AU714917B2 - Libraries of backbone-cyclized peptidomimetics - Google Patents
Libraries of backbone-cyclized peptidomimeticsInfo
- Publication number
- AU714917B2 AU714917B2 AU68361/96A AU6836196A AU714917B2 AU 714917 B2 AU714917 B2 AU 714917B2 AU 68361/96 A AU68361/96 A AU 68361/96A AU 6836196 A AU6836196 A AU 6836196A AU 714917 B2 AU714917 B2 AU 714917B2
- Authority
- AU
- Australia
- Prior art keywords
- group
- peptide
- amino acid
- gly
- library
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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Classifications
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- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
- G01R31/28—Testing of electronic circuits, e.g. by signal tracer
- G01R31/317—Testing of digital circuits
- G01R31/3181—Functional testing
- G01R31/3185—Reconfiguring for testing, e.g. LSSD, partitioning
- G01R31/318533—Reconfiguring for testing, e.g. LSSD, partitioning using scanning techniques, e.g. LSSD, Boundary Scan, JTAG
- G01R31/318541—Scan latches or cell details
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL115096 | 1995-08-29 | ||
| IL11509695A IL115096A (en) | 1995-08-29 | 1995-08-29 | Libraries of backbone cyclized peptidomimetics |
| US08/569042 | 1995-12-07 | ||
| US08/569,042 US6117974A (en) | 1991-10-02 | 1995-12-07 | Libraries of backbone-cyclized peptidomimetics |
| PCT/IL1996/000091 WO1997009344A2 (en) | 1995-08-29 | 1996-08-28 | Librairies of backbone-cyclized peptidomimetics |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU27711/00A Division AU754476B2 (en) | 1995-08-29 | 2000-04-12 | Backbone-cyclized BPI peptidomimetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU6836196A AU6836196A (en) | 1997-03-27 |
| AU714917B2 true AU714917B2 (en) | 2000-01-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU68361/96A Ceased AU714917B2 (en) | 1995-08-29 | 1996-08-28 | Libraries of backbone-cyclized peptidomimetics |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6117974A (enExample) |
| EP (1) | EP0923601A2 (enExample) |
| JP (1) | JPH11500741A (enExample) |
| AU (1) | AU714917B2 (enExample) |
| CA (1) | CA2230861A1 (enExample) |
| WO (1) | WO1997009344A2 (enExample) |
Families Citing this family (35)
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| US6117974A (en) * | 1991-10-02 | 2000-09-12 | Peptor Limited | Libraries of backbone-cyclized peptidomimetics |
| US6407059B1 (en) * | 1994-06-08 | 2002-06-18 | Peptor Limited | Conformationally constrained backbone cyclized peptide analogs |
| US5770687A (en) * | 1995-06-07 | 1998-06-23 | Peptor Limited | Comformationally constrained backbone cyclized somatostatin analogs |
| US6841533B1 (en) | 1995-12-07 | 2005-01-11 | Peptor Limited | Conformationally constrained backbone cyclized interleukin-6 antagonists |
| US6355613B1 (en) * | 1996-07-31 | 2002-03-12 | Peptor Limited | Conformationally constrained backbone cyclized somatostatin analogs |
| IL122343A0 (en) * | 1997-11-27 | 1998-04-05 | Yissum Res Dev Co | Inhibition of nuclear import by backbone cyclic peptide analogs |
| WO1999028339A1 (en) * | 1997-12-02 | 1999-06-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Backbone cyclic peptide fragments and their analogs derived from pban 1-33, useful as insecticides |
| IL136617A0 (en) * | 1997-12-15 | 2001-06-14 | Peptor Ltd | Branched building units for synthesizing cyclic peptides |
| US6355616B1 (en) | 1999-06-25 | 2002-03-12 | Xoma (Us) Technology Ltd. | Derivative compounds derived from or based on bactericidal/permeability-increasing protein |
| AU2001288847A1 (en) * | 2000-09-07 | 2002-03-22 | Biosyntema Inc. | Conformationally constrained labeled peptides for imaging and therapy |
| US20030144260A1 (en) * | 2002-01-03 | 2003-07-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Heterocyclic compounds, method of developing new drug leads and combinatorial libraries used in such method |
| AU2003207940A1 (en) * | 2002-01-03 | 2003-07-30 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Conformationally constrained c-backbone cyclic peptides |
| IL148921A0 (en) | 2002-03-26 | 2002-09-12 | Peptor Ltd | Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy |
| FR2838444B1 (fr) * | 2002-04-10 | 2016-01-01 | Neovacs | Nouveaux peptides et leur application en therapeutique |
| US7147751B2 (en) * | 2002-12-20 | 2006-12-12 | Kimberly-Clark Worldwide, Inc. | Wiping products having a low coefficient of friction in the wet state and process for producing same |
| US6994770B2 (en) * | 2002-12-20 | 2006-02-07 | Kimberly-Clark Worldwide, Inc. | Strength additives for tissue products |
| EP1580559B1 (en) * | 2004-03-23 | 2013-12-25 | Bio-Rad Laboratories, Inc. | Methods for reducing the variance between analyte concentrations taken from complex sample mixtures |
| US20060068661A1 (en) * | 2004-09-29 | 2006-03-30 | Kimberly-Clark Worldwide, Inc. | Wiping products having a high equilibrium moisture and a low coefficient of friction |
| US20060211507A1 (en) * | 2005-03-21 | 2006-09-21 | Intertex, Inc. | Stake for securing inflatable devices |
| WO2006129317A1 (en) * | 2005-05-31 | 2006-12-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | BACKBONE CYCLIZED MELANOCORTIN STIMULATING HORMONE (α S ) ANALOGS |
| US20080015145A1 (en) | 2006-07-11 | 2008-01-17 | Maria Gyongyossy-Issa | Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions |
| EP2082234B1 (en) * | 2006-11-02 | 2012-10-03 | Procognia (Israel) Ltd. | Methods for screening for therapeutic molecules and use of the molecules therefrom |
| EP2417150A2 (en) * | 2009-04-06 | 2012-02-15 | Matrix Laboratories Ltd | An improved process for the preparation of desmopressin or its pharmaceutically acceptable salts |
| US20120270774A1 (en) | 2009-08-28 | 2012-10-25 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Macrocyclic compounds, compositions comprising them and methods for preventing or treating hiv infection |
| FR2956115B1 (fr) | 2010-02-05 | 2012-04-06 | Isp Investments Inc | Nouveaux peptides activateurs de la caspase-14 et compositions les comprenant |
| WO2013026015A1 (en) | 2011-08-18 | 2013-02-21 | Dana-Farber Cancer Institute, Inc. | Muc1 ligand traps for use in treating cancers |
| EP2807182A1 (en) | 2012-01-23 | 2014-12-03 | Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. | Stabilized peptide helices for inhibiting dimerization of chemokine c motif receptor 2 (ccr2) |
| WO2014130949A1 (en) * | 2013-02-25 | 2014-08-28 | The Regents Of The University Of Michigan | Methods and compositions for the treatment of bone remodeling disorders |
| WO2015087334A1 (en) | 2013-12-15 | 2015-06-18 | Yissum Research Develoment Company Of The Hebrew University Of Jerusalem Ltd. | Viperistatin-derived peptides and uses thereof |
| WO2015127451A1 (en) * | 2014-02-24 | 2015-08-27 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Multivalent/multifunctional ligands with agonist activities at opioid receptors and antagonist activities at nk1 receptor for relief of pain |
| EP3464325A1 (en) | 2016-06-07 | 2019-04-10 | Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. | Backbone cyclized inhibitory peptides of myeloid differentiation factor 88 (myd88) |
| US11261215B2 (en) | 2017-09-19 | 2022-03-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Somatostatin prodrugs |
| US20220119474A1 (en) | 2019-02-21 | 2022-04-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Par4 derived peptides, analogs and uses thereof |
| WO2022003673A1 (en) | 2020-06-30 | 2022-01-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Humanin analogs and uses thereof |
| WO2025141573A1 (en) | 2023-12-27 | 2025-07-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Calreticulin peptidomimetic inhibitors and prodrugs |
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| US4011182A (en) * | 1975-03-21 | 1977-03-08 | American Home Products Corporation | Cyclic undecapeptide analogs of somatostatin and intermediates |
| US3988304A (en) * | 1975-08-25 | 1976-10-26 | American Home Products Corporation | Cyclic dodecapeptide derivatives of somatostatin and intermediates thereof |
| US4054558A (en) * | 1976-05-24 | 1977-10-18 | American Home Products Corporation | Cyclic dodecapeptide and intermediates therefor |
| SU798098A1 (ru) * | 1977-12-14 | 1981-01-23 | Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp | Циклический аналог брадикинина,обла-дАющий СпОСОбНОСТью СОздАВАТь пРОлОНги-РОВАННый дЕпРЕССОРНый эффЕКТ B эКСпЕРиМЕН-TE ,A ТАКжЕ ВАСКул РНую пРОНи-цАЕМОСТь B эКСпЕРиМЕНТЕ |
| US4310518A (en) * | 1979-10-31 | 1982-01-12 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
| US4235886A (en) * | 1979-10-31 | 1980-11-25 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
| US4923963A (en) * | 1987-09-02 | 1990-05-08 | Nova Technology Limited Partnership | Bradykinin antagonist peptides |
| EP0334244A3 (en) * | 1988-03-25 | 1991-05-29 | The Procter & Gamble Company | Bradykinin antagonist peptides |
| US5807979A (en) * | 1988-04-08 | 1998-09-15 | The Scripps Research Institute | Synthetic, three-dimensionally stabilized polypeptide mimics of HIV |
| EP0336779A3 (en) * | 1988-04-08 | 1991-08-21 | Scripps Clinic And Research Foundation | Polypeptides stabilized by covalent hydrogen bond replacements |
| US5010175A (en) * | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
| IE63490B1 (en) * | 1988-11-24 | 1995-05-03 | Hoechst Ag | Peptides having bradykinin antagonist action |
| US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| WO1992013878A2 (en) * | 1991-02-07 | 1992-08-20 | Board Of Trustees Of The University Of Illinois | Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same |
| US5475085A (en) * | 1991-02-07 | 1995-12-12 | Molecumetics, Ltd. | Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same |
| DE4119544C1 (enExample) * | 1991-06-13 | 1992-10-15 | Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig, De | |
| US5286846A (en) * | 1991-06-14 | 1994-02-15 | The Government Of The United States Of America As Represented By The Dept. Of Health And Human Services | Amino acid derivative and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides |
| US5364851A (en) * | 1991-06-14 | 1994-11-15 | International Synthecon, Llc | Conformationally restricted biologically active peptides, methods for their production and uses thereof |
| US6117974A (en) * | 1991-10-02 | 2000-09-12 | Peptor Limited | Libraries of backbone-cyclized peptidomimetics |
| IL99628A (en) * | 1991-10-02 | 2004-07-25 | Yissum Res Dev Co | Processes for the preparation of cyclic peptides, and pharmaceutical compositions containing them |
| DE69319733T2 (de) * | 1992-06-04 | 1999-01-14 | Merrell Dow Pharmaceuticals Inc., Cincinnati, Ohio | In der konformation beschränkte peptid analoge als wirkstoff gegen plättchenaggregation |
| US5371070A (en) * | 1992-11-09 | 1994-12-06 | The Salk Institute For Biological Studies | Bicyclic GnRH antagonists and a method for regulating the secretion of gonadotropins |
| EP0788370A4 (en) * | 1993-07-09 | 1998-07-08 | Smithkline Beecham Corp | CYCLIC, PARTIAL RANDOM PEPTIDE LIBRARIES |
| CN1112933C (zh) * | 1994-01-14 | 2003-07-02 | 爱克索马技术有限公司 | 抗真菌的方法和物质 |
| IL109943A (en) * | 1994-06-08 | 2006-08-01 | Develogen Israel Ltd | Conformationally constrained backbone cyclized peptide analogs |
| US5770687A (en) * | 1995-06-07 | 1998-06-23 | Peptor Limited | Comformationally constrained backbone cyclized somatostatin analogs |
| US6051554A (en) * | 1995-06-07 | 2000-04-18 | Peptor Limited | Conformationally constrained backbone cyclized somatostatin analogs |
| JP2007518310A (ja) * | 2003-12-24 | 2007-07-05 | モレックス インコーポレーテッド | 多チャネル導波路構造 |
-
1995
- 1995-12-07 US US08/569,042 patent/US6117974A/en not_active Expired - Fee Related
-
1996
- 1996-08-28 CA CA002230861A patent/CA2230861A1/en not_active Abandoned
- 1996-08-28 JP JP9511044A patent/JPH11500741A/ja not_active Ceased
- 1996-08-28 AU AU68361/96A patent/AU714917B2/en not_active Ceased
- 1996-08-28 WO PCT/IL1996/000091 patent/WO1997009344A2/en not_active Ceased
- 1996-08-28 EP EP96928663A patent/EP0923601A2/en not_active Ceased
-
2000
- 2000-04-20 US US09/553,028 patent/US6706862B1/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| BIOPOLYMERS VOL31 PP745-750 (1991) * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0923601A4 (enExample) | 1999-06-23 |
| US6706862B1 (en) | 2004-03-16 |
| WO1997009344A2 (en) | 1997-03-13 |
| CA2230861A1 (en) | 1997-03-13 |
| US6117974A (en) | 2000-09-12 |
| EP0923601A2 (en) | 1999-06-23 |
| AU6836196A (en) | 1997-03-27 |
| WO1997009344A3 (en) | 1997-05-22 |
| JPH11500741A (ja) | 1999-01-19 |
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| FGA | Letters patent sealed or granted (standard patent) |