JPH0782133A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic, having a good beautifying bleaching effect, which is demonstrated to have a long-term safety to human, since it is used as an internal or external medicine for years. CONSTITUTION:A cosmetic containing at least one solvent extract selected from the group consisting of Cymbopogen nardus, Desmodium gangeticum, Cardiospermum halicacabum, Muraya Koenigii and Smilax zeylanica.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic having a high whitening effect and a high safety.

[0002]

2. Description of the Related Art Cymbopogon nardus is a monocotyledonous net, a plant of the genus Poaceae, Poaceae, and Ogarkaya, which is used as a raw material for mosquito repellents, fragrances, and soaps. Is used for.

Desmodiu
m gangeticum) is a dicotyledonous net, a leaflet subweb, a rose,
It is a plant of the genus Leguminus and genus Nebula, and is used as a therapeutic agent for amenorrhea, abdominal pain.

[0004] Cardiospermum halicaca
bum) is a plant of dicotyledonous net, leaf-seed sub net, sorghum, syringaceae, phyllanthaceae, which is a vine annual plant native to South Africa, but originally a perennial jaundice, gonorrhea, herpes, snake bite. It has been used as a therapeutic drug.

Muraya koenigii
Is a dicotyledonous net, a leaflet subnet, a dwarf eye, and a citrus family plant distributed in India and Sri Lanka, and is commonly found in arid lowlands. As a medicinal substance, it has been used for constipation, abdominal colic, diarrhea, etc.

[0006] Smilax zeyla
nica) was used as a remedy for sexually transmitted diseases, dysentery, and rheumatism in monocotyledonous nets, lilicaceae, Liliaceae, and Shiode plants.

On the other hand, various substances are known as substances having a whitening effect which can be used as a raw material for cosmetics.
Synthetic products do not guarantee safety when applied to human skin for a long period of time, and their use is being limited. On the other hand, many natural products have a weak whitening effect. However, it is a natural product from the viewpoint of safety for human skin, and has been guaranteed for safety by people eating it for many years. Moreover, it has a strong whitening effect and also has other effects on the skin. Was desired.

[0008]

An object of the present invention is to obtain a cosmetic which is safe when applied to the skin, has a large whitening effect and is excellent in safety.

[0009]

[Means for Solving the Problems] In order to solve the above problems, the present inventors screened and investigated plants that have been used for food for many years and confirmed to be safe for the human body, and used as cosmetics. Considered something of value. As a result, Kosugaiya, Desmodium
Gangechikum, Pleurotus cornucopiae, Muraya Coenigii,
Sumirax Zeiranika is a very cosmetic ingredient,
Alternatively, it has been found to be effective as a quasi drug.

[0010] That is, the present invention, Kosuigaya, Desmodium gangeticum (Desmodium gangeticum), Pleurotus cornucopia, Muraya koenigi (Murraya koenigi)
i), Smilax zeylanica
A cosmetic comprising at least one solvent extract selected from the group consisting of:

As a method of utilizing these plants, extraction is performed with water or a hydrophilic organic solvent such as ethanol, methanol or acetone. However, it is natural that extraction with water, ethanol, or a mixed solvent thereof is preferable since it is extraction of cosmetic raw materials. In some cases, a polyhydric alcohol such as glycerin, 1,3 butylene glycol, propylene glycol or the like or a mixed liquid of polyhydric alcohol and water can be used for extraction. Further, freeze-drying and using it as powder is also effective depending on the method of use.

This substance may be used as other cosmetic raw materials such as liquid oils such as squalane and jojoba oil, solid oils such as beeswax and cetyl alcohol, various activators, moisturizers such as glycerin and 1,3 butylene glycol, and various agents. It can be added to prepare cosmetics in various dosage forms. For example, a lotion, a cream, a milky lotion, a pack, or the like may be used depending on the purpose.

[0013]

EXAMPLE An example of an actual usage will be described below, but the present invention is not limited to this example. The production examples of the extracts of Scutellaria japonicus, Desmodium gangechikum, Fusarium chinensis, Muraya Koenigii, and Sumirax zeilanica used in the present invention are shown below.

(Production Example 1) To 10 g of rhizome (dry product) of Spodoptera litura, was added 300 ml of 50% ethanol, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Production Example 2) To 10 g of the whole plant (desiccated) of Desmodium gangechicum was added 300 ml of ethanol, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Production Example 3) To 10 g of whole grass (desiccated) of Desmodium gangechicum was added 300 ml of 50% ethanol aqueous solution, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Production Example 4) To 10 g of the whole plant (dry product) of Pleurotus cornucopiae was added 300 ml of a 50% aqueous ethanol solution, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Production Example 5) To 10 g of Muraya Koenigii branch (dry product) was added 300 ml of ethanol, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Manufacturing Example 6) To 10 g of Muraya Koenigii branch (dried product) was added 300 ml of 50% aqueous ethanol solution, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Production Example 7) To 10 g of the roots (dry product) of Smilax Zeylanica, 300 ml of ethanol was added, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Production Example 8) Smilax Zeylanica root (dry product) was added to 10 g of a 50% ethanol aqueous solution 300.
ml was added and left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Example 1) Lotion (% by weight) Olive oil 0.5 Extract of Production Example 1 0.5 Polyoxyethylene (20 E.O.) sorbitan monostearate 2.0 Polyoxyethylene (60 E.O. ) Hydrogenated castor oil 2.0 Ethanol 10.0 1.0% sodium hyaluronate aqueous solution 5.0 Purified water 80.0

Example 2 Cream (wt%) A Squalane 20.0 Olive oil 2.0 Mink oil 1.0 Jojoba oil 5.0 Beeswax 5.0 Cetostearyl alcohol 2.0 Glycerin monostearate 1.0 Sorbitan Monostearate 2.0 Extract of Production Example 2 1.0 B Purified water 47.9 Polyoxyethylene (20 E.O.) sorbitan monostearate 2.0 Polyoxyethylene (60 E.O.) hydrogenated castor oil 1 0.0 Glycerin 5.0 1.0% sodium hyaluronate aqueous solution 5.0 Methyl paraoxybenzoate 0.1 A and B were weighed and heated to 70 ° C., and A was gradually added to B while stirring. After that, while stirring slowly, 30
Cooled to ° C.

Example 3 A lotion prepared by replacing the extract of Production Example 1 of Example 1 with the extract of Production Example 3.

(Example 4) A cream prepared by replacing the extract of Production Example 2 of Example 2 with the extract of Production Example 4.

Example 5 A lotion prepared by replacing the extract of Production Example 1 of Example 1 with the extract of Production Example 5.

(Example 6) A cream prepared by changing the extract of Production Example 2 of Example 2 into the extract of Production Example 6.

(Example 7) A lotion prepared by changing the extract of Production Example 1 of Example 1 into the extract of Production Example 7.

(Example 8) A cream prepared by replacing the extract of Production Example 2 of Example 2 with the extract of Production Example 8.

(Tyrosinase activity inhibition test) (Test method) Mcllvaln buffer solution 0.9
ml, 1.66 mM Tyrosine solution 1.0 ml, 0.1 wt / v% aqueous solution of the above production example (freeze dried product) Then, after removing ethanol, 1.0 ml (prepared to have a concentration of 0.1 wt / v%) was placed in a screw vial and heated in a 37 ° C. constant temperature water bath for 5 minutes or more. Add 0.1 ml of tyrosinase solution (Sigma, mushroom-derived, 914 units / ml), and add 3
The temperature was kept in a constant temperature water bath at 7 ° C, and after 10 minutes, the absorbance was measured at 475 nm. As a control, pure water was added instead of the sample solution and the same measurement was performed. In this test, the final concentration of the sample was 0.
It will be 033%. (Calculation formula) Tyrosinase activity inhibition rate (%) = {B- (AP)} /
B × 100 However, A: Absorbance of sample specimen B: Absorbance of control P: Absorbance due to coloring of sample specimen (3-fold dilution) The results are shown in Table 1.

[0031]

[Table 1]

(Use test) The face of each of 5 women was divided into left and right, one of which had the lotion and cream of the example applied as a set, and the other of which had the lotion and cream of the comparative example set as a set and used. I got it. Comparative Example 1 is a lotion prepared by changing the extract of Production Example 1 of Example 1 into water, and Comparative Example 2 is a cream prepared by changing the extract of Production Example 2 of Example 2 in water. Have it used once or more every day,
Three months later, I got a score based on the following criteria. In addition, 20 people were divided into 4 groups and experimented using the following samples.

[0033]

[Table 2]

The judgment criteria are as follows, and the total value of these scores is shown in Table 3. Example is very good 3 Example is considerably good 2 Example is slightly good 1 No difference 0 Comparative example is good −1 Comparative example is good −2 Comparative example Is very good -3

[0035]

[Table 3]

[0036]

As is apparent from the results of the tyrosinase activity inhibition test, the plant solvent extract of the present invention has an excellent tyrosinase activity inhibition effect. From the results of the use test, the whitening effect was remarkably higher than that of the cosmetics containing no extract. These plants have been used as internal and external medicines for many years, and their long-term safety for the human body is guaranteed.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Masao Hattori 2556-4-22-203 Gofukusuehiro-cho, Toyama City, Toyama Prefecture (72) Inventor Kenji Shimomura 3-16-32 Funae, Ise City, Mie Prefecture (72) Inventor Nakatani Kayo 774-11 Takamukai, Misono Village, Mie Prefecture

Claims (1)

[Claims] 1. A cosmetic containing at least one solvent extract selected from the group consisting of Kosuigaya, Desmodium gangeticum, Fusenkazura, Muraya koenigii, and Smilax zeylanica.