JPH10265454A5 - - Google Patents

Info

Publication number
JPH10265454A5
JPH10265454A5 JP1998016362A JP1636298A JPH10265454A5 JP H10265454 A5 JPH10265454 A5 JP H10265454A5 JP 1998016362 A JP1998016362 A JP 1998016362A JP 1636298 A JP1636298 A JP 1636298A JP H10265454 A5 JPH10265454 A5 JP H10265454A5
Authority
JP
Japan
Prior art keywords
dihydroxy
oxo
enoic acid
group
dithiaprost
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP1998016362A
Other languages
English (en)
Japanese (ja)
Other versions
JPH10265454A (ja
Filing date
Publication date
Application filed filed Critical
Priority to JP10016362A priority Critical patent/JPH10265454A/ja
Priority claimed from JP10016362A external-priority patent/JPH10265454A/ja
Publication of JPH10265454A publication Critical patent/JPH10265454A/ja
Publication of JPH10265454A5 publication Critical patent/JPH10265454A5/ja
Withdrawn legal-status Critical Current

Links

JP10016362A 1997-01-27 1998-01-12 3,7−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤 Withdrawn JPH10265454A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10016362A JPH10265454A (ja) 1997-01-27 1998-01-12 3,7−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9-27198 1997-01-27
JP2719897 1997-01-27
JP10016362A JPH10265454A (ja) 1997-01-27 1998-01-12 3,7−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤

Publications (2)

Publication Number Publication Date
JPH10265454A JPH10265454A (ja) 1998-10-06
JPH10265454A5 true JPH10265454A5 (enExample) 2005-07-28

Family

ID=12214403

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10016362A Withdrawn JPH10265454A (ja) 1997-01-27 1998-01-12 3,7−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤

Country Status (8)

Country Link
US (1) US5892099A (enExample)
EP (1) EP0855389B1 (enExample)
JP (1) JPH10265454A (enExample)
AT (1) ATE218543T1 (enExample)
DE (1) DE69805665T2 (enExample)
DK (1) DK0855389T3 (enExample)
ES (1) ES2182220T3 (enExample)
PT (1) PT855389E (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043275A (en) * 1998-04-16 2000-03-28 Ono Pharmaceutical Co., Ltd. 3,7-dithiaprostanoic acid derivative
US6437146B1 (en) 1998-09-25 2002-08-20 Fujisawa Pharmaceutical Co., Ltd. Oxazole compounds as prostaglandin e2 agonists or antagonists
AU6427599A (en) * 1998-10-15 2000-05-01 Merck & Co., Inc. Methods for stimulating bone formation
US6414006B1 (en) 1998-10-15 2002-07-02 Merck Frosst Canada & Co. Methods for inhibiting bone resorption
CA2364948C (en) 1999-03-05 2011-04-26 Duke University C16 unsaturated fp-selective prostaglandins analogs
CN1304319A (zh) * 1999-03-16 2001-07-18 东丽株式会社 子宫颈管成熟剂及子宫颈管成熟方法
US6894175B1 (en) * 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
TWI247606B (en) * 1999-11-24 2006-01-21 Ono Pharmaceutical Co Treating agent for osteopenic diseases
JP4618548B2 (ja) * 1999-11-24 2011-01-26 小野薬品工業株式会社 骨量低下疾患治療剤
BR0015781A (pt) * 1999-11-24 2002-12-31 Ono Pharmaceutical Co Composição farmacêutica para tratamento de doenças associadas à diminuição de massa óssea
ATE327751T1 (de) 2000-01-31 2006-06-15 Pfizer Prod Inc Verwendung von aktivatoren des prostaglandinrezeptores 4 zur behandlung von akuter oder chronischer niereninsuffizienz
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) * 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020037914A1 (en) * 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020146439A1 (en) * 2000-03-31 2002-10-10 Delong Mitchell Anthony Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
AU2001290250A1 (en) * 2000-09-21 2002-04-02 Ono Pharmaceutical Co. Ltd. Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient
GB0103269D0 (en) * 2001-02-09 2001-03-28 Glaxo Group Ltd Napthalene derivatives
US6410591B1 (en) 2001-05-08 2002-06-25 Allergan Sales, Inc. 3,7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure
US20050222094A1 (en) * 2001-06-14 2005-10-06 Burk Robert M Treatment of inflammatory bowel disease
US20030027853A1 (en) 2001-06-14 2003-02-06 Allergan Sales, Inc. 3, 7or3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure
US7872045B2 (en) 2001-06-14 2011-01-18 Allergan, Inc. Combination therapy for glaucoma treatment
EP1490055A1 (en) * 2002-03-18 2004-12-29 Pfizer Products Inc. Use of selective ep4 receptor agonists for the treatment of liver failure, loss of patency of the ductus arteriosus, glaucoma or ocular hypertension
AU2003224244A1 (en) * 2002-03-27 2003-10-13 Rosanto Pharmaceuticals Ltd Improvements in pharmaceutical compositions
EP1513589B1 (en) 2002-06-06 2010-11-10 Merck Frosst Canada Ltd. 1,5-disubstituted pyrrolid-2-one derivatives for use as ep4 receptor agonists in the treatment of eye diseases such as glaucoma
US7053085B2 (en) 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
WO2004073589A2 (en) * 2003-02-24 2004-09-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep4 (prostaglandin e2 ep4)
CA2565628A1 (en) * 2004-05-03 2005-11-10 Astellas Pharma Inc. The combination of prostaglandin e2 receptor antagonist and renin-angiotensin system inhibitor for treating renal diseases
EP1782829A1 (en) * 2004-08-10 2007-05-09 Ono Pharmaceutical Co., Ltd. Preventive and/or remedy for hyperkalemia containing ep4 agonist
WO2006047466A2 (en) 2004-10-21 2006-05-04 Duke University Ophthamological drugs
UY30121A1 (es) 2006-02-03 2007-08-31 Glaxo Group Ltd Nuevos compuestos
EP2094839B1 (en) 2006-12-08 2020-02-05 University of Rochester Expansion of hematopoietic stem cells
JP5069752B2 (ja) 2006-12-15 2012-11-07 グラクソ グループ リミテッド Ep4受容体アゴニストとしてのベンズアミド誘導体
GB0721611D0 (en) 2007-11-02 2007-12-12 Glaxo Group Ltd Novel compounds
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
CA2738045C (en) 2010-05-28 2019-02-19 Simon Fraser University Conjugate compounds, methods of making same, and uses thereof
US9650414B1 (en) 2014-05-30 2017-05-16 Simon Fraser University Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
CN107849072B (zh) 2015-06-12 2020-12-15 西蒙弗雷泽大学 酰胺连接的ep4激动剂-二膦酸盐化合物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3168199D1 (en) * 1980-10-31 1985-02-21 Teijin Ltd Novel thiaprostaglandin e1 derivatives, process for production thereof, and pharmaceuticals containing these compounds
JPS57108065A (en) * 1980-12-26 1982-07-05 Teijin Ltd 7-thiaprostaglandin e1 derivative, its preparation, and blood platelet coagulation inhibiting agent containing said derivative as active component
JPS58110562A (ja) * 1981-12-25 1983-07-01 Teijin Ltd 新規な7−チアプロスタグランジンe↓1誘導体類、それらの製造方法及びそれらを活性成分とする薬剤
JPS58148857A (ja) * 1982-02-26 1983-09-05 Teijin Ltd 新規な13,14−ジヒドロ−7−チアプロスタグランジンe↓1類およびその製造方法

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