JPH0840882A - Sheet for plastering skin - Google Patents

Abstract

PURPOSE:To obtain a sheet for plastering skin, useful for, e.g. therapy or prevention of wound, burn, inflammatory part and other diseases of the skin or beauty of it by drying a solution or a gel containing a specified amount of polysaccharides (e.g. agarose) extracted from sea weeds into a sheet shape. CONSTITUTION:Polysaccharides (e.g. agarose) extracted from sea weeds are heated and dissolved in boiling water till the concentration reaches 0.1 to 10wt.%. The resultant solution is transferred to a suitable plate-shaped vessel and cooled to about 20 deg.C to prepare a gel or a viscous solution which is gelatinized after addition of a medical component, a cosmetic component, etc., if necessary. The resultant gel is cut into pieces of several mm thickness. In the case of a viscous solution, it is quickly quenched without applying any treatment thereto and then freeze-dried under vacuum, thus producing the objective sheet for plastering skin, useful for, e.g. therapy or prevention of wound, barn, inflammatory part or other diseases of the skin or skin care of for the purpose of beauty.

Description

Detailed Description of the Invention

[0001] The present invention relates to a sheet-like processed product for skin application. More specifically, the present invention provides a highly safe skin patch sheet suitable for medical or beauty purposes, which is obtained by drying a polysaccharide extracted from seaweed into a sheet.

[0002]

BACKGROUND OF THE INVENTION The skin patch sheet according to the present invention is used as a sheet for treating or preventing skin wounds, burns, inflamed areas and other diseases, or as a skin care sheet for the purpose of beauty. Can be used. Specifically, it is suitable for application to a bandage, a medicated skin patch, an eye patch, a cosmetic sheet, etc., and is cut into an arbitrary shape as needed.

[0003]

2. Description of the Related Art Hitherto, as a skin patch sheet or pack, for example, 5 to 70% by weight of water has been added to an oily continuous phase composed of a high molecular compound such as a natural or synthetic rubbery polymer and an oily component. A film- or sheet-like pack agent (JP-A-55-92306) made of a hydrous gel stable at room temperature, which is contained in the form of particles dispersed therein, a polyurethane foam,
A cosmetic pack sheet having a multilayer structure in which a pressure-sensitive adhesive layer such as an acrylic resin is provided on the surface of a porous elastic sheet such as a rubber foam (JP-A-56-145210), carboxymethylcellulose salt, polyvinyl alcohol, etc. A pack decorative sheet made of a water-soluble polymer (JP-A-58-21608)
No.) has been proposed. In addition, a natural collagen fiber that is dried and processed into a sheet is generally used for cosmetics.

[0004]

Alginic acid and its derivatives, which are widely used as moisturizers and thickeners for cosmetics, and polymer compounds such as gum arabic and carboxymethylcellulose are water-soluble polysaccharides. However, while a suppository made only of a material having such properties has adhesiveness to the skin due to its gel-forming ability, it has a sticky feeling and is not so preferable to use. In addition, a sheet having a multi-layer structure is not easy to manufacture, and accordingly, management is troublesome, resulting in high cost. Further, the dry sheet of collagen fiber used for cosmetics is excellent in terms of touch feeling, feeling of use, and cosmetic effect, but is very expensive as a material, and other liquids, emulsions, It is not as widely used on a daily basis as cosmetics such as cream. Also, because collagen is a protein derived from animal tissue, it cannot be said that it is biologically not necessarily antigenic to living organisms. In addition, in recent years, the trend of animal welfare has helped, and its demand has declined. Tend to be.

In view of these circumstances, the present inventors have conducted intensive studies for the purpose of developing a new skin patch sheet which solves the following problems. (1) Immunologically non-antigenic (highly safe). (2) The skin can be kept hygienic without being used by general bacteria. (3) It has a feeling and usability that is equivalent to or better than that used conventionally. (4) It can be used for multiple purposes from medical treatment to beauty. (5) Mass production is possible industrially by a simple manufacturing method. (6) Stable supply is possible at extremely low cost.

[0006]

Means for Solving the Problems In developing a skin patch sheet that can be used for various purposes from medical treatment to beauty, we focused on a poorly water-soluble polysaccharide derived from seaweed that is easily and inexpensively available. However, various studies have been tried. As a result, by knowing that the solution or gel containing the polysaccharide extracted from seaweed in an amount of 0.1 to 10% is dried into a sheet form, it is possible to obtain a skin patch sheet that achieves the purpose of the title, and the present invention completed. The details will be described below.

The seaweed-derived polysaccharide used in the present invention may be agarose or funorin extracted from red algae, fucoidin extracted from brown algae, or cellulose generally contained in the cell wall of seaweed. . Of course, it doesn't matter even if the agar is used for food.

The skin patch sheet according to the present invention is obtained by drying a solution or gel containing a polysaccharide extracted from seaweed in an amount of 0.1 to 10% into a sheet, and the solution or gel before being dried. In addition, for example, a desired skin patch sheet can be prepared by preparing one containing one or more of the following components and drying the mixture.

(A) Water-soluble polymer compound having gel forming ability and tackiness with water: carboxyalkyl chitin or chitosan, hydroxyalkyl chitin or chitosan, low molecular weight chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin Or chitosan, carboxymethylcellulose, hydroxyethylcellulose, methylcellulose, ethylcellulose, gum arabic, polyvinyl alcohol, polyvinylpyrrolidone, polyvinylmethacrylate, polyacrylic acid salt, polyalkylene oxide such as polyethylene oxide or polypropylene oxide, or a cross-linked polymer thereof, carboxyvinyl polymer , Carrageenan,
Pectin, casein, gelatin, alginic acid and its salts, starch, hyaluronic acid and its salts, chondroitin sulfate, heparin, etc.

(B) Components used as bactericidal and disinfectant acrinol, sulfur, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride, cresol, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate

(C) Ingredients used as anti-inflammatory agents Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d or dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate. , Glycyrrhizic acid and its salts, Glycyrrhetinic acid and its salts, etc.

(D) Components used as astringents Allantoin, tannic acid, zinc sulfate, zinc chloride, zinc oxide, etc.

(E) Extracts of animal tissues or plants, crude drugs (in the case of plants, extraction with one or a mixture of two or more of the group consisting of water, ethanol, propylene glycol and 1,3-butylene glycol) In the case of animal tissue, in addition to the extract obtained by the same method as the above-mentioned plant, an extract obtained by hydrolyzing the tissue may be used as a moisturizing component, or It is used for the purpose of various cosmetic and medical effects known so far.) Asenyak (Asenyaku), Ashitaba, Altea, Arnica,
Avocado, Amacha (sweet tea), Aloe, Aloe vera, Nettle, Ginkgo (Ginkgo leaf, Ginkgo), Fennel (Incense), Turmeric (Yukin), Usubasaicin (Spicy), Ume (Umeume), Vladimir, Uruushi, Neubara ), Hikiokoshi
(Prolonged life grass), Ougi (Yellow radish), Scutellaria baicalensis (Ougon), Yamazakura (Sakura skin), Yellowfin (Yellow oak), Ouren (Yellow), Panax ginseng (Ginseng), Hypericum perforatum (Brother's grass), Odorikosou, Dutch pepper, Orange, Itohimehagi (Denshi),
Nepenthes (Summer hay), Pleurotus cornucopiae (Fanging crow), Enju
(Sophora), mugwort (Guy leaf), banyan tree (Kurakune), kudzu (Kakkon), valerian (Yoshikusa), chamomile, sardine root (melon root), kawara wormwood (茵 chinka), licorice (liquorice), raspberry , Kiwi fruit, Kikyo (Kikyo), Chrysanthemum (Chrysanthemum), Catalpa (Azusa fruit), Rutaceae plant fruit (Cumami fruit), Tachibana (Tachibana peel), Cucumber, Udo or Shishido (Kansai), Apricot (Apricot kernel), Cucumber (Crustal bark, Pellets, Pellets), Clara
(Gourd), camphor tree, kumazasa, grapefruit fruit,
Nikkei (cinnamon skin), Keigai (Keiguy), Ebisugusa (Keimeiko), Malaba morning glory or morning glory (Ken beef), safflower (Safflower), Gobaishi (quintet), gardenia (Yamajoko),
Gentian, honoki (koboku), hinako no kochi (cow knee), goshuyu (gojutsu), burdock, ginseng (schisandra), rice, rice bran, wheat, spinach (comfrey), cypress (saiko), saffron, sabonsou , Hawthorn (yamazako), Hawthorn (sansho), Salvia, Sanshini ginseng (37 ginseng), Shiitake mushroom, Diou (ground yellow), Shikunshi (messenger), purple (purple root), perilla (shiso leaf, shisozi) ), Oyster (persimmon), Peony (peony), Psyllium (Masamuko, Masakisou), Ginger (Ginger), Shobu (Iris), Tonezumimochi (Sadako), Shimosukeso, Birch, Honeysuckle (Kinginka), Shinobi winter , Ivy, Achillea millefolium, Sambucus nigra, Azuki (red azuki bean), Sambucus nigra
(Grafting), mallow, senkyu (river kyu), senburi (our medicine), mulberry (mulberry bark, mulberry leaf), jujube (large jujube), soybean, cod, ginseng (Takebushi ginseng), Hanasuge
(Chinese mother), Waremoko (earthenworm), Dokudami (ten medicinal herbs), Fuyusuminatsukutaketake (caterpillar), Capsicum, physalis (Toroine), Pleurotus cornucopiae, Ryokucha (green tea), Kocha
(Black tea), cloves (cloves), citrus unshiu (chin peel), camellia, camellia, capsicum (chopsticks), touki (toki), quince, daidai (orange rind), waremoko (jimoku), corn (barbaric hair) ), Eucommia ulmotus (Muchu, Fuchu leaf), Tomato, Nanten (Minami Tenmi), Garlic (Large Sun), Barley
(Malt), Chinese cabbage (white moss bark), january beard (barley winter), parsley, peppermint (light load), hamamelis, rose, loquat leaf (silver leaf), matsuhodo (boiled leopard), grape or its leaf, loofah, bodaiju , Button (peony skin), hop, maikai
(My agate flower), pine needles, horse chestnut, mannen wax, swordfish, melissa, meliloto, bokeh (wood melon), bean sprouts, peaches
(Momojin, Momoha), Hyogi (Shooting), Areca (Rhoko), Swordfish (Immothiver's grass), Cornflower, Yukinoshita (Tiger-eared grass), Yamomo (Yakumeume), Hydrangea (Homugi, Yokuinin), Mokomogi, Yamamogi, Lavender , Apple fruit, ganoderma lucidum, lemon fruit, forsythia
(Rensai), Astragalus japonicus, Gentian ginger (Old grass), Hasiridokoro (roth root), Chicken gooseberry, placenta extract of cattle and humans, stomach and duodenum of pigs and cattle, or intestinal extract or its degradation product, water-soluble Collagen, water-soluble collagen derivative,
Collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, silk protein, silk protein hydrolyzate, bovine blood cell protein hydrolyzate, etc.

(F) Microbial metabolites Yeast extract, selenium-containing yeast extract, rice fermentation extract, Euglena extract, lactic acid fermentation product of skim milk powder, etc.

(G) Vitamins Ascorbic acid and its derivative (vitamin C), tocopherol and its derivative (vitamin E), thiamine hydrochloride (vitamin B ₁ ), riboflavin (vitamin B ₂ ),
Pyridoxine hydrochloride (vitamin B ₆ ) etc.

(H) Amino acid (mainly used as a moisturizing component) Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, Hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates, or amino acid derivatives such as pyrrolidonecarboxylic acid

(I) α-hydroxy acid Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

(J) Other natural product pigments, synthetic pigments, fragrances, deodorants / deodorants, preservatives, etc.

In addition, solutions (lotions, sprays and aerosols), creams, ointments, gels, etc. containing one or more of these drugs and components at the time of use, or water and / or ethanol, 1, 1, A sheet containing a solution containing 3-butylene glycol, propylene glycol, a surfactant, etc., or applying it to the skin to treat or prevent skin wounds, burns, inflammation, and other diseases, and beauty It is also possible to attach it to and use it.

Further, if the sheet of the present invention containing or impregnated with the above medicinal or cosmetic ingredients together with water or alcohol is provided as a product further sealed with a film or an aluminum pack, it is very useful. It can be a convenient and convenient portable medicine or cosmetic.

[0021]

[Example] Production example of skin patch sheet Polysaccharides extracted from seaweed (such as agarose and funolin,
Alternatively, commercially available agar) may be dissolved in a boiling water bath by heating to an appropriate concentration, then transferred to an appropriate flat container and cooled to around 20 ° C. to obtain a gel or viscous solution. In addition, when the above-mentioned drug or cosmetic ingredient is added, gelation occurs (the temperature may vary depending on the concentration of the polysaccharide, but 20 to 50
C.) before any mixing and dissolution. This gel is cut to a thickness of a few millimeters, or if it is a viscous solution, it is immediately frozen and then freeze-dried under vacuum.

[0022]

[Example] Examination of amount of use of seaweed-derived polysaccharides The feeling of use of the sheets produced by the method described above was evaluated while varying the concentration of the seaweed-derived polysaccharides. As a result, 0.
It was found that about 1 to 10% by weight gives the most preferable usability as a sheet such as softness, feel and strength.

[0023]

[Examples] Prototype production of various skin patch sheets Prototype medical or cosmetic skin patch sheets to which the above-mentioned various agents, cosmetic ingredients, thickeners, etc. were added. The produced sheets are as shown in Table 1. The skin patch sheet of the present invention is by no means limited to these, and means that various materials can be manufactured according to the purpose.

[Table 1]

[0024]

[Examples] Water Absorption and Water Retention The water absorption and water retention of the skin patch sheet of the present invention are as follows.
The following tests were carried out in order to compare with collagen sheets that have been mainly used for cosmetics. a) Sample (1) Sheet 1 (thickness of about 1 mm, about 15 cm ² , dry weight 0.072 g) manufactured as a prototype in the example (2) Collagen sheet (thickness of about 1 mm, about 15 cm ² , dry weight 0.072 g, Henkel) B) Water absorption capacity and water retention capacity After the sample was fully absorbed with purified water and the weight was measured, the sample was allowed to stand in a temperature-controlled room (28 ° C, humidity 60%) to determine the change in weight over time. c) Results As shown in FIG. It was confirmed that the sheets of the present invention obtained in the examples had higher water absorption. The changes in the water retention capacity with time were the same in both cases.

[Figure 1]

[0025]

[Examples] Skin safety test (human patch test) A closed patch test was conducted for 48 hours on a total of 30 healthy adult male volunteers (25 to 47 years old) and 23 healthy adult female volunteers. a) Specimen (1) Sheet 1 manufactured by trial production in Example containing purified water (2) Filter paper containing purified water (comparison target) b) Method Specimen using Finn chamber and Scanpor tape Was closed-patched inside the upper arm of the volunteer for 48 hours. After the removal, the reaction of the patch was observed 1 hour and 24 hours after the removal. c) Results It was confirmed that all 30 volunteers were unresponsive (negative) within 1 hour and 24 hours after removal without any abnormalities such as erythema and edema.

[0026]

[Examples] Use test by humans and animals The use test was conducted on the following animals and each subject by using the sheet manufactured as a prototype in the examples. Asked for their impressions and opinions.

A) Skin Wound Healing Test Rats (5, 154-168 g) were treated with abatin (2,2,2-tribrom).
oethanol) solution (1.8g dissolved in 100mL purified water,
After anesthesia with 1.6 mL / 100 g), the back part was shaved, and a part of the skin was cut into a circle with a leather punch (internal diameter 9 mm) to prepare two symmetrical skin peel wounds. After the creation of the wound, the major axis and minor axis of the peeled portion were measured daily with a caliper, and the average value of the areas (major axis × minor axis) was calculated as the peeled area. The test drug solution (0.5% allantoin solution) was rubbed on the left side with 1 drop (1 time / day), and on the right side, the same as Sheet 1 (1.5 cm × 1.5 cm) obtained in the example. The one impregnated with the test drug solution was lightly taped to the peeling portion and replaced at the time of measurement every day. The results are shown in FIG.

FIG. 2

B) Carrageenin-induced cutaneous edema inhibition test Rats (5 animals per group, 151-171 g) were depilated on the back, and 1% aqueous carrageenin solution (0.1 mL) was intradermally injected to the left side of the depilated back to the corresponding right side. Was intradermally injected with physiological saline (0.1 mL). Rats were anesthetized and killed 3 hours after carrageenin injection,
The skin of the carrageenin and physiological saline injection site was punched into a circle (diameter 9 mm), the weight of each skin piece was measured, and the edema rate was calculated by the following formula.

[Equation 1] The test drug is the sheet 7 obtained in the example for one group.
To the carrageenin injection site for 3 hours from the injection of carrageenin to the other group, and to the other group, an aqueous solution in which only the various medicinal components added together during the production of the sheet 7 were adjusted to the same concentration. Was applied to or rubbed on the skin containing. The results are shown in Table 2.

[Table 2]

C) Use test as a cosmetic sheet Adult female panelists (8 persons, 24 to 33 years old) were allowed to freely use the sheets and collagen sheets prepared in the examples,
We asked for their impressions and opinions regarding the feeling of use and feel of both parties.
In addition, the questionnaires prepared in advance were also sought and answered by the score method. The results are shown in Tables 3 and 4.

[Table 3]

[Table 4]

[0030]

The skin patch sheet according to the present invention has extremely high safety and can keep the skin hygienic by using a material which is not attacked by general bacteria. Further, at the time of forming the sheet, the versatile application range is expanded by blending pharmaceutical ingredients and beauty ingredients according to the purpose. The simple manufacturing method enables stable supply at a lower cost than conventional sheets, and we believe that it will be able to widely contribute to people's daily lives, from everyday sundries to cosmetics and pharmaceuticals.

[Brief description of drawings]

FIG. 1 shows the water absorption capacity and water retention capacity of the skin patch of the present invention. In the figure, the solid line connecting the ● is the sheet 1 obtained in the example.
Represents the result in. The broken line connecting the triangles shows the results on the collagen sheet.

FIG. 2 shows the results of a rat skin wound healing test. In the figure,
The solid line connecting (1) represents the results when the sheet 1 obtained in the example was used. The broken line connecting the circles represents the results when only the test drug solution was used.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display area A61K 7/48 47/36 N A61L 15/44

Claims (1)

[Claims] 1. 0.1 to 10% of a polysaccharide extracted from seaweed
A sheet for skin application, which is obtained by drying a solution or gel containing a predetermined amount in a sheet form.