PT794790E - Libertacao localizada de factores que aumentam a sobrevivencia de celulas transplantadas - Google Patents
Libertacao localizada de factores que aumentam a sobrevivencia de celulas transplantadasInfo
- Publication number
- PT794790E PT794790E PT95943823T PT95943823T PT794790E PT 794790 E PT794790 E PT 794790E PT 95943823 T PT95943823 T PT 95943823T PT 95943823 T PT95943823 T PT 95943823T PT 794790 E PT794790 E PT 794790E
- Authority
- PT
- Portugal
- Prior art keywords
- microspheres
- egf
- hepatocytes
- cells
- survival
- Prior art date
Links
- 230000004083 survival effect Effects 0.000 title abstract 3
- 239000004005 microsphere Substances 0.000 abstract 5
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 abstract 4
- 102000009024 Epidermal Growth Factor Human genes 0.000 abstract 3
- 101800003838 Epidermal growth factor Proteins 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- 229940116977 epidermal growth factor Drugs 0.000 abstract 3
- 210000003494 hepatocyte Anatomy 0.000 abstract 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- 230000006820 DNA synthesis Effects 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000002870 angiogenesis inducing agent Substances 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000011694 lewis rat Methods 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 210000000713 mesentery Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
- C12N5/0075—General culture methods using substrates using microcarriers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2531/00—Microcarriers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
- C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Developmental Biology & Embryology (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/358,235 US6281015B1 (en) | 1994-12-16 | 1994-12-16 | Localized delivery of factors enhancing survival of transplanted cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT794790E true PT794790E (pt) | 2002-09-30 |
Family
ID=23408836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT95943823T PT794790E (pt) | 1994-12-16 | 1995-12-14 | Libertacao localizada de factores que aumentam a sobrevivencia de celulas transplantadas |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6281015B1 (pt) |
| EP (1) | EP0794790B1 (pt) |
| JP (2) | JP4361134B2 (pt) |
| AT (1) | ATE216255T1 (pt) |
| CA (1) | CA2207286C (pt) |
| DE (1) | DE69526448T2 (pt) |
| DK (1) | DK0794790T3 (pt) |
| ES (1) | ES2176359T3 (pt) |
| PT (1) | PT794790E (pt) |
| WO (1) | WO1996018411A1 (pt) |
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| US20070141107A1 (en) * | 2000-03-15 | 2007-06-21 | Orbusneich Medical, Inc. | Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device |
| US8460367B2 (en) * | 2000-03-15 | 2013-06-11 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
| US20030229393A1 (en) * | 2001-03-15 | 2003-12-11 | Kutryk Michael J. B. | Medical device with coating that promotes cell adherence and differentiation |
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| PL1904093T3 (pl) | 2005-07-19 | 2018-12-31 | Stemgen S.P.A. | Hamowanie przez bmp-4 zdolności do tworzenia guzów przez komórki macierzyste guza |
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| CN111989068A (zh) | 2018-05-24 | 2020-11-24 | 塞拉尼斯伊娃高性能聚合物公司 | 用于持续释放大分子药物化合物的可植入器件 |
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|---|---|---|---|---|
| US1995970A (en) | 1931-04-04 | 1935-03-26 | Du Pont | Polymeric lactide resin |
| US2609347A (en) | 1948-05-27 | 1952-09-02 | Wilson Christopher Lumley | Method of making expanded polyvinyl alcohol-formaldehyde reaction product and product resulting therefrom |
| US2664367A (en) | 1949-09-19 | 1953-12-29 | Wilson Christopher Lumley | Plasticized sponge material and method of making same |
| US2664366A (en) | 1949-09-19 | 1953-12-29 | Wilson Christopher Lumley | Plasticized sponge material and method of making same |
| US2659935A (en) | 1950-03-18 | 1953-11-24 | Christopher L Wilson | Method of making compressed sponges |
| US2653917A (en) | 1950-06-15 | 1953-09-29 | Christopher L Wilson | Method of making an expanded material and the product resulting therefrom |
| US2676945A (en) | 1950-10-18 | 1954-04-27 | Du Pont | Condensation polymers of hydroxyacetic acid |
| US2683136A (en) | 1950-10-25 | 1954-07-06 | Du Pont | Copolymers of hydroxyacetic acid with other alcohol acids |
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| US2846407A (en) | 1954-01-13 | 1958-08-05 | Wilson Christopher Lumley | Method of making a detergent and solvent resistant sponge material |
| DE1228416B (de) | 1957-03-04 | 1966-11-10 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von Polyestern |
| BE634668A (pt) | 1962-07-11 | |||
| US3531561A (en) | 1965-04-20 | 1970-09-29 | Ethicon Inc | Suture preparation |
| BE744162A (fr) | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
| DE2010115A1 (de) | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
| JPS523342B2 (pt) | 1972-01-26 | 1977-01-27 | ||
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| JPS6098823A (ja) | 1983-11-02 | 1985-06-01 | 株式会社東芝 | 電力変換装置 |
| US4880622A (en) | 1986-05-20 | 1989-11-14 | Research Corporation Technologies, Inc. | Water-soluble phosphazene polymers having pharmacological applications |
| WO1990009783A1 (en) * | 1989-02-22 | 1990-09-07 | Massachusetts Institute Of Technology | Delivery system for controlled release of bioactive factors |
| US5019400A (en) | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
| US4946938A (en) | 1989-08-01 | 1990-08-07 | The University Of Pittsburgh | A process for the catalytic synthesis of polyphosphazenes |
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
-
1994
- 1994-12-16 US US08/358,235 patent/US6281015B1/en not_active Expired - Lifetime
-
1995
- 1995-12-14 DK DK95943823T patent/DK0794790T3/da active
- 1995-12-14 PT PT95943823T patent/PT794790E/pt unknown
- 1995-12-14 JP JP51927596A patent/JP4361134B2/ja not_active Expired - Fee Related
- 1995-12-14 CA CA002207286A patent/CA2207286C/en not_active Expired - Fee Related
- 1995-12-14 ES ES95943823T patent/ES2176359T3/es not_active Expired - Lifetime
- 1995-12-14 EP EP95943823A patent/EP0794790B1/en not_active Expired - Lifetime
- 1995-12-14 AT AT95943823T patent/ATE216255T1/de active
- 1995-12-14 WO PCT/US1995/016356 patent/WO1996018411A1/en active IP Right Grant
- 1995-12-14 DE DE69526448T patent/DE69526448T2/de not_active Expired - Lifetime
-
2007
- 2007-08-27 JP JP2007220401A patent/JP2008011863A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2207286C (en) | 2003-10-07 |
| DE69526448D1 (de) | 2002-05-23 |
| WO1996018411A1 (en) | 1996-06-20 |
| ES2176359T3 (es) | 2002-12-01 |
| ATE216255T1 (de) | 2002-05-15 |
| EP0794790A1 (en) | 1997-09-17 |
| CA2207286A1 (en) | 1996-06-20 |
| JP4361134B2 (ja) | 2009-11-11 |
| JPH10510816A (ja) | 1998-10-20 |
| DE69526448T2 (de) | 2002-11-07 |
| DK0794790T3 (da) | 2002-07-22 |
| JP2008011863A (ja) | 2008-01-24 |
| US6281015B1 (en) | 2001-08-28 |
| EP0794790B1 (en) | 2002-04-17 |
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