JPH10510816A - 移植細胞の生存を強化する因子の局所的送達 - Google Patents
移植細胞の生存を強化する因子の局所的送達Info
- Publication number
- JPH10510816A JPH10510816A JP8519275A JP51927596A JPH10510816A JP H10510816 A JPH10510816 A JP H10510816A JP 8519275 A JP8519275 A JP 8519275A JP 51927596 A JP51927596 A JP 51927596A JP H10510816 A JPH10510816 A JP H10510816A
- Authority
- JP
- Japan
- Prior art keywords
- cells
- microspheres
- egf
- factors
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.移植細胞の生存、増殖、または分化を促進するための方法であって、増殖因 子、増殖因子以外の血管由来因子、繊維組織の内部成長を阻害する因子、および 細胞移植部位における腫瘍増殖を阻害する因子からなる群から選択される、生物 活性因子を細胞に投与する工程を包含し、ここで該生物活性因子が、生分解性ポ リマー性マトリックスからの放出によって投与され、その上、またはその中に、 細胞が接着、または懸濁される方法。 2.前記因子が、ヘパリン結合増殖因子、形質転換増殖因子αまたはβ、α線維 芽細胞増殖因子、上皮増殖因子、血管内皮細胞増殖因子、インスリン、グルカゴ ン、およびエストロゲンからなる群から選択される、請求項1に記載の方法。 3.前記細胞が肝細胞でありそして前記因子が上皮増殖因子である、請求項2に 記載の方法。 4.前記細胞の移植時または移植前に、門脈大静脈吻合を行う工程をさらに包含 する、請求項1に記載の方法。 5.前記細胞が、実質および構造細胞からなる群から選択される、請求項1に記 載の方法。 6.前記細胞が、マトリックス上に移植される、請求項1に記載の方法。 7.前記細胞が、ヒドロゲル中に移植懸濁される、請求項6に記載の方法。 8.前記細胞が、100ミクロンと300ミクロンとの間の隙間の間隔を有する繊維状 の生体適合性のポリマー性マトリックス上に付着される、請求項6に記載の方法 。 9.前記生物活性因子が、経時的に該生物活性因子の制御された放出を提供する ミクロスフェア中の細胞に投与される、請求項1に記載の方法。 10.前記生物活性因子が、1ヶ月と数年との間の期間にわたり放出される、請 求項9に記載の方法。 11.前記細胞が、マトリックス上に移植され、前記生物活性因子が、経時的に 生物活性な因子の制御された放出を提供するミクロスフェア中の細胞に投与され 、そして該ミクロスフェアが該マトリックス中に付着または組み込まれる、請求 項1に記載の方法。 12.それを必要な患者に移植するための組成物であって、増殖因子、血管由来 因子、増殖因子以外、繊維組織の内部生長を阻害する因子、および細胞移植部位 における腫瘍増殖を阻害する因子からなる群から選択される、生物活性因子を組 み合わせて移植される細胞を含有し、ここで該細胞がマトリックス上に提供され るか、またはマトリックス中に懸濁される、組成物。 13.前記因子が、ヘパリン結合増殖因子、形質転換増殖因子αまたはβ、α線 維芽細胞増殖因子、上皮増殖因子、血管内皮細胞増殖細胞因子、インスリン、グ ルカゴン、およびエストロゲンからなる群から選択される、請求項12に記載の 組成物。 14.前記細胞が肝細胞であり、そして前記因子が上皮増殖因子である、請求項 13に記載の組成物。 15.前記細胞が、実質細胞および構造細胞からなる群から選択される、請求項 12に記載の組成物。 16.前記細胞が、ヒドロゲルに移植懸濁される、請求項12に記載の組成物。 17.前記細胞が、100ミクロンと300ミクロンとの間の内部空間を有する繊維状 、生体適合性ポリマー性マトリックスに接着される、請求項12に記載の組成物 。 18.前記生物活性因子が、経時的に生物活性因子の制御された放出を提供する ミクロスフェア中の細胞に投与される、請求項12に記載の組成物。 19.前記生物活性因子が、1ケ月と数年との間の期間にわたり放出される、請 求項18に記載の組成物。 20.前記生物活性因子が、経時的に該生物活性因子の制御された放出を提供す るミクロスフェア中の細胞に投与され、そして該ミクロスフェアが該マトリック スに接着または組み込まれる、請求項12に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US358,235 | 1994-12-16 | ||
US08/358,235 US6281015B1 (en) | 1994-12-16 | 1994-12-16 | Localized delivery of factors enhancing survival of transplanted cells |
PCT/US1995/016356 WO1996018411A1 (en) | 1994-12-16 | 1995-12-14 | Localized delivery of factors enhancing survival of transplanted cells |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2007220401A Division JP2008011863A (ja) | 1994-12-16 | 2007-08-27 | 移植細胞の生存を強化する因子の局所的送達 |
Publications (2)
Publication Number | Publication Date |
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JPH10510816A true JPH10510816A (ja) | 1998-10-20 |
JP4361134B2 JP4361134B2 (ja) | 2009-11-11 |
Family
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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JP51927596A Expired - Fee Related JP4361134B2 (ja) | 1994-12-16 | 1995-12-14 | 移植細胞の生存を強化する因子の局所的送達 |
JP2007220401A Pending JP2008011863A (ja) | 1994-12-16 | 2007-08-27 | 移植細胞の生存を強化する因子の局所的送達 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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JP2007220401A Pending JP2008011863A (ja) | 1994-12-16 | 2007-08-27 | 移植細胞の生存を強化する因子の局所的送達 |
Country Status (10)
Country | Link |
---|---|
US (1) | US6281015B1 (ja) |
EP (1) | EP0794790B1 (ja) |
JP (2) | JP4361134B2 (ja) |
AT (1) | ATE216255T1 (ja) |
CA (1) | CA2207286C (ja) |
DE (1) | DE69526448T2 (ja) |
DK (1) | DK0794790T3 (ja) |
ES (1) | ES2176359T3 (ja) |
PT (1) | PT794790E (ja) |
WO (1) | WO1996018411A1 (ja) |
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EP0794790B1 (en) | 2002-04-17 |
DK0794790T3 (da) | 2002-07-22 |
JP2008011863A (ja) | 2008-01-24 |
WO1996018411A1 (en) | 1996-06-20 |
ES2176359T3 (es) | 2002-12-01 |
CA2207286A1 (en) | 1996-06-20 |
JP4361134B2 (ja) | 2009-11-11 |
DE69526448D1 (de) | 2002-05-23 |
DE69526448T2 (de) | 2002-11-07 |
US6281015B1 (en) | 2001-08-28 |
EP0794790A1 (en) | 1997-09-17 |
PT794790E (pt) | 2002-09-30 |
CA2207286C (en) | 2003-10-07 |
ATE216255T1 (de) | 2002-05-15 |
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