JPH09506855A - 抗生物質処方物および薬物耐性感染症への使用 - Google Patents
抗生物質処方物および薬物耐性感染症への使用Info
- Publication number
- JPH09506855A JPH09506855A JP6513093A JP51309394A JPH09506855A JP H09506855 A JPH09506855 A JP H09506855A JP 6513093 A JP6513093 A JP 6513093A JP 51309394 A JP51309394 A JP 51309394A JP H09506855 A JPH09506855 A JP H09506855A
- Authority
- JP
- Japan
- Prior art keywords
- liposome
- lipid
- less
- amikacin
- liposomes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. カプセル封入されたアミノグリコシドを含んでなるリポソームであって 、中性脂質、コレステロールおよび負に帯電した脂質からなり且つ平均粒度が1 00nm未満であり、液体の形態で22℃では少なくとも2週間安定であり、粒 度が著しく変化せずまたカプセル封入されたアミノグリコシドの10%より多く 喪失することがなく、負に帯電した脂質が総脂質の20%未満であるユニラメラ 状小胞である、リポソーム。 2. 負に帯電した脂質がホスファチジルグリセロールである、請求項1に記 載のリポソーム。 3. 負に帯電した脂質がジステアロイルホスファチジルグリセロールである 、請求項2に記載のリポソーム。 4. 負に帯電した脂質のモル量が総脂質モル数の20%未満である、請求項 1に記載のリポソーム。 5. ホスファチジルグリセロールのモル量が総脂質モル数の20%未満であ る、請求項2に記載のリポソーム。 6. ホスファチジルグリセロールのモル量が総脂質モル数の20%未満であ る、請求項3に記載のリポソーム。 7. 負に帯電した脂質のモル量が総脂質モル数の5%未満である、請求項1 に記載のリポソーム。 8. ホスファチジルグリセロールのモル量が総脂質モル数の5%未満である 、請求項2に記載のリポソーム。 9. ホスファチジルグリセロールのモル量が総脂質モル数の5%未満である 、請求項3に記載のリポソーム。 10. ホスファチジルグリセロールのモル量が総脂質モル数の約3%である 、請求項3に記載のリポソーム。 11. 水素化大豆ホスファチジルコリン、コレステロールおよびジステアロ イルホスファチジルグリセロールのモル比が約2:1:0.1であり、アミノグ リコシドの比率が1:9〜1:3である、請求項3に記載のリポソーム。 12. (a) 中性リン脂質およびステロールからなる脂質粉末を形成させ、 (b) この粉末を緩衝液中でアミノグリコシドと混合し、 (c) 脂質混合物の転移温度よりかなり低い温度で混合物を水和させ、 (d) 剪断力を加えることによって、リポソームの粒度を100nm未満の平 均粒度まで減少させることを含む、アミノグリコシドリポソームの製造法。 13. 患者の薬剤耐性細菌感染症の治療法であって、カプセル封入されたア ミノグリコシドを含んでなるリポソームの有効量を患者に投与することを含んで なり、リポソームは、中性脂質、コレステロールおよび負に帯電した脂質からな り平均粒度が100nm未満のユニラメラ状小胞から構成されている、上記方法 。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1992/010591 WO1994012155A1 (en) | 1992-12-02 | 1992-12-02 | Antibiotic formulation and process |
US92/10591 | 1992-12-02 | ||
PCT/US1993/004501 WO1994012156A1 (en) | 1992-12-02 | 1993-05-11 | Antibiotic formulation and use for drug resistant infections |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005167807A Division JP2005320341A (ja) | 1992-12-02 | 2005-06-08 | 感染症治療用組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09506855A true JPH09506855A (ja) | 1997-07-08 |
JP4084846B2 JP4084846B2 (ja) | 2008-04-30 |
Family
ID=22231603
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51309394A Expired - Lifetime JP4084846B2 (ja) | 1992-12-02 | 1993-05-11 | 抗生物質処方物および薬物耐性感染症への使用 |
JP2005167807A Pending JP2005320341A (ja) | 1992-12-02 | 2005-06-08 | 感染症治療用組成物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005167807A Pending JP2005320341A (ja) | 1992-12-02 | 2005-06-08 | 感染症治療用組成物 |
Country Status (11)
Country | Link |
---|---|
US (1) | US5756121A (ja) |
EP (1) | EP0671904B1 (ja) |
JP (2) | JP4084846B2 (ja) |
AT (1) | ATE183082T1 (ja) |
AU (2) | AU3244393A (ja) |
CA (1) | CA2150832C (ja) |
DE (1) | DE69326017T2 (ja) |
DK (1) | DK0671904T3 (ja) |
ES (1) | ES2134846T3 (ja) |
GR (1) | GR3031548T3 (ja) |
WO (2) | WO1994012155A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006514016A (ja) * | 2002-11-26 | 2006-04-27 | ギリアード サイエンシーズ, インコーポレイテッド | リポソーム処方物 |
JP2006514682A (ja) * | 2002-10-29 | 2006-05-11 | トランセイブ, インク. | 抗感染剤の徐放 |
JP2013256503A (ja) * | 2005-07-19 | 2013-12-26 | Insmed Inc | 徐放性抗感染剤 |
JP2015528021A (ja) * | 2012-07-30 | 2015-09-24 | コーディネイティッド プログラム ディベロップメント,エルエルシー | ダイズホスファチジルセリンで作られたコクリエート |
JP2016153431A (ja) * | 2006-04-06 | 2016-08-25 | インスメッド, インコーポレイテッド | 脂質を用いた薬物製剤の高速送達とその処置方法 |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5958449A (en) * | 1992-12-02 | 1999-09-28 | Nexstar Pharmaceuticals, Inc. | Antibiotic formulation and use for bacterial infections |
US6146890A (en) * | 1994-07-03 | 2000-11-14 | Danon; David | Method and system for cultivating macrophages |
US5662929A (en) * | 1994-12-23 | 1997-09-02 | Universite De Montreal | Therapeutic liposomal formulation |
US6726925B1 (en) * | 1998-06-18 | 2004-04-27 | Duke University | Temperature-sensitive liposomal formulation |
US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
GB0111279D0 (en) * | 2001-05-10 | 2001-06-27 | Nycomed Imaging As | Radiolabelled liposomes |
AU2003225689B2 (en) * | 2002-03-05 | 2009-03-26 | Transave, Inc. | Methods for entrapment of bioactive agent in a liposome or lipid complex |
EP3067046B1 (en) | 2005-12-08 | 2020-03-25 | Insmed Incorporated | Lipid-based compositions of antiinfectives for treating pulmonary infections |
US20100196455A1 (en) | 2007-05-04 | 2010-08-05 | Transave, Inc. | Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof |
US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
SI2852391T1 (sl) | 2012-05-21 | 2022-04-29 | Insmed Incorporated | Sistemi za obravnavo pljučnih infekcij |
CA2891487A1 (en) | 2012-11-29 | 2014-06-05 | Insmed Incorporated | Stabilized vancomycin formulations |
DK3466432T3 (da) * | 2014-05-15 | 2020-09-28 | Insmed Inc | Fremgangsmåder til behandling af pulmonale non-tuberkuløse mykobakterielle infektioner |
WO2019156179A1 (ja) * | 2018-02-07 | 2019-08-15 | Jfeスチール株式会社 | 高Mn鋼およびその製造方法 |
WO2019191627A1 (en) | 2018-03-30 | 2019-10-03 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5782311A (en) * | 1980-11-11 | 1982-05-22 | Tanabe Seiyaku Co Ltd | Production of liposome preparation |
FR2521565B1 (fr) * | 1982-02-17 | 1985-07-05 | Dior Sa Parfums Christian | Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees |
US4522803A (en) * | 1983-02-04 | 1985-06-11 | The Liposome Company, Inc. | Stable plurilamellar vesicles, their preparation and use |
FR2534487B1 (fr) * | 1982-10-15 | 1988-06-10 | Dior Christian Parfums | Procede d'homogeneisation de dispersions de phases lamellaires lipidiques hydratees, et suspensions obtenues par ce procede |
US4981692A (en) * | 1983-03-24 | 1991-01-01 | The Liposome Company, Inc. | Therapeutic treatment by intramammary infusion |
US4588578A (en) * | 1983-08-08 | 1986-05-13 | The Liposome Company, Inc. | Lipid vesicles prepared in a monophase |
CA1237670A (en) * | 1983-05-26 | 1988-06-07 | Andrew S. Janoff | Drug preparations of reduced toxicity |
CA1237671A (en) * | 1983-08-01 | 1988-06-07 | Michael W. Fountain | Enhancement of pharmaceutical activity |
EP0158441B2 (en) * | 1984-03-08 | 2001-04-04 | Phares Pharmaceutical Research N.V. | Liposome-forming composition |
JPS6176414A (ja) * | 1984-09-21 | 1986-04-18 | Shionogi & Co Ltd | リポソーム製剤の製法 |
US4753788A (en) * | 1985-01-31 | 1988-06-28 | Vestar Research Inc. | Method for preparing small vesicles using microemulsification |
US5409704A (en) * | 1985-06-26 | 1995-04-25 | The Liposome Company, Inc. | Liposomes comprising aminoglycoside phosphates and methods of production and use |
US5023087A (en) * | 1986-02-10 | 1991-06-11 | Liposome Technology, Inc. | Efficient method for preparation of prolonged release liposome-based drug delivery system |
US5043107A (en) * | 1986-08-21 | 1991-08-27 | Vestar Research, Inc. | Preparation small unilamellar vesicles including polyene antifungal antibiotics |
US4933121A (en) * | 1986-12-10 | 1990-06-12 | Ciba Corning Diagnostics Corp. | Process for forming liposomes |
DE3785198T3 (de) * | 1986-12-23 | 1999-09-02 | Liposome Co Inc | Liposomes präparat und antibiotikum. |
US5043166A (en) * | 1987-01-09 | 1991-08-27 | Hadasit Medical Research, Inc. | Liposome/anthraquinone drug composition and method |
ATE113468T1 (de) * | 1987-07-29 | 1994-11-15 | Liposome Co Inc | Verfahren zur trennung von teilchen nach grösse. |
US4946683A (en) * | 1987-11-18 | 1990-08-07 | Vestar, Inc. | Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes |
US5000887A (en) * | 1988-05-17 | 1991-03-19 | Liposome Technology, Inc. | Preparation of uniform-size liposomes |
BE1001869A3 (fr) * | 1988-10-12 | 1990-04-03 | Franz Legros | Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine. |
US4952405A (en) * | 1988-10-20 | 1990-08-28 | Liposome Technology, Inc. | Method of treating M. avium infection |
US5043165A (en) * | 1988-12-14 | 1991-08-27 | Liposome Technology, Inc. | Novel liposome composition for sustained release of steroidal drugs |
US5270052A (en) * | 1991-04-19 | 1993-12-14 | New England Medical Center Hospitals, Inc. | Methods and compositions for treatment of infection by intracellular parasites |
CA2093381A1 (en) * | 1992-04-07 | 1993-10-08 | Hideyuki Sawahara | Liposome formulation and process for production thereof |
PT100486B (pt) * | 1992-05-14 | 1999-07-30 | Ineti Inst Nac Engenh E Tecnol | Aminoglucosidos lipossomais com altas eficacia de encapsulacao e actividade terapeutica, nomeadamente a netilmicina, e processo para a sua preparcao |
US5276452A (en) * | 1992-06-24 | 1994-01-04 | Raytheon Company | Scan compensation for array antenna on a curved surface |
JP3325665B2 (ja) * | 1993-09-10 | 2002-09-17 | 三菱化学株式会社 | オレフィン重合用触媒およびこれを用いたオレフィン重合体の製造方法 |
-
1992
- 1992-12-02 WO PCT/US1992/010591 patent/WO1994012155A1/en active Application Filing
- 1992-12-02 AU AU32443/93A patent/AU3244393A/en not_active Abandoned
-
1993
- 1993-05-11 AT AT93911272T patent/ATE183082T1/de active
- 1993-05-11 DE DE69326017T patent/DE69326017T2/de not_active Expired - Lifetime
- 1993-05-11 CA CA002150832A patent/CA2150832C/en not_active Expired - Lifetime
- 1993-05-11 AU AU42463/93A patent/AU668179B2/en not_active Expired
- 1993-05-11 EP EP93911272A patent/EP0671904B1/en not_active Expired - Lifetime
- 1993-05-11 WO PCT/US1993/004501 patent/WO1994012156A1/en active IP Right Grant
- 1993-05-11 ES ES93911272T patent/ES2134846T3/es not_active Expired - Lifetime
- 1993-05-11 DK DK93911272T patent/DK0671904T3/da active
- 1993-05-11 JP JP51309394A patent/JP4084846B2/ja not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/469,157 patent/US5756121A/en not_active Expired - Lifetime
-
1999
- 1999-10-15 GR GR990402641T patent/GR3031548T3/el unknown
-
2005
- 2005-06-08 JP JP2005167807A patent/JP2005320341A/ja active Pending
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006514682A (ja) * | 2002-10-29 | 2006-05-11 | トランセイブ, インク. | 抗感染剤の徐放 |
JP2011093925A (ja) * | 2002-10-29 | 2011-05-12 | Transave Inc | 抗感染剤の徐放 |
JP2016104807A (ja) * | 2002-10-29 | 2016-06-09 | インスメッド, インコーポレイテッド | 抗感染剤の徐放 |
JP2006514016A (ja) * | 2002-11-26 | 2006-04-27 | ギリアード サイエンシーズ, インコーポレイテッド | リポソーム処方物 |
JP2010235634A (ja) * | 2002-11-26 | 2010-10-21 | Gilead Sciences Inc | リポソーム処方物 |
JP2013256503A (ja) * | 2005-07-19 | 2013-12-26 | Insmed Inc | 徐放性抗感染剤 |
JP2016153431A (ja) * | 2006-04-06 | 2016-08-25 | インスメッド, インコーポレイテッド | 脂質を用いた薬物製剤の高速送達とその処置方法 |
JP2015528021A (ja) * | 2012-07-30 | 2015-09-24 | コーディネイティッド プログラム ディベロップメント,エルエルシー | ダイズホスファチジルセリンで作られたコクリエート |
Also Published As
Publication number | Publication date |
---|---|
EP0671904A1 (en) | 1995-09-20 |
CA2150832C (en) | 2000-01-11 |
WO1994012156A1 (en) | 1994-06-09 |
DE69326017T2 (de) | 1999-12-23 |
GR3031548T3 (en) | 2000-01-31 |
JP4084846B2 (ja) | 2008-04-30 |
AU3244393A (en) | 1994-06-22 |
ATE183082T1 (de) | 1999-08-15 |
US5756121A (en) | 1998-05-26 |
CA2150832A1 (en) | 1994-06-09 |
DE69326017D1 (de) | 1999-09-16 |
EP0671904B1 (en) | 1999-08-11 |
AU668179B2 (en) | 1996-04-26 |
AU4246393A (en) | 1994-06-22 |
DK0671904T3 (da) | 1999-12-06 |
JP2005320341A (ja) | 2005-11-17 |
WO1994012155A1 (en) | 1994-06-09 |
ES2134846T3 (es) | 1999-10-16 |
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Cognomi | Cognomi AM |
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