JPH10501727A - 分離剤としての大環状抗生物質 - Google Patents
分離剤としての大環状抗生物質Info
- Publication number
- JPH10501727A JPH10501727A JP7521947A JP52194795A JPH10501727A JP H10501727 A JPH10501727 A JP H10501727A JP 7521947 A JP7521947 A JP 7521947A JP 52194795 A JP52194795 A JP 52194795A JP H10501727 A JPH10501727 A JP H10501727A
- Authority
- JP
- Japan
- Prior art keywords
- macrocyclic
- separation
- antibiotic
- enantiomers
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N25/00—Investigating or analyzing materials by the use of thermal means
- G01N25/14—Investigating or analyzing materials by the use of thermal means by using distillation, extraction, sublimation, condensation, freezing, or crystallisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3833—Chiral chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/29—Chiral phases
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3204—Inorganic carriers, supports or substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
- B01J20/3208—Polymeric carriers, supports or substrates
- B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
- B01J20/3208—Polymeric carriers, supports or substrates
- B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
- B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
- B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
- B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44747—Composition of gel or of carrier mixture
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.次のスッテプからなる流体溶液から構成成分を分離する方法。 (a)前記構成成分を含む流体を大環状抗生物質で処理し、前記構成成分を前 記流体から分離し、 (b)前記構成成分を回収する 2.前記処理ステップが、晶化法、析出法、濾過法、電気泳動法、及びクロマト グラフィ−法からなるグル−プから選択された工程によって行われる請求項1記 載の方法。 3.前記大環状抗生物質はアンサマクロライド、マクロライド、大環状ペプチド 、グリコペプチド、ポリエン、及びそれらの誘導体からなるグル−プから選択さ れる請求項1記載の工程。 4.前記工程は晶化法または析出法であり、前記処理ステップは結晶化または析 出を起こす効果的な量の大環状抗生物質を前記流体に加えることからなる請求項 2記載の工程。 5.前記工程は膜濾過法、電気泳動法、クロマトグラフィ−法であり、前記大環 状抗生物質は基材に固着され、前記処理ステップは前記基材に固着した前記大環 状抗生物質に前記流体を接触させることからなる請求項2記載の工程。 6.前記工程は電気泳動法またはクロマトグラフィ−法であり、前記処理ステッ プは移動相添加剤として前記大環状抗生物質を加えることからなる請求項2記載 の工程。 7.鏡像異性体の混合物を個々の鏡像異性体に分離するために、鏡像異性体の混 合物を大環状抗生物質で処理し、前記個々の鏡像異性体を回収するステップから なる鏡像異性体の混合物から鏡像異性体を分離する方法。 8.前記大環状抗生物質はアンサマクロライド、マクロライド、大環状ペプチド 、グリコペプチド、ポリエン、及びそれらの誘導体からなるグル−プから選択さ れる請求項7記載の方法。 9.処理ステップはクロマトグラフィ−分離工程を用いて行われ、鏡像異性体の 前記混合物は、基材に固着されて固定相として作用する前記大環状抗生物質を含 むカラムから溶出するものである請求項7記載の方法。 10.処理ステップは、前記鏡像異性体の混合物は機器で分離される電気泳動を用 いて行われ、前記機器では大環状抗生物質は基材に固着され、固定相として作用 する請求項7記載の方法。 11.鏡像異性体を個々の鏡像異性体に分離するための、基材に固着した大環状抗 生物質からなる分離材料。 12.前記大環状抗生物質はアンサマクロライド、マクロライド、大環状ペプチド 、グリコペプチド、ポリエン、及びそれらの誘導体からなるグル−プから選択さ れる請求項11記載の分離材料。 13.基材はシリカゲル、アルミナ、ポリスチレン、ポリウレタン、ポリビニルア ルコ−ル、ポリアミド、アガロ−ス、セルロ−ス、デキストラン、及び線状/分 岐アミロ−スからなるグル−プから選択される請求項11記載の分離材料。 14.前記大環状抗生物質は前記基材に化学的に結合している請求項11記載の分離 材料。 15.大環状抗生物質は前記基材にコ−ティングされている請求項11記載の分離材 料。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19840994A | 1994-02-22 | 1994-02-22 | |
US08/198,409 | 1994-02-22 | ||
PCT/US1995/002071 WO1995022390A1 (en) | 1994-02-22 | 1995-02-17 | Macrocyclic antibiotics as separation agents |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10501727A true JPH10501727A (ja) | 1998-02-17 |
JP3808500B2 JP3808500B2 (ja) | 2006-08-09 |
Family
ID=22733264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52194795A Expired - Lifetime JP3808500B2 (ja) | 1994-02-22 | 1995-02-17 | 分離剤としての大環状抗生物質 |
Country Status (4)
Country | Link |
---|---|
US (4) | US5626757A (ja) |
EP (1) | EP0748247B1 (ja) |
JP (1) | JP3808500B2 (ja) |
WO (1) | WO1995022390A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003064000A (ja) * | 2001-08-23 | 2003-03-05 | Tokuyama Corp | 光学異性体の分離方法 |
JP2017522579A (ja) * | 2014-07-17 | 2017-08-10 | エイゼットワイピー エルエルシーAzyp,Llc | 液体クロマトグラフィーのための、新たな、超高効率の、表面多孔性粒子(spp)キラル相 |
JPWO2019163245A1 (ja) * | 2018-02-26 | 2020-12-03 | 株式会社島津製作所 | キノン類分析方法とその方法を実施するためのオンラインsfe−sfcシステム |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995022390A1 (en) * | 1994-02-22 | 1995-08-24 | Curators Of The University Of Missouri | Macrocyclic antibiotics as separation agents |
US20030004653A1 (en) * | 1996-05-24 | 2003-01-02 | Michael Flavin | Automated technology of screening of stationary phases |
TW477807B (en) * | 1997-01-10 | 2002-03-01 | Teijin Ltd | Flame-retardant resin composition |
GB9713730D0 (en) * | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
US6331235B1 (en) * | 1998-12-11 | 2001-12-18 | The University Of British Columbia | Chiral separation of benzoporphyrin derivative mono-and di-acids by laser-induced fluorescence capillary electrophoresis |
US20040129640A9 (en) * | 2002-01-18 | 2004-07-08 | National University Of Singapore | Materials comprising polymers or oligomers of saccharides chemically bonded to a support useful for chromatography and electrophoresis applications |
JP2006522328A (ja) * | 2003-03-07 | 2006-09-28 | ユニバーシティ・カレッジ・コークーナショナル・ユニバーシティ・オブ・アイルランド,コーク | クロマトグラフ相の合成のための方法 |
TWI222831B (en) * | 2003-07-09 | 2004-10-21 | Mediatek Inc | Video playback system to generate both progressive and interlace video signals |
US20050112786A1 (en) * | 2003-11-25 | 2005-05-26 | Qing Wang | Method of immobilizing a substance of interest to a solid phase |
US7169307B2 (en) * | 2004-09-02 | 2007-01-30 | Jian Liu | Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from Taxus |
US7182119B2 (en) * | 2004-09-03 | 2007-02-27 | Marvin Lumber And Cedar Company | Screen assembly for outwardly projecting window |
US7788851B2 (en) * | 2004-09-03 | 2010-09-07 | Marvin Lumber And Cedar Company | Window drive mechanism |
US20080311615A1 (en) * | 2006-08-25 | 2008-12-18 | Metametrix, Inc. | Method for chiral separation of lactic acid enantiomers |
JP5339706B2 (ja) * | 2007-10-10 | 2013-11-13 | キヤノン株式会社 | 印刷システム、制御方法、記憶媒体、及びプログラム |
US20100148126A1 (en) * | 2008-11-26 | 2010-06-17 | Board Of Regents, The University Of Texas System | Genomic sequencing using modified protein pores and ionic liquids |
JP5775072B2 (ja) * | 2009-06-17 | 2015-09-09 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 分離剤としてのシクロフルクタン用の組成物および方法 |
WO2013087674A1 (en) * | 2011-12-12 | 2013-06-20 | Technische Universitaet Dortmund | Foam adsorption |
RU2545315C2 (ru) * | 2012-10-10 | 2015-03-27 | Закрытое акционерное общество "Научно-технический центр "Ленхром" | Способ получения хиральной планарной пластины для тонкослойной хроматографии оптических изомеров |
RU2541524C2 (ru) * | 2013-01-23 | 2015-02-20 | Закрытое акционерное общество "НТЦ "Ленхром" | Способ получения тонкослойных хиральных пластин для планарной хроматографии стереоизомеров и их рацемических смесей |
CN106148997A (zh) * | 2016-06-20 | 2016-11-23 | 田东县浙缘农业科技有限公司 | 一种高效毛细管电泳拆分氟比洛芬对映体的方法 |
CN107328874B (zh) * | 2017-06-28 | 2019-12-20 | 南京希麦迪医药科技有限公司 | 一种盐酸帕洛诺司琼光学异构体的拆分试剂及分离检测方法 |
CN107290453B (zh) * | 2017-06-29 | 2019-09-17 | 方达医药技术(上海)有限公司 | 盐酸帕洛诺司琼合成中间产物的hplc分析方法 |
MX2020000265A (es) | 2017-07-07 | 2020-07-22 | Epicentrx Inc | Composiciones para la administración parenteral de agentes terapéuticos. |
CN111116374B (zh) * | 2019-12-04 | 2020-12-15 | 北京理工大学 | 一种氨鲁米特与2-硝基苯甲酸合成π-π键共晶体的方法 |
CN113341055A (zh) * | 2021-06-04 | 2021-09-03 | 河南省科学院生物研究所有限责任公司 | 一种利用高效液相色谱流动相添加法测定苯乳酸异构体含量的方法 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3607700A (en) * | 1967-12-20 | 1971-09-21 | Univ Duke | Electrode for measuring potassium and other specific ion activities |
NO140408C (no) * | 1977-09-19 | 1979-08-29 | Johannes Dale | Fremgangsmaate for total eller selektiv fjerning av salter fra vandig opploesning |
US4290893A (en) * | 1979-05-08 | 1981-09-22 | Yeda Research & Development Co. Ltd. | Separation of amino acids by liquid chromatography using chiral eluants |
EP0073261B1 (de) * | 1981-08-31 | 1985-11-13 | Kernforschungszentrum Karlsruhe Gmbh | Verfahren zum Abtrennen von Cäsiumionen aus Lösungen unter Verwendung einer Adduktverbindung in fester Form aus einem macrocyclischen Polyether und einer anorganischen Heteropolysäure |
US4667024A (en) * | 1983-07-13 | 1987-05-19 | Smithkline Beckman Corporation | Process for the preparation of purified vancomycin class antibiotics |
US4539399A (en) * | 1984-07-27 | 1985-09-03 | Advanced Separation Technologies Inc. | Bonded phase material for chromatographic separations |
FR2575936B1 (fr) * | 1985-01-15 | 1987-02-13 | Rhone Poulenc Spec Chim | Procede de purification de solutions aqueuses de sels de terres rares par extraction liquide-liquide |
DD261844A1 (de) * | 1986-07-09 | 1988-11-09 | Adw Ddr | Verfahren zur praezipitation von fibrinmonomeren |
US4943375A (en) * | 1987-09-04 | 1990-07-24 | Brigham Young University | The process of separating a selected ion from a plurality of other ions in a multiple ion solution by contacting the solution with a macrocyclic ligand bonded to silica which selectively complexes with the desired ion |
DE3810737A1 (de) * | 1988-03-30 | 1989-10-12 | Macherey Nagel Gmbh & Co Kg | Substituierte cyclodextrine |
US5039419A (en) * | 1988-07-13 | 1991-08-13 | Brigham Young University | Sulfur-containing hydrocarbon compounds and process of using same in recovering and concentrating desired ions from solutions thereof |
FR2644469B1 (fr) * | 1989-03-17 | 1991-05-31 | Centre Nat Rech Scient | Element composite comportant un polyether ou copolyether, son procede de preparation et son utilisation pour l'extraction et la separation de cations metalliques |
US4975379A (en) * | 1989-04-10 | 1990-12-04 | Brigham Young University | Analysis of ions present at low concentrations in solutions containing other ions |
US5175110A (en) * | 1989-04-10 | 1992-12-29 | Brigham Young University | Analysis of ions present at low concentrations in solutions containing other ions |
US5154738A (en) * | 1989-09-12 | 1992-10-13 | Advanced Separation Technologies, Inc. | Chiral separation media |
US5064944A (en) * | 1989-09-12 | 1991-11-12 | Advanced Separation Technologies Inc. | Chiral separation media |
US5030352A (en) * | 1990-01-25 | 1991-07-09 | Purdue Research Foundation | Coated media for chromatography |
DE4006923A1 (de) * | 1990-03-06 | 1991-09-12 | Merck Patent Gmbh | Trennmaterialien fuer die chromatographie |
US5100585A (en) * | 1990-04-09 | 1992-03-31 | United States Department Of Energy | Process for the recovery of strontium from acid solutions |
US5110474A (en) * | 1990-04-09 | 1992-05-05 | Arch Development Corporation | Method for liquid chromatographic extraction of strontium from acid solutions |
GB2244135B (en) * | 1990-05-04 | 1994-07-13 | Gen Electric Co Plc | Sensor devices |
US5120443A (en) * | 1991-06-03 | 1992-06-09 | Brigham Young University | Processes for removing, separating and concentrating rhodium, iridium, and ruthenium from solutions using macrocyclic and nonmacrocyclic polyalkylene-polyamine-containing ligands bonded to inorganic supports |
US5356538A (en) * | 1991-06-12 | 1994-10-18 | Idaho Research Foundation, Inc. | Supercritical fluid extraction |
US5288390A (en) * | 1992-03-30 | 1994-02-22 | Sun Company, Inc. (R&M) | Polycyclic aromatic ring cleavage (PARC) process |
US5190661A (en) * | 1992-06-08 | 1993-03-02 | Brigham Young University | Process of removing ions from solutions using a complex with sulfur-containing hydrocarbons |
US5342934A (en) * | 1992-06-19 | 1994-08-30 | The Trustees Of Columbia University In The City Of New York | Enantioselective receptor for amino acid derivatives, and other compounds |
US5338454A (en) * | 1992-08-27 | 1994-08-16 | Supelco, Incorporated | Chiral mobile phase additives for improved liquid-chromatography separations |
US5316679A (en) * | 1993-05-13 | 1994-05-31 | Ibc Advanced Technologies, Inc. | Elution of antimony from solid phases using concentrated sulfuric acid containing dilute hydrochloric acid |
WO1995022390A1 (en) * | 1994-02-22 | 1995-08-24 | Curators Of The University Of Missouri | Macrocyclic antibiotics as separation agents |
-
1995
- 1995-02-17 WO PCT/US1995/002071 patent/WO1995022390A1/en active Application Filing
- 1995-02-17 EP EP95911045A patent/EP0748247B1/en not_active Expired - Lifetime
- 1995-02-17 JP JP52194795A patent/JP3808500B2/ja not_active Expired - Lifetime
- 1995-02-17 US US08/532,581 patent/US5626757A/en not_active Expired - Lifetime
-
1997
- 1997-05-05 US US08/851,485 patent/US5874005A/en not_active Expired - Lifetime
-
1998
- 1998-11-06 US US09/187,369 patent/US5964996A/en not_active Expired - Lifetime
-
1999
- 1999-09-07 US US09/396,974 patent/US6669842B1/en not_active Expired - Fee Related
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003064000A (ja) * | 2001-08-23 | 2003-03-05 | Tokuyama Corp | 光学異性体の分離方法 |
JP2017522579A (ja) * | 2014-07-17 | 2017-08-10 | エイゼットワイピー エルエルシーAzyp,Llc | 液体クロマトグラフィーのための、新たな、超高効率の、表面多孔性粒子(spp)キラル相 |
JPWO2019163245A1 (ja) * | 2018-02-26 | 2020-12-03 | 株式会社島津製作所 | キノン類分析方法とその方法を実施するためのオンラインsfe−sfcシステム |
Also Published As
Publication number | Publication date |
---|---|
WO1995022390A1 (en) | 1995-08-24 |
US5626757A (en) | 1997-05-06 |
US6669842B1 (en) | 2003-12-30 |
EP0748247B1 (en) | 2012-06-20 |
JP3808500B2 (ja) | 2006-08-09 |
EP0748247A1 (en) | 1996-12-18 |
US5964996A (en) | 1999-10-12 |
EP0748247A4 (en) | 1998-05-06 |
US5874005A (en) | 1999-02-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPH10501727A (ja) | 分離剤としての大環状抗生物質 | |
Gübitz et al. | Recent progress in chiral separation principles in capillary electrophoresis | |
US4931498A (en) | Immobilized artificial membranes | |
US4927879A (en) | Method for solid phase membrane mimetics | |
US6074555A (en) | Modified chromatographic support materials | |
JP3444900B2 (ja) | 液体クロマトグラフィ及びカラム充填剤 | |
D'Acquarica | New synthetic strategies for the preparation of novel chiral stationary phases for high-performance liquid chromatography containing natural pool selectors | |
EP1594912B1 (en) | Silica gel bonded with cucurbiturils | |
JP3653798B2 (ja) | 新規な変性シリカゲル | |
Bhushan et al. | Separation of amino acids, their derivatives and enantiomers by impregnated TLC | |
Liu et al. | High efficiency liquid and super‐/subcritical fluid‐based enantiomeric separations: an overview | |
JP3377516B2 (ja) | 蛋白質と炭素鎖が結合した担体 | |
EP1265067B1 (en) | Column packing for chromatography | |
US7008533B2 (en) | Macrocyclic antibiotics as separation agents | |
RU2348455C2 (ru) | Сорбент для хроматографии оптических изомеров и способ его получения | |
JP2792038B2 (ja) | 水溶性高分子物質と低分子成分とが共存する試料の分析方法及び前処理方法並びにクロマトグラフイー用充填剤 | |
JPH06510862A (ja) | エナンチオマー類の分離方法およびこの方法用に適する毛管カラム | |
RU2255802C1 (ru) | Сорбент для разделения оптических изомеров и способ его получения | |
JPH0850120A (ja) | 液体クロマトグラフィ装置 | |
Amstrong | Macrocyclic antibiotics as separation agents | |
US7682836B2 (en) | Selective binding materials | |
JPH0518950A (ja) | アフイニテイクロマトグラフイー用吸着担体 | |
US4812362A (en) | Solid phase N-hydroxysuccinimide reagents | |
Hui et al. | Enantioseparation in CE using macrocyclic antibiotics as chiral selectors | |
US20040144715A1 (en) | Carrier for chromatography, carrier for pre-treatment and kit for preparing the same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20050104 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20050329 |
|
RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20050415 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20050523 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20050428 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050624 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20050830 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20051130 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20060123 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20060425 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20060518 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090526 Year of fee payment: 3 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100526 Year of fee payment: 4 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110526 Year of fee payment: 5 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120526 Year of fee payment: 6 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130526 Year of fee payment: 7 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
EXPY | Cancellation because of completion of term |