JPH11506568A - 磁気反応粒子の改良した製法 - Google Patents
磁気反応粒子の改良した製法Info
- Publication number
- JPH11506568A JPH11506568A JP9500468A JP50046897A JPH11506568A JP H11506568 A JPH11506568 A JP H11506568A JP 9500468 A JP9500468 A JP 9500468A JP 50046897 A JP50046897 A JP 50046897A JP H11506568 A JPH11506568 A JP H11506568A
- Authority
- JP
- Japan
- Prior art keywords
- magnetic
- coating
- particles
- coated
- magnetite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/005—Pretreatment specially adapted for magnetic separation
- B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
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- G—PHYSICS
- G11—INFORMATION STORAGE
- G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
- G11B5/00—Recording by magnetisation or demagnetisation of a record carrier; Reproducing by magnetic means; Record carriers therefor
- G11B5/84—Processes or apparatus specially adapted for manufacturing record carriers
- G11B5/842—Coating a support with a liquid magnetic dispersion
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- G—PHYSICS
- G11—INFORMATION STORAGE
- G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
- G11B5/00—Recording by magnetisation or demagnetisation of a record carrier; Reproducing by magnetic means; Record carriers therefor
- G11B5/84—Processes or apparatus specially adapted for manufacturing record carriers
- G11B5/848—Coating a support with a magnetic layer by extrusion
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
- H01F1/44—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids
- H01F1/445—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids the magnetic component being a compound, e.g. Fe3O4
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/76—Assays involving albumins other than in routine use for blocking surfaces or for anchoring haptens during immunisation
- G01N2333/765—Serum albumin, e.g. HSA
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
- G01N2446/84—Polymer coating, e.g. gelatin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Power Engineering (AREA)
- Hard Magnetic Materials (AREA)
- Compounds Of Iron (AREA)
- Peptides Or Proteins (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.a.磁性出発物質の少なくとも1粒子を複数の、凝集できる、より小さな サイズの粒子に分割して、非被覆微粒子磁性基質を得、 b.該非被覆微粒子磁性基質を液体媒体中に懸濁し、 c.該被覆、懸濁微粒子磁性基質を、微粒子磁性基質の実質的な凝集が起こる 前に、被覆剤が基質に付着するのに十分な時間被覆剤で被覆し、再懸濁できる被 覆磁性粒子を形成させることからなる被覆剤を微粒子磁性基質に直接適用するこ とによる再懸濁できる被覆磁性微粒子の製造法。 2.さらに、被覆工程中で、微粒子磁性基質を少なくとも約45℃にて、被覆 剤が基質に付着するのに十分な時間加熱することからなる請求項1記載の方法。 3.該磁性出発物質が、少なくとも1種の遷移金属酸化物を含む請求項1また は2記載の方法。 4.遷移記載酸化物がマグネタイトである請求項3記載の方法。 5.被覆剤が天然または合成ポリマーである請求項1または2記載の方法。 6.磁性出発物質を、照射、振動、pH変動、音波処理またはこれの組み合わ せの下で分割する請求項1または2記載の方法。 7.被覆した磁性粒子が一般に最大寸法0.2μ以下を有する請求項1または 2記載の方法。 8.微粒子磁性基質の、被覆剤に対する重量比が、約1000:1〜約1:1 0である請求項1または2記載の方法。 9.さらに、磁性被覆粒子を水または水性緩衝液に再懸濁することからなる請 求項1または2記載の方法。 10.さらに、被覆磁性粒子を該被覆に特異的なに二官能性化合物と反応させ る工程を含む請求項1または2記載の方法。 11.さらに、被覆磁性粒子を二官能性化合物と反応させ、得られた粒子を二 官能リガンドと反応させる工程を含む請求項1または2記載の方法。 12.さらに、被覆磁性粒子を活性化剤と反応させ、得られた粒子を二官能リ ガンド反応させる工程を含む請求項1または2記載の方法。 13.加熱を、約60℃〜約85℃の温度で行う請求項2記載の方法。 14.微粒子磁性出発物質を、被覆剤の存在下、約50℃〜約85℃の温度で 細分する請求項2記載の方法。 15.微粒子磁性出発物質を、加熱せずに、被覆剤の実質的に非存在下で細分 し、ついで、細分した出発物質と被覆剤を、加熱しながら接触させる請求項2記 載の方法。 16.磁性出発物質が、 からなる群から選らばれる一対のイオンを含む請求項1記載の方法。 17.さらに、(a)微粒子磁性出発物質の液体混合物を形成し、 (b)該混合物を、約75℃の温度で、40〜180nmのサイズの粒子を生 ずるに十分な時間音波処理して、微粒子磁性出発物質を、液体中に懸濁する、凝 集できる、より小さなサイズの粒子に分割し、 (c)該加熱、非被覆、懸濁した、より小さなサイズの粒子を、該小さなサイ ズの粒子が実質的に凝集する前に、70〜80℃の温度で、被覆剤が基質に付着 するのに十分な時間、被覆剤と接触させて、再懸濁できる、被覆磁性粒子の安定 な懸濁液を形成することからなる請求項2記載の方法。 18.非被覆、懸濁微粒子磁性基質を、再懸濁できる被覆磁性粒子の完全な被 覆を与えるに十分な量以下の被覆剤と接触させる請求項17記載の方法。 19.請求項17の方法により調製された、再懸濁できる、被覆磁性粒子。 20.室温で24時間までの期間、粒子を1モル塩溶液に曝した場合、粒径増 加2倍以下で示される、塩溶液におけるコロイド安定性を示す再懸濁できる被覆 磁性粒子。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/482,448 | 1995-06-07 | ||
US08/482,448 US5698271A (en) | 1989-08-22 | 1995-06-07 | Methods for the manufacture of magnetically responsive particles |
PCT/US1996/005058 WO1996040502A1 (en) | 1995-06-07 | 1996-04-12 | Improved methods for the manufacture of magnetically responsive particles |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH11506568A true JPH11506568A (ja) | 1999-06-08 |
Family
ID=23916123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9500468A Pending JPH11506568A (ja) | 1995-06-07 | 1996-04-12 | 磁気反応粒子の改良した製法 |
Country Status (6)
Country | Link |
---|---|
US (2) | US5698271A (ja) |
EP (1) | EP0842042B1 (ja) |
JP (1) | JPH11506568A (ja) |
CA (1) | CA2220169C (ja) |
DE (1) | DE69632785T2 (ja) |
WO (1) | WO1996040502A1 (ja) |
Cited By (5)
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JP2007046975A (ja) * | 2005-08-09 | 2007-02-22 | Canon Inc | 標識されたプローブ結合物体、その製造方法、及びその利用方法 |
JP2007528784A (ja) * | 2004-02-11 | 2007-10-18 | マサチューセッツ・インスティチュート・オブ・テクノロジー | 多層ポリマー被覆磁性ナノクラスタ |
JP2009109514A (ja) * | 2001-08-23 | 2009-05-21 | Immunivest Corp | 循環腫瘍細胞、断片およびデブリスの分析 |
JPWO2015008842A1 (ja) * | 2013-07-18 | 2017-03-02 | ソマール株式会社 | 磁性粉体、磁性粉体組成物、磁性粉体組成物成形体、及びそれらの製造方法 |
JP2019530796A (ja) * | 2016-07-15 | 2019-10-24 | サウジ アラビアン オイル カンパニーSaudi Arabian Oil Company | 耐腐食性コーティングおよびその作製方法 |
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DE19520398B4 (de) * | 1995-06-08 | 2009-04-16 | Roche Diagnostics Gmbh | Magnetisches Pigment |
EP0907889B1 (en) | 1996-04-25 | 2007-07-04 | BioArray Solutions Ltd. | Light-controlled electrokinetic assembly of particles near surfaces |
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WO1998031461A1 (en) | 1997-01-21 | 1998-07-23 | W.R. Grace & Co.-Conn. | Silica adsorbent on magnetic substrate |
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US6120856A (en) | 2000-09-19 |
EP0842042B1 (en) | 2004-06-23 |
DE69632785D1 (de) | 2004-07-29 |
DE69632785T2 (de) | 2005-07-14 |
CA2220169A1 (en) | 1996-12-19 |
EP0842042A4 (en) | 1998-10-28 |
EP0842042A1 (en) | 1998-05-20 |
US5698271A (en) | 1997-12-16 |
WO1996040502A1 (en) | 1996-12-19 |
CA2220169C (en) | 2007-11-13 |
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