JPH11500741A - バックボーン環化ペプチド類似体のライブラリー - Google Patents

バックボーン環化ペプチド類似体のライブラリー

Info

Publication number
JPH11500741A
JPH11500741A JP9511044A JP51104497A JPH11500741A JP H11500741 A JPH11500741 A JP H11500741A JP 9511044 A JP9511044 A JP 9511044A JP 51104497 A JP51104497 A JP 51104497A JP H11500741 A JPH11500741 A JP H11500741A
Authority
JP
Japan
Prior art keywords
peptide
group
library
amino acid
backbone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP9511044A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11500741A5 (enExample
Inventor
ホーニク，ヴェレド
ギロン，チャイム
Original Assignee
ペプター，リミテッド
イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL11509695A external-priority patent/IL115096A/xx
Application filed by ペプター，リミテッド, イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム filed Critical ペプター，リミテッド
Publication of JPH11500741A publication Critical patent/JPH11500741A/ja
Publication of JPH11500741A5 publication Critical patent/JPH11500741A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
    • G01R31/28—Testing of electronic circuits, e.g. by signal tracer
    • G01R31/317—Testing of digital circuits
    • G01R31/3181—Functional testing
    • G01R31/3185—Reconfiguring for testing, e.g. LSSD, partitioning
    • G01R31/318533—Reconfiguring for testing, e.g. LSSD, partitioning using scanning techniques, e.g. LSSD, Boundary Scan, JTAG
    • G01R31/318541—Scan latches or cell details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP9511044A 1995-08-29 1996-08-28 バックボーン環化ペプチド類似体のライブラリー Ceased JPH11500741A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IL11509695A IL115096A (en) 1995-08-29 1995-08-29 Libraries of backbone cyclized peptidomimetics
US08/569,042 US6117974A (en) 1991-10-02 1995-12-07 Libraries of backbone-cyclized peptidomimetics
US08/569,042 1995-12-07
US115096 1995-12-07
PCT/IL1996/000091 WO1997009344A2 (en) 1995-08-29 1996-08-28 Librairies of backbone-cyclized peptidomimetics

Publications (2)

Publication Number Publication Date
JPH11500741A true JPH11500741A (ja) 1999-01-19
JPH11500741A5 JPH11500741A5 (enExample) 2004-08-12

Family

ID=26323124

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9511044A Ceased JPH11500741A (ja) 1995-08-29 1996-08-28 バックボーン環化ペプチド類似体のライブラリー

Country Status (6)

Country Link
US (2) US6117974A (enExample)
EP (1) EP0923601A2 (enExample)
JP (1) JPH11500741A (enExample)
AU (1) AU714917B2 (enExample)
CA (1) CA2230861A1 (enExample)
WO (1) WO1997009344A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007530947A (ja) * 2004-03-23 2007-11-01 バイオ−ラッド ラボラトリーズ インコーポレーティッド 試料中の分析物化学種の濃度の範囲を縮小させる方法

Families Citing this family (34)

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US6117974A (en) * 1991-10-02 2000-09-12 Peptor Limited Libraries of backbone-cyclized peptidomimetics
US6407059B1 (en) * 1994-06-08 2002-06-18 Peptor Limited Conformationally constrained backbone cyclized peptide analogs
US5770687A (en) * 1995-06-07 1998-06-23 Peptor Limited Comformationally constrained backbone cyclized somatostatin analogs
US6841533B1 (en) 1995-12-07 2005-01-11 Peptor Limited Conformationally constrained backbone cyclized interleukin-6 antagonists
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
IL122343A0 (en) * 1997-11-27 1998-04-05 Yissum Res Dev Co Inhibition of nuclear import by backbone cyclic peptide analogs
AU1254299A (en) * 1997-12-02 1999-06-16 State Of Israel - Ministry Of Agriculture Backbone cyclic peptide fragments and their analogs derived from pban 1-33, use ful as insecticides
AU2053699A (en) * 1997-12-15 1999-07-05 Peptor Ltd. Branched building units for synthesizing cyclic peptides
US6355616B1 (en) * 1999-06-25 2002-03-12 Xoma (Us) Technology Ltd. Derivative compounds derived from or based on bactericidal/permeability-increasing protein
AU2001288847A1 (en) * 2000-09-07 2002-03-22 Biosyntema Inc. Conformationally constrained labeled peptides for imaging and therapy
AU2003207940A1 (en) * 2002-01-03 2003-07-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem Conformationally constrained c-backbone cyclic peptides
US20030144260A1 (en) * 2002-01-03 2003-07-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Heterocyclic compounds, method of developing new drug leads and combinatorial libraries used in such method
IL148921A0 (en) 2002-03-26 2002-09-12 Peptor Ltd Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy
FR2838444B1 (fr) * 2002-04-10 2016-01-01 Neovacs Nouveaux peptides et leur application en therapeutique
US6994770B2 (en) * 2002-12-20 2006-02-07 Kimberly-Clark Worldwide, Inc. Strength additives for tissue products
US7147751B2 (en) * 2002-12-20 2006-12-12 Kimberly-Clark Worldwide, Inc. Wiping products having a low coefficient of friction in the wet state and process for producing same
US20060068661A1 (en) * 2004-09-29 2006-03-30 Kimberly-Clark Worldwide, Inc. Wiping products having a high equilibrium moisture and a low coefficient of friction
US20060211507A1 (en) * 2005-03-21 2006-09-21 Intertex, Inc. Stake for securing inflatable devices
WO2006129317A1 (en) * 2005-05-31 2006-12-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem BACKBONE CYCLIZED MELANOCORTIN STIMULATING HORMONE (α S ) ANALOGS
US20080015145A1 (en) * 2006-07-11 2008-01-17 Maria Gyongyossy-Issa Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
EP2082234B1 (en) * 2006-11-02 2012-10-03 Procognia (Israel) Ltd. Methods for screening for therapeutic molecules and use of the molecules therefrom
WO2010119450A2 (en) * 2009-04-06 2010-10-21 Matrix Laboratories Ltd An improved process for the preparation of desmopressin or its pharmaceutically acceptable salts
WO2011024175A1 (en) 2009-08-28 2011-03-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Macrocyclic compounds, compositions comprising them and methods for preventing or treating hiv infection
FR2956115B1 (fr) 2010-02-05 2012-04-06 Isp Investments Inc Nouveaux peptides activateurs de la caspase-14 et compositions les comprenant
US20130101664A1 (en) 2011-08-18 2013-04-25 Donald W. Kufe Muc1 ligand traps for use in treating cancers
EP2807182A1 (en) 2012-01-23 2014-12-03 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Stabilized peptide helices for inhibiting dimerization of chemokine c motif receptor 2 (ccr2)
WO2014130949A1 (en) * 2013-02-25 2014-08-28 The Regents Of The University Of Michigan Methods and compositions for the treatment of bone remodeling disorders
WO2015087334A1 (en) 2013-12-15 2015-06-18 Yissum Research Develoment Company Of The Hebrew University Of Jerusalem Ltd. Viperistatin-derived peptides and uses thereof
WO2015127451A1 (en) * 2014-02-24 2015-08-27 The Arizona Board Of Regents On Behalf Of The University Of Arizona Multivalent/multifunctional ligands with agonist activities at opioid receptors and antagonist activities at nk1 receptor for relief of pain
CN109415413A (zh) 2016-06-07 2019-03-01 耶路撒冷希伯来大学伊森姆研究发展有限公司 髓样分化因子88(myd88)的主链环化抑制肽
EP3684794B1 (en) 2017-09-19 2025-08-06 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Somatostatin prodrugs
US20220119474A1 (en) 2019-02-21 2022-04-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Par4 derived peptides, analogs and uses thereof
WO2022003673A1 (en) 2020-06-30 2022-01-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Humanin analogs and uses thereof
WO2025141573A1 (en) 2023-12-27 2025-07-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Calreticulin peptidomimetic inhibitors and prodrugs

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US4054558A (en) * 1976-05-24 1977-10-18 American Home Products Corporation Cyclic dodecapeptide and intermediates therefor
SU798098A1 (ru) * 1977-12-14 1981-01-23 Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp Циклический аналог брадикинина,обла-дАющий СпОСОбНОСТью СОздАВАТь пРОлОНги-РОВАННый дЕпРЕССОРНый эффЕКТ B эКСпЕРиМЕН-TE ,A ТАКжЕ ВАСКул РНую пРОНи-цАЕМОСТь B эКСпЕРиМЕНТЕ
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4923963A (en) * 1987-09-02 1990-05-08 Nova Technology Limited Partnership Bradykinin antagonist peptides
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JPH06505486A (ja) * 1991-02-07 1994-06-23 モレキュメティクス，リミティド βターンおよびβバルジのコンフォメーション的に制限された模倣物およびそれらを含有するペプチド
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US5364851A (en) * 1991-06-14 1994-11-15 International Synthecon, Llc Conformationally restricted biologically active peptides, methods for their production and uses thereof
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US6117974A (en) * 1991-10-02 2000-09-12 Peptor Limited Libraries of backbone-cyclized peptidomimetics
DE69319733T2 (de) * 1992-06-04 1999-01-14 Merrell Dow Pharmaceuticals Inc., Cincinnati, Ohio In der konformation beschränkte peptid analoge als wirkstoff gegen plättchenaggregation
US5371070A (en) * 1992-11-09 1994-12-06 The Salk Institute For Biological Studies Bicyclic GnRH antagonists and a method for regulating the secretion of gonadotropins
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US5770687A (en) * 1995-06-07 1998-06-23 Peptor Limited Comformationally constrained backbone cyclized somatostatin analogs
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007530947A (ja) * 2004-03-23 2007-11-01 バイオ−ラッド ラボラトリーズ インコーポレーティッド 試料中の分析物化学種の濃度の範囲を縮小させる方法

Also Published As

Publication number Publication date
EP0923601A4 (enExample) 1999-06-23
WO1997009344A3 (en) 1997-05-22
AU6836196A (en) 1997-03-27
US6706862B1 (en) 2004-03-16
AU714917B2 (en) 2000-01-13
EP0923601A2 (en) 1999-06-23
WO1997009344A2 (en) 1997-03-13
US6117974A (en) 2000-09-12
CA2230861A1 (en) 1997-03-13

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