JPS5869811A - Composition for application to cuticle - Google Patents

Abstract

PURPOSE:To provide the titled composition containing a nylon resin and a water-absorbing polymer, effective especially to the bleeding of incision, scald, etc. and exdative dermal damages, easily preparable and applicable in the form of e.g. sheet, having excellent water vapor permeability and barrier property to bacteria, and high retainability of the drug component. CONSTITUTION:The objective composition contains a nylon resin and a water- absorbing polymer. The nylon resin is preferably an alcohol-soluble nylon from the viewpoints of the simple preparation and the high water permeability of the formed coating film, concretely, CM-4000 (product of Toray Ltd.), ''Zytel -61'' (product of Dupont), etc. The amount of the nylon in the composition is preferably 1-20wt%. The water-absorbing polymer is those which can be swollen with and dispersed in water and nevertheless essentially insoluble in water, e.g. gelatin, agar, etc., and its amount is preferably 0.05-300% of the nylon resin. The amount of the drug component added to the composition is preferably 0-30% of the nylon resin.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a composition for external skin, which is particularly suitable for protecting and treating diseases such as cuts, eczema, burns, and ulcers.

Conventionally, treatments for cuts, eczema, burns, and ulcers include covering the affected area with gauze, non-woven fabric, oiled paper, etc., or applying ointment to gauze, non-woven fabric, etc. and applying it to the affected area. Treatment was being carried out.

However, gas and non-woven fabrics have no resistance to bacteria in the outside air, and they absorb only a small amount of body fluids that ooze out from the affected area, and when the body fluids that ooze out solidify. There are disadvantages such as the adhesive and non-woven fabric sticking to the affected area, causing pain when removing the adhesive and the non-woven fabric, and re-injuring the affected area that has already been healed, delaying the therapeutic effect.
% Also, gauze and nonwoven fabrics have little elasticity and have a problem of being uncomfortable. In addition, oil paper has poor water vapor permeability and has the problem of staining the affected area (tDI), which often makes the affected area worse.

For this reason, treatment methods using body fluid-absorbing fine powders known as gelatin dal, Microphy/N-1, or Desolisan (trade names) are also used, but these treatments are extremely complicated to treat and handle, and require a skilled practitioner. There was a problem in which the treatment could not be fully effective unless it was done by a specialist.

Furthermore, recently, with the aim of simplifying the treatment of the affected area and providing the contradictory functions of gas and moisture exchange and Wi-barrier properties, we have been using fabrics that combine non-woven fabrics, plastics, and film. Although medical sheets obtained by this method have been proposed, they are not necessarily sufficient in terms of effectiveness, manufacturing method, and compatibility with drug solutions. The inventors of the present invention have conducted extensive research to solve the above-mentioned drawbacks, and have found that a film-like material obtained by blending a water-absorbing polymer substance with nylon resin has excellent water vapor permeability, It has excellent repellent properties and high body fluid absorption ability, and also has good drug retention and release properties when combined with drugs, making it effective for bleeding and exudative skin injuries, and more easily. It has been found that it can be used and that its manufacture can be simplified, and the present invention has been completed.

The present invention will be described in detail below. The composition for skin according to the present invention contains a nylon resin and a water-absorbing polymeric substance, and is particularly suitable for cuts.

It is suitably applied to rashes, burns, ulcer-like bleeding, and exudative skin injuries, and can be prepared in the form of a sheet or a liquid that can be applied to the affected area to form a film.

In the present invention, the nylon resin includes nylon 6,
Nylon 66, Nylon 6101, Nylon 11. All general nylon resins (/lyamide resins) such as nylon 12 can be used, but alcohol-soluble nylon is particularly preferred from the viewpoint of easy composition production and high moisture permeability of the formed film. I really like it.

In this case, examples of the alcohol-soluble nylon include copolymer-modified nylon, copolymer-modified nylon, and the like.

As copolymer type nylon, nylon 6/66/
610, nylon 6/66/12, nylon 6/69'
/12, nylon 6/612/12, nylon 6/66
/69/12, nylon 6/66/11/12, nylon 6/66/612/12, nylon 6/66/screw (
Examples include ternary or higher copolymers such as 4-aminocyclohexyl)methane-6, specifically C
M-4000, CM-4001, CM-8000, Ji,
Ditiru-61, 63°69 manufactured by Bonn, Urutatsuamide I A, IC, 5A manufactured by BA8F.

6A, 10, and Diaden Dohiro manufactured by Daicel Corporation may be used. In addition, Toresin F 30 and F30C manufactured by Teikoku Kagaku Sangyo Co., Ltd. are modified 6-nylons in which the hydrogen at the α position is replaced with a dimethylamino group, and the hydrogen in the amide group is replaced with an alkoxyal group.

F30X or the like may be used, and the copolymerized-modified nylon is a combination of a copolymerized type and a modified type, such as Diamid X Seeds manufactured by Daicel Corporation. Note that the nylons exemplified above all have melting points in the range of 80 to 160°C.

In the present invention, the above-mentioned nylons may be used singly or in combination of two or more.

In addition, when preparing a composition in a liquid form using alcohol-soluble nylon, the amount added is not limited to %, but it is preferably 1 to 20 inches (weight -1 or less) of the entire composition. If the amount of nylon is too small, the film formed by one application may be too thin, and if the amount of nylon is too large, the composition may have high viscosity (), resulting in poor dissolution workability and usability. .

Also, as a water-absorbing polymer substance, it swells in water.

Dispersible but substantially insoluble substances can be used, such as gelatin, agar, shazenshi, which is the shell of carmae grass, and gelatin-metal salt (aluminum aing) crosslinked product. crosslinked gelatin, such as gelatin-aldehyde compound (dialdehyde danden, formaldehyde) crosslinked product, etc. are preferably used, and crosslinked products of synthetic water-soluble substances are also preferably used.

It is also possible to use water-soluble synthetic polymer water-absorbing resins in which other water-soluble polymer substances are introduced into a water-soluble polymer substance by graft polymerization, or synthetic polymers having a hydrophilic segment and a hydrophobic segment or ment. Examples of hydrophilic synthetic polymeric water-absorbing resins include starch acrylonitrile graft polymers and saponified products thereof, crosslinked copolymers of starch and acrylic acid or its salts, saponified products of vinyl acetate-acrylic acid ester copolymers, and acrylamide. hydrolyzate of polymers,
Hydrolysates of acrylamide polymers, cross-linked products of acrylic acid or its salts, etc. are listed.Specifically, commercially available products include Sununi and Toy-300 manufactured by Sanyo Chemical Co., Ltd., Wonder Shell manufactured by Kao Corporation, and Sumitomo Chemical. Hydrol S-5O manufactured by Nippon Shokubai, Aqualic CA manufactured by Nippon Shokubai, PX manufactured by Showa Denko, 80P manufactured by General Mills, FX manufactured by Exlan, etc. may be used.

Note that these water-absorbing polymeric substances may be used alone or in combination of two or more.

Further, the water-absorbing polymeric substance may be in the form of powder or granules, and its size is not particularly limited, but in the case of powder or granules, the amount is 150 mesh.

In the case of fibers, it is preferable to have a diameter of 10μ or less and a length of 1 mm or less, which improves the uniformity and water absorption performance of a food coating with such a small size.

The amount of the water-absorbing polymer substance blended is not necessarily limited, but it is preferably 0.05 to 300% based on the amount of nylon resin, and if the amount of the water-absorbing polymer substance is too small, the effect cannot be sufficiently achieved. If the amount is too large, the nylon may not form a sufficiently continuous layer when formed into a sheet, resulting in a decrease in membrane strength, a decrease in flexibility, and the formation of pores.

In addition to the above components, the present invention includes 1. If necessary, other polymer compounds such as polyvinylpyrrolidone, polyvinylpyrrolidone/vinyl acetate copolymer, methyl vinyl ether/maleic anhydride copolymer, ? Reacrylic acid esters, polyacrylic acid/salts, calquivinyl polymer, hydrophilic urethane prepolymer, etc. can be blended in an amount of 0 to 30% based on the amount of nylon resin.

In this case, the hydrophilic urethane prepolymer is particularly effective because it makes the nylon coating flexible, improves mechanical strength such as tensile strength 9, improves water permeability, and increases the stability of the nylon coating over time. It is. ll Water-based urethane! death? It has a plasticizing effect on Rimmer's nylon resin, and is not only effective as a plasticizer, but also has the effect of increasing film strength and as a release agent that improves peeling performance. It gives very good properties.

As this hydrophilic urethane prepolymer, polyhydric alcohols having a valence of 2 or more, ethylene oxide, charcoal 31, and several 3
A polymer or random copolymer (molecular weight 5
00-2000), linear or branched polyalkylene glycol or stream ether? A urethane prepolymer having two or more isocyanate groups at the molecular end or in the molecular chain obtained by the reaction of lyol with a compound having divalent or higher inocyanate groups can be preferably used, and specifically, Toho Chemical Co., Ltd. Kogyo Co., Ltd. No-Issel 0I (-IA
, UP-200 manufactured by Lion Corporation, etc. may be used.

In addition, the above-mentioned urethane prepolymers may be used alone or in combination of two or more. Also,
The blending amount of the urethane prepolymer is not necessarily limited, but it is preferably 0.5 to 251% of the nylon resin.If the blending amount of the urethane prepolymer is too small, the effect may not be fully exhibited. If it is too large, the tensile strength of the nylon coating may be reduced.

The skin composition according to the present invention is particularly suitable for use in bleeding and exudative skin disorders, but in this case, in order to impart barrier properties against bacteria, antibacterial properties, and active therapeutic effects, Fungicide.

Anti-inflammatory agents, antibiotics 1 or 2 of the drugs in the tissue repair agent ring
It is also possible to mix 0 to 30 Is of these or more species to the nylon resin.

Furthermore, in order to control the release properties and percutaneous absorption of these drugs from the sheet, polyhydric alcohols such as glopylene glycol, lyethylene glycol, and chrycerin,
Esters such as isopropyl myristic acid, lanolin,
Cape Vaseline oils, waxes, and surfactants can also be blended.

There is no particular restriction on the amount of the compound to be added, but when the composition is formed into a sheet, it may be blended so that it is contained in the sheet.

In addition, the skin composition of the present invention can be formed into a sheet form as described above, or can be prepared into a liquid form that can form a film on the skin. Any material can be used as long as it dissolves the . However, lower alcohols such as ethanol, f-banol, and ingrono-4-nol, and mixed solvents of these lower alcohols and water can be particularly advantageously used.

In addition, when using a mixed solvent of lower alcohol and water,
The ratio is preferably 95:5 to 6:40 by weight.

There are no particular limitations on the method for producing the skin composition of the present invention. For example, when it is in liquid form, the nylon resin is dissolved in an appropriate surface solvent, and then the nylon resin is added to the KIN aqueous polymeric material, and as necessary. It can be prepared by adding the desired ingredients, and when forming it into a sheet, apply this liquid to a sheet with a flow coater etc., volatilize the solvent, dry it,
A method may be adopted in which nylon resin is thermally melted, a water-absorbing polymer substance and other desired components are mixed therein, kneaded, and then molded into a sheet.

The composition for outer skin according to the present invention, by blending a water-absorbing polymer substance with a nylon resin, has a coating that has very good water absorption properties and can quickly remove body fluids such as sweat and blood. It can absorb large amounts of water, has excellent moisture permeability, and can smoothly dissipate moisture into the outside air. It can be used without inconveniences such as staining the affected area. Moreover, it has good barrier properties against bacteria, etc., and can protect the affected area. It can be maintained well. Furthermore,
The film has high flexibility and strength, does not adhere to the affected area due to body fluids, and can be easily removed without damaging the affected area when peeled off after use. Moreover, when a drug is retained, the drug retention and release properties are good), and furthermore, the composition of the present invention is easy to use and has good manufacturability.

In this way, when actually applied, the nylon coating containing a water-absorbing polymer substance can resist external physical stimulation and invasion of bacteria for a long time without staining the affected area, and can also be peeled off and removed after use. It hardly causes any damage to the affected area, and therefore it can be effectively used for cuts, burns, exudative skin diseases, etc.

EXAMPLES Hereinafter, the present invention will be specifically explained with reference to examples, but the present invention is not limited to the following examples.

[Example 1] Water-based polymer material (Nippon Shokubai Co., Ltd. Aquari, RiC'A)
2jl cal xyvinyl polymer
0.3 A water-absorbing polymer substance and a xyvinyl polymer were added to an IP-soluble nylon solution, and this was applied in a sheet form and dried to form a sheet with a thickness of 50μ. This sheet was cut into an appropriate size. It can be used by cutting the sheet and pasting it on the affected area with adhesive tape, or by applying adhesive to the periphery of one side of the sheet and pasting it on the affected area. Also, by soaking the affected area with alcohol and pasting it,
Adheres well without using any adhesive.

As is clear from the results of the experiments described below, the sheet with the above formulation has water vapor permeability, body fluid absorption, bacteria barrier properties,
It had excellent removability and excellent flexibility and strength, making it suitable for retaining bacteria in the crevice. [Example 2] Water-absorbing polymeric material (Aquarium, RiCA)
2j' Hydrophilic urethane! Repolymer (manufactured by Lion Corporation)
1.5j'UP-200) Using the above ingredients, a 50μ sheet was molded in the same manner as in Example 1.

In addition to the features of the sheet of Example 1, this sheet was even more flexible and showed sufficient followability to the movements of the joints.

[Example 3] Pendelkonium chloride 0. OIJ' Chlorhexicine gluconate 0.
0IJP Diphenhydra ξn O,l
pNaphazoline hydrochloride 0. IP water-absorbing polymer material (shazenshi) 10.
OF polyvinylpyrrolidone (K-90)
50% in the same manner as in Example 1 from components with a content of 0.5% or more.
A sheet of μ was molded.

This material also has excellent antibacterial properties and is highly effective as a sheet for treating wounds and exudative skin injuries, and could be removed without damaging the wound.

[Example 4] Sulfascine 1.0JP gluconate'Chlorhexidine 0.01j'
Allantoin 0.5JP water-absorbing substance (cross-linked product of child and dodangun)
From the components above ts and op, 50μ was prepared in the same manner as in Example 1.
A sheet was formed.

This product is extremely effective for burns and ulcers with erosive surfaces, promotes epidermal formation, and can be smoothly removed without damaging new tissue after use.

Please note that in the above examples, the gelatin-dialdehyde cross-linked product is a 100% aqueous solution of gelatin.
A product obtained by adding dialdehyde Dangun 17F to P and reacting with heating was dried and pulverized.

Next, the sheets obtained in the above examples were examined for their water vapor permeability, body fluid absorption, peel strength, II barrier properties, and antibacterial properties using the following methods. For comparison, the
These percentages also apply to oJo nylon sheets and gases.
I looked into gender.

(1) Put 10p of water into a cylindrical cup (manufactured by F-Las) with a water vapor permeability radius of 171, and leave the mouth of this cup in a temperature and humidity chamber on various sunglass sheets for 24 hours, then measure the water loss. , the value was converted to C1ma5, and this was used as an index of water vapor permeability.

(2) Body fluid absorption amount 10 cIg + Convert,
It was defined as body fluid volume.

(3) Peeling force: 1 at 37°C using a cigarette filter as a substitute body fluid.
011 Gelatin-1 Soak it in a ribinyl pyrrolidone solution and soak it thoroughly. Immediately place it on a sangur sheet, dry it completely, and measure it with a tensilon meter.
The force when peeled off at a speed of 1 minute was used as an index of releasability. Furthermore, in order to prevent the sheet from elongating when it was peeled off, cellochive was attached to the back of the sheet at the time of measurement.

(4) Place the sheet on a bacterial barrier agar plate (8CD for bacteria, GP for yeast). I immersed this in the test bacteria solution for 1 minute! - / 4' - Place a disk (manufactured by Toyo Seisakusho) and leave it for 1 hour or 24 hours, then remove the disk and sheet and culture (bacteria at 37°C).
, 24-48 hours; yeast at 27°C.

After culturing for 6 days), the presence or absence of growth of these bacteria is visually determined.

Evaluation criteria +: Sono transmission -si non-transparent (5) Antibacterial properties of the sheet Sterile agar medium (fine@l-18CD) with salt at 50°C.

Yeast is GP) and test bacteria solution is 0.11+! //Medium 100
After inoculating the mixture so that the total amount is 117, and mixing well, it is dispensed into a sterilized petri dish for 15 to 20 days and solidified. A sheet is placed on this plate and cultured (conditions are the same as in (4)). After incubation, the width of these inhibition zones is measured to determine the antibacterial properties.

Evaluation Criteria 12: No antibacterial property, width of inhibition zone 1 point or less ±: Antibacterial property, 1 to 3-10: I, 3 to 5■ +2 I 5■ or more In addition, above (4) and (5) In the experiment, the following bacteria were used as test bacteria.

Bacteria: Gram-positive bacteria: Yellow pyrocystis 11 (8t) Durham-negative bacteria: Escherichia coli (IC-Coli) Pseudomonas aeruginosa (PI) Yeast Cancita (C&) The above results are shown in Tables 1 to 3.

Table 1 Physical properties Table 2 1 Barrier properties Table 3 Antibacterial properties The above results show that the sheets of the examples all have extremely high water vapor permeability, are less likely to stain the affected area, and absorb less body fluid than conventional gauze. It is more than 4 times more than the amount of water, and can quickly exude body fluids from the surface of the affected area. It also has a low peeling force and is less likely to damage new tissue when removed after use. It is also a bacterial barrier. It has been shown that the sheet has antibacterial properties and prevents the invasion of germs in the outside air, and that it also has antibacterial properties when it contains a bactericidal agent.

Claims (1)

[Scope of Claims] 1. A skin composition comprising a nylon resin and a water-absorbing polymeric substance that swells and disperses in water but is substantially insoluble in water. 2. The composition according to claim 1, wherein the nylon resin is alcohol-flexible nylon. 3. The water-absorbing polymeric substance is gelatin, agar, Chinese cabbage,
Crosslinked Gelatin 9 A crosslinked product of a synthetic water-soluble substance, a product obtained by introducing another polymeric substance into a water-soluble main polymeric substance by graft polymerization, or a synthetic polymer having a hydrophilic segment and a hydrophobic segment. The composition according to item 1 or item 2. 4. The composition according to any one of claims 1 to 3, wherein the composition is formed in a sheet form.