CA2081025A1 - Carboxymethylmannoglucans and derivatives thereof - Google Patents

Carboxymethylmannoglucans and derivatives thereof

Info

Publication number
CA2081025A1
CA2081025A1 CA002081025A CA2081025A CA2081025A1 CA 2081025 A1 CA2081025 A1 CA 2081025A1 CA 002081025 A CA002081025 A CA 002081025A CA 2081025 A CA2081025 A CA 2081025A CA 2081025 A1 CA2081025 A1 CA 2081025A1
Authority
CA
Canada
Prior art keywords
salt
represent
carboxymethylmannoglucan
general formula
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002081025A
Other languages
English (en)
French (fr)
Inventor
Kazuhiro Inoue
Teruomi Ito
Takayuki Kawaguchi
Katsutoshi Aono
Satoshi Okuno
Toshiro Yano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Drug Delivery System Institute Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2081025A1 publication Critical patent/CA2081025A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0087—Glucomannans or galactomannans; Tara or tara gum, i.e. D-mannose and D-galactose units, e.g. from Cesalpinia spinosa; Tamarind gum, i.e. D-galactose, D-glucose and D-xylose units, e.g. from Tamarindus indica; Gum Arabic, i.e. L-arabinose, L-rhamnose, D-galactose and D-glucuronic acid units, e.g. from Acacia Senegal or Acacia Seyal; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CA002081025A 1991-02-21 1992-02-21 Carboxymethylmannoglucans and derivatives thereof Abandoned CA2081025A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2754491 1991-02-21
JP27544/1991 1991-02-21
JP360395/1991 1991-12-27
JP36039591 1991-12-27

Publications (1)

Publication Number Publication Date
CA2081025A1 true CA2081025A1 (en) 1992-08-22

Family

ID=26365480

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002081025A Abandoned CA2081025A1 (en) 1991-02-21 1992-02-21 Carboxymethylmannoglucans and derivatives thereof

Country Status (9)

Country Link
US (3) US5567690A (enExample)
EP (1) EP0526649B1 (enExample)
JP (1) JPH0784481B2 (enExample)
AT (1) ATE166361T1 (enExample)
CA (1) CA2081025A1 (enExample)
DE (1) DE69225542T2 (enExample)
DK (1) DK0526649T3 (enExample)
ES (1) ES2117664T3 (enExample)
WO (1) WO1992014759A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465188B1 (en) 1990-06-11 2002-10-15 Gilead Sciences, Inc. Nucleic acid ligand complexes
JPH0784481B2 (ja) * 1991-02-21 1995-09-13 株式会社デイ・デイ・エス研究所 カルボキシメチルマンノグルカン及びその誘導体
WO1994019376A1 (fr) * 1993-02-26 1994-09-01 Drug Delivery System Institute, Ltd. Derive de polysaccharide et vehicule de medicament
US8071737B2 (en) * 1995-05-04 2011-12-06 Glead Sciences, Inc. Nucleic acid ligand complexes
DE19524515A1 (de) * 1995-07-05 1997-01-09 Deutsches Krebsforsch Saccharid-Konjugate
TW527183B (en) 1996-06-06 2003-04-11 Daiichi Seiyaku Co Drug complex
TW409058B (en) 1996-06-06 2000-10-21 Daiichi Seiyaku Co Method for preparation of a drug complex
US6387853B1 (en) 1998-03-27 2002-05-14 Bj Services Company Derivatization of polymers and well treatments using the same
HK1040052B (zh) 1998-05-22 2006-09-15 第一制药株式会社 药物复合物
EP1619210A1 (en) 1998-10-30 2006-01-25 Daiichi Pharmaceutical Co., Ltd. DDS compounds and method for assaying the same
CN1133654C (zh) * 1999-08-05 2004-01-07 武汉大学 灵芝α-(1→3)-D-葡聚糖羧甲基化衍生物及其用途和制备方法
CN100457766C (zh) * 2006-09-26 2009-02-04 重庆邮电大学 非天然活性葡聚四糖烷基苷类化合物及其制备方法和应用
CN115746153A (zh) * 2022-11-09 2023-03-07 华东理工大学 环甘露聚糖及其制备方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1053718B (it) * 1973-04-04 1981-10-10 Zambeletti Spa L Metodo per prolungare l azione di farmaci attraverso la formazione di composti mcromolecolari
JPS5366442A (en) * 1976-11-18 1978-06-13 Takuma Sasaki Antitumors
JPS5385000A (en) * 1976-12-31 1978-07-26 Akira Misaki Glucan and its preparation
JPS6045163B2 (ja) * 1977-07-01 1985-10-08 協和醗酵工業株式会社 新規組成物
JPS5461112A (en) * 1977-10-24 1979-05-17 Ono Pharmaceut Co Ltd Oncostatic polysaccharide* its preparation* and oncostatic drugs containing it as an effective component
DE3071815D1 (en) * 1980-08-05 1986-12-11 Debat Lab Use of glycosylglucanes in the treatment of infections of the large intestines
US4454289A (en) * 1981-03-06 1984-06-12 Takara Shuzo Co., Ltd. Polysaccharides having anticarcinogenic activity and method for producing same
JPS59124901A (ja) * 1982-12-29 1984-07-19 Dai Ichi Seiyaku Co Ltd 多糖誘導体
JPS61152634A (ja) * 1984-12-27 1986-07-11 Sugiyama Sangyo Kagaku Kenkyusho 固定化生理活性物質の製造法
IL73972A0 (en) * 1984-12-31 1985-03-31 Yeda Res & Dev Agents based on platinum compounds
AU589752B2 (en) * 1986-06-27 1989-10-19 Kawasaki Jukogyo K.K. Dispersant for carbonaceous solid water slurry
DE3624307C1 (de) * 1986-07-18 1987-11-12 Agfa Gevaert Ag Vorrichtung zum Aufnehmen und Absetzen von Spulen
GB8713662D0 (en) * 1987-06-11 1987-07-15 Skandigen Ab Hyaluronic acid derivatives
JPS63310827A (ja) * 1987-06-15 1988-12-19 Sanwa Kagaku Kenkyusho Co Ltd ニコチン酸誘導体を主剤とする徐放性製剤
JPH0659409B2 (ja) * 1987-10-06 1994-08-10 義明 本里 架橋グルコマンナンイオン交換体
IT1224421B (it) * 1987-12-29 1990-10-04 Lamberti Flli Spa Galattomannani modificati e realtivo procedimento di preparazione
JPH01190636A (ja) * 1988-01-22 1989-07-31 Green Cross Corp:The 制癌作用物質複合体
US5026735A (en) * 1988-06-08 1991-06-25 Minnesota Mining And Manufacturing Company Treatment of hazardous materials with aqueous air foam of polyhydroxy polymer
US5124363A (en) * 1988-06-08 1992-06-23 Minnesota Mining And Manufacturing Company Aqueous air foams of polyhydroxy polymer
ATE96668T1 (de) * 1989-02-22 1993-11-15 Sanwa Kagaku Kenkyusho Co Pharmazeutische zusammensetzung, die ein hydantoin-derivat enthaelt.
JP2726520B2 (ja) * 1989-10-20 1998-03-11 名糖産業株式会社 有機磁性複合体
JPH0784481B2 (ja) * 1991-02-21 1995-09-13 株式会社デイ・デイ・エス研究所 カルボキシメチルマンノグルカン及びその誘導体
JPH0539521A (ja) * 1991-08-02 1993-02-19 Nippon Steel Corp 含クロム溶鋼の脱炭精錬法

Also Published As

Publication number Publication date
US5863908A (en) 1999-01-26
US5567690A (en) 1996-10-22
DK0526649T3 (da) 1998-10-07
ATE166361T1 (de) 1998-06-15
ES2117664T3 (es) 1998-08-16
DE69225542T2 (de) 1998-09-10
JPH0784481B2 (ja) 1995-09-13
JPH0784481B1 (enExample) 1995-09-13
EP0526649A4 (en) 1993-09-08
US5863907A (en) 1999-01-26
WO1992014759A1 (fr) 1992-09-03
EP0526649A1 (en) 1993-02-10
EP0526649B1 (en) 1998-05-20
DE69225542D1 (de) 1998-06-25

Similar Documents

Publication Publication Date Title
CA2332054C (en) Platinum complex, its preparation and therapeutic application
Petter et al. Cooperative binding by aggregated mono-6-(alkylamino)-. beta.-cyclodextrins
US4424346A (en) Derivatives of chitins, chitosans and other polysaccharides
US5688931A (en) Polysaccharide derivatives and drug carriers
Kritchenkov et al. Click reactions in chitosan chemistry
AU2017385332B2 (en) Composition of mannuronic dicarboxylic acid
EP0240098A2 (en) Oligo and polysaccharides for the treatment of diseases caused by retroviruses
US5863907A (en) Carboxymethylmannoglucans and derivatives thereof
US5574023A (en) Intramolecularly crosslinked (1→3)-β-D-glucans
JPWO1992014759A1 (ja) カルボキシメチルマンノグルカン及びその誘導体
OHMORI et al. Dissociation of a glucan fraction (CO-1) from protein-bound polysaccharide of Cordyceps ophioglossoides and analysis of its antitumor effect
CA1226575A (en) Mannoglucan derivatives and process for preparing the same
EP0307827A2 (en) Novel macromolecular complexes, process for producing same and medicinal use of such complexes
CN108743963A (zh) 一种含有四价铂的抗癌偶联物及其制备方法和应用
JPH04503078A (ja) 塩基性ポリエン・マクロライドの新規な可溶性非毒性誘導体，その調製及び適用
CA2331464C (en) Platinum complex, its preparation and therapeutic application
CA1102792A (en) Process for the preparation of novel daunomycin derivatives and their aglycones
US5401742A (en) Polymeric conjugate of methotrexate compound and pyran copolymer and method for the preparation thereof
WO1987007142A1 (fr) Nouveaux complexes, procede pour leur preparation, et leur emploi medicinal
Reza Karimi et al. In Vitro Photodynamic Activities of Amphiphilic Phthalocyanine‐Amino Appended β‐Cyclodextrin Conjugates as Efficient Schiff Base Photosensitizer
WO1993021193A1 (fr) Complexe de platine et agent antineoplasique
RU2121839C1 (ru) Средство, обладающее противоопухолевой и анальгетической активностью
KR100307724B1 (ko) 당질-백금(ii)착물 복합체 항암제 및 그 제조방법
Li et al. Development of polymer-based fluorescent nanocomposites for synergistic inhibition of non-small cell lung cancer with gefitinib
Todorova et al. Carminomycin-Chitosan: A Conjugated Antituimor Antibiotic

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued