CA2210349A1 - Bibliotheque de substances mimetiques de retournement astreintes a une conformation et procedes associes - Google Patents

Bibliotheque de substances mimetiques de retournement astreintes a une conformation et procedes associes

Info

Publication number
CA2210349A1
CA2210349A1 CA 2210349 CA2210349A CA2210349A1 CA 2210349 A1 CA2210349 A1 CA 2210349A1 CA 2210349 CA2210349 CA 2210349 CA 2210349 A CA2210349 A CA 2210349A CA 2210349 A1 CA2210349 A1 CA 2210349A1
Authority
CA
Canada
Prior art keywords
turn
amino acid
library
reverse
mimetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2210349
Other languages
English (en)
Inventor
Michael Kahn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecumetics Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2210349A1 publication Critical patent/CA2210349A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Bibliothèques de substances mimétiques de retournement astreintes à une conformation et procédés de construction desdites bibliothèques. Lesdites substances mimétiques de retournement incluent des substances mimétiques à virage bêta, à virage gamma et à renflement bêta qui miment la conformation biologiquement active d'un peptide linéaire. Dans un mode de réalisation préféré, une bibliothèque matrice est construite sur la base de la séquence d'acides aminés du peptide linéaire et contient une pluralité de substances mimétiques à virage bêta, à virage gamma et à renflement bêta de tailles annulaires différentes. La bibliothèque matrice est ensuite criblée dans une analyse adaptée pour identifier un élément de bibliothèque matrice biologiquement actif. Une bibliothèque optimisée est ensuite construite sur la base de la structure de l'élément de matrice biologiquement actif et comprend des substitutions de la séquence d'acides aminés dudit élément. Ladite bibliothèque optimisée est alors criblée de la même manière pour identifier une substance mimétique de retournement biologiquement active. Des procédés concernant l'identification d'éléments de bibliothèque qui entrent en interaction avec des cibles biologiques appropriées et l'utilisation desdits éléments en tant qu'agents diagnostiques, prophylactiques et/ou thérapeutiques sont également décrits.
CA 2210349 1995-01-20 1996-01-19 Bibliotheque de substances mimetiques de retournement astreintes a une conformation et procedes associes Abandoned CA2210349A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37590495A 1995-01-20 1995-01-20
US08/375,904 1995-01-20

Publications (1)

Publication Number Publication Date
CA2210349A1 true CA2210349A1 (fr) 1996-07-25

Family

ID=23482840

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2210349 Abandoned CA2210349A1 (fr) 1995-01-20 1996-01-19 Bibliotheque de substances mimetiques de retournement astreintes a une conformation et procedes associes

Country Status (5)

Country Link
EP (1) EP0804460A1 (fr)
JP (1) JPH10512570A (fr)
AU (1) AU4761996A (fr)
CA (1) CA2210349A1 (fr)
WO (1) WO1996022304A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184223B1 (en) 1995-10-27 2001-02-06 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
WO1998046631A1 (fr) * 1997-04-11 1998-10-22 Eli Lilly And Company Echantillotheques combinatoires de macrocycles peptidomimetiques et procedes correspondants
AU742747B2 (en) * 1998-03-24 2002-01-10 Mimetica Pty Ltd Peptide turn mimetics
AUPP254898A0 (en) * 1998-03-24 1998-04-23 University Of Queensland, The Peptide turn mimetics
CA2284459C (fr) 1999-10-04 2012-12-11 Neokimia Inc. Synthese combinatoire de bibliotheques de composes macrocycliques utiles pour la decouverte de medicaments
WO2004035587A1 (fr) 2002-10-17 2004-04-29 Myriad Genetics, Inc. Mimetiques de coudes inverses, composition et techniques associees
DE602004018782D1 (de) * 2003-07-31 2009-02-12 Tranzyme Pharma Inc Räumlich definierte makrocyclen, die peptidbindungssurrogate enthalten
SI1648922T1 (sl) 2003-07-31 2011-03-31 Tranzyme Pharma Inc Prostorsko opredeljene makrocikliäśne spojine uporabne za odkrivanje zdravil
US8088733B2 (en) 2006-07-06 2012-01-03 Tranzyme Pharma Inc. Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders
JP2009040696A (ja) * 2007-08-07 2009-02-26 Kikkoman Corp 新規アンジオテンシン変換酵素阻害ペプチド
US8008291B2 (en) 2008-02-29 2011-08-30 Mimetica Pty Ltd 3-aminoalkyl-1,4-diazepan-2-one melanocortin-5 receptor antagonists
US8343958B2 (en) 2008-02-29 2013-01-01 Mimetica Pty Ltd 3-aminoalkyl-1,4-diazepan-2-one melanocortin-5-receptor antagonists
US8377925B2 (en) 2008-02-29 2013-02-19 Mimetica Pty Ltd Methods of modulating the activity of the MC5 receptor and treatment of conditions related to this receptor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992013878A2 (fr) * 1991-02-07 1992-08-20 Board Of Trustees Of The University Of Illinois Produits mimetiques de conformation restreinte de tours beta et bombements beta, et peptides les contenant
JPH07509723A (ja) * 1992-08-06 1995-10-26 モレキュメティクス，リミティド 反転型ターンの立体配座的に拘束されたミメティックスと前者を含有するペプチド
WO1994008051A1 (fr) * 1992-10-01 1994-04-14 The Trustees Of Columbia University In The City Of New York Banques chimiques combinatoires complexes codees avec des etiquettes
NZ267843A (en) * 1993-05-27 1997-10-24 Selectide Corp Libraries of synthetic test compound attached to separate phase synthesis supports

Also Published As

Publication number Publication date
WO1996022304A1 (fr) 1996-07-25
AU4761996A (en) 1996-08-07
JPH10512570A (ja) 1998-12-02
EP0804460A1 (fr) 1997-11-05

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Legal Events

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