AU712934B2 - Device and method for concentrating plasma - Google Patents
Device and method for concentrating plasma Download PDFInfo
- Publication number
- AU712934B2 AU712934B2 AU61476/96A AU6147696A AU712934B2 AU 712934 B2 AU712934 B2 AU 712934B2 AU 61476/96 A AU61476/96 A AU 61476/96A AU 6147696 A AU6147696 A AU 6147696A AU 712934 B2 AU712934 B2 AU 712934B2
- Authority
- AU
- Australia
- Prior art keywords
- valve
- concentrate
- ultrafiltration unit
- chamber
- fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
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- A61M1/3406—Physical characteristics of the filtrate, e.g. urea
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Water Supply & Treatment (AREA)
- Anesthesiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
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| US481239 | 1995-06-06 | ||
| PCT/US1996/008289 WO1996039208A1 (en) | 1995-06-06 | 1996-06-05 | Device and method for concentrating plasma |
Publications (2)
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| AU6147696A AU6147696A (en) | 1996-12-24 |
| AU712934B2 true AU712934B2 (en) | 1999-11-18 |
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| AU61476/96A Expired AU712934B2 (en) | 1995-06-06 | 1996-06-05 | Device and method for concentrating plasma |
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| US (2) | US6010627A (enExample) |
| EP (1) | EP0836487A1 (enExample) |
| JP (1) | JPH11508813A (enExample) |
| AU (1) | AU712934B2 (enExample) |
| CA (1) | CA2222506C (enExample) |
| WO (1) | WO1996039208A1 (enExample) |
Families Citing this family (138)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
| US7033334B2 (en) | 1996-09-24 | 2006-04-25 | Samolyk Keith A | Hemo-concentrator system for autologous blood recovery |
| US7745106B2 (en) * | 1997-06-24 | 2010-06-29 | Cascade Medical Enterprises, Llc | Methods and devices for separating liquid components |
| US6979307B2 (en) | 1997-06-24 | 2005-12-27 | Cascade Medical Enterprises Llc | Systems and methods for preparing autologous fibrin glue |
| US7291122B2 (en) * | 2000-03-24 | 2007-11-06 | Immunocept, L.L.C. | Hemofiltration methods for treatment of diseases in a mammal |
| US8535258B2 (en) * | 2000-03-24 | 2013-09-17 | Immunocept, L.L.C. | Hemofiltration methods for treatment of diseases in a mammal |
| US6787040B2 (en) * | 2000-05-16 | 2004-09-07 | Immunocept, L.L.C. | Method and system for colloid exchange therapy |
| US8597516B2 (en) * | 2000-05-16 | 2013-12-03 | Immunocept, L.L.C. | Methods and systems for colloid exchange therapy |
| ES2287254T3 (es) * | 2001-02-05 | 2007-12-16 | Millipore Corporation | Deteccion de microorganismos. |
| US6692700B2 (en) * | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
| US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
| US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
| US6649072B2 (en) | 2001-11-16 | 2003-11-18 | Robert Brandt | Method for producing autologous platelet-rich plasma |
| US6820506B2 (en) * | 2002-03-27 | 2004-11-23 | 3M Innovative Properties Company | Multi-chambered pump-valve device |
| US7374678B2 (en) * | 2002-05-24 | 2008-05-20 | Biomet Biologics, Inc. | Apparatus and method for separating and concentrating fluids containing multiple components |
| US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| US20040182795A1 (en) * | 2003-03-21 | 2004-09-23 | Randel Dorian | Apparatus and method for concentration of plasma from whole blood |
| US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| US20030205538A1 (en) * | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US6905612B2 (en) * | 2003-03-21 | 2005-06-14 | Hanuman Llc | Plasma concentrate apparatus and method |
| US7845499B2 (en) * | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| DE10392686T5 (de) | 2002-05-24 | 2005-07-07 | Biomet Mfg. Corp., Warsaw | Vorrichtung und Verfahren zum Trennen und Konzentrieren von Flüssigkeiten, welche mehrere Komponenten enthalten |
| US6982038B2 (en) * | 2002-06-14 | 2006-01-03 | Medtronic, Inc. | Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma |
| ITMI20021553A1 (it) * | 2002-07-15 | 2004-01-15 | Dideco Spa | Emoconcentratore in circuito ematico extracorporeo |
| WO2004009207A1 (en) * | 2002-07-18 | 2004-01-29 | Hanuman Llc | Plasma concentrating apparatus and method |
| WO2004014315A2 (en) * | 2002-08-13 | 2004-02-19 | Arbios Systems, Inc. | Selective plasma exchange therapy |
| AU2003257684A1 (en) * | 2002-08-23 | 2004-03-11 | Asahi Medical Co., Ltd. | Fibrin-containing composition |
| US20040186407A1 (en) * | 2003-03-17 | 2004-09-23 | Kimberly Walker | Concentrator and filter apparatus for treatment of blood |
| US7207964B2 (en) * | 2003-03-17 | 2007-04-24 | Hemavation, Llc | Apparatus and method for down-regulating immune system mediators in blood |
| US7291450B2 (en) * | 2003-03-28 | 2007-11-06 | Smith & Nephew, Inc. | Preparation of a cell concentrate from a physiological solution |
| EP2407243B1 (en) | 2003-07-31 | 2020-04-22 | Handylab, Inc. | Multilayered microfluidic device |
| US7354515B2 (en) * | 2004-02-23 | 2008-04-08 | Millennium Medical Technologies, Inc. | Fluid concentrator |
| JP2005239613A (ja) * | 2004-02-25 | 2005-09-08 | Asahi Kasei Medical Co Ltd | フィブリノーゲン組成液及びその製法 |
| US7763209B2 (en) * | 2004-03-11 | 2010-07-27 | Handylab, Inc. | Sample preparation device and method |
| ES2553097T3 (es) * | 2004-05-03 | 2015-12-04 | Handylab, Inc. | Procesamiento de muestras que contienen polinucleótidos |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| US20060019234A1 (en) * | 2004-07-22 | 2006-01-26 | Shanbrom Technologies, Llc | Modern blood banking employing improved cell preservation composition |
| WO2006029270A1 (en) * | 2004-09-07 | 2006-03-16 | Smith & Nephew, Inc. | Methods and devices for sterile field transfer |
| US8308340B2 (en) * | 2004-11-23 | 2012-11-13 | Smith & Nephew, Inc. | Composite mixer |
| WO2006086201A2 (en) * | 2005-02-07 | 2006-08-17 | Hanuman Llc | Platelet rich plasma concentrate apparatus and method |
| EP1848472B1 (en) * | 2005-02-07 | 2015-04-01 | Hanuman LLC | Platelet rich plasma concentrate apparatus and method |
| US7866485B2 (en) | 2005-02-07 | 2011-01-11 | Hanuman, Llc | Apparatus and method for preparing platelet rich plasma and concentrates thereof |
| ES2426172T3 (es) * | 2005-02-07 | 2013-10-21 | Hanuman Llc | Dispositivo concentrador de plasma |
| US7694828B2 (en) | 2005-04-27 | 2010-04-13 | Biomet Manufacturing Corp. | Method and apparatus for producing autologous clotting components |
| US20070042326A1 (en) * | 2005-06-01 | 2007-02-22 | Osseous Technologies Of America | Collagen antral membrane expander |
| SE528214C2 (sv) * | 2005-06-23 | 2006-09-26 | Proliff Ab | Förfarande för framställning av blodplättslysat |
| EP1945815A4 (en) * | 2005-10-11 | 2009-02-18 | Handylab Inc | DEVICE FOR PREPARING SAMPLE OF POLYNUCLEOTIDES |
| US8747669B1 (en) * | 2005-12-29 | 2014-06-10 | Spf Innovations, Llc | Method and apparatus for the filtration of biological samples |
| US7510654B2 (en) * | 2005-12-29 | 2009-03-31 | Spf Innovations, Llc | Method and apparatus for the filtration of biological samples |
| US8883490B2 (en) * | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US9040288B2 (en) | 2006-03-24 | 2015-05-26 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
| US8088616B2 (en) | 2006-03-24 | 2012-01-03 | Handylab, Inc. | Heater unit for microfluidic diagnostic system |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US8430813B2 (en) * | 2006-05-26 | 2013-04-30 | Depuy Spine, Inc. | Illuminated surgical access system including a surgical access device and integrated light emitter |
| EP2091647A2 (en) | 2006-11-14 | 2009-08-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US7806276B2 (en) * | 2007-04-12 | 2010-10-05 | Hanuman, Llc | Buoy suspension fractionation system |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| US8092837B2 (en) * | 2007-04-27 | 2012-01-10 | Biomet Manufacturing Corp | Fibrin based glue with functionalized hydrophilic polymer protein binding agent |
| JP2010531142A (ja) * | 2007-06-22 | 2010-09-24 | サークル バイオロジクス、 エルエルシー． | 液体濃縮装置、オートロガスな濃縮体液、およびそれらの使用方法 |
| US8133671B2 (en) * | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US20090136385A1 (en) * | 2007-07-13 | 2009-05-28 | Handylab, Inc. | Reagent Tube |
| USD621060S1 (en) | 2008-07-14 | 2010-08-03 | Handylab, Inc. | Microfluidic cartridge |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| ES2648798T3 (es) | 2007-07-13 | 2018-01-08 | Handylab, Inc. | Materiales de captura de polinucleótidos y métodos de utilización de los mismos |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| EP2259774B1 (en) | 2008-02-27 | 2012-12-12 | Biomet Biologics, LLC | Methods and compositions for delivering interleukin-1 receptor antagonist |
| EP2254991B1 (en) | 2008-02-29 | 2018-08-22 | Biomet Manufacturing, LLC | A system and process for separating a material |
| US10046081B2 (en) | 2008-04-11 | 2018-08-14 | The Henry M Jackson Foundation For The Advancement Of Military Medicine, Inc. | Electrospun dextran fibers and devices formed therefrom |
| TW201006517A (en) * | 2008-05-22 | 2010-02-16 | Asahi Kasei Medical Co Ltd | Filtration method |
| US8012077B2 (en) * | 2008-05-23 | 2011-09-06 | Biomet Biologics, Llc | Blood separating device |
| US20100009351A1 (en) * | 2008-07-11 | 2010-01-14 | Handylab, Inc. | Polynucleotide Capture Materials, and Method of Using Same |
| USD618820S1 (en) | 2008-07-11 | 2010-06-29 | Handylab, Inc. | Reagent holder |
| USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
| US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
| US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| USD632801S1 (en) | 2009-05-22 | 2011-02-15 | Circle Biologics, Llc. | Fluid concentrator |
| US8734854B2 (en) | 2009-07-09 | 2014-05-27 | Orogen Biosciences Inc. | Process for removing growth factors from platelets |
| US9011800B2 (en) * | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| US8454907B2 (en) | 2009-08-12 | 2013-06-04 | Orogen Holdings, Llc | Growth factor extractor |
| US8444699B2 (en) | 2010-02-18 | 2013-05-21 | Biomet Manufacturing Corp. | Method and apparatus for augmenting bone defects |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| US9555171B2 (en) | 2010-09-30 | 2017-01-31 | Depuy Mitek, Llc | Methods and devices for collecting separate components of whole blood |
| US20120213754A1 (en) * | 2011-02-23 | 2012-08-23 | Stem Cell Partners Llc | Method of Preconditioning of Cell Suspensions |
| US9011684B2 (en) | 2011-03-07 | 2015-04-21 | Spinesmith Holdings, Llc | Fluid concentrator with removable cartridge |
| JP6088487B2 (ja) | 2011-04-15 | 2017-03-01 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | 走査リアルタイムマイクロ流体熱サイクラーと同期熱サイクリング及び走査光学検出の方法 |
| US9162186B2 (en) * | 2011-07-22 | 2015-10-20 | Chromedx Corp. | Sample filtration assembly |
| AU2012315595B2 (en) | 2011-09-30 | 2015-10-22 | Becton, Dickinson And Company | Unitized reagent strip |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| US9603356B2 (en) * | 2011-10-24 | 2017-03-28 | Kaneka Corporation | Method for producing cell concentrate |
| CN104040238B (zh) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | 多核苷酸样品制备装置 |
| JP6262152B2 (ja) | 2012-02-03 | 2018-01-17 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | 分子診断試験の分布及び試験間のコンパチビリティ判断のための外部ファイル |
| US10265388B2 (en) | 2012-02-21 | 2019-04-23 | Cytonics Corporation | Systems, compositions, and methods for transplantation |
| EP2644259A1 (en) | 2012-03-29 | 2013-10-02 | Roche Diagniostics GmbH | Micro flow filtration system and flow filtration method |
| EP2644258A1 (en) * | 2012-03-29 | 2013-10-02 | Roche Diagniostics GmbH | Micro flow filtration system and flow filtration method for a fluid sample |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| CN109486757A (zh) | 2012-08-30 | 2019-03-19 | 株式会社钟化 | 细胞浓缩液的制造方法 |
| US10493194B2 (en) * | 2012-10-23 | 2019-12-03 | Spinesmith Partners, L.P. | Automated device for point-of-care cell processing |
| US9421498B2 (en) * | 2012-11-12 | 2016-08-23 | Pall Corporation | Systems and methods for conditioning a filter assembly |
| CA2876445C (en) * | 2012-12-09 | 2015-10-06 | James Samsoondar | Automated ultra-filtration system |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US10300188B2 (en) | 2013-06-03 | 2019-05-28 | Avance Medical Sàrl | Extemporaneous preparation of autologous fibrin |
| DE102013012676A1 (de) * | 2013-07-31 | 2015-02-05 | Mann + Hummel Gmbh | Vorrichtung zur Querstromfiltration |
| EP3038635A4 (en) | 2013-08-28 | 2017-04-05 | Cytonics Corporation | Systems, compositions, and methods for transplantation and treating conditions |
| DE102013017036B4 (de) | 2013-10-15 | 2017-05-04 | Mann + Hummel Gmbh | Blutfiltervorrichtung |
| JP5896571B2 (ja) * | 2013-10-15 | 2016-03-30 | キム ホンＫｉｍ Ｈｏｎｇ | 全血から高濃縮血漿を抽出する装置及び方法 |
| US9550028B2 (en) | 2014-05-06 | 2017-01-24 | Biomet Biologics, LLC. | Single step desiccating bead-in-syringe concentrating device |
| JP5946866B2 (ja) * | 2014-05-09 | 2016-07-06 | キム ホンＫｉｍ Ｈｏｎｇ | 高濃縮血漿抽出装置 |
| ITMO20140360A1 (it) * | 2014-12-16 | 2016-06-16 | Biomed Device S R L | Metodo per il riempimento di contenitori con emocomponenti freschi |
| US9713810B2 (en) | 2015-03-30 | 2017-07-25 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| US9757721B2 (en) | 2015-05-11 | 2017-09-12 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| US10927347B2 (en) * | 2015-05-15 | 2021-02-23 | Black Tie Medical Inc. | Device and method for breaking down and sizing harvested fat |
| WO2016200800A1 (en) | 2015-06-08 | 2016-12-15 | Becton, Dickinson And Company | Filtration cell and method for filtering a biological sample |
| ITUB20154668A1 (it) * | 2015-10-14 | 2017-04-14 | Mario Goisis | Dispositivo per la filtrazione del grasso estratto con procedure chirurgiche di liposuzione |
| GB2543660B (en) * | 2015-10-19 | 2018-04-25 | Cytosystems Ltd | Filtration apparatus comprising two movable ports moved from a first to second position thrugh rotation of the membrane housing |
| EP3373853A4 (en) | 2015-11-12 | 2019-07-10 | St. Teresa Medical, Inc. | METHOD FOR SEALING A DUROTOMY |
| CA3015231A1 (en) | 2016-03-02 | 2017-09-08 | Becton, Dickinson And Company | Biological fluid separation device |
| WO2017214498A1 (en) * | 2016-06-09 | 2017-12-14 | Becton, Dickinson And Company | Biological fluid separation device |
| US20180099069A1 (en) * | 2016-10-11 | 2018-04-12 | St. Teresa Medical, Inc. | Hemostatic products |
| WO2018132594A1 (en) | 2017-01-11 | 2018-07-19 | Spinalcyte, Llc | Methods of enhancing fibroblast therapeutic activity |
| WO2019089717A1 (en) | 2017-11-02 | 2019-05-09 | St. Teresa Medical, Inc. | Fibrin sealant products |
| US11364323B2 (en) | 2018-09-17 | 2022-06-21 | Rejuvablast LLC | Combination grafts for tissue repair or regeneration applications |
| KR102246738B1 (ko) * | 2018-11-22 | 2021-04-30 | 주식회사 파인메딕스 | 의료기기 |
| US20220001091A1 (en) * | 2020-07-03 | 2022-01-06 | Prim Sigma Technologies, Inc. | System for Liquid Component Fractionation and Application Method Thereof |
| EP4643980A1 (en) * | 2022-12-27 | 2025-11-05 | Toray Industries, Inc. | Method for producing concentrated liquid of stock solution |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0076665A2 (en) * | 1981-10-02 | 1983-04-13 | E.I. Du Pont De Nemours And Company | Method and apparatus for plasmapheresis |
| FR2515965A1 (fr) * | 1981-11-06 | 1983-05-13 | Can Med Inc | Seringue, notamment pour creer une depression dans un appareil de separation de plasma |
| WO1984000892A1 (en) * | 1982-08-24 | 1984-03-15 | Baxter Travenol Lab | Increased yield blood component collection systems and methods |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4004975A (en) * | 1975-12-30 | 1977-01-25 | The United States Of America As Represented By The Secretary Of The Navy | Method of isolating and cryopreserving human white cells from whole blood |
| DE2800934C2 (de) * | 1977-01-10 | 1986-09-18 | Robert Aaron Guilford Conn. Levine | Verfahren zur Durchführung von Volumenmessungen an der Zwischenschicht zwischen der Erythrozytenschicht und der Plasmaschicht einer zentrifugierten Blutprobe |
| AT359652B (de) * | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
| DE3009126A1 (de) * | 1980-03-10 | 1981-10-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Verfahren zur gewinnung von funktionell und morphologisch intakten und lebensfaehigen leukozyten aus blut |
| AT366916B (de) * | 1980-04-02 | 1982-05-25 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen |
| ATE20824T1 (de) * | 1981-06-25 | 1986-08-15 | Serapharm Gmbh & Co Kg | Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung. |
| US4680025A (en) * | 1982-08-24 | 1987-07-14 | Baxter Travenol Laboratories, Inc. | Blood component collection systems and methods |
| DE3371869D1 (en) * | 1982-11-30 | 1987-07-09 | Takeda Chemical Industries Ltd | Apparatus for blood treatment |
| JPS6011166A (ja) * | 1983-06-30 | 1985-01-21 | Toyobo Co Ltd | 臨床検査用血漿の採取方法 |
| US4627879A (en) * | 1984-09-07 | 1986-12-09 | The Trustees Of Columbia University In The City Of New York | Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma |
| US4696748A (en) * | 1984-10-16 | 1987-09-29 | Asahi Medical Co., Ltd. | Plasma separator and a process for preparing the same |
| AU596954B2 (en) * | 1984-11-29 | 1990-05-24 | Curatech, Inc. | Wound healing agents |
| DE3688029T2 (de) * | 1985-03-13 | 1993-06-24 | Baxter Int | Sammlungssystem fuer blutplaettchen. |
| AT382783B (de) * | 1985-06-20 | 1987-04-10 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes |
| DK475386D0 (da) * | 1986-10-03 | 1986-10-03 | Weis Fogh Ulla Sivertsen | Fremgangsmaade og apparat til fremstilling af biologiske stoffer |
| US4978336A (en) * | 1987-09-29 | 1990-12-18 | Hemaedics, Inc. | Biological syringe system |
| US5290552A (en) * | 1988-05-02 | 1994-03-01 | Matrix Pharmaceutical, Inc./Project Hear | Surgical adhesive material |
| US5464535A (en) * | 1988-07-18 | 1995-11-07 | University Of Utah | Filter for on-line plasma sampling |
| US5428008A (en) * | 1989-04-14 | 1995-06-27 | Prp, Inc. | Therapeutic composition of micellar structures capable of promoting hemotasis |
| US5008012A (en) * | 1989-05-25 | 1991-04-16 | Asahi Medical Co., Ltd. | Compact plasma separator and an apparatus containing the same |
| US5226877A (en) * | 1989-06-23 | 1993-07-13 | Epstein Gordon H | Method and apparatus for preparing fibrinogen adhesive from whole blood |
| US5039401A (en) * | 1990-05-16 | 1991-08-13 | Eastman Kodak Company | Blood collection and centrifugal separation device including a valve |
| US5030215A (en) * | 1990-01-03 | 1991-07-09 | Cryolife, Inc. | Preparation of fibrinogen/factor XIII precipitate |
| US5185001A (en) * | 1990-01-18 | 1993-02-09 | The Research Foundation Of State University Of New York | Method of preparing autologous plasma fibrin and application apparatus therefor |
| US5102407A (en) * | 1990-03-13 | 1992-04-07 | Miles Inc. | Blood separation system |
| FR2679251B1 (fr) * | 1991-07-18 | 1993-11-12 | Nord Assoc Essor Transfusion San | Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique. |
| CA2074671A1 (en) * | 1991-11-04 | 1993-05-05 | Thomas Bormann | Device and method for separating plasma from a biological fluid |
| US5330974A (en) * | 1993-03-01 | 1994-07-19 | Fibratek, Inc. | Therapeutic fibrinogen compositions |
| JPH06269497A (ja) * | 1993-03-23 | 1994-09-27 | Mitsubishi Rayon Co Ltd | 冷凍用成分分離血の調製方法 |
| US5437598A (en) * | 1994-01-21 | 1995-08-01 | Cobe Laboratories, Inc. | Automation of plasma sequestration |
| US5585007A (en) * | 1994-12-07 | 1996-12-17 | Plasmaseal Corporation | Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant |
| US5674394A (en) * | 1995-03-24 | 1997-10-07 | Johnson & Johnson Medical, Inc. | Single use system for preparation of autologous plasma |
-
1996
- 1996-06-05 JP JP9500939A patent/JPH11508813A/ja active Pending
- 1996-06-05 WO PCT/US1996/008289 patent/WO1996039208A1/en not_active Ceased
- 1996-06-05 EP EP96919026A patent/EP0836487A1/en not_active Withdrawn
- 1996-06-05 AU AU61476/96A patent/AU712934B2/en not_active Expired
- 1996-06-05 CA CA002222506A patent/CA2222506C/en not_active Expired - Lifetime
- 1996-06-19 US US08/668,075 patent/US6010627A/en not_active Expired - Lifetime
-
1999
- 1999-11-19 US US09/444,018 patent/US6342157B1/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0076665A2 (en) * | 1981-10-02 | 1983-04-13 | E.I. Du Pont De Nemours And Company | Method and apparatus for plasmapheresis |
| FR2515965A1 (fr) * | 1981-11-06 | 1983-05-13 | Can Med Inc | Seringue, notamment pour creer une depression dans un appareil de separation de plasma |
| WO1984000892A1 (en) * | 1982-08-24 | 1984-03-15 | Baxter Travenol Lab | Increased yield blood component collection systems and methods |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11508813A (ja) | 1999-08-03 |
| EP0836487A1 (en) | 1998-04-22 |
| CA2222506C (en) | 2007-07-24 |
| US6342157B1 (en) | 2002-01-29 |
| US6010627A (en) | 2000-01-04 |
| WO1996039208A1 (en) | 1996-12-12 |
| CA2222506A1 (en) | 1996-12-12 |
| AU6147696A (en) | 1996-12-24 |
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| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| PC | Assignment registered |
Owner name: INTERPORE INTERNATIONAL INC. Free format text: FORMER OWNER WAS: QUANTIC BIOMEDICAL PARTNERS |