DE69530368D1 - Vinca-alkaloid vesikel mit erhöhter wirksamkeit und tumor-zielausrichtung - Google Patents
Vinca-alkaloid vesikel mit erhöhter wirksamkeit und tumor-zielausrichtungInfo
- Publication number
- DE69530368D1 DE69530368D1 DE69530368T DE69530368T DE69530368D1 DE 69530368 D1 DE69530368 D1 DE 69530368D1 DE 69530368 T DE69530368 T DE 69530368T DE 69530368 T DE69530368 T DE 69530368T DE 69530368 D1 DE69530368 D1 DE 69530368D1
- Authority
- DE
- Germany
- Prior art keywords
- vinca alkaloid
- tumor targeting
- vesicle
- increased effectiveness
- liposome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26605994A | 1994-06-27 | 1994-06-27 | |
US08/389,663 US5714163A (en) | 1994-06-27 | 1995-02-16 | Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties |
PCT/US1995/008037 WO1996000057A1 (en) | 1994-06-27 | 1995-06-27 | Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69530368D1 true DE69530368D1 (de) | 2003-05-22 |
DE69530368T2 DE69530368T2 (de) | 2003-12-18 |
Family
ID=26951608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69530368T Expired - Lifetime DE69530368T2 (de) | 1994-06-27 | 1995-06-27 | Vinca-alkaloid vesikel mit erhöhter wirksamkeit und tumor-zielausrichtung |
Country Status (9)
Country | Link |
---|---|
US (2) | US5714163A (de) |
EP (1) | EP0734252B1 (de) |
AT (1) | ATE237311T1 (de) |
AU (1) | AU684209B2 (de) |
CA (1) | CA2191077C (de) |
DE (1) | DE69530368T2 (de) |
DK (1) | DK0734252T3 (de) |
ES (1) | ES2197919T3 (de) |
WO (1) | WO1996000057A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5714163A (en) * | 1994-06-27 | 1998-02-03 | Nexstar Pharmaceuticals, Inc. | Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties |
US5876728A (en) * | 1995-02-15 | 1999-03-02 | Howard David Kass | Natural composition extracted from plants used in the treatment of cancer |
US5800833A (en) * | 1995-02-27 | 1998-09-01 | University Of British Columbia | Method for loading lipid vesicles |
US6740335B1 (en) * | 1997-09-16 | 2004-05-25 | Osi Pharmaceuticals, Inc. | Liposomal camptothecin formulations |
US6120800A (en) * | 1997-09-25 | 2000-09-19 | Nexstar Pharmaceuticals, Inc. | Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties |
US7244450B2 (en) * | 1999-04-01 | 2007-07-17 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
US6723338B1 (en) * | 1999-04-01 | 2004-04-20 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
BRPI0009448B8 (pt) * | 1999-04-01 | 2021-05-25 | Univ Texas | kit para uso no tratamento de uma neoplasia em um mamífero |
US7311924B2 (en) | 1999-04-01 | 2007-12-25 | Hana Biosciences, Inc. | Compositions and methods for treating cancer |
EP1685843A1 (de) * | 1999-06-30 | 2006-08-02 | Ruey J. Dr. Yu | Oligosaccharidealdonsäure und ihre topische Verabreichung |
US6335023B1 (en) | 1999-06-30 | 2002-01-01 | Ruey J. Yu | Oligosaccharide aldonic acids and their topical use |
US7452545B2 (en) * | 2001-11-13 | 2008-11-18 | Yu Ruey J | Oligosaccharide aldonic acids and their topical use |
AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
EP1372664A1 (de) | 2001-03-01 | 2004-01-02 | Hollis-Eden Pharmaceuticals Inc. | Verwendung von steroiden für die behandlung von blutzellenmangel |
WO2002089772A1 (en) * | 2001-05-09 | 2002-11-14 | Inex Pharmaceuticals Corporation | Anti-angiogenic therapy using liposome-encapsulated chemotherapeutic agents |
US8980310B2 (en) * | 2002-12-31 | 2015-03-17 | Bharat Serums and Vaccines, Ltd. | Non-pegylated long-circulating liposomes |
US20070014719A1 (en) | 2004-09-29 | 2007-01-18 | Reading Christopher L | Steroid analogs and characterization and treatment methods |
US20070026061A1 (en) * | 2005-05-25 | 2007-02-01 | Nahid Ali | Liposomal formulation and use thereof |
EP1932517A3 (de) * | 2006-12-11 | 2008-07-16 | Universiteit Utrecht Holding B.V. | Liposomen beinhaltend Polyphenolderivaten und deren Verfahren zur Nachbeladung |
PL387296A1 (pl) * | 2009-02-17 | 2010-08-30 | Instytut Farmaceutyczny | Sposób aktywnego zamykania amfifilowych substancji czynnych w strukturach liposomowych |
US11458199B2 (en) * | 2012-08-21 | 2022-10-04 | Opko Pharmaceuticals, Llc | Liposome formulations |
MX2015005992A (es) | 2012-11-20 | 2016-03-07 | Spectrum Pharmaceuticals Inc | Metodo mejorado para la preparacion de la vincristina liposomal encapsulada para el uso terapeutico. |
TWI678213B (zh) | 2015-07-22 | 2019-12-01 | 美商史倍壯製藥公司 | 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物 |
WO2018136002A1 (en) | 2017-01-18 | 2018-07-26 | Temasek Life Sciences Laboratory Limited | Hyperstabilized liposomes increase targeting of mitotic cells |
US10836788B2 (en) | 2019-02-05 | 2020-11-17 | SD Chem, Inc. | Aqueous suspension compositions, formulations, and water dispersible dry compositions comprising 16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-ketone and hydrates, derivatives, and analogs thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1270198C (en) * | 1984-08-08 | 1990-06-12 | Marcel B Bally | ENCAPSULATION OF ANTINEOPLASTIC AGENTS IN LIPOSONES |
US5019369A (en) * | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
IE58981B1 (en) * | 1985-10-15 | 1993-12-15 | Vestar Inc | Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles |
JPH0714865B2 (ja) * | 1986-10-28 | 1995-02-22 | 武田薬品工業株式会社 | リポソ−ム製剤およびその製造法 |
AU604288B2 (en) * | 1987-01-26 | 1990-12-13 | Vestar, Inc. | Phospholipid delivery vehicle for aqueous-insoluble active ingredients |
IL91664A (en) * | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
US5032401A (en) * | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
ES2067755T3 (es) * | 1989-06-22 | 1995-04-01 | Vestar Inc | Proceso de encapsulado. |
US5322862A (en) * | 1990-05-22 | 1994-06-21 | Nippon Kayaku Kabushiki Kaisha | Resin molding composition for preventing gnawing damage by animals |
EP0661044A1 (de) * | 1991-07-03 | 1995-07-05 | NeXstar Pharmaceuticals, Inc. | Arzneistoff enthaltende Liposomen |
DE69113640T2 (de) * | 1991-07-03 | 1996-03-07 | Vestar Inc | Beladungstechnik zur herstellung arzneistoffhaltiger liposomen. |
US5714163A (en) * | 1994-06-27 | 1998-02-03 | Nexstar Pharmaceuticals, Inc. | Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties |
-
1995
- 1995-02-16 US US08/389,663 patent/US5714163A/en not_active Expired - Lifetime
- 1995-06-27 AT AT95926111T patent/ATE237311T1/de active
- 1995-06-27 DK DK95926111T patent/DK0734252T3/da active
- 1995-06-27 CA CA002191077A patent/CA2191077C/en not_active Expired - Lifetime
- 1995-06-27 AU AU29984/95A patent/AU684209B2/en not_active Expired
- 1995-06-27 ES ES95926111T patent/ES2197919T3/es not_active Expired - Lifetime
- 1995-06-27 DE DE69530368T patent/DE69530368T2/de not_active Expired - Lifetime
- 1995-06-27 WO PCT/US1995/008037 patent/WO1996000057A1/en active IP Right Grant
- 1995-06-27 EP EP95926111A patent/EP0734252B1/de not_active Expired - Lifetime
-
1997
- 1997-09-25 US US08/937,935 patent/US5888537A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5888537A (en) | 1999-03-30 |
CA2191077C (en) | 2008-02-05 |
DK0734252T3 (da) | 2003-07-21 |
EP0734252A1 (de) | 1996-10-02 |
AU684209B2 (en) | 1997-12-04 |
AU2998495A (en) | 1996-01-19 |
ES2197919T3 (es) | 2004-01-16 |
ATE237311T1 (de) | 2003-05-15 |
DE69530368T2 (de) | 2003-12-18 |
WO1996000057A1 (en) | 1996-01-04 |
US5714163A (en) | 1998-02-03 |
CA2191077A1 (en) | 1996-01-04 |
EP0734252B1 (de) | 2003-04-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: HARWARDT NEUMANN MUELLER & PARTNER PATENTANWAELTE, 5 |