JPH1077292A5 - - Google Patents
Info
- Publication number
- JPH1077292A5 JPH1077292A5 JP1997222854A JP22285497A JPH1077292A5 JP H1077292 A5 JPH1077292 A5 JP H1077292A5 JP 1997222854 A JP1997222854 A JP 1997222854A JP 22285497 A JP22285497 A JP 22285497A JP H1077292 A5 JPH1077292 A5 JP H1077292A5
- Authority
- JP
- Japan
- Prior art keywords
- androstane
- diol
- dione
- dimethylaminoethoxyimino
- dimethylaminopropoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19633349.0 | 1996-08-19 | ||
| DE19633349A DE19633349A1 (de) | 1996-08-19 | 1996-08-19 | Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH1077292A JPH1077292A (ja) | 1998-03-24 |
| JPH1077292A5 true JPH1077292A5 (https=) | 2005-05-19 |
| JP4297994B2 JP4297994B2 (ja) | 2009-07-15 |
Family
ID=7802998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP22285497A Expired - Lifetime JP4297994B2 (ja) | 1996-08-19 | 1997-08-19 | 心臓血管系に活性のある新規の６−ヒドロキシおよび６−オキソ−アンドロスタン誘導体およびそれらを含有する製薬用組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5914324A (https=) |
| EP (1) | EP0825197B1 (https=) |
| JP (1) | JP4297994B2 (https=) |
| AT (1) | ATE196768T1 (https=) |
| DE (2) | DE19633349A1 (https=) |
| DK (1) | DK0825197T3 (https=) |
| ES (1) | ES2151698T3 (https=) |
| GR (1) | GR3034821T3 (https=) |
| PT (1) | PT825197E (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1317031B1 (it) * | 2000-05-17 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi. |
| US20080119447A1 (en) * | 2005-09-30 | 2008-05-22 | James Yarger | 6-alkoxyalkyl estradiol derivatives and methods of use |
| US8168621B2 (en) | 2005-09-30 | 2012-05-01 | Endece, Llc | 6-substituted estradiol derivatives and methods of use |
| US10174070B2 (en) * | 2005-09-30 | 2019-01-08 | Endece Llc | 6-substituted estradiol derivatives and methods of use |
| TWI392682B (zh) * | 2006-04-13 | 2013-04-11 | Sigma Tau Ind Farmaceuti | 作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物 |
| TWI389917B (zh) * | 2006-04-13 | 2013-03-21 | Sigma Tau Ind Farmaceuti | 作為心血管疾病治療藥物的雄甾烷與雄甾烯之氮雜環烷基衍生物 |
| TWI372762B (en) * | 2006-06-23 | 2012-09-21 | Sigma Tau Ind Farmaceuti | Amino derivatives of b-homoandrostanes and b-heteroandrostanes |
| JP5290189B2 (ja) | 2006-11-30 | 2013-09-18 | エンディース エルエルシー | ６−アルコキシアルキルエストラジオール誘導体およびその使用 |
| WO2009047101A1 (en) | 2007-10-12 | 2009-04-16 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Aminooxime derivatives of 2- and/or 4-substituted androstanes and androstenes as medicaments for cardiovascular disorders |
| WO2010149666A1 (en) | 2009-06-22 | 2010-12-29 | Medexis S.A. | Methods for treating neoplasia |
| AU2011284606A1 (en) * | 2010-07-30 | 2013-03-14 | Pharmacellion Ltd | Compounds and methods for treating neoplasia |
| BR112013005843A2 (pt) | 2010-09-14 | 2019-12-10 | Endece Llc | derivativos de er-beta 6-substituído por desmetil-estradiol |
| CN103315968B (zh) * | 2013-06-26 | 2015-04-01 | 中国生命药物治疗有限公司 | 一种注射用粉针剂及其制备方法 |
| CN103360457B (zh) * | 2013-07-31 | 2015-10-07 | 中国生命药物治疗有限公司 | 一种雄甾烷二酮衍生物晶型及其制备方法 |
| DK3599243T3 (da) | 2018-07-26 | 2023-07-10 | Cvie Therapeutics Ltd | 17beta-heterocyklyl-digitalis-lignende forbindelser til behandlingen af hjertesvigt |
| AU2019432709B2 (en) | 2019-03-05 | 2025-10-16 | Windtree Therapeutics, Inc. | Istaroxime-containing intravenous formulation for the treatment of acute heart failure (AHF) |
| DK3805243T3 (da) | 2019-10-09 | 2024-01-02 | Windtree Therapeutics Inc | Androstanderivater med aktivitet som rene eller hovedsageligt rene stimulatorer af serca2a til behandling af hjertesvigt |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2863885A (en) * | 1958-02-10 | 1958-12-09 | Upjohn Co | 17-isonitrosoandrostanes |
| GB1175219A (en) * | 1967-06-22 | 1969-12-23 | Ici Ltd | 3-Aminoalkoxycarbonylmethylene Steroid Derivatives |
| CH504427A (de) * | 1967-12-06 | 1971-03-15 | Ciba Geigy Ag | Verfahren zur Herstellung neuer 4-Imino-19-nor-A-homosteroid-triene |
| US5144017A (en) * | 1988-07-13 | 1992-09-01 | University Of Manitoba | Compounds that bind to digitalis receptor |
| GB9201224D0 (en) * | 1992-01-21 | 1992-03-11 | Erba Carlo Spa | Difluoromethylenandrostenone derivatives and process for their preparation |
| DE4227605C2 (de) * | 1992-08-20 | 1995-02-16 | Sigma Tau Ind Farmaceuti | 17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten |
| DE4232656C2 (de) * | 1992-09-29 | 1995-01-12 | Sigma Tau Ind Farmaceuti | Cyclopentanperhydrophenanthren-17-furyl-3ß-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen |
| DE4344236A1 (de) * | 1993-12-23 | 1995-06-29 | Sigma Tau Ind Farmaceuti | Neue 17-Iminomethylalkenyl-5beta,14beta-androstan- und 17-Iminoalkyl-5beta,14beta-androstan-Derivate , die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten |
-
1996
- 1996-08-19 DE DE19633349A patent/DE19633349A1/de not_active Withdrawn
-
1997
- 1997-07-09 AT AT97111651T patent/ATE196768T1/de active
- 1997-07-09 ES ES97111651T patent/ES2151698T3/es not_active Expired - Lifetime
- 1997-07-09 PT PT97111651T patent/PT825197E/pt unknown
- 1997-07-09 EP EP97111651A patent/EP0825197B1/en not_active Expired - Lifetime
- 1997-07-09 DE DE69703228T patent/DE69703228T2/de not_active Expired - Lifetime
- 1997-07-09 DK DK97111651T patent/DK0825197T3/da active
- 1997-07-10 US US08/891,030 patent/US5914324A/en not_active Expired - Lifetime
- 1997-08-19 JP JP22285497A patent/JP4297994B2/ja not_active Expired - Lifetime
-
2000
- 2000-11-10 GR GR20000402508T patent/GR3034821T3/el unknown
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