ES2134846T3 - Formulacion de antibiotico y uso para infecciones resistentes a farmacos. - Google Patents

Formulacion de antibiotico y uso para infecciones resistentes a farmacos.

Info

Publication number
ES2134846T3
ES2134846T3 ES93911272T ES93911272T ES2134846T3 ES 2134846 T3 ES2134846 T3 ES 2134846T3 ES 93911272 T ES93911272 T ES 93911272T ES 93911272 T ES93911272 T ES 93911272T ES 2134846 T3 ES2134846 T3 ES 2134846T3
Authority
ES
Spain
Prior art keywords
formulation
drug resistant
resistant infections
antibiotic formulation
aminoglycoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93911272T
Other languages
English (en)
Inventor
Evan M Hersh
Eskild A Petersen
Richard T Proffitt
Kevin R Bracken
Su-Ming Chiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nexstar Pharmaceuticals Inc
Original Assignee
Nexstar Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexstar Pharmaceuticals Inc filed Critical Nexstar Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2134846T3 publication Critical patent/ES2134846T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Abstract

UNA FORMULACION DE AMINOGLICOSIDO LIPOSOMAL QUE CONSTA DE UN LIPIDO NEUTRO, LIPIDOS CARGADOS NEGATIVAMENTE Y UN ESTEROL. LA FORMULACION CONTIENE VESICULAS UNILAMINARES QUE TIENEN UN TAMAÑO MEDIO POR DEBAJO DE 100 NM. SE DESCRIBE UN PROCESO DE FABRICACION DE LIPOSOMAS CONTENIENDO UN AMINOGLICOSIDO DONDE LA TEMPERATURA DE HIDRATACION ESTA SIGNIFICATIVAMENTE POR DEBAJO DE LA TEMPERATURA DE TRANSICION DE LA FORMULACION. UN METODO PARA EL TRATAMIENTO DE BACTERIAS SUSCEPTIBLES Y RESISTENTES AL FARMACO.
ES93911272T 1992-12-02 1993-05-11 Formulacion de antibiotico y uso para infecciones resistentes a farmacos. Expired - Lifetime ES2134846T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1992/010591 WO1994012155A1 (en) 1992-12-02 1992-12-02 Antibiotic formulation and process

Publications (1)

Publication Number Publication Date
ES2134846T3 true ES2134846T3 (es) 1999-10-16

Family

ID=22231603

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93911272T Expired - Lifetime ES2134846T3 (es) 1992-12-02 1993-05-11 Formulacion de antibiotico y uso para infecciones resistentes a farmacos.

Country Status (11)

Country Link
US (1) US5756121A (es)
EP (1) EP0671904B1 (es)
JP (2) JP4084846B2 (es)
AT (1) ATE183082T1 (es)
AU (2) AU3244393A (es)
CA (1) CA2150832C (es)
DE (1) DE69326017T2 (es)
DK (1) DK0671904T3 (es)
ES (1) ES2134846T3 (es)
GR (1) GR3031548T3 (es)
WO (2) WO1994012155A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
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US5958449A (en) 1992-12-02 1999-09-28 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for bacterial infections
US6146890A (en) * 1994-07-03 2000-11-14 Danon; David Method and system for cultivating macrophages
US5662929A (en) * 1994-12-23 1997-09-02 Universite De Montreal Therapeutic liposomal formulation
US6726925B1 (en) * 1998-06-18 2004-04-27 Duke University Temperature-sensitive liposomal formulation
US6613352B2 (en) 1999-04-13 2003-09-02 Universite De Montreal Low-rigidity liposomal formulation
GB0111279D0 (en) * 2001-05-10 2001-06-27 Nycomed Imaging As Radiolabelled liposomes
EP1490027A4 (en) * 2002-03-05 2010-11-10 Transave Inc METHODS OF TRAPPING BIOACTIVE AGENT IN A LIPOSOME OR LIPID COMPLEX
US7544369B2 (en) * 2002-10-29 2009-06-09 Transave, Inc. Sustained release of antiinfectives
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
US7879351B2 (en) * 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
EP1567130A2 (en) * 2002-11-26 2005-08-31 Gilead Sciences, Inc. Method of drug loading in liposomes by gradient
CA2896083A1 (en) 2005-12-08 2007-06-14 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof
WO2008137717A1 (en) * 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
JP6402097B2 (ja) 2012-05-21 2018-10-10 インスメッド インコーポレイテッド 肺感染症を処置するためのシステム
CA2879931C (en) 2012-07-30 2020-12-15 Coordinated Program Development, Llc Cochleates made with soy phosphatidylserine
RU2018135921A (ru) 2012-11-29 2019-02-05 Инсмед Инкорпорейтед Стабилизированные составы ванкомицина
BR112016026699B1 (pt) * 2014-05-15 2022-09-13 Insmed Incorporated Uso de uma composição farmaceutica de amicacina ou de um sal farmaceuticamente aceitável desta
JP6590120B1 (ja) * 2018-02-07 2019-10-16 Ｊｆｅスチール株式会社 高Ｍｎ鋼およびその製造方法
JP7460534B2 (ja) 2018-03-30 2024-04-02 インスメッド インコーポレイテッド リポソーム医薬品の連続製造方法

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JPS5782311A (en) * 1980-11-11 1982-05-22 Tanabe Seiyaku Co Ltd Production of liposome preparation
FR2521565B1 (fr) * 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
FR2534487B1 (fr) * 1982-10-15 1988-06-10 Dior Christian Parfums Procede d'homogeneisation de dispersions de phases lamellaires lipidiques hydratees, et suspensions obtenues par ce procede
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US4981692A (en) * 1983-03-24 1991-01-01 The Liposome Company, Inc. Therapeutic treatment by intramammary infusion
CA1237670A (en) * 1983-05-26 1988-06-07 Andrew S. Janoff Drug preparations of reduced toxicity
CA1237671A (en) * 1983-08-01 1988-06-07 Michael W. Fountain Enhancement of pharmaceutical activity
DE3585967D1 (de) * 1984-03-08 1992-06-11 Phares Pharma Holland Liposombildende zusammensetzung.
JPS6176414A (ja) * 1984-09-21 1986-04-18 Shionogi & Co Ltd リポソーム製剤の製法
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US5409704A (en) * 1985-06-26 1995-04-25 The Liposome Company, Inc. Liposomes comprising aminoglycoside phosphates and methods of production and use
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US5043107A (en) * 1986-08-21 1991-08-27 Vestar Research, Inc. Preparation small unilamellar vesicles including polyene antifungal antibiotics
US4933121A (en) * 1986-12-10 1990-06-12 Ciba Corning Diagnostics Corp. Process for forming liposomes
ATE87503T1 (de) * 1986-12-23 1993-04-15 Liposome Co Inc Liposomes praeparat und antibiotikum.
US5043166A (en) * 1987-01-09 1991-08-27 Hadasit Medical Research, Inc. Liposome/anthraquinone drug composition and method
DE3852037T2 (de) * 1987-07-29 1995-03-23 Liposome Co Inc Verfahren zur trennung von teilchen nach grösse.
US4946683A (en) * 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
US5000887A (en) * 1988-05-17 1991-03-19 Liposome Technology, Inc. Preparation of uniform-size liposomes
BE1001869A3 (fr) * 1988-10-12 1990-04-03 Franz Legros Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine.
US4952405A (en) * 1988-10-20 1990-08-28 Liposome Technology, Inc. Method of treating M. avium infection
US5043165A (en) * 1988-12-14 1991-08-27 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs
US5270052A (en) * 1991-04-19 1993-12-14 New England Medical Center Hospitals, Inc. Methods and compositions for treatment of infection by intracellular parasites
CA2093381A1 (en) * 1992-04-07 1993-10-08 Hideyuki Sawahara Liposome formulation and process for production thereof
PT100486B (pt) * 1992-05-14 1999-07-30 Ineti Inst Nac Engenh E Tecnol Aminoglucosidos lipossomais com altas eficacia de encapsulacao e actividade terapeutica, nomeadamente a netilmicina, e processo para a sua preparcao
US5276452A (en) * 1992-06-24 1994-01-04 Raytheon Company Scan compensation for array antenna on a curved surface
JP3325665B2 (ja) * 1993-09-10 2002-09-17 三菱化学株式会社 オレフィン重合用触媒およびこれを用いたオレフィン重合体の製造方法

Also Published As

Publication number Publication date
AU668179B2 (en) 1996-04-26
WO1994012155A1 (en) 1994-06-09
DK0671904T3 (da) 1999-12-06
GR3031548T3 (en) 2000-01-31
AU3244393A (en) 1994-06-22
WO1994012156A1 (en) 1994-06-09
EP0671904B1 (en) 1999-08-11
DE69326017T2 (de) 1999-12-23
JP4084846B2 (ja) 2008-04-30
CA2150832A1 (en) 1994-06-09
CA2150832C (en) 2000-01-11
JPH09506855A (ja) 1997-07-08
DE69326017D1 (de) 1999-09-16
ATE183082T1 (de) 1999-08-15
JP2005320341A (ja) 2005-11-17
EP0671904A1 (en) 1995-09-20
AU4246393A (en) 1994-06-22
US5756121A (en) 1998-05-26

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