JPH078869B2 - イミダゾジアゼピン誘導体類 - Google Patents

イミダゾジアゼピン誘導体類

Info

Publication number
JPH078869B2
JPH078869B2 JP4179406A JP17940692A JPH078869B2 JP H078869 B2 JPH078869 B2 JP H078869B2 JP 4179406 A JP4179406 A JP 4179406A JP 17940692 A JP17940692 A JP 17940692A JP H078869 B2 JPH078869 B2 JP H078869B2
Authority
JP
Japan
Prior art keywords
benzodiazepine
imidazo
triazolo
fluoro
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP4179406A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05202051A (ja
Inventor
ルネ・ボラー
バルター・ガスナー
マクス・ゲレツケ
エミリオ・キブルツ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JPH05202051A publication Critical patent/JPH05202051A/ja
Publication of JPH078869B2 publication Critical patent/JPH078869B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP4179406A 1991-06-17 1992-06-12 イミダゾジアゼピン誘導体類 Expired - Lifetime JPH078869B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH179191 1991-06-17
CH01140/92-9 1992-04-08
CH114092 1992-04-08
CH01791/91-0 1992-04-08

Publications (2)

Publication Number Publication Date
JPH05202051A JPH05202051A (ja) 1993-08-10
JPH078869B2 true JPH078869B2 (ja) 1995-02-01

Family

ID=25686778

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4179406A Expired - Lifetime JPH078869B2 (ja) 1991-06-17 1992-06-12 イミダゾジアゼピン誘導体類

Country Status (15)

Country Link
US (1) US5387585A (esLanguage)
EP (1) EP0519307A3 (esLanguage)
JP (1) JPH078869B2 (esLanguage)
KR (1) KR930000517A (esLanguage)
AU (1) AU655472B2 (esLanguage)
CA (1) CA2069382A1 (esLanguage)
CZ (1) CZ185092A3 (esLanguage)
FI (1) FI922827A7 (esLanguage)
HU (1) HU9201929D0 (esLanguage)
IE (1) IE921945A1 (esLanguage)
IL (1) IL102175A0 (esLanguage)
IS (1) IS3878A (esLanguage)
NO (1) NO922367L (esLanguage)
NZ (1) NZ243091A (esLanguage)
TW (1) TW201311B (esLanguage)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100923399B1 (ko) * 2004-10-20 2009-10-23 에프. 호프만-라 로슈 아게 이미다조-벤조다이아제핀 유도체
KR100923393B1 (ko) * 2004-12-14 2009-10-23 에프. 호프만-라 로슈 아게 Ｇａｂａ 수용체 조절제로서 테트라사이클릭이미다조-벤조다이아제핀

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
JPH10298078A (ja) * 1997-05-06 1998-11-10 Mitsubishi Chem Corp 抗不安薬
TWI239333B (en) 2000-11-16 2005-09-11 Hoffmann La Roche Benzodiazepine derivatives as GABA A receptor modulators
US6686352B2 (en) * 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
EP1461323B1 (en) * 2001-06-12 2013-10-09 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CA2581918A1 (en) * 2004-10-12 2006-04-20 Henner Knust Imidazo(1,5-a)triazolo(1,5-d) benzodiazepine deratives for the treatment of cognitive disorders
RU2007114763A (ru) 2004-10-20 2008-11-27 Ф.Хоффманн-Ля Рош Аг (Ch) Галогенозамещенные производные бензодиазепинов
ES2348356T3 (es) 2005-10-11 2010-12-03 F. Hoffmann-La Roche Ag Derivados de imidazo-benzodiazepina.
CA2738650C (en) * 2008-09-23 2017-07-04 Johns Hopkins University Fused diimidazodiazepine compounds and methods of use and manufacture thereof
US9322831B2 (en) 2008-09-23 2016-04-26 The Johns Hopkins University DDX3 as a biomarker for cancer and methods related thereto
AU2014240289B2 (en) * 2008-09-23 2015-12-03 The Johns Hopkins University Fused diimidazodiazepine compounds and methods of use and manufacture thereof
BR112013012062B1 (pt) 2010-11-15 2020-06-02 Agenebio, Inc Composto derivado da piridazina ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica e uso do composto
SG11201601682RA (en) 2013-09-06 2016-04-28 Aurigene Discovery Tech Ltd 1,2,4-oxadiazole derivatives as immunomodulators
CA2934553C (en) 2013-12-20 2023-10-31 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
RS62960B1 (sr) 2015-03-10 2022-03-31 Aurigene Discovery Tech Ltd Jedinjenja 1,2,4-oksadiazola i tiadiazola kao imunomodulatori
CU20170118A7 (es) * 2015-03-10 2018-02-08 Aurigene Discovery Tech Ltd Compuestos de tiadiazol y 1,2,4-oxadiazol 3-sustituidos como inmunomoduladores
MA42624A (fr) 2015-06-19 2021-04-28 Agenebio Inc Dérivés de benzodiazépine, compositions et méthodes de traitement de la déficience cognitive
CN109311868B (zh) 2015-12-22 2022-04-01 尚医治疗有限责任公司 用于治疗癌症和炎性疾病的化合物
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EP3642209B1 (en) 2017-06-21 2023-11-29 Shy Therapeutics LLC Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
SG11202003081WA (en) 2017-10-11 2020-05-28 Aurigene Discovery Tech Ltd Crystalline forms of 3-substituted 1,2,4-oxadiazole
EP3703683A1 (en) 2017-11-03 2020-09-09 Aurigene Discovery Technologies Limited Dual inhibitors of tim-3 and pd-1 pathways
WO2019087092A1 (en) 2017-11-06 2019-05-09 Aurigene Discovery Technologies Limited Conjoint therapies for immunomodulation
US11414425B2 (en) 2018-06-19 2022-08-16 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EP3898609A1 (en) 2018-12-19 2021-10-27 Shy Therapeutics LLC Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
CS249146B2 (en) * 1984-01-19 1987-03-12 Hoffmann La Roche Method of new imidazodiazepine's derivatives production
US4897392A (en) * 1989-07-03 1990-01-30 Hoechst-Roussel Pharmaceuticals, Inc. 4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines
DK443589D0 (da) * 1989-09-08 1989-09-08 Ferrosan As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK41191D0 (da) * 1991-03-07 1991-03-07 Novo Nordisk As Heterocycliske forbindelser, deres fremstilling og anvendelse

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100923399B1 (ko) * 2004-10-20 2009-10-23 에프. 호프만-라 로슈 아게 이미다조-벤조다이아제핀 유도체
KR100923393B1 (ko) * 2004-12-14 2009-10-23 에프. 호프만-라 로슈 아게 Ｇａｂａ 수용체 조절제로서 테트라사이클릭이미다조-벤조다이아제핀

Also Published As

Publication number Publication date
NO922367D0 (no) 1992-06-16
IS3878A (is) 1992-12-18
TW201311B (esLanguage) 1993-03-01
US5387585A (en) 1995-02-07
NO922367L (no) 1992-12-18
IL102175A0 (en) 1993-01-14
AU655472B2 (en) 1994-12-22
FI922827A7 (fi) 1992-12-18
KR930000517A (ko) 1993-01-15
EP0519307A3 (en) 1993-04-21
CA2069382A1 (en) 1992-12-18
NZ243091A (en) 1994-11-25
AU1823492A (en) 1992-12-24
CZ185092A3 (en) 1993-12-15
IE921945A1 (en) 1992-12-30
EP0519307A2 (de) 1992-12-23
FI922827A0 (fi) 1992-06-17
JPH05202051A (ja) 1993-08-10
HU9201929D0 (en) 1992-08-28

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