JPH10512570A - コンホメーション的に制限された逆ターンライブラリおよびそれらに関連する方法 - Google Patents

コンホメーション的に制限された逆ターンライブラリおよびそれらに関連する方法

Info

Publication number
JPH10512570A
JPH10512570A JP8522413A JP52241396A JPH10512570A JP H10512570 A JPH10512570 A JP H10512570A JP 8522413 A JP8522413 A JP 8522413A JP 52241396 A JP52241396 A JP 52241396A JP H10512570 A JPH10512570 A JP H10512570A
Authority
JP
Japan
Prior art keywords
turn
library
amino acid
reverse
mimetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8522413A
Other languages
English (en)
Japanese (ja)
Inventor
カーン，マイケル
Original Assignee
モレキュメティックス リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by モレキュメティックス リミテッド filed Critical モレキュメティックス リミテッド
Publication of JPH10512570A publication Critical patent/JPH10512570A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP8522413A 1995-01-20 1996-01-19 コンホメーション的に制限された逆ターンライブラリおよびそれらに関連する方法 Pending JPH10512570A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37590495A 1995-01-20 1995-01-20
US08/375,904 1995-01-20
PCT/US1996/000786 WO1996022304A1 (fr) 1995-01-20 1996-01-19 Bibliotheque de substances mimetiques de retournement astreintes a une conformation et procedes associes

Publications (1)

Publication Number Publication Date
JPH10512570A true JPH10512570A (ja) 1998-12-02

Family

ID=23482840

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8522413A Pending JPH10512570A (ja) 1995-01-20 1996-01-19 コンホメーション的に制限された逆ターンライブラリおよびそれらに関連する方法

Country Status (5)

Country Link
EP (1) EP0804460A1 (fr)
JP (1) JPH10512570A (fr)
AU (1) AU4761996A (fr)
CA (1) CA2210349A1 (fr)
WO (1) WO1996022304A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009040696A (ja) * 2007-08-07 2009-02-26 Kikkoman Corp 新規アンジオテンシン変換酵素阻害ペプチド
US8008440B2 (en) 1999-10-04 2011-08-30 Tranzyme Pharma Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184223B1 (en) 1995-10-27 2001-02-06 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
EP1015479A4 (fr) * 1997-04-11 2002-07-24 Lilly Co Eli Echantillotheques combinatoires de macrocycles peptidomimetiques et procedes correspondants
AU742747B2 (en) * 1998-03-24 2002-01-10 Mimetica Pty Ltd Peptide turn mimetics
AUPP254898A0 (en) * 1998-03-24 1998-04-23 University Of Queensland, The Peptide turn mimetics
AU2003284120A1 (en) 2002-10-17 2004-05-04 Myriad Genetics, Inc. Reverse-turn mimetics and composition and methods relating thereto
JP4928262B2 (ja) * 2003-07-31 2012-05-09 トランザイム・ファーマ 薬物発見に有用な空間的に規定された大環状化合物
JP4928263B2 (ja) * 2003-07-31 2012-05-09 トランザイム・ファーマ ペプチド結合サロゲートを組み入れた空間的に規定された大環状分子
US8088733B2 (en) 2006-07-06 2012-01-03 Tranzyme Pharma Inc. Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders
US8377925B2 (en) 2008-02-29 2013-02-19 Mimetica Pty Ltd Methods of modulating the activity of the MC5 receptor and treatment of conditions related to this receptor
US8343958B2 (en) 2008-02-29 2013-01-01 Mimetica Pty Ltd 3-aminoalkyl-1,4-diazepan-2-one melanocortin-5-receptor antagonists
US8008291B2 (en) 2008-02-29 2011-08-30 Mimetica Pty Ltd 3-aminoalkyl-1,4-diazepan-2-one melanocortin-5 receptor antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0573608A1 (fr) * 1991-02-07 1993-12-15 Molecumetics, Ltd. Produits mimetiques de conformation restreinte de tours beta et bombements beta, et peptides les contenant
CA2141447A1 (fr) * 1992-08-06 1994-02-17 Michael Kahn Mimetiques de conformation inverse restreinte et peptides les renfermant
ES2204910T3 (es) * 1992-10-01 2004-05-01 The Trustees Of Columbia University In The City Of New York Bibliotecas quimicas combinatorias complejas codificadas con señales.
JP3394777B2 (ja) * 1993-05-27 2003-04-07 セレクタイド コーポレーション 位相学的に分離された、コードされた固相ライブラリー

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008440B2 (en) 1999-10-04 2011-08-30 Tranzyme Pharma Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
US8188216B2 (en) 1999-10-04 2012-05-29 Tranzyme Pharma Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
JP2012140400A (ja) * 1999-10-04 2012-07-26 Tranzyme Pharma Inc 創薬に有用な大環状化合物ライブラリーのコンビナトリアル合成
JP2012162528A (ja) * 1999-10-04 2012-08-30 Tranzyme Pharma Inc 創薬に有用な大環状化合物ライブラリーのコンビナトリアル合成
JP2015057390A (ja) * 1999-10-04 2015-03-26 オセラ・セラピューティクス・インコーポレイテッドＯｃｅｒａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 創薬に有用な大環状化合物ライブラリーのコンビナトリアル合成
US9018419B2 (en) 1999-10-04 2015-04-28 Ocera Therapeutics, Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
US9409945B2 (en) 1999-10-04 2016-08-09 Ocera Therapeutics, Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
JP2017075154A (ja) * 1999-10-04 2017-04-20 オセラ・セラピューティクス・インコーポレイテッドＯｃｅｒａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 創薬に有用な大環状化合物ライブラリーのコンビナトリアル合成
JP2009040696A (ja) * 2007-08-07 2009-02-26 Kikkoman Corp 新規アンジオテンシン変換酵素阻害ペプチド

Also Published As

Publication number Publication date
WO1996022304A1 (fr) 1996-07-25
CA2210349A1 (fr) 1996-07-25
AU4761996A (en) 1996-08-07
EP0804460A1 (fr) 1997-11-05

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