JP6895860B2 - Slimming foods and topical compositions - Google Patents
Slimming foods and topical compositions Download PDFInfo
- Publication number
- JP6895860B2 JP6895860B2 JP2017187308A JP2017187308A JP6895860B2 JP 6895860 B2 JP6895860 B2 JP 6895860B2 JP 2017187308 A JP2017187308 A JP 2017187308A JP 2017187308 A JP2017187308 A JP 2017187308A JP 6895860 B2 JP6895860 B2 JP 6895860B2
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- Japan
- Prior art keywords
- extract
- slimming
- simaroubaceae
- essential oil
- hibamata
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Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Description
本発明は、ニガキ科アフリカマンゴノキ属植物またはその抽出物及びヒバマタ科ヒバマタ属海藻またはその抽出物を含有する優れた痩身効果のある痩身用食品組成物及び痩身用外用剤組成物に関する。 The present invention relates to a slimming food composition having an excellent slimming effect and a slimming external preparation composition containing the Simaroubaceae African Mangonoki genus plant or an extract thereof and the Hibamata family Hibamata genus seaweed or an extract thereof.
現代日本では食生活の欧米化や日常の生活様式の変化により、肥満の人が増えている。肥満とは脂肪組織、及び種々の臓器に過剰に脂肪が蓄積した状態である。特に内臓周辺に脂肪が蓄積した内臓脂肪型肥満はコレステロール値や血糖値が高くなりやすく、糖尿病をはじめとする生活習慣病や動脈硬化など各種疾患のリスクを高めることが知られている。肥満の予防解消はこれら疾患からのリスクを軽減し、外見上の問題だけでなく、身体への負担を軽減することにもつながる。 In modern Japan, the number of obese people is increasing due to the westernization of eating habits and changes in daily lifestyles. Obesity is a condition in which excess fat is accumulated in adipose tissue and various organs. In particular, it is known that visceral fat obesity, in which fat is accumulated around the viscera, tends to increase cholesterol level and blood sugar level, and increases the risk of various diseases such as lifestyle-related diseases such as diabetes and arteriosclerosis. Preventing and eliminating obesity reduces the risk of these diseases, which not only reduces appearance problems but also reduces the burden on the body.
肥満の予防解消は、エネルギー摂取と消費のバランス改善が必要である。一方で、健康食品等の飲食物を摂取することや外用剤を塗布することにより、手軽に十分な痩身効果を有する痩身用食品組成物及び外用剤組成物が求められている。 To prevent and eliminate obesity, it is necessary to improve the balance between energy intake and consumption. On the other hand, there is a demand for slimming food compositions and external preparation compositions that easily have a sufficient slimming effect by ingesting foods and drinks such as health foods and applying external preparations.
これまで痩身効果を有する成分の探索や検討が盛んに行われてきており、例えばヨモギ抽出組成物は、脱共役蛋白質誘発促進剤として、肥満防止効果があることが知られている（特許文献１）。また、パセリ抽出物を配合する身体用組成物は、セルライト解消効果やむくみ解消効果に優れていることが知られている（特許文献２）。 So far, the search and study of components having a slimming effect have been actively carried out. For example, the mugwort extract composition is known to have an obesity-preventing effect as an uncoupling protein induction promoter (Patent Document 1). ). Further, it is known that a composition for a body containing a parsley extract is excellent in an effect of eliminating cellulite and an effect of eliminating swelling (Patent Document 2).
一方近年、スーパーフードと呼ばれる食品が注目されており、例えばアフリカで薬草として食されているアフリカマンゴノキは、体重やコレステロール減少効果があることが見出されている（特許文献３）。また、ヒバマタは、ヨーロッパにて食されている珍しい海藻であり、その海藻又はその抽出物を含有する飲食物及び外用剤に痩身効果があることが開示されている（特許文献４、５）。
しかし、未だ十分な痩身効果を有する痩身用食品組成物及び外用剤組成物は得られていない。
On the other hand, in recent years, foods called superfoods have been attracting attention. For example, African mangonoki, which is eaten as a medicinal herb in Africa, has been found to have an effect of reducing body weight and cholesterol (Patent Document 3). In addition, Hibamata is a rare seaweed that is eaten in Europe, and it is disclosed that foods and drinks and external preparations containing the seaweed or its extract have a slimming effect (Patent Documents 4 and 5).
However, a slimming food composition and an external preparation composition having a sufficient slimming effect have not yet been obtained.
本発明は、上記事情を鑑みてなされたものであり、優れた痩身効果を有する痩身用食品組成物及び痩身用外用剤組成物を提供することを目的とする。 The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a slimming food composition and a slimming external preparation composition having an excellent slimming effect.
本発明者は上記課題を解決するために鋭意研究を重ねた結果、ニガキ科アフリカマンゴノキ属植物またはその抽出物とヒバマタ科ヒバマタ属海藻またはその抽出物とを併用することにより、極めて優れた痩身効果を得られることを見出し、本発明を完成することに至
った。
As a result of intensive research to solve the above problems, the present inventor has achieved extremely excellent slimming by using a plant of the genus Simaroubaceae or its extract in combination with a seaweed of the genus Hibamata of the family Simaroubaceae or its extract. We have found that an effect can be obtained and have completed the present invention.
即ち、本発明は、ニガキ科アフリカマンゴノキ属植物またはその抽出物及びヒバマタ科ヒバマタ属海藻またはその抽出物を含有する痩身用食品組成物及び痩身用外用剤組成物を提供する。本発明の食品組成物は、錠剤、粉末剤、顆粒剤、カプセル剤、ドリンク剤、ゼリーにより提供されることが好ましく、本発明の外用剤組成物は、クリーム、ペースト剤、ジェル、軟膏、ローション、乳液、パック、パウダー、ハップ剤により提供されることが好ましい。 That is, the present invention provides a slimming food composition and a slimming external preparation composition containing the Simaroubaceae African Mangonoki genus plant or an extract thereof and the Hibamata family Hibamata genus seaweed or an extract thereof. The food composition of the present invention is preferably provided by tablets, powders, granules, capsules, drinks and jellies, and the external preparation composition of the present invention is a cream, paste, gel, ointment or lotion. , Milky lotions, packs, powders, and salves are preferred.
本発明の痩身用食品組成物及び痩身用外用剤組成物は、優れた痩身効果を発揮することができる。
また、本発明の痩身用食品組成物及び痩身用外用剤組成物は、植物原料や海藻原料に由来し、安全及び手軽に摂取、または使用することができる。
The slimming food composition and the slimming external preparation composition of the present invention can exhibit an excellent slimming effect.
In addition, the slimming food composition and the slimming external preparation composition of the present invention are derived from plant raw materials and seaweed raw materials, and can be safely and easily ingested or used.
以下、本発明について詳細に説明する。
本発明の痩身用食品組成物及び痩身用外用剤組成物は、ニガキ科アフリカマンゴノキ属植物またはその抽出物及びヒバマタ科ヒバマタ属海藻またはその抽出物を含有するものである。
本発明の痩身用組成物は、経口で摂取することが痩身効果の観点から望ましく、さらに手軽に摂取できる観点からも、食品組成物が好ましい。
Hereinafter, the present invention will be described in detail.
The slimming food composition and the slimming external preparation composition of the present invention contain a plant of the genus Simaroubaceae or an extract thereof and a seaweed of the genus Hibamata of the family Simaroubaceae or an extract thereof.
The slimming composition of the present invention is preferably taken orally from the viewpoint of slimming effect, and is preferably a food composition from the viewpoint of being easily ingested.
本発明において「痩身」とは、体重の減少及び体重の維持を含む、体重の増加を抑制することや、ウエストやヒップなどの体の寸法の維持及び減少を含む、寸法の増加を抑制することを意味するものである。 In the present invention, "slimming" means suppressing weight gain, including weight loss and weight maintenance, and suppressing weight gain, including maintaining and reducing body dimensions such as waist and hips. Means.
（１）ニガキ科アフリカマンゴノキ属植物またはその抽出物
本発明で用いるニガキ科アフリカマンゴノキ属植物またはその抽出物とは、ニガキ科（Ｓｉｍａｒｏｕｂａｃｅａｅ）アフリカマンゴノキ属（Ｉｒｖｉｎｇａ ｇａｂｏｎｅｎｓｉｓ）に属する植物の幹や茎、葉、果実、果皮及び／又は種子等の各種部位、好ましくは種子及び／又は果実、またはそれらから得られる抽出物であれば特に限定されず、例えば、アフリカマンゴノキ（Ｉｒｖｉｎｇａ ｇａｂｏｎｅｎｓｉｓ）の種子又は果実、またはそれらから得られる抽出物である。
(1) Simaroubaceae African Mangonoki genus plant or its extract The Simaroubaceae African Mangonoki genus plant or its extract used in the present invention is the trunk of a plant belonging to the Simaroubaceae African Mangonoki genus (Irvinga gabonensis). Various parts such as stems, leaves, fruits, peels and / or seeds, preferably seeds and / or fruits, or extracts obtained from them are not particularly limited, and for example, Simaroubaceae (Irvinga gabonensis). Seeds or fruits, or extracts obtained from them.
ニガキ科アフリカマンゴノキ属植物は、その各種部位を未乾燥のまま、または乾燥させた後、そのままで、あるいは、破砕または粉砕後に使用することができる。 The Simaroubaceae African Mangonoki plant can be used as it is, or after crushing or crushing its various parts in an undried state or after being dried.
（２）ヒバマタ科ヒバマタ属海藻またはその抽出物
本発明で用いるヒバマタ科ヒバマタ属海藻またはその抽出物とは、ヒバマタ科（Ｆｕｃａｃｅａｅ）ヒバマタ属（Ｆｕｃｕｓ）に属する海藻の藻体の任意の部分（特に葉状体）、またはそれらから得られる抽出物であれば特に限定されず、例えば、ヒバマタ（Ｆｕｃｕｓ ｄｉｓｔｉｃｈｕｓ）の藻体の任意の部分（特に葉状体）、またはそれらから得られる抽出物である。
(2) Rockweed seaweed or its extract The rockweed seaweed or its extract used in the present invention is any part (particularly) of the algae of the rockweed belonging to the rockweed family (Fucaceae) and the genus Rockweed (Fucus). It is not particularly limited as long as it is a foliate body) or an extract obtained from them, and is, for example, any part (particularly a foliate body) of the algae of the rockweed (Fucus disticus), or an extract obtained from them.
ヒバマタ科ヒバマタ属海藻は、その藻体の任意の部分（特に葉状体）を未乾燥のまま、または乾燥させた後、そのままで、あるいは、破砕または粉砕後に使用することができる。 The rockweed seaweed of the genus Rockweed can be used as it is, or after crushing or crushing any part of the algae (particularly the fronds), undried or dried.
（３）抽出方法
各抽出物を得る方法としては、例えば植物の幹や茎、葉、果実、果皮及び／又は種子等の各種部位（特に種子）、藻類の任意の部分（特に葉状体）、あるいはその破砕物を抽出溶媒に浸漬して抽出する方法（溶媒抽出法）や超臨界状態下にて抽出する方法（超臨界抽出法）、圧搾して圧搾液を得る方法（圧搾法）などが挙げられる。また、市販品を用いることもできる。
(3) Extraction method As a method for obtaining each extract, for example, various parts (particularly seeds) such as stems and stems, leaves, fruits, peels and / or seeds of plants, arbitrary parts of algae (particularly foliate bodies), and the like. Alternatively, a method of immersing the crushed material in an extraction solvent for extraction (solvent extraction method), a method of extracting under a supercritical state (supercritical extraction method), a method of squeezing to obtain a squeezed liquid (squeezing method), etc. Can be mentioned. Moreover, a commercially available product can also be used.
溶媒抽出法における抽出溶媒としては特に制限はなく、水や、メタノール、エタノール、プロパノール、ブタノールなどの低級１価アルコール；プロピレングリコール、ジプロピレングリコール、ブチレングリコール、グリセリンなどの多価アルコール；酢酸メチル、酢酸エチルなどのエステル類；アセトン、メチルエチルケトンなどのケトン類；ジエチルエーテル、テトラヒドロフランなどのエーテル類；クロロホルム、四塩化炭素などのハロゲン化炭化水素類；ヘキサン、ヘプタン、シクロヘキサンなどの炭化水素類が挙げられる。これらの抽出溶媒は１種を単独で用いてもよいし、２種以上の混合溶媒を用いてもよい。水、低級１価アルコール、多価アルコール、エステル類、ケトン類、エーテル類が好適に用いられ、特に水、エタノール、１，３−ブチレングリコールが好適に用いられ、水がより好適に用いられる。 The extraction solvent in the solvent extraction method is not particularly limited, and water and lower monohydric alcohols such as methanol, ethanol, propanol and butanol; polyhydric alcohols such as propylene glycol, dipropylene glycol, butylene glycol and glycerin; methyl acetate, Esters such as ethyl acetate; Ketones such as acetone and methyl ethyl ketone; Ethers such as diethyl ether and tetrahydrofuran; Halogenized hydrocarbons such as chloroform and carbon tetrachloride; Hydrocarbons such as hexane, heptane and cyclohexane. .. One of these extraction solvents may be used alone, or two or more kinds of mixed solvents may be used. Water, lower monohydric alcohols, polyhydric alcohols, esters, ketones and ethers are preferably used, particularly water, ethanol and 1,3-butylene glycol are preferably used, and water is more preferably used.
また、抽出溶媒に浸漬する条件としては特に制限はなく、例えば抽出対象の植物を２０〜４０℃の抽出溶媒中に１時間〜７日間、浸漬するという条件が挙げられる。
超臨界抽出法にて抽出する場合、そのときに用いる超臨界流体は特に限定されないが、例えば水や二酸化炭素等があげられる。
また、得られた抽出液や圧搾液に対し熱風乾燥、減圧乾燥、噴霧乾燥又は凍結乾燥などの乾燥処理を行い、乾燥物としてもよい。
The conditions for immersing the plant in the extraction solvent are not particularly limited, and examples thereof include a condition in which the plant to be extracted is immersed in the extraction solvent at 20 to 40 ° C. for 1 hour to 7 days.
When extracting by the supercritical extraction method, the supercritical fluid used at that time is not particularly limited, and examples thereof include water and carbon dioxide.
Further, the obtained extract or pressed liquid may be subjected to a drying treatment such as hot air drying, vacuum drying, spray drying or freeze drying to obtain a dried product.
本発明においては痩身効果の観点から、前記植物、前記海藻の抽出物を使用することが好ましい。 In the present invention, it is preferable to use the extract of the plant and the seaweed from the viewpoint of the slimming effect.
（４）痩身用食品組成物
本発明の痩身用食品組成物は、ニガキ科アフリカマンゴノキ属植物またはその抽出物及びヒバマタ科ヒバマタ属海藻またはその抽出物を含有する、すなわち、これらを併用することを特徴とする。
(4) Slimming food composition The slimming food composition of the present invention contains a plant of the genus Simaroubaceae or an extract thereof and a seaweed of the genus Hibamata of the family Simaroubaceae or an extract thereof, that is, a combination thereof. It is characterized by.
本発明の痩身用食品組成物におけるニガキ科アフリカマンゴノキ属植物またはその抽出物とヒバマタ科ヒバマタ属海藻またはその抽出物との割合としては、適宜選択され得るが、痩身効果がより優れるという観点から、抽出物（ニガキ科アフリカマンゴノキ属植物及び／又はヒバマタ科ヒバマタ属海藻を用いる場合は、これらから得られる抽出物として換算）の乾燥物の重量比で９：１〜１：９が好ましく、８：２〜２：８がより好ましい。 The ratio of the Simaroubaceae plant of the genus Simaroubaceae or its extract to the seaweed of the genus Simaroubaceae or its extract in the slimming food composition of the present invention can be appropriately selected, but from the viewpoint of superior slimming effect. , 9: 1 to 1: 9 is preferable in terms of the weight ratio of the dried product of the extract (when using Simaroubaceae African Mangonoki plant and / or Hibamata family Hibamata seaweed, it is converted as an extract obtained from these). 8: 2 to 2: 8 is more preferable.
本発明の痩身用食品組成物としては、上述のようにして得たニガキ科アフリカマンゴノキ属植物またはその抽出物及びヒバマタ科ヒバマタ属海藻またはその抽出物の混合物をそのまま食品組成物としても良いし、ニガキ科アフリカマンゴノキ属植物またはその抽出物及びヒバマタ科ヒバマタ属海藻またはその抽出物に、食品分野で慣用の賦形剤、増量剤、甘味料、香料、着色料などの添加剤を配合し、製剤化して食品組成物としても良い。本発明において使用可能な賦形剤、増量剤としては例えば、マルチトール、セルロース、デキストリン、マルトデキストリン、シクロデキストリン、ステアリン酸カルシウム、イヌリン、炭酸マグネシウム、二酸化ケイ素、沈降シリカ、ラクトース、デンプン、水、アルコール、グリセリン、ハチミツなどが挙げられる。本発明において使用可能な甘味料としては例えば、アスパルテーム、L‐フェニルアラニン、キシリトール、D-ソルビトール、グルコース、フルクトース、ガラクトース、マンノース、スクラロース、マルトース、キシロース、マルチトール、マンニトール、エリスリトール、ソルビトール、サッカリン、サ
ッカリンナトリウム、アスセルファムカリウム、ステビア抽出物、カンゾウ抽出物、ハチミツ、ミラクリン、モネリンなどが挙げられる。本発明において使用可能な香料としては例えば、ジャコウ、シベット、カストリウム、アンバーグリス等の天然動物性香料、アニス精油、アンゲリカ精油、イランイラン精油、イリス精油、ウイキョウ精油、オレンジ精油、カナンガ精油、カラウェー精油、カルダモン精油、グアヤクウッド精油、クミン精油、黒文字精油、ケイ皮精油、シンナモン精油、ゲラニウム精油、コパイババルサム精油、コリアンデル精油、シソ精油、シダーウッド精油、シトロネラ精油、ジャスミン精油、ジンジャーグラス精油、杉精油、スペアミント精油、西洋ハッカ精油、大茴香精油、チュベローズ精油、丁字精油、橙花精油、冬緑精油、トルーバルサム精油、バチュリー精油、バラ精油、パルマローザ精油、桧精油、ヒバ精油、白檀精油、プチグレン精油、ベイ精油、ベチバ精油、ベルガモット精油、ペルーバルサム精油、ボアドローズ精油、芳樟精油、マンダリン精油、ユーカリ精油、ライム精油、ラベンダー精油、リナロエ精油、レモングラス精油、レモン精油、ローズマリー(マンネンロウ)精油、和種ハッカ精油等の植物性香料、その他合成香料などが挙げられる。本発明において使用可能な着色料としては例えば、赤キャベツ色素、赤米色素、アカネ色素、アナトー色素、イカスミ色素、ウコン色素、エンジュ色素、オキアミ色素、柿色素、カラメル、金、銀、クチナシ色素、コーン色素、タマネギ色素、タマリンド色素、スピルリナ色素、ソバ全草色素、チェリー色素、海苔色素、ハイビスカス色素、ブドウ果汁色素、マリーゴールド色素、紫イモ色素、紫ヤマイモ色素、ラック色素、タール色素、ベニバナ色素、アントシアニン色素、ルチンなどが挙げられる。
As the food composition for slimming of the present invention, a mixture of Simaroubaceae African Mangonoki plant or its extract and Simaroubaceae Hibamata seaweed or its extract obtained as described above may be used as it is as a food composition. , Simaroubaceae African Mangonoki plant or its extract and Hibamata family Hibamata seaweed or its extract are mixed with additives such as excipients, bulking agents, sweeteners, fragrances and colorants commonly used in the food field. , May be formulated as a food composition. Excipients and bulking agents that can be used in the present invention include, for example, martitol, cellulose, dextrin, maltodextrin, cyclodextrin, calcium stearate, inulin, magnesium carbonate, silicon dioxide, precipitated silica, lactose, starch, water, alcohol. , Glycerin, honey, etc. Examples of sweeteners that can be used in the present invention include aspartame, L-phenylalanine, xylitol, D-sorbitol, glucose, fructose, galactose, mannose, sucralose, maltose, xylose, martitol, mannitol, erythritol, sorbitol, saccharin, and sodium saccharin. , Aspartame potassium, stevia extract, fructose extract, honey, miraculin, mannitol and the like. Examples of the fragrances that can be used in the present invention include natural animal fragrances such as jako, civet, castorium, and amberglis, anis essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, uikyo essential oil, orange essential oil, cananga essential oil, and caraway essential oil. , Cardamon essential oil, Guayakwood essential oil, Cumin essential oil, Black letter essential oil, Kay skin essential oil, Cinnamon essential oil, Geranium essential oil, Copaiba balsam essential oil, Korean del essential oil, Perilla essential oil, Cedarwood essential oil, Citronella essential oil, Jasmine essential oil, Ginger glass essential oil, Cedar essential oil, Spare mint essential oil, western peppermint oil, large scented essential oil, tuberose essential oil, choji essential oil, orange flower essential oil, winter green essential oil, true balsam essential oil, butchery essential oil, rose essential oil, palmarosa essential oil, 桧 essential oil, hiba essential oil, ebony essential oil, petitgrain essential oil, Bay essential oil, Bechiba essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boadrose essential oil, Hokaku essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaroe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary (Mannenro) essential oil, Japanese Seed Hacka essential oil and other vegetable fragrances, and other synthetic fragrances. Examples of the colorants that can be used in the present invention include red cabbage pigment, red rice pigment, red rice pigment, annatto pigment, squid pigment, turmeric pigment, enju pigment, okiami pigment, persimmon pigment, caramel, gold, silver, and cuttlefish pigment. Corn pigment, onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, seaweed pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yamaimo pigment, rack pigment, tar pigment, Benibana pigment , Anthocyanin pigment, rutin and the like.
また、本発明の痩身用食品組成物は、痩身のために使用される公知の素材を配合することもできる。このような素材としては、例えば、ブドウ種子抽出物、キノコキトサン、乳酸菌、イヌリン、イソマルトデキストリン等が例示される。 The slimming food composition of the present invention can also contain known materials used for slimming. Examples of such a material include grape seed extract, mushroom chitosan, lactic acid bacteria, inulin, isomaltodextrin and the like.
本発明の痩身用食品組成物の剤形としては特に制限されないが、例えば錠剤、粉末剤、顆粒剤、カプセル剤、ドリンク剤、ゼリーなどが挙げられ、本発明においては錠剤が好適である。また、ニガキ科アフリカマンゴノキ属植物またはその抽出物及びヒバマタ科ヒバマタ属海藻またはその抽出物を通常の飲食品、例えばクッキーなどの菓子類、スープ類、飲料などの種々の飲食品に配合したものであっても良い。 The dosage form of the slimming food composition of the present invention is not particularly limited, and examples thereof include tablets, powders, granules, capsules, drinks, and jellies, and tablets are suitable in the present invention. In addition, Simaroubaceae African mangonoki plants or their extracts and Hibamata family Hibamata seaweeds or their extracts are blended with ordinary foods and drinks, such as confectionery such as cookies, soups, and various foods and drinks such as beverages. It may be.
本発明の痩身用食品組成物におけるニガキ科アフリカマンゴノキ属植物またはその抽出物及びヒバマタ科ヒバマタ属海藻またはその抽出物の含有量としては特に限定されるものではないが、製剤化する場合、剤形や摂取回数、配合する賦形剤や添加剤の種類などに応じて適宜選択され得る。例えばいずれも抽出物を用いた錠剤の場合、ニガキ科アフリカマンゴノキ属植物の抽出物とヒバマタ科ヒバマタ属海藻の抽出物の総含有量が乾燥物として０．１〜５０質量％という量が好適であり、１〜４０質量％という量がより好適である。 The content of the Simaroubaceae African Mangonoki plant or its extract and the Hibamata rockweed seaweed or its extract in the slimming food composition of the present invention is not particularly limited, but when it is formulated, it is an agent. It can be appropriately selected depending on the shape, the number of times of ingestion, the type of excipient or additive to be blended, and the like. For example, in the case of tablets using extracts, the total content of the extract of Simaroubaceae African mangonoki plant and the extract of rockweed seaweed is preferably 0.1 to 50% by mass as a dried product. Therefore, an amount of 1 to 40% by mass is more preferable.
本発明の効果を得るために有効なニガキ科アフリカマンゴノキ属植物またはその抽出物とヒバマタ科ヒバマタ属海藻またはその抽出物の総量は、例えば抽出物（ニガキ科アフリカマンゴノキ属植物及び／又はヒバマタ科ヒバマタ属海藻を用いる場合は、これらから得られる抽出物として換算）の乾重量として通常成人１日当たり１００〜１５００ｍｇ、好ましくは３００〜１２００ｍｇである。
この範囲の量を１日１〜３回、食前に摂取するのが好ましく、１日１回夕食前に摂取するのがより好ましい。製剤化する場合は摂取量、摂取回数、剤形に応じた摂取形態とすればよい。
The total amount of the Simaroubaceae African Mangonoki plant or its extract and the Hibamata family Hibamata seaweed or its extract, which are effective for obtaining the effect of the present invention, is, for example, an extract (Simoubaceae African Mangonoki plant and / or Hibamata). When the family Simaroubaceae seaweed is used, the dry weight of the extract obtained from these seaweeds) is usually 100 to 1500 mg, preferably 300 to 1200 mg per day for adults.
It is preferable to take an amount in this range 1 to 3 times a day before meals, and more preferably once a day before dinner. When it is formulated, it may be ingested according to the amount of intake, the number of times of ingestion, and the dosage form.
（５）痩身用外用剤組成物
本発明の痩身用外用剤組成物は、ニガキ科アフリカマンゴノキ属植物またはその抽出物及びヒバマタ科ヒバマタ属海藻またはその抽出物を含有する、すなわち、これらを併用す
ることを特徴とする。
(5) External preparation composition for slimming The external preparation composition for slimming of the present invention contains a plant of the genus Simaroubaceae or an extract thereof and a seaweed of the genus Hibamata of the family Simaroubaceae or an extract thereof, that is, a combination thereof. It is characterized by doing.
本発明の痩身用外用剤組成物におけるニガキ科アフリカマンゴノキ属植物またはその抽出物とヒバマタ科ヒバマタ属海藻またはその抽出物との割合としては、適宜選択され得るが、痩身効果がより優れるという観点から、抽出物（ニガキ科アフリカマンゴノキ属植物及び／又はヒバマタ科ヒバマタ属海藻を用いる場合は、これらから得られる抽出物として換算）の乾燥物の重量比で９：１〜１：９が好ましく、８：２〜２：８がより好ましい。 The ratio of the Simaroubaceae plant of the genus Simaroubaceae or its extract to the seaweed of the genus Simaroubaceae or its extract in the external preparation composition for slimming of the present invention can be appropriately selected, but from the viewpoint that the slimming effect is more excellent. 9: 1 to 1: 9 is preferable in terms of the weight ratio of the dried product of the extract (when using Simaroubaceae African Mangonoki plant and / or Hibamata family Hibamata seaweed, it is converted as an extract obtained from these). , 8: 2 to 2: 8, more preferred.
本発明の痩身用外用剤組成物には、上記各種成分の他に、通常の外用剤において使用される公知の機能性成分、例えば、保湿剤、エモリエント剤、血行促進剤、細胞賦活化剤、抗酸化剤、抗炎症剤、抗菌剤、美白剤、過酸化物抑制剤などを配合することができる。例えば、グリセリン、ブチレングリコール、尿素、アミノ酸類などの保湿剤；スクワラン、マカデミアナッツ油、オリーブ油、ホホバ油、シリコン油などのエモリエント剤；ビタミンＥ類、トウガラシチンキなどの血行促進剤；核酸などの細胞賦活化剤；ジブチルヒドロキシトルエン（ＢＨＴ）、ジブチルヒドロキシアニソール（ＢＨＡ）、酢酸トコフェロール、アスコルビン酸類などの抗酸化剤；グリチルリチン、アラントインなどの抗炎症剤；ヒノキチオール、塩化ベンザルコニウム、クロルヘキシジン塩、パラヒドロキシ安息香酸エステルなどの抗菌剤；アスコルビン酸、アルブチンなどの美白剤； スーパーオキシドジスムターゼ（ＳＯＤ）などの過酸化物抑制剤等の種々の公知物質等を配合することができる。また、オウゴンエキス、イチョウエキス、シャクヤクエキス、胎盤抽出物、乳酸菌培養抽出物などの植物・動物・微生物由来の各種抽出物なども自由に添加して使用することができる。また、痩身のために使用される公知の素材を配合することもできる。このような素材としては、例えば、ブドウ種子抽出物、キノコキトサン、乳酸菌、イヌリン、イソマルトデキストリン等が例示される。 In addition to the above-mentioned various components, the external preparation composition for slimming of the present invention includes known functional components used in ordinary external preparations, such as moisturizers, emollients, blood circulation promoters, and cell activators. Antioxidants, anti-inflammatory agents, antibacterial agents, whitening agents, peroxide inhibitors and the like can be blended. For example, moisturizers such as glycerin, butylene glycol, urea, and amino acids; emollients such as squalane, macadamia nut oil, olive oil, jojoba oil, and silicon oil; blood circulation promoters such as vitamin E and sugarcane tincture; cell activation of nucleic acids, etc. Agents: Antioxidants such as dibutylhydroxytoluene (BHT), dibutylhydroxyanisole (BHA), tocopherol acetate, ascorbic acids; Antioxidants such as glycyrrhizin, allantin; Hinokithiol, benzalkonium chloride, chlorhexidine salt, parahydroxybenzoic acid Various known substances such as antibacterial agents such as acid esters; whitening agents such as ascorbic acid and arbutin; and peroxide inhibitors such as superoxide dismutase (SOD) can be blended. In addition, various extracts derived from plants, animals, and microorganisms such as ginger extract, ginkgo extract, shakuyaku extract, placenta extract, and lactic acid bacterium culture extract can be freely added and used. It is also possible to blend known materials used for slimming. Examples of such a material include grape seed extract, mushroom chitosan, lactic acid bacteria, inulin, isomaltodextrin and the like.
本発明の外用剤組成物とは、外用可能な剤であって、その剤型は特に制限がなく、例えば、クリーム（ゲルクリームを含む）、ペースト剤、ジェル、軟膏、ローション、乳液、パック、パウダー、ハップ剤などが例示でき、好ましくは、乳液、クリーム、ペースト剤、ジェル、軟膏、特に好ましくはクリーム、ペースト剤、ジェル、軟膏である。 The external preparation composition of the present invention is a preparation that can be applied externally, and the dosage form thereof is not particularly limited. For example, creams (including gel creams), pastes, gels, ointments, lotions, emulsions, packs, etc. Examples thereof include powders and haptics, preferably emulsions, creams, pastes, gels and ointments, and particularly preferably creams, pastes, gels and ointments.
また、本発明の外用剤組成物には、その剤型化のために界面活性剤、油脂類などの基材成分や、必要に応じて溶媒、増粘剤、防腐剤、等張化剤、酸化防止剤、紫外線吸収剤、キレート剤、香料、着色料などの種々の添加剤を併用できる。溶媒としては例えば水やエタノール、プロパノール、プロピレングリコール、１，３‐ブチレングリコール、グリセリンなどのアルコール類を用いることができる。外用剤に本発明の痩身用組成物を適用する場合、皮膚刺激性の低いエタノールや１，３‐ブチレングリコールなどを用いることが好適である。上記の界面活性剤としては、特に限定されるものではないが、一般的な非イオン界面活性剤、陰イオン界面活性剤、陽イオン界面活性剤、両性界面活性剤を用いることができる。例えば、高級アルコールのアルキレンオキサイド付加物、高級アルキルアミンのアルキレンオキサイド付加物、高級脂肪酸アミドのアルキレンオキサイド付加物、多価アルコールの脂肪酸エステル、硬化ひまし油のアルキレンオキサイド付加物、ポリエチレングリコールソルビタンアルキルエステル、ステロールなどのアルキレンオキサイド付加物等の非イオン界面活性剤；アルキル硫酸ナトリウム、アルキロイルメチルタウリンナトリウム、α−オレフィンスルホン酸ナトリウム、ポリオキシアルキレンアルキルエーテル硫酸ナトリウム等の陰イオン界面活性剤；塩化アルキルピリジニウム、塩化ジステアリルジメリルアンモニウム等の陽イオン界面活性剤；アミノプロピオン酸ナトリウム、アルキルポリアミノエチルグリシンなどの両性界面活性剤が挙げられる。そして、これらのうち１種または２種以上の界面活性剤を選択して使用することができる。 In addition, the external preparation composition of the present invention contains base components such as surfactants and oils and fats for its dosage form, and if necessary, solvents, thickeners, preservatives, isotonic agents, etc. Various additives such as antioxidants, UV absorbers, chelating agents, fragrances and colorants can be used in combination. As the solvent, for example, water, alcohols such as ethanol, propanol, propylene glycol, 1,3-butylene glycol, and glycerin can be used. When the slimming composition of the present invention is applied to an external preparation, it is preferable to use ethanol, 1,3-butylene glycol, etc., which have low skin irritation. The above-mentioned surfactant is not particularly limited, but general nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants can be used. For example, higher alcohol alkylene oxide adducts, higher alkylamine alkylene oxide adducts, higher fatty acid amide alkylene oxide adducts, polyhydric alcohol fatty acid esters, hardened castor oil alkylene oxide adducts, polyethylene glycol sorbitan alkyl esters, sterols. Nonionic surfactants such as alkylene oxide adducts such as; anionic surfactants such as sodium alkylsulfate, sodium alcoholylmethyltaurine, sodium α-olefin sulfonate, sodium polyoxyalkylene alkyl ether sulfates; alkylpyridinium chloride, etc. Cationic surfactants such as distearyl dimeryl ammonium chloride; amphoteric surfactants such as sodium aminopropionate and alkylpolyaminoethylglycine. Then, one or more of these surfactants can be selected and used.
本発明において使用可能な基材成分としては、特に限定されるものではないが、例えば
、オリーブ油、ツバキ油、アボカド油、マカデミアナッツ油、杏仁油、ホホバ油、スクワラン、スクワレン、馬油など、一般的に知られている油脂類を挙げることができる。
The base material component that can be used in the present invention is not particularly limited, but is generally such as olive oil, camellia oil, avocado oil, macadamia nut oil, apricot oil, jojoba oil, squalane, squalane, and horse oil. Examples of oils and fats known to.
本発明において使用可能な増粘剤としては、特に限定されるものではないが、例えば、ポリビニルアルコール、ポリビニルアクリルアミド、ポリエチレングリコール、およびこれらの各種誘導体；ヒドロキシアルキルセルロースなどのセルロース類およびその誘導体；デキストラン、ゼラチン、アラビアガム、トラガントガムなどのガム類；カルボキシビニルポリマーなどの水溶性高分子などが挙げられる。 The thickener that can be used in the present invention is not particularly limited, but for example, polyvinyl alcohol, polyvinylacrylamide, polyethylene glycol, and various derivatives thereof; celluloses such as hydroxyalkyl cellulose and derivatives thereof; dextran. , Gum such as gelatin, gum arabic, tragant gum; water-soluble polymer such as carboxyvinyl polymer and the like.
本発明において使用可能な防腐剤としては、特に限定されるものではないが、例えば、パラヒドロキシ安息香酸エステル、パラオキシ安息香酸塩とその誘導体、フェノキシエタノール、ヒノキチオール、塩化ベンザルコニウム、クロルヘキシジン塩などが挙げられる。
本発明において使用可能な等張化剤としては、特に限定されるものではないが、例えば、塩化ナトリウム、塩化カリウム、塩化カルシウムなどの無機塩類が挙げられる。
Examples of the preservative that can be used in the present invention include, but are not limited to, parahydroxybenzoic acid ester, paraoxybenzoate and its derivatives, phenoxyethanol, hinokitiol, benzalkonium chloride, chlorhexidine salt and the like. Be done.
The isotonic agent that can be used in the present invention is not particularly limited, and examples thereof include inorganic salts such as sodium chloride, potassium chloride, and calcium chloride.
本発明において使用可能な紫外線吸収剤としては、特に限定されるものではないが、例えば、パラアミノ安息香酸、ベンゾフェノン系紫外線吸収剤、ベンゾトリアゾール系紫外線吸収剤などが挙げられる。
本発明において使用可能なキレート剤としては、特に限定されるものではないが、例えば、エチレンジアミン四酢酸、フィチン酸、クエン酸およびこれらの水溶性塩などが挙げられる。
The ultraviolet absorber that can be used in the present invention is not particularly limited, and examples thereof include para-aminobenzoic acid, a benzophenone-based ultraviolet absorber, and a benzotriazole-based ultraviolet absorber.
The chelating agent that can be used in the present invention is not particularly limited, and examples thereof include ethylenediaminetetraacetic acid, phytic acid, citric acid, and water-soluble salts thereof.
本発明の痩身用外用剤組成物におけるニガキ科アフリカマンゴノキ属植物またはその抽出物及びヒバマタ科ヒバマタ属海藻またはその抽出物の含有量としては特に限定されるものではないが、製剤化する場合、剤形や使用回数、配合する賦形剤や添加剤の種類などに応じて適宜選択され得る。例えばいずれも抽出物を用いたクリームの場合、ニガキ科アフリカマンゴノキ属植物の抽出物とヒバマタ科ヒバマタ属海藻の抽出物の総含有量が乾燥物として０．０１〜３０質量％という量が好適である。 The content of the Simaroubaceae African Mangonoki plant or its extract and the Hibamata family Hibamata seaweed or its extract in the external preparation composition for slimming of the present invention is not particularly limited, but when it is formulated, it is not particularly limited. It can be appropriately selected depending on the dosage form, the number of times of use, the type of excipient and additive to be blended, and the like. For example, in the case of creams using extracts, the total content of the extracts of plants of the genus Simaroubaceae and the genus Seaweed of the family Simaroubaceae is preferably 0.01 to 30% by mass as a dried product. Is.
本発明の効果を得るために有効なニガキ科アフリカマンゴノキ属植物またはその抽出物とヒバマタ科ヒバマタ属海藻またはその抽出物の総量は、例えば抽出物（ニガキ科アフリカマンゴノキ属植物及び／又はヒバマタ科ヒバマタ属海藻を用いる場合は、これらから得られる抽出物として換算）の乾重量として通常成人１日当たりウエストとヒップに使用する場合、１〜１０００ｍｇである。
この範囲の量をクリームの場合１日１回１〜５ｇ、入浴後にウエストとヒップにマッサージしながら塗擦するのが好ましく、製剤化する場合は塗擦量、剤形に応じた使用形態とすればよい。
The total amount of the Simaroubaceae African Mangonoki plant or its extract and the Hibamata family Hibamata seaweed or its extract, which are effective for obtaining the effect of the present invention, is, for example, an extract (Simoubaceae African Mangonoki plant and / or Hibamata). When using Simaroubaceae seaweed, the dry weight of the extract obtained from these seaweeds is usually 1 to 1000 mg per day for adults when used on the waist and hips.
In the case of cream, the amount in this range is 1 to 5 g once a day, and it is preferable to rub it while massaging the waist and hips after bathing. ..
（１）食品組成物の製造
１−１．原料の製造
〈製造例１〉アフリカマンゴノキ（ニガキ科アフリカマンゴノキ属植物）抽出物
アフリカマンゴノキ（Ｉｒｖｉｎｇｉａ ｇａｂｏｎｅｎｓｉｓ）の種子を５０ｇ採取し、圧搾した。これを濾過し、得られた圧搾液を噴霧乾燥して乾燥粉末状のアフリカマンゴノキ抽出物を４．８ｇ得た。
(1) Production of food composition 1-1. Production of Raw Material <Production Example 1> Extract of African mango tree (Simaroubaceae plant belonging to the genus African mango tree) 50 g of seeds of African mango tree (Irvingia gabonensis) were collected and squeezed. This was filtered, and the obtained squeezed liquid was spray-dried to obtain 4.8 g of a dry powdered African mango tree extract.
〈製造例２〉ヒバマタ（ヒバマタ科ヒバマタ属海藻）抽出物
ヒバマタ（Ｆｕｃｕｓ Ｄｉｓｔｉｃｈｕｓ）の葉状体５０ｇを採取し、５００ｍＬの精製水に３０℃で５時間、浸漬した。これを濾過し、得られた抽出液から水を減圧留去し
た後、凍結乾燥して乾燥粉末状のヒバマタ抽出物を３．６ｇ得た。
<Production Example 2> Extract of rockweed (Rockweed seaweed) 50 g of fronds of Rockweed (Fucus disticus) were collected and immersed in 500 mL of purified water at 30 ° C. for 5 hours. This was filtered, water was distilled off from the obtained extract under reduced pressure, and then freeze-dried to obtain 3.6 g of a dry powdery rockweed extract.
〈比較製造例１〉ヨモギ抽出物
ヨモギ（Ａｒｔｅｍｉｓｉａ ｐｒｉｎｃｅｐｓ）の葉を５０ｇ採取し、５００ｍＬの精製水に３０℃で５時間、浸漬した。これを濾過し、得られた抽出液から水を減圧留去した後、凍結乾燥して乾燥粉末状のヨモギ抽出物を５．２ｇ得た。
<Comparative Production Example 1> Mugwort Extract 50 g of leaves of Mugwort (Artemisia springs) were collected and immersed in 500 mL of purified water at 30 ° C. for 5 hours. This was filtered, water was distilled off from the obtained extract under reduced pressure, and then freeze-dried to obtain 5.2 g of a dry powdery mugwort extract.
〈比較製造例２〉パセリ抽出物
パセリ（Ｐｅｔｒｏｓｅｌｉｕｍ ｓａｔｉｃｕｍ）の葉と茎を５０ｇ採取し、５００ｍＬの精製水に３０℃で５時間、浸漬した。これを濾過し、得られた抽出液から水を減圧留去した後、凍結乾燥して乾燥粉末状のパセリ抽出物を２．９ｇ得た。
<Comparative Production Example 2> Parsley Extract 50 g of leaves and stems of parsley (Petroselium saticum) were collected and immersed in 500 mL of purified water at 30 ° C. for 5 hours. This was filtered, water was distilled off from the obtained extract under reduced pressure, and then freeze-dried to obtain 2.9 g of a dry powdery parsley extract.
１−２．食品組成物（錠剤）の製造
〈実施例１〉
製造例１で得られたアフリカマンゴノキ抽出物を２５ｇ、製造例２で得られたヒバマタ抽出物を７５ｇ、賦形剤としてマルチトール１００ｇ及びセルロース１００ｇを混合した。これを打錠機にて打錠して１粒３００ｍｇの錠剤を得た。
1-2. Production of food composition (tablet) <Example 1>
25 g of the African mango tree extract obtained in Production Example 1, 75 g of the Hibamata extract obtained in Production Example 2, and 100 g of maltitol and 100 g of cellulose were mixed as excipients. This was tableted with a tableting machine to obtain 300 mg tablets per tablet.
〈実施例２、３、比較例１〜７〉
表１の組成に変えたこと以外は、実施例１と同様にして錠剤を得た。
<Examples 2 and 3, Comparative Examples 1 to 7>
Tablets were obtained in the same manner as in Example 1 except that the compositions were changed to those shown in Table 1.
１−３．外用剤組成物（ゲルクリーム）の製造
〈実施例４〉
ゲル化剤（ＳＥＰＩＧＥＬ ３０５：ＳＥＰＰＩＣ社）４ｇ、ワセリン２ｇ、オリーブ油２ｇを８０℃で加温させて溶解し、Ａ成分とした。製造例１で得られたアフリカマンゴノキ抽出物０．２５ｇと製造例２で得られたヒバマタ抽出物０．７５ｇに精製水を適量加えて溶解させ、Ｃ成分とした。１，３−ブチレングリコール３ｇ、精製水残量、防腐剤適量を８０℃で加温させて溶解し、Ｂ成分とした。なお精製水残量とは、ゲルクリームの全量を１００ｇに調製するための量を意味する。続いて、Ｂ成分をＡ成分に撹拌しながら徐々に加え乳化した。その乳化した溶液を冷却しながら撹拌し、４０℃でＣ成分を添加し、３５℃で調製を終了した。
1-3. Production of external preparation composition (gel cream) <Example 4>
4 g of a gelling agent (SEPIGEL 305: SEPPIC), 2 g of petrolatum, and 2 g of olive oil were heated at 80 ° C. and dissolved to obtain a component A. An appropriate amount of purified water was added to 0.25 g of the African mango tree extract obtained in Production Example 1 and 0.75 g of the Hibamata extract obtained in Production Example 2 and dissolved to obtain C component. 3 g of 1,3-butylene glycol, the remaining amount of purified water, and an appropriate amount of preservative were heated at 80 ° C. and dissolved to obtain B component. The remaining amount of purified water means the amount for preparing the total amount of gel cream to 100 g. Subsequently, the B component was gradually added to the A component with stirring and emulsified. The emulsified solution was stirred while cooling, the C component was added at 40 ° C., and the preparation was completed at 35 ° C.
〈実施例５，６、比較例８〜１４〉
表２の組成に変えたこと以外は、実施例４と同様にして外用剤を得た。
<Examples 5 and 6, Comparative Examples 8 to 14>
An external preparation was obtained in the same manner as in Example 4 except that the composition was changed to that shown in Table 2.
（２）評価
２−１．食品組成物（錠剤）
２−１−１．試験方法
実施例及び比較例の食品組成物について、以下の使用方法にて痩身効果の試験を行った。
試験は３０歳代〜５０歳代の健常な日本人男女計７０名を被験者とした。ＢＭＩが２２以上３０未満の者を対象とした。体重減少の治療を受けている者、ハーブ薬を含む医薬品を服用中の者、妊娠・授乳・妊娠を計画している者、その他、医師が適さないと認めた者は除外した。ランダムに７人ずつ選択し、１０グループに分けた。その１０グループに表１に示した１０種類の錠剤をそれぞれ摂取させた。摂取期間は１２週間で、被験者は、各グループとも毎日１回、夕食前に、実施例に記した錠剤４錠（有効成分の合計含有量が４００ｍｇ）を摂取した。
(2) Evaluation 2-1. Food composition (tablet)
2-1-1. Test method The slimming effect of the food compositions of Examples and Comparative Examples was tested by the following methods of use.
The test consisted of a total of 70 healthy Japanese men and women in their 30s to 50s. Those with a BMI of 22 or more and less than 30 were targeted. Those who were treated for weight loss, those who were taking medicines including herbal medicines, those who were planning to become pregnant, breastfeeding, or pregnant, and those who were deemed unsuitable by a doctor were excluded. Seven people were randomly selected and divided into 10 groups. The 10 groups were allowed to ingest each of the 10 types of tablets shown in Table 1. The ingestion period was 12 weeks, and the subjects ingested 4 tablets (total content of active ingredient 400 mg) described in the examples once daily before dinner in each group.
試験開始前と試験終了後とで試験対象者の体重を測定し、各グループの７名の体重変化の平均値を算出して評価した。なお、被験者には、上述のとおり錠剤を毎日、定時に摂取
することを除いて、それまでの食生活、喫煙量及び運動などの日常生活を変えることのない様にした。なお、試験期間中、体調の異常を訴えたものはいなかった。
The body weights of the test subjects were measured before the start of the test and after the end of the test, and the average value of the weight changes of 7 persons in each group was calculated and evaluated. As described above, the subjects were not allowed to change their daily activities such as eating habits, smoking amount, and exercise, except that they took tablets daily on a regular basis. No one complained of any abnormal physical condition during the test period.
２−１−２．試験結果
各グループの試験前後の測定結果を表１に示す。
2-1-2. Test results Table 1 shows the measurement results before and after the test for each group.
体重変化の平均値は、アフリカマンゴノキ抽出物単独（比較例２）の場合０．７Ｋｇの減少、ヒバマタ抽出物単独（比較例３）の場合０．６Ｋｇの減少で、単独で使用した場合では変化は少ないものであった。 The average value of body weight change was 0.7 kg reduction in the case of African mango tree extract alone (Comparative Example 2) and 0.6 kg reduction in the case of Hibamata extract alone (Comparative Example 3). The change was small.
これに対し、アフリカマンゴノキ抽出物とヒバマタ抽出物を併用した場合、体重変化の平均値は、実施例１では２．０Ｋｇ減少、実施例２では２．２Ｋｇ減少、実施例３では２．１Ｋｇ減少し、それぞれを単独で使用した場合と比較して、痩身効果が著しく向上していることが明らかとなった。 On the other hand, when the African mango tree extract and the rockweed extract were used in combination, the average value of the body weight change was decreased by 2.0 kg in Example 1, decreased by 2.2 kg in Example 2, and 2.1 kg in Example 3. It was found that the slimming effect was significantly improved as compared with the case where each was used alone.
２−２．外用剤組成物（ゲルクリーム）
２−２−１．試験方法
実施例及び比較例の外用剤について、以下の使用方法にて痩身効果の試験を行った。
試験は３０歳代〜５０歳代の健常な日本人男女計７０名を被験者とした。ＢＭＩが２２以上３０未満の者を対象とした。体重減少の治療を受けている者、ハーブ薬を含む医薬品を服用中の者、妊娠・授乳・妊娠を計画している者、その他、医師が適さないと認めた者は除外した。ランダムに７人ずつ選択し、１０グループに分けた。その１０グループに表２に示した１０種類の外用剤をそれぞれ使用させた。使用期間は１２週間で、被験者は、各グループとも毎日１回、入浴後に、実施例に記した外用剤を手のひらに２ｇ取り、マッサージしながら塗擦して、これを３ヶ月間続けた。試験開始前と試験終了後とで試験対象者のウエスト及びヒップの寸法を測定し、各グループの７名のウエスト変化及びヒップ変化の平均値を算出して評価した。なお、被験者には、上述のとおり外用剤を毎日、定時に使用することを除いて、それまでの食生活、喫煙量及び運動などの日常生活を変えることのない様にした。なお、試験期間中、体調の異常を訴えたものはいなかった。
2-2. Topical composition (gel cream)
2-2-1. Test method The slimming effect of the external preparations of Examples and Comparative Examples was tested by the following usage methods.
The test consisted of a total of 70 healthy Japanese men and women in their 30s to 50s. Those with a BMI of 22 or more and less than 30 were targeted. Those who were treated for weight loss, those who were taking medicines including herbal medicines, those who were planning to become pregnant, breastfeeding, or pregnant, and those who were deemed unsuitable by a doctor were excluded. Seven people were randomly selected and divided into 10 groups. The 10 groups were allowed to use each of the 10 types of external preparations shown in Table 2. The period of use was 12 weeks, and each group took 2 g of the external preparation described in the example on the palm after bathing once a day, and rubbed it while massaging, and this was continued for 3 months. The waist and hip dimensions of the test subjects were measured before the start of the test and after the end of the test, and the average value of the waist change and hip change of 7 persons in each group was calculated and evaluated. In addition, as described above, the subjects were not allowed to change their daily lives such as eating habits, smoking amount and exercise, except that the external preparation was used every day on a regular basis. No one complained of any abnormal physical condition during the test period.
２−２−２．試験結果
各グループの試験前後の測定結果を表２に示す。
2-2-2. Test results Table 2 shows the measurement results before and after the test for each group.
ウエスト変化及びヒップ変化の平均値は、アフリカマンゴノキ抽出物単独（比較例９）の場合それぞれ０．３ｃｍ及び０．１ｃｍの減少、ヒバマタ抽出物単独（比較例１０）の場合それぞれ０．７ｃｍ及び０．８ｃｍの減少で、単独で使用した場合では変化は少ないものであった。 The average values of waist change and hip change were decreased by 0.3 cm and 0.1 cm for African mango tree extract alone (Comparative Example 9), 0.7 cm and 0.7 cm for Hibamata extract alone (Comparative Example 10), respectively. The decrease was 0.8 cm, and there was little change when used alone.
これに対し、アフリカマンゴノキ抽出物とヒバマタ抽出物を併用した場合、体重変化の
平均値は、実施例４では２．８ｃｍ及び２．９ｃｍ減少、実施例５では３．０ｃｍ及び２．５ｃｍ減少、実施例６では２．５ｃｍ及び２．７ｃｍ減少し、それぞれを単独で使用した場合と比較して、痩身効果が著しく向上していることが明らかとなった。
On the other hand, when the African mango tree extract and the rockweed extract were used in combination, the average values of body weight changes decreased by 2.8 cm and 2.9 cm in Example 4, and decreased by 3.0 cm and 2.5 cm in Example 5. In Example 6, the decrease was 2.5 cm and 2.7 cm, and it was clarified that the slimming effect was remarkably improved as compared with the case where each was used alone.
本発明の痩身用食品組成物及び痩身用外用剤組成物は、優れた痩身効果を発揮し、安全及び手軽に摂取、または使用することができるため、体重及び寸法の減少のための有効な手段を提供できる。 Since the slimming food composition and the external preparation for slimming of the present invention exert an excellent slimming effect and can be safely and easily ingested or used, they are effective means for reducing body weight and size. Can be provided.
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