembly Methods 0.000 description 3
- 239000003114 blood coagulation factor Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003102 growth factor Substances 0.000 description 3
- 238000001631 haemodialysis Methods 0.000 description 3
- 230000000322 hemodialysis Effects 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 229920002492 poly(sulfone) Polymers 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 229930024421 Adenine Natural products 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- 108020004705 Codon Proteins 0.000 description 2
- 108010014173 Factor X Proteins 0.000 description 2
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 description 2
- 229960000643 adenine Drugs 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 230000002489 hematologic effect Effects 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000004081 narcotic agent Substances 0.000 description 2
- 210000004623 platelet-rich plasma Anatomy 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 238000004382 potting Methods 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 231100000816 toxic dose Toxicity 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- RSGFPIWWSCWCFJ-VAXZQHAWSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O RSGFPIWWSCWCFJ-VAXZQHAWSA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 108010039627 Aprotinin Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 108010014172 Factor V Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010062237 Renal impairment Diseases 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000000504 antifibrinolytic agent Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229960004405 aprotinin Drugs 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000020764 fibrinolysis Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000002615 hemofiltration Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000005541 medical transmission Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 229940045641 monobasic sodium phosphate Drugs 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 231100000065 noncytotoxic Toxicity 0.000 description 1
- 230000002020 noncytotoxic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 231100000857 poor renal function Toxicity 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 239000012465 retentate Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000015067 sauces Nutrition 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- BAZAXWOYCMUHIX-UHFFFAOYSA-M sodium perchlorate Chemical compound [Na+].[O-]Cl(=O)(=O)=O BAZAXWOYCMUHIX-UHFFFAOYSA-M 0.000 description 1
- 229910001488 sodium perchlorate Inorganic materials 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- PKIDNTKRVKSLDB-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;hydrate Chemical compound O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PKIDNTKRVKSLDB-UHFFFAOYSA-K 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
- A61M1/3406—Physical characteristics of the filtrate, e.g. urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
- A61M1/341—Regulation parameters by measuring the filtrate rate or volume
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/18—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/15—Detection of leaks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/44—Cartridge types
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Water Supply & Treatment (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48123995A | 1995-06-06 | 1995-06-06 | |
| US481,239 | 1995-06-06 | ||
| PCT/US1996/008289 WO1996039208A1 (en) | 1995-06-06 | 1996-06-05 | Device and method for concentrating plasma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH11508813A true JPH11508813A (ja) | 1999-08-03 |
| JPH11508813A5 JPH11508813A5 (enExample) | 2004-07-22 |
Family
ID=23911183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9500939A Pending JPH11508813A (ja) | 1995-06-06 | 1996-06-05 | 血漿を濃縮するための装置及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6010627A (enExample) |
| EP (1) | EP0836487A1 (enExample) |
| JP (1) | JPH11508813A (enExample) |
| AU (1) | AU712934B2 (enExample) |
| CA (1) | CA2222506C (enExample) |
| WO (1) | WO1996039208A1 (enExample) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005239613A (ja) * | 2004-02-25 | 2005-09-08 | Asahi Kasei Medical Co Ltd | フィブリノーゲン組成液及びその製法 |
| JP2012011225A (ja) * | 2005-02-07 | 2012-01-19 | Hanuman Llc | 多血小板血漿濃縮装置および方法 |
| JP5403827B2 (ja) * | 2008-05-22 | 2014-01-29 | 旭化成メディカル株式会社 | 濾過方法 |
| JP2014094376A (ja) * | 2012-11-12 | 2014-05-22 | Pall Corp | フィルタアセンブリをコンディショニングするためのシステムおよび方法 |
| JP2015077384A (ja) * | 2013-10-15 | 2015-04-23 | キム ホンＫｉｍ Ｈｏｎｇ | 全血から高濃縮血漿を抽出する装置及び方法 |
| JP2015516289A (ja) * | 2012-03-29 | 2015-06-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 流体試料のためのマイクロフロー濾過システム及びフロー濾過方法 |
| JP2015213732A (ja) * | 2014-05-09 | 2015-12-03 | キム ホンＫｉｍ Ｈｏｎｇ | 高濃縮血漿抽出装置及び方法 |
| JP2017538506A (ja) * | 2014-12-16 | 2017-12-28 | バイオームド デバイス エス．アール．エル． | 新鮮な血液成分で容器を充填する方法 |
| WO2024143357A1 (ja) * | 2022-12-27 | 2024-07-04 | 東レ株式会社 | 原液の濃縮液の製造方法 |
Families Citing this family (129)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
| US7033334B2 (en) * | 1996-09-24 | 2006-04-25 | Samolyk Keith A | Hemo-concentrator system for autologous blood recovery |
| US6979307B2 (en) * | 1997-06-24 | 2005-12-27 | Cascade Medical Enterprises Llc | Systems and methods for preparing autologous fibrin glue |
| US7745106B2 (en) * | 1997-06-24 | 2010-06-29 | Cascade Medical Enterprises, Llc | Methods and devices for separating liquid components |
| US8535258B2 (en) * | 2000-03-24 | 2013-09-17 | Immunocept, L.L.C. | Hemofiltration methods for treatment of diseases in a mammal |
| US7291122B2 (en) * | 2000-03-24 | 2007-11-06 | Immunocept, L.L.C. | Hemofiltration methods for treatment of diseases in a mammal |
| US6787040B2 (en) * | 2000-05-16 | 2004-09-07 | Immunocept, L.L.C. | Method and system for colloid exchange therapy |
| US8597516B2 (en) * | 2000-05-16 | 2013-12-03 | Immunocept, L.L.C. | Methods and systems for colloid exchange therapy |
| JP4266637B2 (ja) * | 2001-02-05 | 2009-05-20 | ミリポア・コーポレイション | 微生物の検出 |
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
| US6852287B2 (en) * | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
| US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
| US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
| US6649072B2 (en) | 2001-11-16 | 2003-11-18 | Robert Brandt | Method for producing autologous platelet-rich plasma |
| US6820506B2 (en) * | 2002-03-27 | 2004-11-23 | 3M Innovative Properties Company | Multi-chambered pump-valve device |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US20040182795A1 (en) * | 2003-03-21 | 2004-09-23 | Randel Dorian | Apparatus and method for concentration of plasma from whole blood |
| US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| US7374678B2 (en) * | 2002-05-24 | 2008-05-20 | Biomet Biologics, Inc. | Apparatus and method for separating and concentrating fluids containing multiple components |
| US6905612B2 (en) * | 2003-03-21 | 2005-06-14 | Hanuman Llc | Plasma concentrate apparatus and method |
| US7553413B2 (en) * | 2005-02-07 | 2009-06-30 | Hanuman Llc | Plasma concentrator device |
| US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| WO2003099412A1 (en) * | 2002-05-24 | 2003-12-04 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
| US6982038B2 (en) * | 2002-06-14 | 2006-01-03 | Medtronic, Inc. | Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma |
| ITMI20021553A1 (it) * | 2002-07-15 | 2004-01-15 | Dideco Spa | Emoconcentratore in circuito ematico extracorporeo |
| WO2004009207A1 (en) * | 2002-07-18 | 2004-01-29 | Hanuman Llc | Plasma concentrating apparatus and method |
| JP2005535394A (ja) * | 2002-08-13 | 2005-11-24 | アルビオス テクノロジーズ インコーポレーティッド | 選択的血漿交換方法 |
| JPWO2004018615A1 (ja) * | 2002-08-23 | 2005-12-08 | 旭化成メディカル株式会社 | フィブリン含有組成物 |
| US20040186407A1 (en) * | 2003-03-17 | 2004-09-23 | Kimberly Walker | Concentrator and filter apparatus for treatment of blood |
| US7207964B2 (en) * | 2003-03-17 | 2007-04-24 | Hemavation, Llc | Apparatus and method for down-regulating immune system mediators in blood |
| US7291450B2 (en) * | 2003-03-28 | 2007-11-06 | Smith & Nephew, Inc. | Preparation of a cell concentrate from a physiological solution |
| EP3718635A1 (en) | 2003-07-31 | 2020-10-07 | Handylab, Inc. | Processing particle-containing samples |
| US7354515B2 (en) * | 2004-02-23 | 2008-04-08 | Millennium Medical Technologies, Inc. | Fluid concentrator |
| US7763209B2 (en) * | 2004-03-11 | 2010-07-27 | Handylab, Inc. | Sample preparation device and method |
| AU2005241080B2 (en) * | 2004-05-03 | 2011-08-11 | Handylab, Inc. | Processing polynucleotide-containing samples |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| US20060019234A1 (en) * | 2004-07-22 | 2006-01-26 | Shanbrom Technologies, Llc | Modern blood banking employing improved cell preservation composition |
| AU2005282392A1 (en) * | 2004-09-07 | 2006-03-16 | Smith & Nephew, Inc. | Methods and devices for sterile field transfer |
| US8308340B2 (en) * | 2004-11-23 | 2012-11-13 | Smith & Nephew, Inc. | Composite mixer |
| US7708152B2 (en) * | 2005-02-07 | 2010-05-04 | Hanuman Llc | Method and apparatus for preparing platelet rich plasma and concentrates thereof |
| US7866485B2 (en) | 2005-02-07 | 2011-01-11 | Hanuman, Llc | Apparatus and method for preparing platelet rich plasma and concentrates thereof |
| US7694828B2 (en) | 2005-04-27 | 2010-04-13 | Biomet Manufacturing Corp. | Method and apparatus for producing autologous clotting components |
| US20070042326A1 (en) * | 2005-06-01 | 2007-02-22 | Osseous Technologies Of America | Collagen antral membrane expander |
| SE528214C2 (sv) * | 2005-06-23 | 2006-09-26 | Proliff Ab | Förfarande för framställning av blodplättslysat |
| WO2007044917A2 (en) * | 2005-10-11 | 2007-04-19 | Handylab, Inc. | Polynucleotide sample preparation device |
| US7384549B2 (en) * | 2005-12-29 | 2008-06-10 | Spf Innovations, Llc | Method and apparatus for the filtration of biological solutions |
| US8747669B1 (en) * | 2005-12-29 | 2014-06-10 | Spf Innovations, Llc | Method and apparatus for the filtration of biological samples |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US9040288B2 (en) | 2006-03-24 | 2015-05-26 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US8088616B2 (en) | 2006-03-24 | 2012-01-03 | Handylab, Inc. | Heater unit for microfluidic diagnostic system |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US8430813B2 (en) * | 2006-05-26 | 2013-04-30 | Depuy Spine, Inc. | Illuminated surgical access system including a surgical access device and integrated light emitter |
| US8709787B2 (en) | 2006-11-14 | 2014-04-29 | Handylab, Inc. | Microfluidic cartridge and method of using same |
| US7806276B2 (en) * | 2007-04-12 | 2010-10-05 | Hanuman, Llc | Buoy suspension fractionation system |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| US8092837B2 (en) * | 2007-04-27 | 2012-01-10 | Biomet Manufacturing Corp | Fibrin based glue with functionalized hydrophilic polymer protein binding agent |
| WO2009002849A2 (en) * | 2007-06-22 | 2008-12-31 | Millennium Medical Technologies, Inc. | Fluid concentrator, autologous concentrated body fluids, and uses thereof |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| USD621060S1 (en) | 2008-07-14 | 2010-08-03 | Handylab, Inc. | Microfluidic cartridge |
| US20090136385A1 (en) * | 2007-07-13 | 2009-05-28 | Handylab, Inc. | Reagent Tube |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| EP3222733B1 (en) | 2007-07-13 | 2021-04-07 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
| US9186677B2 (en) * | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| PL2259774T3 (pl) | 2008-02-27 | 2013-04-30 | Biomet Biologics Llc | Sposoby i kompozycje dla wprowadzania antagonisty receptora interleukiny-1 |
| US8337711B2 (en) * | 2008-02-29 | 2012-12-25 | Biomet Biologics, Llc | System and process for separating a material |
| US10046081B2 (en) | 2008-04-11 | 2018-08-14 | The Henry M Jackson Foundation For The Advancement Of Military Medicine, Inc. | Electrospun dextran fibers and devices formed therefrom |
| US8012077B2 (en) * | 2008-05-23 | 2011-09-06 | Biomet Biologics, Llc | Blood separating device |
| USD618820S1 (en) | 2008-07-11 | 2010-06-29 | Handylab, Inc. | Reagent holder |
| US20100009351A1 (en) * | 2008-07-11 | 2010-01-14 | Handylab, Inc. | Polynucleotide Capture Materials, and Method of Using Same |
| USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
| US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
| US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| USD632801S1 (en) | 2009-05-22 | 2011-02-15 | Circle Biologics, Llc. | Fluid concentrator |
| US8734854B2 (en) | 2009-07-09 | 2014-05-27 | Orogen Biosciences Inc. | Process for removing growth factors from platelets |
| US9011800B2 (en) * | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| US8454907B2 (en) | 2009-08-12 | 2013-06-04 | Orogen Holdings, Llc | Growth factor extractor |
| US8444699B2 (en) * | 2010-02-18 | 2013-05-21 | Biomet Manufacturing Corp. | Method and apparatus for augmenting bone defects |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| US9555171B2 (en) | 2010-09-30 | 2017-01-31 | Depuy Mitek, Llc | Methods and devices for collecting separate components of whole blood |
| US20120213754A1 (en) * | 2011-02-23 | 2012-08-23 | Stem Cell Partners Llc | Method of Preconditioning of Cell Suspensions |
| US9011684B2 (en) | 2011-03-07 | 2015-04-21 | Spinesmith Holdings, Llc | Fluid concentrator with removable cartridge |
| ES2617599T3 (es) | 2011-04-15 | 2017-06-19 | Becton, Dickinson And Company | Termociclador microfluídico de exploración en tiempo real y métodos para termociclado sincronizado y detección óptica de exploración |
| US9162186B2 (en) * | 2011-07-22 | 2015-10-20 | Chromedx Corp. | Sample filtration assembly |
| BR112014007440B1 (pt) | 2011-09-30 | 2020-11-03 | Becton, Dickinson And Company | lâmina de reagentes unificada e métodos para detectar a presença ou ausência de ponta de pipeta dentro de bainha de pipeta e para determinar o comprimento de ponta de pipeta dentro de bainha de pipeta na mesma |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| US9603356B2 (en) * | 2011-10-24 | 2017-03-28 | Kaneka Corporation | Method for producing cell concentrate |
| CN104040238B (zh) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | 多核苷酸样品制备装置 |
| DK2810080T3 (da) | 2012-02-03 | 2024-06-17 | Becton Dickinson Co | Eksterne filer til fordeling af molekylære diagnostiske tests og bestemmelse af kompatabilitet imellem tests |
| US10265388B2 (en) | 2012-02-21 | 2019-04-23 | Cytonics Corporation | Systems, compositions, and methods for transplantation |
| EP2644259A1 (en) | 2012-03-29 | 2013-10-02 | Roche Diagniostics GmbH | Micro flow filtration system and flow filtration method |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| EP2891710B1 (en) | 2012-08-30 | 2018-10-17 | Kaneka Corporation | Method for producing cell concentrate |
| US10493194B2 (en) * | 2012-10-23 | 2019-12-03 | Spinesmith Partners, L.P. | Automated device for point-of-care cell processing |
| EP3446773A1 (en) * | 2012-12-09 | 2019-02-27 | Relay Medical Corp. | Automated ultra-filtration system |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| WO2014195252A2 (en) * | 2013-06-03 | 2014-12-11 | Avance Medical Sàrl | Extemporaneous preparation of autologous fibrin |
| DE102013012676A1 (de) * | 2013-07-31 | 2015-02-05 | Mann + Hummel Gmbh | Vorrichtung zur Querstromfiltration |
| EP3038635A4 (en) | 2013-08-28 | 2017-04-05 | Cytonics Corporation | Systems, compositions, and methods for transplantation and treating conditions |
| DE102013017036B4 (de) * | 2013-10-15 | 2017-05-04 | Mann + Hummel Gmbh | Blutfiltervorrichtung |
| US9550028B2 (en) | 2014-05-06 | 2017-01-24 | Biomet Biologics, LLC. | Single step desiccating bead-in-syringe concentrating device |
| US9713810B2 (en) | 2015-03-30 | 2017-07-25 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| US9757721B2 (en) | 2015-05-11 | 2017-09-12 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| US10927347B2 (en) * | 2015-05-15 | 2021-02-23 | Black Tie Medical Inc. | Device and method for breaking down and sizing harvested fat |
| US11344849B2 (en) | 2015-06-08 | 2022-05-31 | Becton, Dickinson And Company | Filtration cell and method for filtering a biological sample |
| ITUB20154668A1 (it) * | 2015-10-14 | 2017-04-14 | Mario Goisis | Dispositivo per la filtrazione del grasso estratto con procedure chirurgiche di liposuzione |
| GB2543660B (en) * | 2015-10-19 | 2018-04-25 | Cytosystems Ltd | Filtration apparatus comprising two movable ports moved from a first to second position thrugh rotation of the membrane housing |
| AU2016351557A1 (en) | 2015-11-12 | 2018-05-31 | St. Teresa Medical, Inc. | A method of sealing a durotomy |
| EP3423827B1 (en) | 2016-03-02 | 2025-12-17 | Becton, Dickinson and Company | Biological fluid separation device |
| US10709370B2 (en) * | 2016-06-09 | 2020-07-14 | Becton, Dickinson And Company | Biological fluid separation device |
| CA3033757A1 (en) * | 2016-10-11 | 2018-04-19 | St. Teresa Medical, Inc. | Hemostatic products |
| JP7333272B2 (ja) | 2017-01-11 | 2023-08-24 | スパイナルサイト， エルエルシー | 線維芽細胞治療活性を増強する方法 |
| US10953128B2 (en) | 2017-11-02 | 2021-03-23 | St. Teresa Medical, Inc. | Fibrin sealant products |
| WO2020060809A1 (en) | 2018-09-17 | 2020-03-26 | Rejuvablast LLC | Combination grafts for tissue repair or regeneration applications |
| KR102246738B1 (ko) * | 2018-11-22 | 2021-04-30 | 주식회사 파인메딕스 | 의료기기 |
| US20220001091A1 (en) * | 2020-07-03 | 2022-01-06 | Prim Sigma Technologies, Inc. | System for Liquid Component Fractionation and Application Method Thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4004975A (en) * | 1975-12-30 | 1977-01-25 | The United States Of America As Represented By The Secretary Of The Navy | Method of isolating and cryopreserving human white cells from whole blood |
| IT1103118B (it) * | 1977-01-10 | 1985-10-14 | Levine Robert A | Dispositiov e tecnica per migliorare la separazione degli strati di cellule in campioni di sangue centrifugati |
| AT359652B (de) * | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
| DE3009126A1 (de) * | 1980-03-10 | 1981-10-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Verfahren zur gewinnung von funktionell und morphologisch intakten und lebensfaehigen leukozyten aus blut |
| AT366916B (de) * | 1980-04-02 | 1982-05-25 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen |
| ATE20824T1 (de) * | 1981-06-25 | 1986-08-15 | Serapharm Gmbh & Co Kg | Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung. |
| BR8205658A (pt) * | 1981-10-02 | 1983-08-30 | Du Pont | Processo e aparelho de plasmaferese por filtracao |
| FR2515965A1 (fr) * | 1981-11-06 | 1983-05-13 | Can Med Inc | Seringue, notamment pour creer une depression dans un appareil de separation de plasma |
| US4680025A (en) * | 1982-08-24 | 1987-07-14 | Baxter Travenol Laboratories, Inc. | Blood component collection systems and methods |
| EP0118473A4 (en) * | 1982-08-24 | 1985-09-16 | Baxter Travenol Lab | COLLECTION SYSTEMS FOR BLOOD COMPONENTS WITH IMPROVED YIELD AND METHOD. |
| CA1226821A (en) * | 1982-11-30 | 1987-09-15 | Junichi Azuma | Apparatus for blood treatment |
| JPS6011166A (ja) * | 1983-06-30 | 1985-01-21 | Toyobo Co Ltd | 臨床検査用血漿の採取方法 |
| US4627879A (en) * | 1984-09-07 | 1986-12-09 | The Trustees Of Columbia University In The City Of New York | Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma |
| US4696748A (en) * | 1984-10-16 | 1987-09-29 | Asahi Medical Co., Ltd. | Plasma separator and a process for preparing the same |
| WO1986003122A1 (en) * | 1984-11-29 | 1986-06-05 | Curatech, Inc. | Wound healing agents |
| WO1986005410A1 (en) * | 1985-03-13 | 1986-09-25 | Baxter Travenol Laboratories, Inc. | Platelet collection system |
| AT382783B (de) * | 1985-06-20 | 1987-04-10 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes |
| DK475386D0 (da) * | 1986-10-03 | 1986-10-03 | Weis Fogh Ulla Sivertsen | Fremgangsmaade og apparat til fremstilling af biologiske stoffer |
| US4978336A (en) * | 1987-09-29 | 1990-12-18 | Hemaedics, Inc. | Biological syringe system |
| US5290552A (en) * | 1988-05-02 | 1994-03-01 | Matrix Pharmaceutical, Inc./Project Hear | Surgical adhesive material |
| US5464535A (en) * | 1988-07-18 | 1995-11-07 | University Of Utah | Filter for on-line plasma sampling |
| US5428008A (en) * | 1989-04-14 | 1995-06-27 | Prp, Inc. | Therapeutic composition of micellar structures capable of promoting hemotasis |
| US5008012A (en) * | 1989-05-25 | 1991-04-16 | Asahi Medical Co., Ltd. | Compact plasma separator and an apparatus containing the same |
| US5226877A (en) * | 1989-06-23 | 1993-07-13 | Epstein Gordon H | Method and apparatus for preparing fibrinogen adhesive from whole blood |
| US5039401A (en) * | 1990-05-16 | 1991-08-13 | Eastman Kodak Company | Blood collection and centrifugal separation device including a valve |
| US5030215A (en) * | 1990-01-03 | 1991-07-09 | Cryolife, Inc. | Preparation of fibrinogen/factor XIII precipitate |
| US5185001A (en) * | 1990-01-18 | 1993-02-09 | The Research Foundation Of State University Of New York | Method of preparing autologous plasma fibrin and application apparatus therefor |
| US5102407A (en) * | 1990-03-13 | 1992-04-07 | Miles Inc. | Blood separation system |
| FR2679251B1 (fr) * | 1991-07-18 | 1993-11-12 | Nord Assoc Essor Transfusion San | Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique. |
| CA2074671A1 (en) * | 1991-11-04 | 1993-05-05 | Thomas Bormann | Device and method for separating plasma from a biological fluid |
| US5330974A (en) * | 1993-03-01 | 1994-07-19 | Fibratek, Inc. | Therapeutic fibrinogen compositions |
| JPH06269497A (ja) * | 1993-03-23 | 1994-09-27 | Mitsubishi Rayon Co Ltd | 冷凍用成分分離血の調製方法 |
| US5437598A (en) * | 1994-01-21 | 1995-08-01 | Cobe Laboratories, Inc. | Automation of plasma sequestration |
| US5585007A (en) * | 1994-12-07 | 1996-12-17 | Plasmaseal Corporation | Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant |
| US5674394A (en) * | 1995-03-24 | 1997-10-07 | Johnson & Johnson Medical, Inc. | Single use system for preparation of autologous plasma |
-
1996
- 1996-06-05 AU AU61476/96A patent/AU712934B2/en not_active Expired
- 1996-06-05 JP JP9500939A patent/JPH11508813A/ja active Pending
- 1996-06-05 CA CA002222506A patent/CA2222506C/en not_active Expired - Lifetime
- 1996-06-05 WO PCT/US1996/008289 patent/WO1996039208A1/en not_active Ceased
- 1996-06-05 EP EP96919026A patent/EP0836487A1/en not_active Withdrawn
- 1996-06-19 US US08/668,075 patent/US6010627A/en not_active Expired - Lifetime
-
1999
- 1999-11-19 US US09/444,018 patent/US6342157B1/en not_active Expired - Lifetime
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005239613A (ja) * | 2004-02-25 | 2005-09-08 | Asahi Kasei Medical Co Ltd | フィブリノーゲン組成液及びその製法 |
| JP2012011225A (ja) * | 2005-02-07 | 2012-01-19 | Hanuman Llc | 多血小板血漿濃縮装置および方法 |
| JP5403827B2 (ja) * | 2008-05-22 | 2014-01-29 | 旭化成メディカル株式会社 | 濾過方法 |
| US9272245B2 (en) | 2008-05-22 | 2016-03-01 | Asahi Kasei Medical Co., Ltd. | Filtration method |
| JP2015516289A (ja) * | 2012-03-29 | 2015-06-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 流体試料のためのマイクロフロー濾過システム及びフロー濾過方法 |
| JP2014094376A (ja) * | 2012-11-12 | 2014-05-22 | Pall Corp | フィルタアセンブリをコンディショニングするためのシステムおよび方法 |
| JP2015077384A (ja) * | 2013-10-15 | 2015-04-23 | キム ホンＫｉｍ Ｈｏｎｇ | 全血から高濃縮血漿を抽出する装置及び方法 |
| JP2015213732A (ja) * | 2014-05-09 | 2015-12-03 | キム ホンＫｉｍ Ｈｏｎｇ | 高濃縮血漿抽出装置及び方法 |
| JP2017538506A (ja) * | 2014-12-16 | 2017-12-28 | バイオームド デバイス エス．アール．エル． | 新鮮な血液成分で容器を充填する方法 |
| WO2024143357A1 (ja) * | 2022-12-27 | 2024-07-04 | 東レ株式会社 | 原液の濃縮液の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2222506A1 (en) | 1996-12-12 |
| WO1996039208A1 (en) | 1996-12-12 |
| AU712934B2 (en) | 1999-11-18 |
| CA2222506C (en) | 2007-07-24 |
| US6342157B1 (en) | 2002-01-29 |
| AU6147696A (en) | 1996-12-24 |
| US6010627A (en) | 2000-01-04 |
| EP0836487A1 (en) | 1998-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH11508813A (ja) | 血漿を濃縮するための装置及び方法 | |
| JP4173205B2 (ja) | 自家移植用血漿とフィブリンゲルの調合 | |
| JP2963539B2 (ja) | 血液凝固因子の濃縮物を血液試料から調製するための装置 | |
| US6214338B1 (en) | Plasma concentrate and method of processing blood for same | |
| US7008394B2 (en) | System and method for processing bone marrow | |
| US5296465A (en) | Ultra pure hemoglobin solutions and blood-substitutes | |
| CA2095623C (en) | System and method for processing biological fluids | |
| ES2032802T5 (es) | Sucedaneo de sangre semisintetico extrapuro. | |
| US8603821B2 (en) | Method for preparing serum and serum preparation apparatus | |
| CN105263540A (zh) | 用于交叉流过滤的设备 | |
| KR20050083627A (ko) | 선택적 혈장 교환 치료 | |
| JP2010005410A (ja) | 血小板グルー創傷密封材 | |
| JP2001276181A (ja) | 不要物除去フィルター付血液バッグ | |
| JP2002526172A (ja) | 生物学的流体フィルターおよびシステム | |
| Castino et al. | The filtration of plasma from whole blood: A novel approach to clinical detoxification | |
| CN108472406A (zh) | 减少组织粘连的方法、组合物和试剂盒 | |
| TW202200226A (zh) | 血液分離裝置及血液製品 | |
| Perepechkin et al. | Hollow fibres for medical applications. A review | |
| JP2010030919A (ja) | トロンビンとフィブリノーゲンの連続的製造方法 | |
| JP2002322070A (ja) | 血液ろ過方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070605 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20070904 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20071015 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080701 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20081001 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20090210 |