JPH0784481B1 - - Google Patents
Info
- Publication number
- JPH0784481B1 JPH0784481B1 JP4504624A JP50462492A JPH0784481B1 JP H0784481 B1 JPH0784481 B1 JP H0784481B1 JP 4504624 A JP4504624 A JP 4504624A JP 50462492 A JP50462492 A JP 50462492A JP H0784481 B1 JPH0784481 B1 JP H0784481B1
- Authority
- JP
- Japan
- Prior art keywords
- rings
- carboxymethylmannoglucan
- mannopyranose
- salt
- opened
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical group OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical group OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000004044 tetrasaccharides Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000008034 disappearance Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000000979 retarding effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0087—Glucomannans or galactomannans; Tara or tara gum, i.e. D-mannose and D-galactose units, e.g. from Cesalpinia spinosa; Tamarind gum, i.e. D-galactose, D-glucose and D-xylose units, e.g. from Tamarindus indica; Gum Arabic, i.e. L-arabinose, L-rhamnose, D-galactose and D-glucuronic acid units, e.g. from Acacia Senegal or Acacia Seyal; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4-504624A JPH0784481B2 (ja) | 1991-02-21 | 1992-02-21 | カルボキシメチルマンノグルカン及びその誘導体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2754491 | 1991-02-21 | ||
| JP3-27544 | 1991-02-21 | ||
| JP36039591 | 1991-12-27 | ||
| JP3-360395 | 1991-12-27 | ||
| JP4-504624A JPH0784481B2 (ja) | 1991-02-21 | 1992-02-21 | カルボキシメチルマンノグルカン及びその誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO1992014759A1 JPWO1992014759A1 (ja) | 1993-04-02 |
| JPH0784481B1 true JPH0784481B1 (enExample) | 1995-09-13 |
| JPH0784481B2 JPH0784481B2 (ja) | 1995-09-13 |
Family
ID=26365480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4-504624A Expired - Lifetime JPH0784481B2 (ja) | 1991-02-21 | 1992-02-21 | カルボキシメチルマンノグルカン及びその誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US5567690A (enExample) |
| EP (1) | EP0526649B1 (enExample) |
| JP (1) | JPH0784481B2 (enExample) |
| AT (1) | ATE166361T1 (enExample) |
| CA (1) | CA2081025A1 (enExample) |
| DE (1) | DE69225542T2 (enExample) |
| DK (1) | DK0526649T3 (enExample) |
| ES (1) | ES2117664T3 (enExample) |
| WO (1) | WO1992014759A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041818B2 (en) | 1998-10-30 | 2006-05-09 | Daiichi Pharmaceutical Co., Ltd. | DDS compound and method for measurement thereof |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6465188B1 (en) * | 1990-06-11 | 2002-10-15 | Gilead Sciences, Inc. | Nucleic acid ligand complexes |
| DK0526649T3 (da) * | 1991-02-21 | 1998-10-07 | Drug Delivery System Inst Ltd | Carboxymethylmannoglucan og derivater deraf. |
| DK0640622T3 (da) * | 1993-02-26 | 2000-10-23 | Drug Delivery System Inst Ltd | Polysaccharidderivat og lægemiddelbærer |
| US8071737B2 (en) * | 1995-05-04 | 2011-12-06 | Glead Sciences, Inc. | Nucleic acid ligand complexes |
| DE19524515A1 (de) | 1995-07-05 | 1997-01-09 | Deutsches Krebsforsch | Saccharid-Konjugate |
| TW527183B (en) | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
| TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
| US6387853B1 (en) | 1998-03-27 | 2002-05-14 | Bj Services Company | Derivatization of polymers and well treatments using the same |
| EP1080732A4 (en) | 1998-05-22 | 2004-08-25 | Daiichi Seiyaku Co | DRUG COMPOSITION |
| CN1133654C (zh) * | 1999-08-05 | 2004-01-07 | 武汉大学 | 灵芝α-(1→3)-D-葡聚糖羧甲基化衍生物及其用途和制备方法 |
| CN100457766C (zh) * | 2006-09-26 | 2009-02-04 | 重庆邮电大学 | 非天然活性葡聚四糖烷基苷类化合物及其制备方法和应用 |
| CN115746153A (zh) * | 2022-11-09 | 2023-03-07 | 华东理工大学 | 环甘露聚糖及其制备方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1053718B (it) * | 1973-04-04 | 1981-10-10 | Zambeletti Spa L | Metodo per prolungare l azione di farmaci attraverso la formazione di composti mcromolecolari |
| JPS5366442A (en) * | 1976-11-18 | 1978-06-13 | Takuma Sasaki | Antitumors |
| JPS5385000A (en) * | 1976-12-31 | 1978-07-26 | Akira Misaki | Glucan and its preparation |
| JPS6045163B2 (ja) * | 1977-07-01 | 1985-10-08 | 協和醗酵工業株式会社 | 新規組成物 |
| JPS5461112A (en) * | 1977-10-24 | 1979-05-17 | Ono Pharmaceut Co Ltd | Oncostatic polysaccharide* its preparation* and oncostatic drugs containing it as an effective component |
| DE3071815D1 (en) * | 1980-08-05 | 1986-12-11 | Debat Lab | Use of glycosylglucanes in the treatment of infections of the large intestines |
| US4454289A (en) * | 1981-03-06 | 1984-06-12 | Takara Shuzo Co., Ltd. | Polysaccharides having anticarcinogenic activity and method for producing same |
| JPS59124901A (ja) * | 1982-12-29 | 1984-07-19 | Dai Ichi Seiyaku Co Ltd | 多糖誘導体 |
| JPS61152634A (ja) * | 1984-12-27 | 1986-07-11 | Sugiyama Sangyo Kagaku Kenkyusho | 固定化生理活性物質の製造法 |
| IL73972A0 (en) * | 1984-12-31 | 1985-03-31 | Yeda Res & Dev | Agents based on platinum compounds |
| AU589752B2 (en) * | 1986-06-27 | 1989-10-19 | Kawasaki Jukogyo K.K. | Dispersant for carbonaceous solid water slurry |
| DE3624307C1 (de) * | 1986-07-18 | 1987-11-12 | Agfa Gevaert Ag | Vorrichtung zum Aufnehmen und Absetzen von Spulen |
| GB8713662D0 (en) * | 1987-06-11 | 1987-07-15 | Skandigen Ab | Hyaluronic acid derivatives |
| JPS63310827A (ja) * | 1987-06-15 | 1988-12-19 | Sanwa Kagaku Kenkyusho Co Ltd | ニコチン酸誘導体を主剤とする徐放性製剤 |
| JPH0659409B2 (ja) * | 1987-10-06 | 1994-08-10 | 義明 本里 | 架橋グルコマンナンイオン交換体 |
| IT1224421B (it) * | 1987-12-29 | 1990-10-04 | Lamberti Flli Spa | Galattomannani modificati e realtivo procedimento di preparazione |
| JPH01190636A (ja) * | 1988-01-22 | 1989-07-31 | Green Cross Corp:The | 制癌作用物質複合体 |
| US5026735A (en) * | 1988-06-08 | 1991-06-25 | Minnesota Mining And Manufacturing Company | Treatment of hazardous materials with aqueous air foam of polyhydroxy polymer |
| US5124363A (en) * | 1988-06-08 | 1992-06-23 | Minnesota Mining And Manufacturing Company | Aqueous air foams of polyhydroxy polymer |
| DE69004290T2 (de) * | 1989-02-22 | 1994-05-26 | Sanwa Kagaku Kenkyusho Co | Pharmazeutische Zusammensetzung, die ein Hydantoin-Derivat enthält. |
| JP2726520B2 (ja) * | 1989-10-20 | 1998-03-11 | 名糖産業株式会社 | 有機磁性複合体 |
| DK0526649T3 (da) * | 1991-02-21 | 1998-10-07 | Drug Delivery System Inst Ltd | Carboxymethylmannoglucan og derivater deraf. |
| JPH0539521A (ja) * | 1991-08-02 | 1993-02-19 | Nippon Steel Corp | 含クロム溶鋼の脱炭精錬法 |
-
1992
- 1992-02-21 DK DK92905093T patent/DK0526649T3/da active
- 1992-02-21 AT AT92905093T patent/ATE166361T1/de not_active IP Right Cessation
- 1992-02-21 WO PCT/JP1992/000184 patent/WO1992014759A1/ja not_active Ceased
- 1992-02-21 JP JP4-504624A patent/JPH0784481B2/ja not_active Expired - Lifetime
- 1992-02-21 ES ES92905093T patent/ES2117664T3/es not_active Expired - Lifetime
- 1992-02-21 DE DE69225542T patent/DE69225542T2/de not_active Expired - Fee Related
- 1992-02-21 CA CA002081025A patent/CA2081025A1/en not_active Abandoned
- 1992-02-21 EP EP92905093A patent/EP0526649B1/en not_active Expired - Lifetime
-
1995
- 1995-03-02 US US08/397,560 patent/US5567690A/en not_active Expired - Fee Related
-
1996
- 1996-07-30 US US08/681,981 patent/US5863907A/en not_active Expired - Fee Related
- 1996-07-30 US US08/689,095 patent/US5863908A/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041818B2 (en) | 1998-10-30 | 2006-05-09 | Daiichi Pharmaceutical Co., Ltd. | DDS compound and method for measurement thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| US5863908A (en) | 1999-01-26 |
| DE69225542D1 (de) | 1998-06-25 |
| JPH0784481B2 (ja) | 1995-09-13 |
| EP0526649A1 (en) | 1993-02-10 |
| DE69225542T2 (de) | 1998-09-10 |
| DK0526649T3 (da) | 1998-10-07 |
| US5567690A (en) | 1996-10-22 |
| US5863907A (en) | 1999-01-26 |
| CA2081025A1 (en) | 1992-08-22 |
| ES2117664T3 (es) | 1998-08-16 |
| EP0526649A4 (en) | 1993-09-08 |
| WO1992014759A1 (fr) | 1992-09-03 |
| ATE166361T1 (de) | 1998-06-15 |
| EP0526649B1 (en) | 1998-05-20 |
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